Proceedings of the ... IEEE Conference on Nanotechnology. IEEE Conference on Nanotechnology最新文献

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Electrochemical Zero-Mode Waveguide Studies of Single Enzyme Reactions. 单酶反应的电化学零模波导研究。
Proceedings of the ... IEEE Conference on Nanotechnology. IEEE Conference on Nanotechnology Pub Date : 2018-07-01 Epub Date: 2019-01-28 DOI: 10.1109/nano.2018.8626402
Donghoon Han, Seung-Ryong Kwon, Kaiyu Fu, Garrison M Crouch, Paul W Bohn
{"title":"Electrochemical Zero-Mode Waveguide Studies of Single Enzyme Reactions.","authors":"Donghoon Han,&nbsp;Seung-Ryong Kwon,&nbsp;Kaiyu Fu,&nbsp;Garrison M Crouch,&nbsp;Paul W Bohn","doi":"10.1109/nano.2018.8626402","DOIUrl":"https://doi.org/10.1109/nano.2018.8626402","url":null,"abstract":"<p><p>Because electron transfer reactions are fundamental to life processes, such as respiration, vision, and energy catabolism, it is critically important to understand the relationship between functional states of individual redox enzymes and the macroscopically observed phenotype, which results from averaging over all copies of the same enzyme. To address this problem, we have developed a new technology, based on a bifunctional nanoelectrochemical-nanophotonic architecture - the electrochemical zero mode waveguide (E-ZMW) - that can couple biological electron transfer reactions to luminescence, making it possible to observe single electron transfer events in redox enzymes. Here we describe E-ZMW architectures capable of supporting potential-controlled redox reactions with single copies of the oxidoreductase enzyme, glutathione reductase, GR, and extend these capabilities to electron transfer events where reactive oxygen species are synthesized within the ~100 zL volume of the nanopore.</p>","PeriodicalId":89614,"journal":{"name":"Proceedings of the ... IEEE Conference on Nanotechnology. IEEE Conference on Nanotechnology","volume":"2018 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/nano.2018.8626402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38917531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrophoretic Mobility of Lipoprotein Nanoparticle Mimics. 脂蛋白纳米颗粒模拟物的电泳迁移率。
Min S Wang, Scott M Reed
{"title":"Electrophoretic Mobility of Lipoprotein Nanoparticle Mimics.","authors":"Min S Wang, Scott M Reed","doi":"10.1109/NANO.2011.6144448","DOIUrl":"10.1109/NANO.2011.6144448","url":null,"abstract":"<p><p>Lipoprotein particles (LPPs) are biological nanoparticles whose physiological roles are greatly influenced by their sizes. The four major classes of LP are: very low density lipoprotein, intermediate density lipoprotein, low density lipoprotein (LDL) and high density lipoprotein. Since the predominance of small, dense LDLs is associated with increased risk of coronary artery disease (CAD) and diabetes mellitus, LPP profiling can be used to predict metabolic risk factors. Highly tunable LPP mimics can be synthesized using nanoparticles to carefully control for size, lipid composition and surface charge to facilitate the study LPPs in CAD. Here, we engineered LPP mimics using gold nanoparticles between 10-50 nm in diameters. We measured the mobility and zeta potential of these LPP mimics and showed that each mimics have distinct electrokinetic properties and are electrostatically stable.</p>","PeriodicalId":89614,"journal":{"name":"Proceedings of the ... IEEE Conference on Nanotechnology. IEEE Conference on Nanotechnology","volume":" ","pages":"1652-1656"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307787/pdf/nihms352836.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30520039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testing in EHS: What is the Current Status of Experimentation? EHS测试:实验的现状是什么?
