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Journal of organ dysfunction最新文献

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Sepsis-associated myocardial dysfunction: from bedside to bench 脓毒症相关心肌功能障碍:从床边到实验台上
Journal of organ dysfunction Pub Date : 2009-07-11 DOI: 10.1080/17471060701200451
M. Maeder, P. Hunziker
{"title":"Sepsis-associated myocardial dysfunction: from bedside to bench","authors":"M. Maeder, P. Hunziker","doi":"10.1080/17471060701200451","DOIUrl":"https://doi.org/10.1080/17471060701200451","url":null,"abstract":"Although the hemodynamic profile of sepsis is characterized by a high cardiac output state, there is clear evidence of myocardial dysfunction in patients with severe sepsis and septic shock. Cardiac abnormalities in sepsis include various degrees of left ventricular systolic dysfunction, left ventricular diastolic dysfunction, and right ventricular dysfunction. Possible underlying mechanisms include direct negative inotropic effects of circulating depressant substances, altered G-protein coupling, myocardial β1-receptor desensitization, and cytopathic hypoxia due to microcirculatory and metabolic abnormalities of the cardiomyocytes. We discuss herein the conflicting findings of the heterogeneous studies conducted in this field and, based on clinical data and findings from experimental work, hypothesize on the underlying pathophysiology and the mechanisms of established and innovative therapies.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"18 1","pages":"79-90"},"PeriodicalIF":0.0,"publicationDate":"2009-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84588760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Cyclic adenosine monophosphate signaling and organ dysfunction in septic shock 脓毒性休克中单磷酸环腺苷信号传导与器官功能障碍
Journal of organ dysfunction Pub Date : 2009-07-11 DOI: 10.1080/17471060802549517
M. Dahle, P. Risøe, Jacob E. Wang, A. Aasen
{"title":"Cyclic adenosine monophosphate signaling and organ dysfunction in septic shock","authors":"M. Dahle, P. Risøe, Jacob E. Wang, A. Aasen","doi":"10.1080/17471060802549517","DOIUrl":"https://doi.org/10.1080/17471060802549517","url":null,"abstract":"Herein we review some of the existing knowledge on how the intracellular signaling mediator cyclic adenosine monophosphate (cAMP) regulates mechanisms involved in sepsis and septic shock, focusing on inflammation and hemodynamics. Elevating cAMP by inhibition of the cAMP-hydrolyzing phosphodiesterases has been reported to protect organ function in animal models of systemic inflammation and endotoxic shock and, likewise, increased survival from septic shock has been reported in mice deficient in specific cAMP phosphodiesterase isoforms. The cAMP signaling pathway modulates inflammation by attenuating proinflammatory cytokine release, neutrophil infiltration, degranulation and cytotoxic responses. cAMP also controls hemodynamics by regulating cardiovascular function, endothelial barrier function and platelet activation. There is a need to obtain a more detailed understanding of cAMP signaling, and to further evaluate the future potential of sepsis treatment targeting this pathway.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"9 1","pages":"38-50"},"PeriodicalIF":0.0,"publicationDate":"2009-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84470752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Application of proteomic techniques to human tissues 蛋白质组学技术在人体组织中的应用
Journal of organ dysfunction Pub Date : 2009-07-11 DOI: 10.1080/17471060701682203
Annely M. Richardson, J. Rodriguez-Canales, G. Gannot, S. Libutti, R. Chuaqui, M. Tangrea
{"title":"Application of proteomic techniques to human tissues","authors":"Annely M. Richardson, J. Rodriguez-Canales, G. Gannot, S. Libutti, R. Chuaqui, M. Tangrea","doi":"10.1080/17471060701682203","DOIUrl":"https://doi.org/10.1080/17471060701682203","url":null,"abstract":"Pathology has evolved over the past 30 years to incorporate molecular analysis of tissue samples for the assessment of disease states. With the advent of molecular pathology has come the development of new technologies to evaluate the tissue specimen at the molecular level. In this review, we will focus on proteomic analysis of human tissues. The importance of tissue preservation as well as the specific isolation of cell populations via microdissection will be addressed. In addition, the molecular evaluation of the tissue specimen with current proteomic techniques, including 2D polyacrylamide gel electrophoresis, Western blotting, protein arrays and mass spectrometry, will also be discussed. Finally, two new technologies will be introduced: direct tissue mass spectrometry and layered expression scanning. These new methods maintain the 2D architecture of the tissue throughout the proteomic analysis process, providing additional information that is typically lost with microdissected samples. The challenging...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"25 1","pages":"110-118"},"PeriodicalIF":0.0,"publicationDate":"2009-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84623412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Blood coagulation and inflammation in acute lung injury 急性肺损伤中的凝血和炎症
Journal of organ dysfunction Pub Date : 2009-07-11 DOI: 10.1080/17471060701388645
R. Ferrer, M. Adda, A. Navas, M. Pasini, A. Artigas
