Recent patents on endocrine, metabolic & immune drug discovery最新文献_第5页

New Approaches on Leishmaniasis Treatment and Prevention: A Review of Recent Patents. 治疗和预防利什曼病的新途径:近期专利综述。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1872214809666150921111956

Juliana F Barbosa, Sônia M de Figueiredo, Fabricio M Monteiro, Fabiana Rocha-Silva, Cidiane Gaciele-Melo, Sabrina S C Coelho, Sandra Lyon, Rachel B Caligiorne

{"title":"New Approaches on Leishmaniasis Treatment and Prevention: A Review of Recent Patents.","authors":"Juliana F Barbosa, Sônia M de Figueiredo, Fabricio M Monteiro, Fabiana Rocha-Silva, Cidiane Gaciele-Melo, Sabrina S C Coelho, Sandra Lyon, Rachel B Caligiorne","doi":"10.2174/1872214809666150921111956","DOIUrl":"https://doi.org/10.2174/1872214809666150921111956","url":null,"abstract":"Leishmaniasis is considered a neglected tropical disease having a worldwide distribution. The disease is caused by protozoa belonging to the genus Leishmania, being clinically divided into visceral leishmaniasis (VL), cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL). Domestic dogs are the main parasite reservoir and effectively participate in the protozoa transmission. The human leishmaniasis treatment is based on a selection of therapeutic compounds, but the available drugs are toxic, presenting adverse side effects. The decision to treat or not to treat seropositive dogs is under discussion in some countries, because treatment is even more toxic to animals and, also, can generate drug resistant strains. Therefore, very few treatment choices have reached the clinic for this disease and there is an urgent need of new chemotherapy for both humans and animals. This study presents a review of new patents related to treatment and prevention of Leishmania infections. Some of these patents are related to new vaccine formulations for combating leishmaniasis. Likewise, the inventions related to the cream formulations for the treatment of cutaneous leishmaniasis are very important, avoiding the side effects of drugs during the treatment. Furthermore, anti leishmaniasis products that are extracted from nature has increasingly been patented each year, demonstrating the importance of bioprospection studies to improve the armamentarium of anti leishmaniasis drugs. ","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"9 2","pages":"90-102"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34022932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Is Innate Immunity and Inflammasomes Involved in Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)? 先天免疫和炎性小体参与肌萎缩性侧索硬化症(ALS)的发病机制吗?

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1872214809666150407111420

Caroline M O Volpe, Jose A Nogueira-Machado

{"title":"Is Innate Immunity and Inflammasomes Involved in Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)?","authors":"Caroline M O Volpe, Jose A Nogueira-Machado","doi":"10.2174/1872214809666150407111420","DOIUrl":"https://doi.org/10.2174/1872214809666150407111420","url":null,"abstract":"Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's disease is an axonopathy with adultonset, progressive and irreversible degeneration of upper and lower motor neurons. Around 90% of ALS is considered as sporadic ALS (sALS) without apparent genetic cause while in the familial type of ALS (fALS) at least one affected blood relative needs to be identified. Both sALS and fALS show similar progression and pathological profile. Biochemical and immunological roles have been reported for both types of ALS. It has been suggested that mutation in SOD1 gene would be responsible for the oxidative stress and neurotoxicity. Besides, oxidative stress, protein aggregation, altered cholinergic synapse, neuro-inflammation and production of pro-inflammatory cytokines have also been reported. Thus, the focus of the present review was on biochemical and immunological biomarkers and pathogenic mechanism. Regulatory T cells, pro-inflammatory cytokines and activation of pro-inflammatory signaling pathway are discussed. The activation of NRL inflammasomes in ALS and the involvement of IL-18, IL-1β and caspases-1 are also suggested. The presence and importance of HMGB-1 (DAMP) and activation of Tolllike receptors and/or RAGE also are envisaged. The patents US20140212508, WO2014145776, WO2014145118, US20140255371, US20140194427, US20140243400, WO2014128254, WO2014076702, WO2014071449, WO2014043696, WO2014001742, and WO2013082299 are summarized. This review intends to evaluate the biochemical and immunological responses and the involvement of inflammasomes in the pathogenesis of ALS. In the present review, we suggest hypothetical model for ALS pathogenesis and we discuss some patents that suggest new treatment and/or therapeutic targets. Due to a large number of patents covering therapy and control of neurodegenerative diseases, our focus was restricted only to discuss the latest registered patents in 2014.","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"9 1","pages":"40-5"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1872214809666150407111420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33192032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Effect of infertility on the sexual function of couples: state of the art. 不孕对夫妻性功能的影响:最新进展。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1872214809666150416151811