Donald R Baer, Ajay S Karakoti, Prabhakaran Munusamy, Brian D Thrall, Joel G Pounds, Justin G Teeguarden, James E Amonette, Galya Orr, Paul G Tratnyek, James T Nurmi
{"title":"Testing in EHS: What is the Current Status of Experimentation?","authors":"Donald R Baer,&nbsp;Ajay S Karakoti,&nbsp;Prabhakaran Munusamy,&nbsp;Brian D Thrall,&nbsp;Joel G Pounds,&nbsp;Justin G Teeguarden,&nbsp;James E Amonette,&nbsp;Galya Orr,&nbsp;Paul G Tratnyek,&nbsp;James T Nurmi","doi":"10.1109/NANO.2011.6144671","DOIUrl":"https://doi.org/10.1109/NANO.2011.6144671","url":null,"abstract":"<p><p>This paper explores some of the fundamental and practical issues related to the behavior of nanoparticles in the environment and their potential impacts on human health. In our research we have explored the reactive behaviors of nanoparticles with contaminants in the environment, how nanoparticle change in response to their environment and time, and how nanoparticles interact with biological systems of various types. It has become apparent that researchers often underestimate the difficulties of preparing and delivering well characterized nanoparticles for specific types of testing or applications. Difficulties arise in areas that range from not understanding what imparts the \"nano\" character of a particle to not knowing the impacts of minor species on the properties of high surface area materials. Some of our adventures and misadventures serve as examples of some of these issues as they relate to providing well defined particles for biological studies.</p>","PeriodicalId":89614,"journal":{"name":"Proceedings of the ... IEEE Conference on Nanotechnology. IEEE Conference on Nanotechnology","volume":" ","pages":"18-19"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/NANO.2011.6144671","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32439055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticles for Uveal Melanoma Treatment. 纳米粒子用于治疗葡萄膜黑色素瘤。
Proceedings of the ... IEEE Conference on Nanotechnology. IEEE Conference on Nanotechnology Pub Date : 2008-09-03 Epub Date: 2008-08-18 DOI: 10.1109/NANO.2008.245
Sheng Zhang, Jun Zhou, Zhibing Hu, Ashwin Nair, Liping Tang
{"title":"Nanoparticles for Uveal Melanoma Treatment.","authors":"Sheng Zhang, Jun Zhou, Zhibing Hu, Ashwin Nair, Liping Tang","doi":"10.1109/NANO.2008.245","DOIUrl":"10.1109/NANO.2008.245","url":null,"abstract":"<p><p>Chemotherapy is a common treatment for uveal melanoma. Rapid clearance of injected drug from the vitreous, necessitates repeated injections in to the eye. We have investigated the use of hydrogel particles to deliver chemotherapeutic drugs to the uveal melanoma site. Fluorescent dye-labeled nano- and micro-particles were injected intravenously into the animal. Particle accumulation in the uveal tissue was studied. The nanoparticles showed a much higher accumulation in the uveal tissue than the microparticles. The optimal particle size is between 100 and 300 nm. These particles could be decorated with targeting moieties and loaded with chemotherapeutic drugs to achieve sustained release at the cancerous site.</p>","PeriodicalId":89614,"journal":{"name":"Proceedings of the ... IEEE Conference on Nanotechnology. IEEE Conference on Nanotechnology","volume":"2008 ","pages":"822-825"},"PeriodicalIF":0.0,"publicationDate":"2008-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474326/pdf/nihms339295.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30992046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Quantum Dots for Enhanced Tumor Imaging. 新型量子点增强肿瘤成像。
Ashwin Nair, Jinhui Shen, Paul Thevenot, Tong Cai, Zhibing Hu, Liping Tang
{"title":"Novel Quantum Dots for Enhanced Tumor Imaging.","authors":"Ashwin Nair, Jinhui Shen, Paul Thevenot, Tong Cai, Zhibing Hu, Liping Tang","doi":"10.1109/NANO.2008.197","DOIUrl":"10.1109/NANO.2008.197","url":null,"abstract":"<p><p>So as to develop an effective tool for tumor imaging, we have embedded quantum dots (QD) in hydrogel nanoparticles. Their uptake in cancer cells has been studied in vitro and in a mice tumor model. Compared with QD alone, the QDs embedded in nanoparticles showed higher uptake in the tumor tissue. This novel conjugate can serve as a good imaging tool and also has the potential to serve as a carrier for drugs.</p>","PeriodicalId":89614,"journal":{"name":"Proceedings of the ... IEEE Conference on Nanotechnology. IEEE Conference on Nanotechnology","volume":"8 ","pages":"650-653"},"PeriodicalIF":0.0,"publicationDate":"2008-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261784/pdf/nihms339294.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30405415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic Nanoparticles to Enhance Cell Seeding and Distribution in Tissue Engineering Scaffolds. 磁性纳米颗粒增强细胞在组织工程支架中的播种和分布。
Paul Thevenot, Syed Sohaebuddin, Narayan Poudyal, J Ping Liu, Liping Tang
{"title":"Magnetic Nanoparticles to Enhance Cell Seeding and Distribution in Tissue Engineering Scaffolds.","authors":"Paul Thevenot, Syed Sohaebuddin, Narayan Poudyal, J Ping Liu, Liping Tang","doi":"10.1109/NANO.2008.196","DOIUrl":"10.1109/NANO.2008.196","url":null,"abstract":"<p><p>The success of tissue engineering scaffolds is intimately linked with the ability of the seeded cells to adequately distribute and proliferate within the scaffold matrix. In tissue engineering scaffolds, it is difficult to achieve adequate distribution due to the hydrophobic nature of most scaffold materials and poor initial distribution following scaffold seeding. In this study, we investigated the distribution of cells in PLGA salt-leached scaffolds after seeding with magnetic nanoparticle loaded cells with a neodymium magnet placed below. The combined use of magnetic nanoparticle seeded cells and magnetic force was able to not only increase the total number of scaffold adherent cells, but also increase the infiltration and distribution compared with controls. This method to control the distribution of cells may provide a method to increase the functionality of tissue engineering scaffolds.</p>","PeriodicalId":89614,"journal":{"name":"Proceedings of the ... IEEE Conference on Nanotechnology. IEEE Conference on Nanotechnology","volume":"2008 ","pages":"646-649"},"PeriodicalIF":0.0,"publicationDate":"2008-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279920/pdf/nihms339296.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30471849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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