Recent patents on endocrine, metabolic & immune drug discovery最新文献_第8页

Immunotherapy with dendritic cells as a cancer treatment: perspectives and therapeutic potential. 树突状细胞作为肿瘤治疗的免疫疗法:观点和治疗潜力。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2013-09-01 DOI: 10.2174/18722148113079990001

André A R Aleixo, Márcia A Michelin, Eddie F C Murta

引用次数: 5

Effect of fasting ramadan in diabetes control status - application of extensive diabetes education, serum creatinine with HbA1c statistical ANOVA and regression models to prevent hypoglycemia. 斋戒对糖尿病控制状况的影响——应用广泛的糖尿病教育、血清肌酐与HbA1c的统计方差分析和回归模型预防低血糖。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2013-09-01 DOI: 10.2174/18715303113139990010

Kamran M A Aziz

{"title":"Effect of fasting ramadan in diabetes control status - application of extensive diabetes education, serum creatinine with HbA1c statistical ANOVA and regression models to prevent hypoglycemia.","authors":"Kamran M A Aziz","doi":"10.2174/18715303113139990010","DOIUrl":"https://doi.org/10.2174/18715303113139990010","url":null,"abstract":"Ramadan fasting is an obligatory duty for Muslims. Unique physiologic and metabolic changes occur during fasting which requires adjustments of diabetes medications. Although challenging, successful fasting can be accomplished if pre-Ramadan extensive education is provided to the patients. Current research was conducted to study effective Ramadan fasting with different OHAs/insulins without significant risk of hypoglycemia in terms of HbA1c reductions after Ramadan. ANOVA model was used to assess HbA1c levels among different education statuses. Serum creatinine was used to measure renal functions. Pre-Ramadan diabetes education with alteration of therapy and dosage adjustments for OHAs/insulin was done. Regression models for HbA1c before Ramadan with FBS before sunset were also synthesized as a tool to prevent hypoglycemia and successful Ramadan fasting in future. Out of 1046 patients, 998 patients fasted successfully without any episodes of hypoglycemia. 48 patients (4.58%) experienced hypoglycemia. Χ(2) Test for CRD/CKD with hypoglycemia was also significant (p-value < 0.001). Significant associations and linear regression were found for HbA1c and sunset FBS; RBS post-dawn with RBS mid-day and FBS at sunset. The proposed regression models of this study can be used as a guide in future for Ramadan diabetes management. Some relevant patents are also outlined in this paper. ","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"7 3","pages":"233-51"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31673615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Effect of radio frequency waves of electromagnetic field on the tubulin. 电磁场射频波对微管蛋白的影响。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2013-09-01 DOI: 10.2174/18722148113079990007

Mousavi Taghi, Riazi Gholamhosein, Rezayi-Zarchi Saeed

引用次数: 8

Current research on how infertility affects the sexuality of men and women. 目前关于不孕如何影响男性和女性性行为的研究。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2013-09-01 DOI: 10.2174/18722148113079990009

Sany R Ferraresi, Lucia A S Lara, Marcos F S de Sá, Rosana M Reis, Ana C J S Rosa e Silva

引用次数: 25

The dual role of free fatty acid signaling in inflammation and therapeutics. 游离脂肪酸信号在炎症和治疗中的双重作用。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2013-09-01 DOI: 10.2174/18715303113139990041