Lucia A Lara, Priscilla B Salomao, Adriana P M S Romao, Rosana M Reis, Paula A Navarro, Ana Carolina J S Rosa-e-Silva, Rui A Ferriani

{"title":"Effect of infertility on the sexual function of couples: state of the art.","authors":"Lucia A Lara, Priscilla B Salomao, Adriana P M S Romao, Rosana M Reis, Paula A Navarro, Ana Carolina J S Rosa-e-Silva, Rui A Ferriani","doi":"10.2174/1872214809666150416151811","DOIUrl":"https://doi.org/10.2174/1872214809666150416151811","url":null,"abstract":"Objective: Assess the state of the art on the relationship between infertility and the sexual function of couples.Data sources: The PubMed, Lilacs, and Google Scholar databases were searched for articles that assessed the sexual function of infertile couples (IC). Recent patents on this subject were assessed.Study selection: Quantitative studies published in the English language (case-control, cross-sectional, cohort, multicenter, observational studies, randomized controlled trials, meta-analyses, systematic reviews) that used structured and semi-structured questionnaires for quantitative assessment of the sexual function of infertile couples were identified using the search terms: \"infertile couple\" and \"sexuality\", \"sexual dysfunction\", \"sexual function\", \"sexual disorder\", \"hypoactive sexual desire\".Data extraction: One researcher identified 12 studies, and extracted data on 1871 IC. Five studies used different instruments to assess different aspects of sexual function and 7 studies assessed sexual function based on sub-domains of instruments used to evaluate marital relationships.Data synthesis: Incongruent results due to different objectives and methodologies, the lack of specific questionnaires to assess sexual function, and uncontrolled social and relationship variables that could have interfered with sexual function were evident in most studies.Conclusion: The lack of standardized methodology or validated tools in most studies prevents to establish the impact of infertility on the sexual function of IC.","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"9 1","pages":"46-53"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1872214809666150416151811","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33223037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Neurovascular complications of ovarian hyperstimulation syndrome (OHSS): from pathophysiology to recent treatment options. 卵巢过度刺激综合征(OHSS)的神经血管并发症:从病理生理学到最近的治疗选择。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2014-01-01 DOI: 10.2174/1872214808666140606142820

Rocco S Calabro, Giuseppe Gervasi, Antonino Leo, Rosaria De Luca, Tina Balletta, Carmela Casella, Onofrio Triolo, Placido Bramanti

{"title":"Neurovascular complications of ovarian hyperstimulation syndrome (OHSS): from pathophysiology to recent treatment options.","authors":"Rocco S Calabro, Giuseppe Gervasi, Antonino Leo, Rosaria De Luca, Tina Balletta, Carmela Casella, Onofrio Triolo, Placido Bramanti","doi":"10.2174/1872214808666140606142820","DOIUrl":"https://doi.org/10.2174/1872214808666140606142820","url":null,"abstract":"Ovarian hyperstimulation syndrome (OHSS) is a severe iatrogenic complication of ovulation induction, which has a very serious impact on the patient's health, as it is often associated with a high morbidity and mortality risk. Indeed, patients classified as having severe OHSS presented with liquid imbalance signs (such as rapid weight gain, tense ascites, respiratory difficulty and progressive oliguria), which are related to the fluid shift from the intravascular space to third space compartments subsequent to an increased capillary permeability. In this way, cardiovascular system findings include decreased intravascular volume, decreased blood pressure, decreased central venous perfusion, and compensatory increased heart rate and cardiac output with arterial vasodilation might be found concomitantly. Notwithstanding that venous thromboembolic phenomena are a possible complication in advanced phases of OHSS, arterial ischemia involving the cerebral circulation is a rare but recently reported problem. The pathogenesis of thromboembolism in OHSS is not fully understood, even though hemoconcentration and blood hyperviscosity seem to play a role in developing thrombotic changes into both venous and arterial system. Interestingly, the presence of cardiac abnormalities in combination with inherited or acquired hypercoagulable state seems to increase the risk of cerebral infarct in these subjects, as recently shown by our group. This review is aimed at investigating the pathomechanism and the management of neurovascular complications related to OHSS, including new treatment options. ","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"8 2","pages":"109-16"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32400746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Surfactant protein D in chornic obstructive pulmonary disease (COPD). 慢性阻塞性肺疾病(COPD)的表面活性蛋白D。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2014-01-01 DOI: 10.2174/1872214808666140209142640

