Wiley interdisciplinary reviews. Membrane transport and signaling最新文献

L-type Ca²⁺ channels in heart and brain. 心脏和大脑中的l型Ca2+通道。

Wiley interdisciplinary reviews. Membrane transport and signaling Pub Date : 2014-03-01 DOI: 10.1002/wmts.102

Jörg Striessnig, Alexandra Pinggera, Gurjot Kaur, Gabriella Bock, Petronel Tuluc

{"title":"L-type Ca2+ channels in heart and brain.","authors":"Jörg Striessnig, Alexandra Pinggera, Gurjot Kaur, Gabriella Bock, Petronel Tuluc","doi":"10.1002/wmts.102","DOIUrl":"https://doi.org/10.1002/wmts.102","url":null,"abstract":"L-type calcium channels (Cav1) represent one of the three major classes (Cav1-3) of voltage-gated calcium channels. They were identified as the target of clinically used calcium channel blockers (CCBs; so-called calcium antagonists) and were the first class accessible to biochemical characterization. Four of the 10 known α1 subunits (Cav1.1-Cav1.4) form the pore of L-type calcium channels (LTCCs) and contain the high-affinity drug-binding sites for dihydropyridines and other chemical classes of organic CCBs. In essentially all electrically excitable cells one or more of these LTCC isoforms is expressed, and therefore it is not surprising that many body functions including muscle, brain, endocrine, and sensory function depend on proper LTCC activity. Gene knockouts and inherited human diseases have allowed detailed insight into the physiological and pathophysiological role of these channels. Genome-wide association studies and analysis of human genomes are currently providing even more hints that even small changes of channel expression or activity may be associated with disease, such as psychiatric disease or cardiac arrhythmias. Therefore, it is important to understand the structure-function relationship of LTCC isoforms, their differential contribution to physiological function, as well as their fine-tuning by modulatory cellular processes.","PeriodicalId":89646,"journal":{"name":"Wiley interdisciplinary reviews. Membrane transport and signaling","volume":"3 2","pages":"15-38"},"PeriodicalIF":0.0,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wmts.102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32220207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 146

Regulation of high-voltage-activated Ca²⁺ channel function, trafficking, and membrane stability by auxiliary subunits. 辅助亚基对高压激活Ca2+通道功能、运输和膜稳定性的调节。

Wiley interdisciplinary reviews. Membrane transport and signaling Pub Date : 2013-09-01 DOI: 10.1002/wmts.93

Ricardo Felix, Aida Calderón-Rivera, Arturo Andrade

{"title":"Regulation of high-voltage-activated Ca2+ channel function, trafficking, and membrane stability by auxiliary subunits.","authors":"Ricardo Felix, Aida Calderón-Rivera, Arturo Andrade","doi":"10.1002/wmts.93","DOIUrl":"https://doi.org/10.1002/wmts.93","url":null,"abstract":"Voltage-gated Ca2+ (CaV) channels mediate Ca2+ ions influx into cells in response to depolarization of the plasma membrane. They are responsible for initiation of excitation-contraction and excitation-secretion coupling, and the Ca2+ that enters cells through this pathway is also important in the regulation of protein phosphorylation, gene transcription, and many other intracellular events. Initial electrophysiological studies divided CaV channels into low-voltage-activated (LVA) and high-voltage-activated (HVA) channels. The HVA CaV channels were further subdivided into L, N, P/Q, and R-types which are oligomeric protein complexes composed of an ion-conducting CaVα1 subunit and auxiliary CaVα2δ, CaVβ, and CaVγ subunits. The functional consequences of the auxiliary subunits include altered functional and pharmacological properties of the channels as well as increased current densities. The latter observation suggests an important role of the auxiliary subunits in membrane trafficking of the CaVα1 subunit. This includes the mechanisms by which CaV channels are targeted to the plasma membrane and to appropriate regions within a given cell. Likewise, the auxiliary subunits seem to participate in the mechanisms that remove CaV channels from the plasma membrane for recycling and/or degradation. Diverse studies have provided important clues to the molecular mechanisms involved in the regulation of CaV channels by the auxiliary subunits, and the roles that these proteins could possibly play in channel targeting and membrane Stabilization.","PeriodicalId":89646,"journal":{"name":"Wiley interdisciplinary reviews. Membrane transport and signaling","volume":"2 5","pages":"207-220"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wmts.93","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32442461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Proton channels in non-phagocytic cells of the immune system. 免疫系统非吞噬细胞中的质子通道。

Wiley interdisciplinary reviews. Membrane transport and signaling Pub Date : 2013-03-01 DOI: 10.1002/wmts.78

Melania Capasso

引用次数: 2

P2X receptor channels in endocrine glands. 内分泌腺的 P2X 受体通道

Wiley interdisciplinary reviews. Membrane transport and signaling Pub Date : 2013-01-01 DOI: 10.1002/wmts.89