Caroline M O Volpe, José A Nogueira-Machado

{"title":"The dual role of free fatty acid signaling in inflammation and therapeutics.","authors":"Caroline M O Volpe, José A Nogueira-Machado","doi":"10.2174/18715303113139990041","DOIUrl":"https://doi.org/10.2174/18715303113139990041","url":null,"abstract":"Obesity, type 2 diabetes, insulin resistance, dyslipidemia, cardiovascular diseases and atherosclerosis have all been associated with high levels of free fatty acid (FFA). In the present review, we suggest that FFA may act as either pro- or anti-inflammatory agents depending on the chemical structure. Saturated fatty acids (SFA) and polyunsaturated fatty acids (PUFA) significantly differ in their contributions to inflammation. While SFAs have been shown to induce inflammation, PUFAs have anti-inflammatory effects by downregulating NF-kappaB, IL-1β, TNF-α and IL-6 despite upregulating of IL-10. It is suggested that FFA may activate Toll Like Receptor-4 (TLR4) and G protein-coupled receptors (GPCR) activating signaling pathways that promote production and release of inflammatory cytokines (IL-6 and TFN-α). Fatty acid action on TLR4, peroxisome proliferator-activated receptors (PPARs) and GPCRs are potential therapeutic targets for controlling FFA-induced inflammation. Approaches that downregulate the inflammatory properties of free fatty acid are discussed in this manuscript. In this review, some patents associated with controlling FFA effects are also reported. ","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"7 3","pages":"189-97"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31626743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Role of mitochondrial translocator protein (18 kDa) on mitochondrial- related cell death processes. 线粒体转位蛋白(18kda)在线粒体相关细胞死亡过程中的作用。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2013-05-01 DOI: 10.2174/1872214811307020002

Beatriz Caballero, Leo Veenman, Moshe Gavish

{"title":"Role of mitochondrial translocator protein (18 kDa) on mitochondrial- related cell death processes.","authors":"Beatriz Caballero, Leo Veenman, Moshe Gavish","doi":"10.2174/1872214811307020002","DOIUrl":"https://doi.org/10.2174/1872214811307020002","url":null,"abstract":"The 18 kDa translocator protein (TSPO) is able to modulate several mitochondria-related cell death processes due to close association with proteins and other molecules involved to the mitochondrial permeability transition pore. In this way, herein we review cell death mechanisms targeting mitochondria, including programmed cell death type I, II and III. Several proteins involved in these cell death processes and with a possible interplay with the TSPO are also discussed including the voltage dependent anion channel, the adenine nucleotide transporter, cardiolipin, and the Bcl-2 family proteins. Noteworthy, TSPO has been also implicated in various other functions including mitochondrial respiration, immune and phagocytic host-defense response, microglial activation, inflammation, cell growth and differentiation, cancer, cell proliferation, ischemia, and mental and neuropathological disorders. We focused in recent studies of the TSPO particularly on cancer and neurodegeneration, thus presenting the TSPO as a core element in the role of mitochondria in diseases and related processes. Clinical benefit may be attainable by increasing pharmacological knowledge related to the TSPO. Recent patents typically relate to diagnosis and treatment of TSPO-related pathological conditions including cancer, and inflammatory conditions, as well as disorders associated with central nervous system, such as neurodegeneration, convulsions, anxiety, mental disorders, and dementia.","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"7 2","pages":"86-101"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31294135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Patents on enhancing the potency and longevity of highly valuable protein hormones. 提高高价值蛋白质激素效力和寿命的专利。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2013-05-01 DOI: 10.2174/1872214811307020008

Fuad Fares, Eyal Fima, Avri Havron

{"title":"Patents on enhancing the potency and longevity of highly valuable protein hormones.","authors":"Fuad Fares, Eyal Fima, Avri Havron","doi":"10.2174/1872214811307020008","DOIUrl":"https://doi.org/10.2174/1872214811307020008","url":null,"abstract":"One major issue regarding the clinical use of many peptides is their short half-life span in the body, due to the rapid clearance from the circulation. Thus, at the clinical level, there is a need for a regime of frequent injections of the peptides into the patients to overcome this low stability factor. The major strategies for overcoming this problem by pharmaceutical companies are based on chemical techniques and using specific peptidase inhibitors or cocktails. For this purpose, the cassette gene contains the sequence of the carboxyl-terminal peptide (CTP) of human chorionic gonadotropin β subunit which was ligated to the coding sequence of follitropin (FSH), erythropoietin (EPO), growth hormone (GH) and thus to increase the longevity and bioactivity of these proteins in vivo. Interestingly, FSH-CTP and GH-CTP were found to be not immunogenic in humans. FSH-CTP was approved by The European Commission. In addition, GH-CTP is not toxic and it passed successfully clinical trials Phase II in adults. Thus, using this technology seems to be promising in designing long acting peptides. Development of long acting peptides will diminish the cost of these drugs and perhaps reduce the number of injections in the clinical protocols. The article also summarizes some relevant patents.","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"7 2","pages":"148-54"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31316252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Role of mitochondria on muscle cell death and meat tenderization. 线粒体在肌肉细胞死亡和肉嫩化中的作用。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2013-05-01 DOI: 10.2174/1872214811307020005