Dolores Moreno, Alexis Garcia, Diego Lema, Juan B De Sanctis

引用次数: 7

Ultra-fast acting insulin analogues. 超速效胰岛素类似物。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2014-01-01 DOI: 10.2174/1872214808666140714112644

Sanjay Kalra, Yashdeep Gupta

引用次数: 13

Contribution of ALDH2 polymorphism to alcoholism-associated hypertension. ALDH2多态性对酒精相关性高血压的贡献

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2014-01-01 DOI: 10.2174/1872214808666141020162000

Nan Hu, Yingmei Zhang, Sreejayan Nair, Bruce W Culver, Jun Ren

{"title":"Contribution of ALDH2 polymorphism to alcoholism-associated hypertension.","authors":"Nan Hu, Yingmei Zhang, Sreejayan Nair, Bruce W Culver, Jun Ren","doi":"10.2174/1872214808666141020162000","DOIUrl":"https://doi.org/10.2174/1872214808666141020162000","url":null,"abstract":"Chronic alcohol intake is considered as an independent lifestyle factor that may influence the risk of a number of cardiovascular anomalies including hypertension. In healthy adults, binge drinking and chronic alcohol ingestion lead to the onset and development of hypertension although the precise mechanism(s) remains obscure. Although oxidative stress and endothelial injury have been postulated to play a major contributing role to alcoholism-induced hypertension, recent evidence depicted a rather unique role for the genotype of the acetaldehyde-metabolizing enzyme mitochondrial aldehyde dehydrogenase (ALDH2), which is mainly responsible for detoxifying ethanol consumed, in alcoholism-induced elevation of blood pressure. Genetic polymorphism of ALDH2 in human results in altered ethanol pharmacokinetic properties and ethanol metabolism, leading to accumulation of the ethanol metabolite acetaldehyde following alcohol intake. The unfavorable consequence of the ALDH2 variants is believed to be governed by the accumulation of the ethanol metabolite acetaldehyde. Presence of the mutant or inactive ALDH2*2 gene often results in an increased risk of hypertension in human. Such association between blood pressure and ALDH2 enzymatic activity may be affected by the interplay between gene and environment, such as life style and ethnicity. The aim of this mini-review is to summarize the possible contribution of ALDH2 genetic polymorphism in the onset and development of alcoholism-related development of hypertension. Furthermore, the double-edged sword of ALDH2 gene and genetic polymorphism in alcoholism and alcoholic tissue damage and relevant patents will be discussed. ","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"8 3","pages":"180-5"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32778547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Innovative models for the empowerment of patients with type 2 diabetes: the CAIPaDi program. 为2型糖尿病患者赋权的创新模式:CAIPaDi项目。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2014-01-01 DOI: 10.2174/1872214808999141110155515

Sergio Hernandez-Jimenez, Cristina Garcia-Ulloa, Roopa Mehta, Carlos A Aguilar-Salinas, David Kershenobich-Stalnikowitz

{"title":"Innovative models for the empowerment of patients with type 2 diabetes: the CAIPaDi program.","authors":"Sergio Hernandez-Jimenez, Cristina Garcia-Ulloa, Roopa Mehta, Carlos A Aguilar-Salinas, David Kershenobich-Stalnikowitz","doi":"10.2174/1872214808999141110155515","DOIUrl":"https://doi.org/10.2174/1872214808999141110155515","url":null,"abstract":"Empowerment interventions for chronic diseases are an evolving process. No agreement exists regarding the necessary components and methodologies to be applied. Systematic reviews have assessed the effect of self-management interventions. Improvements in illness beliefs, adherence to drug therapy and glucose monitoring have been reported. In the long term, no major changes have been achieved in weight, physical activity, smoking status, and depression scores. There is a need for additional studies. The CAIPaDi (Centro de Atención Integral del Paciente con Diabetes) program is an intervention designed to provide education and empowerment techniques (using simple low-cost interactive tools) over a short period of time followed by at-distance support using internet or cell phone technology. The target population consists of patients with type 2 diabetes, free of chronic complications who are non-smokers. The intervention is composed of four monthly visits followed by a continuous at-distance support system. At each visit, patients stay for six hours in the center. Information is presented in group sessions. Empowerment techniques are applied during individual exchanges with the team or during facilitated group sessions. In summary, empowerment programs are an unmet need in many healthcare services. This review also discusses relevant studies and patents in the management of type 2 diabetes. ","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"8 3","pages":"202-9"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32801893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Treatment of antipsychotic-induced hyperprolactinemia: an update on the role of the dopaminergic receptors D2 partial agonist aripiprazole. 抗精神病药诱导的高催乳素血症的治疗:多巴胺能受体D2部分激动剂阿立哌唑作用的最新进展。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2014-01-01 DOI: 10.2174/1872214807666131229125700

