Biomedicine & Pharmacotherapy最新文献

{"title":"Corrigendum to “Methyleugenol alleviates pulmonary vascular remodeling in rats with high-altitude pulmonary hypertension by improving pulmonary smooth muscle cell function” [Biomed. Pharmacother. 187 (2025) 118109]","authors":"Yang Yu , Yurong Wang , Ziqi Yang , Zhanqiang Li , Dianxiang Lu , Xingmei Nan","doi":"10.1016/j.biopha.2026.119202","DOIUrl":"10.1016/j.biopha.2026.119202","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119202"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Advanced implications of nanotechnology in disease control and environmental perspectives” [Biomed. Pharmacother. 158 (2023) 114172]","authors":"Partha Biswas , Shakil Ahmed Polash , Dipta Dey , Md. Abu Kaium , Aar Rafi Mahmud , Farhana Yasmin , Sumit Kumar Baral , Md. Aminul Islam , Tanjim Ishraq Rahaman , Asif Abdullah , Tanzila Ismail Ema , Dhrubo Ahmed Khan , Shabana Bibi , Hitesh Chopra , Mohamed Kamel , Agnieszka Najda , Maged M.A. Fouda , UmmeSalma M. Rehan , Mayyadah Mheidat , Rawidh Alsaidalani , Md. Nazmul Hasan","doi":"10.1016/j.biopha.2026.119204","DOIUrl":"10.1016/j.biopha.2026.119204","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119204"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"Stress-driven discovery in the natural products: A gateway towards new drugs\" [Biomedicine & Pharmacotherapy 109 (2019) 459-467]","authors":"Syed Shams ul Hassan , Hui-zi Jin , Tareq Abu-Izneid , Abdur Rauf , Muhammad Ishaq , Hafiz Ansar Rasul Suleria","doi":"10.1016/j.biopha.2026.119149","DOIUrl":"10.1016/j.biopha.2026.119149","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119149"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146777013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"Electroacupuncture facilitates M2 macrophage polarization and its potential role in the regulation of inflammatory response\" [Biomedicine & Pharmacotherapy 140 (2021) 111655]","authors":"Huai-Fu Wang , Li Chen , Ya Xie , Xiao-Fang Wang , Kun Yang , Ying Ning , Jia-Yue He , Wei-Jun Ding","doi":"10.1016/j.biopha.2026.119207","DOIUrl":"10.1016/j.biopha.2026.119207","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119207"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"Protective role of Pleurotus florida against streptozotocin-induced hyperglycemia in rats: A preclinical study\" [Biomedicine & Pharmacotherapy 170 (2024) 116005]","authors":"Venkata Krishna Karempudi , Tamilselvan Amutha Gokul , Kamatchi Ramesh Kumar , Veeramani Veeramanikandan , Daoud Ali , Federica Impellitteri , Caterina Faggio , Hammad Ullah , Maria Daglia , Paulraj Balaji","doi":"10.1016/j.biopha.2026.119208","DOIUrl":"10.1016/j.biopha.2026.119208","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119208"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Volatile anesthetics sevoflurane targets leukemia stem/progenitor cells via Wnt/β-catenin inhibition” [Biomed. Pharmacother. 107 (2018), 1294–1301]","authors":"Xuguang Ruan , Weihang Jiang , Pingrui Cheng , Lingyan Huang , Xuelan Li , Yingyi He , Minyi Mai , Zhimin Tan","doi":"10.1016/j.biopha.2026.119107","DOIUrl":"10.1016/j.biopha.2026.119107","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119107"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"Yap-Hippo promotes A549 lung cancer cell death via modulating MIEF1-related mitochondrial stress and activating JNK pathway\" [Biomedicine & Pharmacotherapy 113 (2019) 108754]","authors":"Jiayu Zhou , Shizhen Zhang , Zhijun Li , Zhoumiao Chen , Yong Xu , Weiwen Ye , Zhengfu He","doi":"10.1016/j.biopha.2026.119214","DOIUrl":"10.1016/j.biopha.2026.119214","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119214"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of CDK12/CDK13 and development of inhibitors and degraders","authors":"Zixin Li ,&nbsp;Yankun Ke ,&nbsp;Rui Zhang,&nbsp;Ruya Zhang,&nbsp;Longlong Zhang","doi":"10.1016/j.biopha.2026.119077","DOIUrl":"10.1016/j.biopha.2026.119077","url":null,"abstract":"<div><div>Cancer poses a significant threat to human health and lifespan and remains a persistent focus of biomedical research. Cyclin–dependent kinases 12 and 13 (CDK12/13) serve as crucial regulators of transcript elongation, the DNA damage response (DDR), and the maintenance of genomic stability. The selective inhibition of these kinases is highly effective in cancer therapy. This study systematically reviews the current landscape of the development of CDK12/13 inhibitors and degraders, elucidating their roles in various tumor types, with a particular emphasis on the applications in breast cancer. The advancement of CDK12/13–targeted therapeutics represents a convergence of fields and produces proven clinical benefits in oncology, pharmacology, and related disciplines. Consequently, elucidating the therapeutic mechanisms of CDK12/13 inhibition has significant translational value for precision oncology. In addition, through bioinformatics techniques, we identified new candidate targets for CDK12/13, contributing to the enrichment of the regulatory network of CDK12/13.</div></div>","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"196 ","pages":"Article 119077"},"PeriodicalIF":7.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folate receptor 1 activation suppresses high glucose-induced amyloidogenesis in neurons via STAT3/Nrf2 pathway-dependent mitigation of mitochondrial oxidative stress","authors":"Dae Hyun Kim ,&nbsp;Hyo Youn Jo ,&nbsp;Yeon Ju Oh ,&nbsp;Jae Ryong Lim ,&nbsp;Chang Woo Chae ,&nbsp;Young Hyun Jung ,&nbsp;Ho Jae Han ,&nbsp;Hyun Jik Lee","doi":"10.1016/j.biopha.2026.119074","DOIUrl":"10.1016/j.biopha.2026.119074","url":null,"abstract":"<div><div>Diabetes is a major risk factor for diabetic encephalopathy (DE), which is closely associated with sporadic Alzheimer’s disease. Folic acid (FA) receptor signaling can suppress generation of neuropathogenic amyloid-beta (Aβ) induced by high extracellular glucose, suggesting that enhanced activation of this pathway could be a therapeutic strategy against DE-associated dementia, but the precise molecular signaling mechanisms are unclear. We report that high glucose levels increased the expression of amyloid precursor protein (APP) and β-secretase (BACE1) in cultured neurons and concomitantly induced amyloidogenesis, while FA treatment suppressed high glucose-stimulated expression of APP and BACE1, Aβ release, and accumulation of mitochondrial reactive oxygen species. Expression of nuclear factor erythroid 2-related factor 2 (Nrf2) was minimal under high glucose conditions, but was significantly upregulated together with downstream antioxidant enzymes following FA co-treatment. High glucose stimulation also increased folate receptor 1 (FOLR1) mRNA expression, suggesting a compensatory protective response. While treatment with 5-methyltetrahydrofolate (5-MTHF), the activated form of folate, did not significantly alter high glucose-induced upregulation of APP and BACE1, knockdown of <em>FOLR1</em> mRNA reduced high glucose-stimulated Nrf2 expression and further augmented APP and BACE1 expression under high glucose conditions. Treatment with the STAT3 inhibitor 5′15-DPP also abolished high glucose-stimulated Nrf2 expression and increased APP and BACE1 expression levels. These findings indicate that FA/FOLR1 activation suppresses high glucose-induced amyloidogenesis by mitigating mitochondrial oxidative stress via STAT3/Nrf2 pathway signaling. In conclusion, present study suggests that the FA/FOLR1/STAT3/Nrf2 pathway is an effective therapeutic target for DE.</div></div>","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"196 ","pages":"Article 119074"},"PeriodicalIF":7.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Diacerein protects liver against APAP-induced injury via targeting JNK and inhibiting JNK-mediated oxidative stress and apoptosis” [Biomed. Pharmacother. 149(2022) 112917]","authors":"Mengyang Wang ,&nbsp;Jinfeng Sun ,&nbsp;Tianxiang Yu ,&nbsp;Minxiu Wang ,&nbsp;Leiming Jin ,&nbsp;Shiqi Liang ,&nbsp;Wu Luo ,&nbsp;Yi Wang ,&nbsp;Gao Li ,&nbsp;Guang Liang","doi":"10.1016/j.biopha.2026.119088","DOIUrl":"10.1016/j.biopha.2026.119088","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"196 ","pages":"Article 119088"},"PeriodicalIF":7.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}