Stanko S Stojilkovic, Hana Zemkova

{"title":"P2X receptor channels in endocrine glands.","authors":"Stanko S Stojilkovic, Hana Zemkova","doi":"10.1002/wmts.89","DOIUrl":"10.1002/wmts.89","url":null,"abstract":"The endocrine system is the system of ductless glands and single cells that synthetize hormones and release them directly into the bloodstream. Regulation of endocrine system is very complex and ATP and its degradable products ADP and adenosine contribute to its regulation acting as extracellular messengers for purinergic receptors. These include P2X receptors, a family of ligand-gated ion channels which expression and roles in endocrine tissues are reviewed here. There are seven mammalian purinergic receptor subunits, denoted P2X1 through P2X7, and the majority of these subunits are also expressed in secretory and non-secretory cells of endocrine system. Functional channels have been identified in the neuroendocrine hypothalamus, the posterior and anterior pituitary, the thyroid gland, the adrenals, the endocrine pancreas, the gonads and the placenta. Native channels are capable of promoting calcium influx through its pore in both excitable and non-excitable cells, as well as of increasing electrical activity in excitable cells by membrane depolarization. This leads to generation of calcium transients and stimulation of hormone release. The pattern of expression and action of P2XRs in endocrine system suggests that locally produced ATP amplifies and synchronizes the secretory responses of individual cells.","PeriodicalId":89646,"journal":{"name":"Wiley interdisciplinary reviews. Membrane transport and signaling","volume":"2 4","pages":"173-180"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780426/pdf/nihms474024.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31764427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gap junctions and Bystander Effects: Good Samaritans and executioners. 缝隙连接和旁观者效应:好心人和刽子手。

Wiley interdisciplinary reviews. Membrane transport and signaling Pub Date : 2013-01-01 Epub Date: 2012-12-11 DOI: 10.1002/wmts.72

David C Spray, Regina Hanstein, Sandra V Lopez-Quintero, Randy F Stout, Sylvia O Suadicani, Mia M Thi

引用次数: 56

Solute Carrier Family SLC41, what do we really know about it? 溶质载波系列SLC41，我们对它到底了解多少?

Wiley interdisciplinary reviews. Membrane transport and signaling Pub Date : 2013-01-01 DOI: 10.1002/wmts.95

Andrea Fleig, Monika Schweigel-Röntgen, Martin Kolisek

{"title":"Solute Carrier Family SLC41, what do we really know about it?","authors":"Andrea Fleig, Monika Schweigel-Röntgen, Martin Kolisek","doi":"10.1002/wmts.95","DOIUrl":"https://doi.org/10.1002/wmts.95","url":null,"abstract":"The 41st family of solute carriers (SLC41) comprises three members A1, A2 and A3, which are distantly homologous to bacterial Mg2+ channel MgtE. SLC41A1 was recently characterized as being an Na+/Mg2+ exchanger (NME; a predominant cellular Mg2+ efflux system). Little is known about the exact function of SLC41A2 and SLC41A3, although, these proteins have also been linked to Mg2+ transport in human (animal) cells. The molecular biology (including membrane topology, cellular localization, transcriptomics and proteomics) of SLC41A2 and SLC41A3 compared with SLC41A1 has only been poorly explored. Significantly more data with regard to function, functional regulation, involvement in cellular signalling, complex-forming ability, spectrum of binding partners and involvement in the pathophysiology of human diseases are available for SLC41A1. Three recent observations namely the identification of the null mutation, c.698G>T, in SLC41A1 underlying the nephronophthisis-like phenotype, the recognition of a putative link between SLC41A1 and Parkinson's disease, and the observation that nearly 55% of preeclamptic placental samples overexpress SLC41A1, marks the protein as a possible therapeutic target of these diseases. A potential role of the SLC41 family of Mg2+ transporters in the pathophysiology of human diseases is further substantiated by the finding that SLC41A3 knockout mice develop abnormal locomotor coordination.","PeriodicalId":89646,"journal":{"name":"Wiley interdisciplinary reviews. Membrane transport and signaling","volume":"2 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wmts.95","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31955866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Coupling of P2Y receptors to G proteins and other signaling pathways. P2Y受体与G蛋白和其他信号通路的偶联。

Wiley interdisciplinary reviews. Membrane transport and signaling Pub Date : 2012-11-01 DOI: 10.1002/wmts.62

Laurie Erb, Gary A Weisman

引用次数: 157

Molecular Structure of P2Y Receptors: Mutagenesis, Modeling, and Chemical Probes. P2Y 受体的分子结构：突变、建模和化学探针。

Wiley interdisciplinary reviews. Membrane transport and signaling Pub Date : 2012-09-12 DOI: 10.1002/wmts.68

