Sameh A. Hashem , Iyad Sultan , Maysa Al-Hussaini , Feras Hawari , Sameer Yaser
{"title":"Pulmonary sarcoid-like reaction in metastatic synovial sarcoma","authors":"Sameh A. Hashem , Iyad Sultan , Maysa Al-Hussaini , Feras Hawari , Sameer Yaser","doi":"10.1016/j.rmedc.2010.01.004","DOIUrl":"https://doi.org/10.1016/j.rmedc.2010.01.004","url":null,"abstract":"<div><p>A 22-year-old female patient, with synovial sarcoma of the left thigh, was treated with marginal resection and adjuvant chemoradiotherapy. Two years later, she developed sub-pleural metastatic nodules that were resected. Follow-up chest CT-scans revealed small yet new left lower lobe sub-pleural nodules, which were observed closely. These lesions progressed over time and, 20 months later, the patient underwent pulmonary metastasectomy. Histopathology examination of the lung tissue showed changes consistent with a sarcoid-like reaction. There were no systemic manifestations of sarcoidosis. To date, there have been no reported cases of sarcoid-like reaction associated with synovial sarcoma. Reporting this case, therefore, may help to improve our overall understanding of the relationship between malignancy and sarcoid-like reactions in the lungs.</p></div>","PeriodicalId":89478,"journal":{"name":"Respiratory medicine CME","volume":"4 1","pages":"Pages 20-23"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedc.2010.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137091389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johannes Schulze, Ulrich Zissler, Martin Christmann, Martin Rosewich, Stefan Zielen
{"title":"Allergic bronchopulmonary aspergillosis (ABPA) an IgE mediated disease?","authors":"Johannes Schulze, Ulrich Zissler, Martin Christmann, Martin Rosewich, Stefan Zielen","doi":"10.1016/j.rmedc.2009.12.004","DOIUrl":"https://doi.org/10.1016/j.rmedc.2009.12.004","url":null,"abstract":"<div><p>This case is about a 6-year-old boy with cystic fibrosis (CF), suffering from allergic bronchopulmonary aspergillosis (ABPA) with total atelectasis of the left lung. To prove the hypothesis that IgE mediated disease is the major pathomechanism of ABPA, a bronchial provocation with <em>Aspergillus fumigatus</em> was performed before and after treatment with omalizumab (OMA). We could demonstrate for the first time that OMA completely suppresses the early allergic reaction (EAR) after bronchial allergen challenge with <em>Aspergillus</em>. Moreover, as has been shown by others, our patient showed a marked improvement of FEV<sub>1</sub> without a relapse after tapering systemic steroid treatment.</p></div>","PeriodicalId":89478,"journal":{"name":"Respiratory medicine CME","volume":"4 1","pages":"Pages 33-34"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedc.2009.12.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137091393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed M.A. Adlan , Simon E. Brill , Harman T. Saman , David J. Evans
{"title":"Misleading chest radiograph in a case of allergic bronchopulmonary aspergillosis","authors":"Ahmed M.A. Adlan , Simon E. Brill , Harman T. Saman , David J. Evans","doi":"10.1016/j.rmedc.2011.03.001","DOIUrl":"https://doi.org/10.1016/j.rmedc.2011.03.001","url":null,"abstract":"<div><p>We present a case of apparent convincing bilateral hilar lymphadenopathy on a chest radiograph, which on further investigation was found to be allergic bronchopulmonary aspergillosis with symmetrical bilateral apical lower lobe infiltrates. This case demonstrates the role of three-dimensional imaging for disorders of the hila and mediastinum, which are poorly delineated on plain radiography.</p></div>","PeriodicalId":89478,"journal":{"name":"Respiratory medicine CME","volume":"4 4","pages":"Pages 196-197"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedc.2011.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137225891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pneumomediastinum in interstitial lung disease-A case report","authors":"Nandita Nadig, Carey Thomson","doi":"10.1016/j.rmedc.2010.08.003","DOIUrl":"https://doi.org/10.1016/j.rmedc.2010.08.003","url":null,"abstract":"<div><p>Pneumomediastinum (PM) is a relatively rare disease and is defined as changes in pressure gradients within the thoracic cavity secondary to increases in intrathoracic pressure which ultimately leads to rupture of alveoli and dissection of air along the fascial planes of the tracheobronchial tree. PM differs from secondary pneumomediastinum in that the latter, by definition, requires a pathologic etiology. Although the presence of secondary pneumomediastinum on radiographic imaging may be the result of significantly serious events such as chest trauma, esophageal rupture, or infection with gas producing organisms, the natural history of PM tends to be benign and self-limiting, resolving over approximately one week. In this report we describe a case of a patient with underlying pulmonary fibrosis presenting with persistent dyspnea found to have pneumomediastinum on computed tomography (CT) that resolved completely over a 3 day period with the use of high concentration oxygen therapy.