Verónica Sierra, Mamen Oliván

{"title":"Role of mitochondria on muscle cell death and meat tenderization.","authors":"Verónica Sierra, Mamen Oliván","doi":"10.2174/1872214811307020005","DOIUrl":"https://doi.org/10.2174/1872214811307020005","url":null,"abstract":"The possibility that mitochondria are involved in cellular dysfunction is particularly high in situations associated with increases in free radical activity, like hypoxia or ischemia; therefore its potential role in the muscle post-mortem metabolism is reviewed. In the dying muscle, different routes of cell death catabolism (apoptosis, autophagy) may occur having great influence on the process of conversion of muscle into meat. Mitochondria are the first and also one of the main organelles affected by post-mortem changes; therefore they are decisive in the subsequent cellular responses influencing the pathway to cell demise and thus, the final meat quality. Depending on the cell death programme followed by muscle cells after exsanguination, diverse proteases would be activated to a different extent, which is also reviewed in order to understand how they affect meat tenderization. This review also summarizes recent patents relating cell death processes and meat tenderness. Further research is encouraged as there is still a need of knowledge on cell death post-mortem processes to increase our understanding of the conversion of muscle into meat.","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"7 2","pages":"120-9"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31349002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Galectin-9 in cancer therapy. 半凝集素-9在癌症治疗中的作用。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2013-05-01 DOI: 10.2174/1872214811307020006

Shintaro Fujihara, Hirohito Mori, Hideki Kobara, Kazi Rafiq, Toshiro Niki, Mitsuomi Hirashima, Tsutomu Masaki

{"title":"Galectin-9 in cancer therapy.","authors":"Shintaro Fujihara, Hirohito Mori, Hideki Kobara, Kazi Rafiq, Toshiro Niki, Mitsuomi Hirashima, Tsutomu Masaki","doi":"10.2174/1872214811307020006","DOIUrl":"https://doi.org/10.2174/1872214811307020006","url":null,"abstract":"Galectin-9 is a tandem-repeat type galectin with two carbohydrate-recognition domains, and it was first identified as an eosinophil chemoattractant and activation factor. Subsequent studies revealed that galectin-9, similar to other galectins, modulates a variety of biological functions including cell aggregation and adhesion, as well as apoptosis of tumor cells. Galectin-9 has recently been shown to have an anti-proliferative effect on cancer cells. Recent studies have uncovered additional mechanisms by which T cell immunoglobulin mucin-3 (Tim-3), a receptor for galectin-9, negatively regulates T cell responses by promoting CD8+ T cell exhaustion and inducing expansion of myeloid-derived suppressor cells. These mechanisms are involved in tumor growth and escape from immunity. In many solid cancers, the loss of galectin-9 expression is closely associated with metastatic progression, and treatment with recombinant galectin-9 prevents metastatic spread in various preclinical cancer models. Here, we review the biology and physiological role of galectin-9, and discuss the therapeutic potential of galectin-9 in cancer as well as relevant patents.","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"7 2","pages":"130-7"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31323404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Mitochondria in cancer stem cells: a target for therapy. 癌症干细胞中的线粒体:治疗的靶标。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2013-05-01 DOI: 10.2174/18722148113079990006

Rute Loureiro, Katia A Mesquita, Paulo J Oliveira, Ignacio Vega-Naredo

引用次数: 49