Domenico De Berardis, Michele Fornaro, Nicola Serroni, Stefano Marini, Monica Piersanti, Marilde Cavuto, Alessandro Valchera, Monica Mazza, Gabriella Girinelli, Felice Iasevoli, Giampaolo Perna, Giovanni Martinotti, Massimo Di Giannantonio

{"title":"Treatment of antipsychotic-induced hyperprolactinemia: an update on the role of the dopaminergic receptors D2 partial agonist aripiprazole.","authors":"Domenico De Berardis, Michele Fornaro, Nicola Serroni, Stefano Marini, Monica Piersanti, Marilde Cavuto, Alessandro Valchera, Monica Mazza, Gabriella Girinelli, Felice Iasevoli, Giampaolo Perna, Giovanni Martinotti, Massimo Di Giannantonio","doi":"10.2174/1872214807666131229125700","DOIUrl":"https://doi.org/10.2174/1872214807666131229125700","url":null,"abstract":"Hyperprolactinemia is an unwanted adverse effect present in several typical and atypical antipsychotics. Aripiprazole is a drug with partial agonist activity at the level of dopamine receptors D2, which may be effective for antipsychotic- induced hyperprolactinemia. Therefore, we analyzed the literature concerning the treatment of antipsychoticinduced hyperprolactinemia with aripiprazole by updating a previous paper written on the same topic. More recent studies were reviewed. They showed that there are two options for the treatment of antipsychotic-induced hyperprolactinemia with aripiprazole. The safest strategy may require the addition of aripiprazole to ongoing treatments, in the case patients had previously responded to antipsychotic drugs and then developed hyperprolactinemia. However, it is advisable to monitor the patients in case relapses and/or side effect, although rare, might occur. Switching drugs should be considered when a patient does not appear to be responding to the previous antipsychotic, thus developing hyperprolactinemia. A cross-taper switch should always be considered, but the risk of a relapse in the disorder may occur more frequently and the patients should be closely monitored. However, limitations must be considered and further studies are needed to definitely elucidate this important issue. Some relevant patents are also described in this review. ","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"8 1","pages":"30-7"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1872214807666131229125700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31984310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Immunomodulatory properties of green propolis. 绿色蜂胶的免疫调节特性。

Recent patents on endocrine, metabolic & immune drug discovery Pub Date : 2014-01-01 DOI: 10.2174/1872214808666140619115319

Sonia M de Figueiredo, Jose A Nogueira-Machado, Bruno de M Almeida, Sheila R L Abreu, Jose A S de Abreu, Sidney A V Filho, Nancy S Binda, Rachel B Caligiorne

{"title":"Immunomodulatory properties of green propolis.","authors":"Sonia M de Figueiredo, Jose A Nogueira-Machado, Bruno de M Almeida, Sheila R L Abreu, Jose A S de Abreu, Sidney A V Filho, Nancy S Binda, Rachel B Caligiorne","doi":"10.2174/1872214808666140619115319","DOIUrl":"https://doi.org/10.2174/1872214808666140619115319","url":null,"abstract":"Propolis is a resinous material collected by honeybees from numerous plants and serves as a defense against intruders. Because of its relevant curative properties, it is now gaining popularity in health foods and in cosmetic products. Understanding the underlying molecular mechanisms of phytochemicals has become a good strategy in bioprospection for new anti-inflammatory compounds. The biological activity of propolis derives from its high levels of phenolic acids, while flavonoids are thought to account for the activity of propolis extracts. The comprehension of the relationship between propolis and the immune system has progressed in the last years, recent articles have provided important contributions to this investigation field. Studies have shown that propolis suppressed the \"IL-6-induced phosphorylation of signal transducer and STAT3\", an essential cytokine-activated transcription factor in Th17 development. Therefore, action mechanisms of \"propolis on Th17 differentiation could be instrumental in controlling disturbed cytokine networks in inflammation, autoimmune diseases, and infections.\" The use of propolis has been proposed in some patents as: WO201363714; CN102885854, WO2013142936, US20130266521, and US20130129808, which are related to the treatment of dental diseases; adjuvant in anti-cancer treatment; in cosmetic products; as an anti-inflammatory agent and natural antibiotic. Although there are many publications regarding the propolis efficacy, its applicability to human health and mechanisms of action are not completely understood, creating opportunities for new studies. ","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"8 2","pages":"85-94"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32439587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24