Kenneth A Jacobson, M P Suresh Jayasekara, Stefano Costanzi

{"title":"Molecular Structure of P2Y Receptors: Mutagenesis, Modeling, and Chemical Probes.","authors":"Kenneth A Jacobson, M P Suresh Jayasekara, Stefano Costanzi","doi":"10.1002/wmts.68","DOIUrl":"10.1002/wmts.68","url":null,"abstract":"There are eight subtypes of P2Y receptors (P2YRs) that are activated, and in some cases inhibited, by a range of extracellular nucleotides. These nucleotides are ubiquitous, but their extracellular concentration can rise dramatically in response to hypoxia, ischemia, or mechanical stress, injury, and release through channels and from vesicles. Two subclasses of P2YRs were defined based on clustering of sequences, second messengers, and receptor sequence analysis. The numbering system for P2YR subtypes is discontinuous; i.e., P2Y(1-14)Rs have been defined, but six of the intermediate-numbered cloned receptor sequences (e.g., P2y(3), P2y(5), P2y(7-10)) are not functional mammalian nucleotide receptors. Of these two clusters, the P2Y(12-14) subtypes couple via Gα(i) to inhibit adenylate cyclase, while the remaining subtypes couple through Gα(q) to activate phospholipase C. Collectively, the P2YRs respond to both purine and pyrimidine nucleotides, in the form of 5'-mono- and dinucleotides and nucleoside-5'-diphosphosugars. In recent years, the medicinal chemistry of P2Y receptors has advanced significantly, to provide selective agonists and antagonists for many but not all of the subtypes. Ligand design has been aided by insights from structural probing using molecular modelling and mutagenesis. Currently, the molecular modelling of the receptors is effectively based on the X-ray structure of the CXCR4 receptor, which is the closest to the P2Y receptors among all the currently crystallized receptors in terms of sequence similarity. It is now a challenge to develop novel and selective P2YR ligands for disease treatment (although antagonists of the P2Y(12)R are already widely used as antithrombotics).","PeriodicalId":89646,"journal":{"name":"Wiley interdisciplinary reviews. Membrane transport and signaling","volume":"1 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547624/pdf/nihms405846.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31176727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A contribution to the history of the proton channel. 对质子通道历史的贡献。

Wiley interdisciplinary reviews. Membrane transport and signaling Pub Date : 2012-09-01 Epub Date: 2012-08-06 DOI: 10.1002/wmts.59

Robert Meech

{"title":"A contribution to the history of the proton channel.","authors":"Robert Meech","doi":"10.1002/wmts.59","DOIUrl":"10.1002/wmts.59","url":null,"abstract":"The low numbers of hydrogen ions in physiological solutions encouraged the assumption that H(+) currents flowing through conductive pathways would be so small as to be unmeasurable even if theoretically possible. Evidence for an H(+)-based action potential in the luminescent dinoflagellate Noctiluca and for an H(+)-conducting channel created by the secretions of the bacterium Bacillus brevis, did little to alter this perception. The clear demonstration of H(+) conduction in molluscan neurons might have provided the breakthrough but the new pathway was without an easily demonstrable function, and escaped general attention. Indeed the extreme measures that must be taken to successfully isolate H(+) currents meant that it was some years before proton channels were identified in mammalian cells. However, with the general availability of patch-clamp techniques and evidence for an important role in mammalian neutrophils, the stage was set for a series of structure/function studies with the potential to make the proton channel the best understood channel of all. In addition, widespread genomic searches have established that proton channels play important roles in processes ranging from fertilization of the human ovum to the progression of breast cancer. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.","PeriodicalId":89646,"journal":{"name":"Wiley interdisciplinary reviews. Membrane transport and signaling","volume":"1 5","pages":"533-557"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31200243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"mGlu Receptors in the Retina" - WIREs Membrane Transport and Signaling. "视网膜中的 mGlu 受体" - WIREs 膜传输与信号传导。

Wiley interdisciplinary reviews. Membrane transport and signaling Pub Date : 2012-09-01 DOI: 10.1002/wmts.43

Anuradha Dhingra, Noga Vardi

{"title":"\"mGlu Receptors in the Retina\" - WIREs Membrane Transport and Signaling.","authors":"Anuradha Dhingra, Noga Vardi","doi":"10.1002/wmts.43","DOIUrl":"10.1002/wmts.43","url":null,"abstract":"Glutamate, a key neurotransmitter in the vertebrate retina, acts via ionotropic and metabotropic receptors. Retina expresses mRNA for all metabotropic glutamate receptors and proteins for all but mGluR3. Every retinal cell class expresses one or more of these receptors. In general, these receptors are present presynaptically and serve to modulate synaptic transmission. While mGluRs on the photoreceptor terminal act as autoreceptors to titer glutamate levels, those on horizontal cell processes seem to shape the light response. Similarly, autoreceptors on bipolar axon terminals modulate glutamate release and the receptors on amacrine and ganglion cells modulate feedforward signals by modulating K+ or Ca2+ current to fine tune light responses. Since most of the mGluR sub-types are present in amacrine and ganglion cells that belong to many cell types, the pathways downstream of mGluRs are highly diverse with primarily modulatory effects. An exception to most mGluRs which have modulatory function is mGluR6 because it plays a key role in the feedforward transmission from photoreceptors to ON bipolar cells and is also required for the correct localization of the synaptic proteins in the dendritic tips. In humans, mutations in the gene encoding mGluR6 cause autosomal recessive night blindness. In addition, mGluRs appear to play a trophic role in development and after retinal damage, suggesting potential future therapeutic implications.","PeriodicalId":89646,"journal":{"name":"Wiley interdisciplinary reviews. Membrane transport and signaling","volume":"1 5","pages":"641-653"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755759/pdf/nihms479862.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31705773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0