</p></div>","PeriodicalId":89478,"journal":{"name":"Respiratory medicine CME","volume":"4 2","pages":"Pages 79-80"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedc.2010.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137401431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bronchiolitis obliterans with organizing pneumonia associated with Aspergillus fumigatus","authors":"Cantürk Tasci , Metin Ozkan , Nuri Karadurmus , Ilkin Naharci , Mustafa Cakar , Mukerrem Safali , Bulent Karaman , Hayati Bilgic","doi":"10.1016/j.rmedc.2010.09.004","DOIUrl":"https://doi.org/10.1016/j.rmedc.2010.09.004","url":null,"abstract":"<div><p>Bronchiolitis obliterans organizing pneumonia (BOOP) was described in 1985 as a distinct entity, with different clinical, radiographic, and prognostic features than the airway disorder obliterative bronchiolitis and the interstitial fibrotic lung disorder usual interstitial pneumonia/idiopathic pulmonary fibrosis.</p><p>The BOOP pattern may be idiopathic or may occur secondary to some of the following clinical conditions: Idiopathic pulmonary fibrosis, Wegener granulomatosis; at the wall of lung abscesses, lymphomas, other neoplasms or after healing of infectious diseases. At these conditions, clinical symptoms are primarily due underlying disorders.</p><p>We presented a case of BOOP mimicking a malignant disorder and occurring after Aspergillus infection in a patient with chronic obstructive pulmonary disease.</p></div>","PeriodicalId":89478,"journal":{"name":"Respiratory medicine CME","volume":"4 2","pages":"Pages 64-66"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedc.2010.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137401425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multiple cystic echinococcosis mimicking metastatic malignancy","authors":"Yavuz Havlucu , Levent Ozdemir , Erkan Sahin","doi":"10.1016/j.rmedc.2009.09.018","DOIUrl":"https://doi.org/10.1016/j.rmedc.2009.09.018","url":null,"abstract":"<div><p>Cystic echinococcosis is seen worldwide. Considerable public health problems are encountered in endemic areas, such as South and Central America, the Middle East, sub-Saharan Africa, Russia, China, Australia and New Zealand. We have presented a case of innumerable cystic echinococcosis of lung and liver. The multiple lesions of cystic echinococcosis in chest X-ray graphy can imitate the metastatic malignancy of lung.</p></div>","PeriodicalId":89478,"journal":{"name":"Respiratory medicine CME","volume":"3 3","pages":"Pages 132-134"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedc.2009.09.018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91958476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pulmonary fibrosis predating microscopic polyangiitis by seven years","authors":"Angeliki M. Tsimogianni, Magda Stratiki, Grigoris Stratakos, Spyros Zakynthinos, Paraskeyi Katsaounou","doi":"10.1016/j.rmedc.2009.12.005","DOIUrl":"https://doi.org/10.1016/j.rmedc.2009.12.005","url":null,"abstract":"<div><p>A 63-year-old man, ex-smoker with renal failure of recent onset was admitted at the respiratory department with massive haemoptysis. Previous X-rays and CT scans showed pulmonary fibrosis of seven-year duration. Subsequently, he developed high fever, large haemoptysis, new infiltrates and respiratory failure despite broad-spectrum antibiotic treatment. Antineutrophilic antibodies of the perinuclear type with specificity against myeloperoxidase were detected and microscopic polyangiitis was diagnosed. Immunosuppressive treatment with methylprednisolone pulses and cyclophosphamide was started with initially favorable response, but later the patient developed a hospital-acquired pneumonia which was treated successfully with meropenem. As pulmonary haemorrhage recurred, he was transferred to intensive care for plasmapheresis which was considered the last treatment option. Unfortunately he died from septic shock.</p></div><div><h3>Conclusion</h3><p>Asymptomatic pulmonary fibrosis can predate microscopic polyangiitis by several years and is associated with unfavorable prognosis of the vasculitis. Appreciation of this finding would lead to faster diagnosis and better management of these patients.</p></div>","PeriodicalId":89478,"journal":{"name":"Respiratory medicine CME","volume":"3 4","pages":"Pages 207-210"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedc.2009.12.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137088177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Molassiotis , G. Bryan , A. Caress , C. Bailey , J. Smith
