Advances in genomics and genetics最新文献_第2页

Core breast cancer-associated molecules: The Essence 核心乳腺癌相关分子:精华

Advances in genomics and genetics Pub Date : 2013-12-31 DOI: 10.14456/TJG.2013.144

P. Patmasiriwat

{"title":"Core breast cancer-associated molecules: The Essence","authors":"P. Patmasiriwat","doi":"10.14456/TJG.2013.144","DOIUrl":"https://doi.org/10.14456/TJG.2013.144","url":null,"abstract":"Various cellular factors in which their proliferative functions are inter-related (i.e., genes, proteins, miRNA) have been increasingly reported, both in normal cell and cancer. Increase in cellular proliferative rate in cancer is attributed to deregulation of mechanisms related to cell cycle, tumor suppressor and apoptotic control pathways. In this regard, there must be some error occurring within the functional molecules in one or more of these pathways. For instances, gene mutation or amplification, chromosome aberration, epigenetic change, abnormal increase or decrease of some miRNA or derangement of interacting proteins. In breast cancer, alike other cancers, cell cycle driving genes usually express at the level higher than normal and sometimes known as “proliferative or cancer signature” genes. Noteworthy, some cancer-associated genes express at a low level in cancer and are not recognized as the proliferative or cancer signature in spite of their obvious roles on tumorigenesis. The genes include those known to express for cell cycle inhibitors, intercellular adhesive molecules, proteins which function for DNA repairing and genome stability and molecules that contribute in apoptosis. This review gathers and concludes the roles of key molecules believed to be breast cancer associated to date. Cumulative knowledge of molecular cross-talking signals in normal mammary epithelium guides us to understand how deviated molecules and distorted regulations occur in breast cancer. In addition, no single molecule can provide full cellular proliferative function and this is also true in cancer. Hence, targeted therapy for cancer with highly specific inhibitor to such a single molecule expected to be the leading cancer actor is generally not guarantee of the therapeutic successful, and should be performed with careful consideration.","PeriodicalId":89652,"journal":{"name":"Advances in genomics and genetics","volume":"99 1","pages":"128-140"},"PeriodicalIF":0.0,"publicationDate":"2013-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75531460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association study of the MMP1 gene polymorphism with knee osteoarthritis in Thais by high resolution melting (HRM) analysis 通过高分辨率融化(HRM)分析研究泰国人MMP1基因多态性与膝骨关节炎的关系

Advances in genomics and genetics Pub Date : 2013-12-31 DOI: 10.14456/TJG.2013.115

Thitiya Poonpet, S. Honsawek, N. Tammachote, S. Kanitnate, R. Tammachote

{"title":"Association study of the MMP1 gene polymorphism with knee osteoarthritis in Thais by high resolution melting (HRM) analysis","authors":"Thitiya Poonpet, S. Honsawek, N. Tammachote, S. Kanitnate, R. Tammachote","doi":"10.14456/TJG.2013.115","DOIUrl":"https://doi.org/10.14456/TJG.2013.115","url":null,"abstract":"Osteoarthritis (OA) is the most common chronic joint disease in aging people. It is characterized by the degeneration and loss of the cartilage at the joint surface, accompanied by subchondral bone changes. Since the first characteristic of OA is the loss of collagen network, matrix metalloproteinases (MMPs) with collagenase activity are of interest as the possible cause of OA. The objective of this study was to investigate the association between a deletion SNP in MMP1 promoter (rs1799750; 1G/2G) and knee OA susceptibility in a Thai population. The study subjects consisted of 108 knee OA patients and 119 healthy controls. SNP genotyping was carried out by high resolution melting (HRM) analysis on the CFX96 TM real-time PCR system (Bio-Rad). The melt profiles from all DNA samples were processed by Precision Melt Analysis TM software. The allele frequencies (2G and 1G) and genotype distributions (2G/2G, 2G/1G and 1G/1G) were compared between patients and controls using the StatCalc program. The results showed that all genotypes are normally distributed, and the 2G allele is the major allele in this study population. No statistically significant association was found from all alleles and genotypes tested, both in the whole group and gender stratified groups. In conclusion, a SNP in the promoter of MMP1 was not associated with knee OA susceptibility in a Thai population.","PeriodicalId":89652,"journal":{"name":"Advances in genomics and genetics","volume":"23 1","pages":"181-192"},"PeriodicalIF":0.0,"publicationDate":"2013-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86830598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of gene based markers for mapping analysis in oil palm 油棕基因定位分析标记的开发

Advances in genomics and genetics Pub Date : 2013-12-31 DOI: 10.14456/TJG.2013.116

S. Jeennor

引用次数: 0

Sexing and genetic diversity in the genus Charadrius based on CHD gene 基于CHD基因的龙葵属植物性别及遗传多样性研究

Advances in genomics and genetics Pub Date : 2013-12-31 DOI: 10.14456/TJG.2013.114

S. Poeaim

{"title":"Sexing and genetic diversity in the genus Charadrius based on CHD gene","authors":"S. Poeaim","doi":"10.14456/TJG.2013.114","DOIUrl":"https://doi.org/10.14456/TJG.2013.114","url":null,"abstract":"Charadrius spp. are migratory shorebirds in Thailand during the non-breeding season inwhich adult plumages are not clearly sexually dimorphic. In this work, a molecular approach was used to determine the gender and genetic diversity. Amplification of intron length polymorphisms in chromo-helicase-DNA-binding ( CHD ) genes on both Z and W chromosomes of three Charadrius spp. included 87 lesser sand plover ( Charadrius mongolus ), 27 greater sand plover ( C. leschenaultii ) and 3 kentish plover ( C. alexandrinus ). The resulting PCR products from 2550F/2718R primer showed fragments on a conventional agarose gel electrophoresis with size differences ranging from 200 bp between the two respective ZW allele. Males were identified by the presence of a single band about 650 bp ( CHD-Z ). Heterogametic females were identified by the presence of a second additional fragment length of approximately 450 bp ( CHD-W ). The CHD-Z fragments were purified and analysed by sequencing. The multiple sequence comparison was accomplished using ClustalX and PHYLIP software. These data demonstrate that the CHD-Z sequence related with morphology and can be used for genetic diversity study. The results of molecular sex determination and genetic diversity analyses will also have implications for shorebird conservation.","PeriodicalId":89652,"journal":{"name":"Advances in genomics and genetics","volume":"159 1","pages":"141-149"},"PeriodicalIF":0.0,"publicationDate":"2013-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73277193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

การศึกษาคุณสมบัติของ Iduronate-2-Sulfatase ของผู้ป่วยคนไทยที่เป็นโรค Hunter: พยาธิกาเนิดทางชีวเคมีและโมเลกุล 泰国Hunter患者的iduronatt -2- sulfatase特点:生物化学和分子病理学

Advances in genomics and genetics Pub Date : 2013-10-12 DOI: 10.14456/TJG.2013.33

วรรัตน์ แช่มพัฒนชัย

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การตรวจการแสดงออกของยีน AFP, albumin, TGF-β1 และ Snail จากเลือดของ ผู้ป่วยมะเร็งตับชนิด hepatocellular carcinoma ด้วยวิธี real-time RT-PCR เพื่อใช้ เป็น molecular biomarkers: การศึกษาเบื้องต้น 通过重播-PCR法检测肝细胞癌患者的血液中f、albumin、tgf - 1和Snail的表达。以molecular biomarker为例:初步研究

Advances in genomics and genetics Pub Date : 2013-10-12 DOI: 10.14456/TJG.2013.84

ธีรยุทธ ปิ่นแก้ว

引用次数: 0

Multiplex PCR เหมาะสาหรับการศึกษาระบาดวิทยาของไรฝุ่น 多重PCRเหมาะสาหรับการศึกษาระบาดวิทยาของไรฝุ่น

Advances in genomics and genetics Pub Date : 2013-10-12 DOI: 10.14456/TJG.2013.16

ณัฐ มาลัยนวล

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การตรวจการกลายของยีน BRAF ในโรคมะเร็งต่อมไทรอยด์ 甲状腺癌中BRF基因突变的检测

Advances in genomics and genetics Pub Date : 2013-10-12 DOI: 10.14456/TJG.2013.82

อัญชลี ไหลพิริยกุล

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การตรวจหา markers ที่จาเพาะในมะเร็งท่อน้าดี: ผลการศึกษาเบื้องต้น 癌症靶向检测:初步研究

Advances in genomics and genetics Pub Date : 2013-10-12 DOI: 10.14456/TJG.2013.86

ณิชาพร วงศ์สิโรจน์กุล

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โครงสร้างบางส่วนของยีน cyp1a ในปลากะพงขาว (Lates calcarifer) 白鲈的一些基因结构。

Advances in genomics and genetics Pub Date : 2013-10-12 DOI: 10.14456/TJG.2013.45

วราลี งามดี

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