{"title":"Pharmacological and non-pharmacological interventions for cough in adults with respiratory and non-respiratory diseases: A systematic review of the literature","authors":"A. Molassiotis , G. Bryan , A. Caress , C. Bailey , J. Smith","doi":"10.1016/j.rmedc.2010.11.001","DOIUrl":"https://doi.org/10.1016/j.rmedc.2010.11.001","url":null,"abstract":"<div><p>The management of cough in adults with respiratory and non-respiratory illnesses is suboptimal and based mostly on clinical opinions rather than evidence. A systematic review was carried out assessing all trials in adult patients with respiratory and non-respiratory diseases (excluding cancer) that had chronic cough as primary or secondary outcome. A total of 1177 trials were retrieved and 75 met the criteria for inclusion in the review. The vast majority were in patients with asthma and chronic obstructive pulmonary disease (COPD). Cough was the primary outcome in less than one-quarter of the studies. The measurement of cough was variable, mostly using unvalidated scales or being part of an overall ‘symptoms’ score. Positive results were overall seen with the use of corticosteroids, leukotriene receptor antagonists, mast cell stabilizers, ipratropium bromide, neltenexine, iodinised glycerol and lidocaine. Speech pathology training and symptom monitoring through SMS messages (accompanied by treatment adjustments) have also shown promise. Evidence for established anti-tussive agents such as codeine was scarce, with positive studies from the 1960s, whilst more recent studies showed no effect in patients with COPD. Many studies had conflicting results. It is imperative that the management of cough and its evidence base be improved, using higher quality research designs and with cough being the primary outcome of trials.</p></div>","PeriodicalId":89478,"journal":{"name":"Respiratory medicine CME","volume":"3 4","pages":"Pages 199-206"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedc.2010.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137088178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Sverzellati , P. Spagnolo , S. Harari , M. De Filippo , M. Zompatori , C. Rossi
{"title":"Thoracic-abdominal MDCT: A one-stop-shop procedure for diagnosis of lymphangioleiomyomatosis","authors":"N. Sverzellati , P. Spagnolo , S. Harari , M. De Filippo , M. Zompatori , C. Rossi","doi":"10.1016/j.rmedc.2009.12.003","DOIUrl":"https://doi.org/10.1016/j.rmedc.2009.12.003","url":null,"abstract":"<div><p>A 62-year-old asymptomatic woman was referred for an abdominal multidetector CT (MDCT) scan to evaluate a renal angyomiolipoma. Upper MDCT images revealed multiple, bilateral pulmonary cystic lesion in the costo-phrenic sulci and a thin-section MDCT scan of the chest was consequently performed. Thin-section MDCT showed several thin-walled cysts uniformly distributed throughout the lung parenchyma consistent with lymphangioleiomyomatosis (LAM). This radiological approach secured a definite diagnosis of LAM, thus avoiding further invasive procedures.</p></div>","PeriodicalId":89478,"journal":{"name":"Respiratory medicine CME","volume":"3 4","pages":"Pages 218-219"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedc.2009.12.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137088180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tim Lahm , Helena N. Spartz , Dean A. Hawley , Diane S. Leland , Karen M. Wolf , Homer L. Twigg III , Michael D. Ober
{"title":"Fatal adenovirus serotype 21 infection associated with hemophagocytic lymphohistiocytosis and multiorgan failure","authors":"Tim Lahm , Helena N. Spartz , Dean A. Hawley , Diane S. Leland , Karen M. Wolf , Homer L. Twigg III , Michael D. Ober","doi":"10.1016/j.rmedc.2009.11.003","DOIUrl":"https://doi.org/10.1016/j.rmedc.2009.11.003","url":null,"abstract":"<div><p>Recent reports describe an increase in the incidence of fatal adenovirus infections. Several severe cases have been linked to adenovirus serotype 21. The exact etiology for this unexpectedly high mortality remains unknown. We report the case of a patient with severe adenovirus serotype 21 pneumonia resulting in hemophagocytic lymphohistiocytosis (HLH) with acute respiratory distress syndrome and rapidly progressive multiorgan dysfunction syndrome (MODS). HLH describes a cytokine storm due to uncontrolled accumulation of activated T-lymphocytes and activated histiocytes. This results in organ infiltration with these cells, and subsequent hemophagocytosis of erythrocytes, leukocytes and platelets. In its most severe form, HLH leads to a sepsis-like picture and MODS. The association between adenovirus 21 and HLH may at least in part explain the recently observed increase in incidence of fatal adenoviral infections. We suggest that HLH should be considered in cases of severe adenoviral infection. If HLH is present, aggressive treatment is warranted.</p></div>","PeriodicalId":89478,"journal":{"name":"Respiratory medicine CME","volume":"3 4","pages":"Pages 223-225"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmedc.2009.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137088182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}