{"title":"Blood coagulation and inflammation in acute lung injury","authors":"R. Ferrer, M. Adda, A. Navas, M. Pasini, A. Artigas","doi":"10.1080/17471060701388645","DOIUrl":"https://doi.org/10.1080/17471060701388645","url":null,"abstract":"The acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are part of a devastating syndrome characterized by acute onset, hypoxemia and bilateral infiltrates on chest radiography. ALI/ARDS is the response of the lung to a local or systemic insult, resulting in local inflammation and coagulation disorders, which lead to increased inflammatory pulmonary edema. ARDS is a major cause of morbidity, death, and expense in intensive care units. ALI and ARDS are associated with increased procoagulant and reduced fibrinolytic activities, mainly in alveoli and in interstitial spaces in the lung. Fibrin deposition, which is the hallmark of early-phase ALI, stimulates fibroblast aggregation and collagen secretion, participating in the constitution of pulmonary fibrosis. Despite the significant progress in the understanding of the disease made over the past 10 years, the only clinical intervention found to have a significant impact on mortality in ARDS is the use of low tidal volume ventilation. In se...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"9 1","pages":"101-109"},"PeriodicalIF":0.0,"publicationDate":"2009-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75140516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Thyroid hormones and multiple organ dysfunction syndrome 甲状腺激素与多器官功能障碍综合征
Journal of organ dysfunction Pub Date : 2009-07-11 DOI: 10.1080/17471060802409720
R. Peeters, G. Berghe
{"title":"Thyroid hormones and multiple organ dysfunction syndrome","authors":"R. Peeters, G. Berghe","doi":"10.1080/17471060802409720","DOIUrl":"https://doi.org/10.1080/17471060802409720","url":null,"abstract":"Marked changes in thyroid hormone levels occur in critical illness and multiple organ dysfunction syndrome (MODS), with a decrease in the active hormone T3 and an increase in the inactive metabolite rT3. The magnitude of these changes is related to the severity of the disease. Studies addressing the thyrotropic axis in critical illness do not make a clear distinction between patients with and without MODS. However, a distinction can be made between the acute and the more chronic phase of critical illness, and it can be assumed that patients who require intensive care for several days will have some degree of MODS. This review therefore focuses on the thyroid axis in patients receiving intensive care for several days. The mechanisms behind the observed changes, the potential positive and/or negative effects of them and their possible therapeutic consequences will be discussed.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"4 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2009-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86258604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Toll-like receptors in the pathogenesis of inflammatory diseases toll样受体在炎症性疾病发病机制中的作用
Journal of organ dysfunction Pub Date : 2009-07-11 DOI: 10.1080/17471060701200410
J. K. Lee, D. Hwang, J. Lee
{"title":"Toll-like receptors in the pathogenesis of inflammatory diseases","authors":"J. K. Lee, D. Hwang, J. Lee","doi":"10.1080/17471060701200410","DOIUrl":"https://doi.org/10.1080/17471060701200410","url":null,"abstract":"Toll-like receptors (TLRs) are newly established immune receptors which are critical for host defense through the activation of both innate and adaptive immunity. TLRs can recognize molecules with both microbial and non-microbial origins. Emerging evidence now suggests that TLRs are implicated in the pathogenesis of many chronic diseases, including sepsis, atherosclerosis, ischemia/reperfusion-mediated organ dysfunction, rheumatoid arthritis, diabetes, and cancer. Therefore, an understanding of the role of TLRs in inducing chronic inflammation will provide new insights to help design an effective intervention strategy for inflammatory diseases.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"440 1","pages":"119-128"},"PeriodicalIF":0.0,"publicationDate":"2009-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76474683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Phosphodiesterase inhibition downregulates intestinal injury and inducible nitric oxide synthase activity after hemorrhagic shock 磷酸二酯酶抑制可下调失血性休克后肠道损伤和诱导型一氧化氮合酶活性
Journal of organ dysfunction Pub Date : 2009-07-11 DOI: 10.1080/17471060802516698
J. Deree, W. Loomis, James G. Putnam, P. Wolf, Todd W. Costantini, D. Hoyt, R. Coimbra
{"title":"Phosphodiesterase inhibition downregulates intestinal injury and inducible nitric oxide synthase activity after hemorrhagic shock","authors":"J. Deree, W. Loomis, James G. Putnam, P. Wolf, Todd W. Costantini, D. Hoyt, R. Coimbra","doi":"10.1080/17471060802516698","DOIUrl":"https://doi.org/10.1080/17471060802516698","url":null,"abstract":"Objective. Previous work suggests that supplementation of Ringer's lactate (RL) resuscitation with pentoxifylline (PTX) abrogates distant organ injury after hemorrhage. The aim of this work was to determine whether PTX can effectively attenuate resuscitation-induced intestinal injury and pro-inflammatory mediator production. Material and methods. Male Sprague–Dawley rats underwent 60 min of hypotension followed by resuscitation with RL or RL + PTX (25 mg/kg). The ileum was examined for injury. Nitric acid and pro-inflammatory cytokines were measured using an enzyme-linked immunosorbent assay. Inducible nitric oxide synthase (iNOS) and phosphorylation of nuclear factor (NF)-κB and signal transducer and activator of transcription (STAT)-3 were evaluated using Western blotting. Results. RL resuscitation led to a marked increase in all parameters over the control. The addition of PTX significantly reduced histologic injury and levels of iNOS, NO, tumor necrosis factor-α, interleukin-6, and cytokine-induced ne...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"1 1","pages":"51-58"},"PeriodicalIF":0.0,"publicationDate":"2009-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83753161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophage migration inhibitory factor and multiple organ dysfunction syndrome 巨噬细胞迁移抑制因子与多器官功能障碍综合征
Journal of organ dysfunction Pub Date : 2009-07-11 DOI: 10.1080/17471060802443653
S. Yende, D. Angus, R. Bucala
{"title":"Macrophage migration inhibitory factor and multiple organ dysfunction syndrome","authors":"S. Yende, D. Angus, R. Bucala","doi":"10.1080/17471060802443653","DOIUrl":"https://doi.org/10.1080/17471060802443653","url":null,"abstract":"During severe sepsis, organ dysfunction is an important predictor of poor outcomes. Animal and human studies suggest that macrophage migration inhibitory factor (MIF) plays a detrimental role in organ dysfunction in severe sepsis. However, MIF is a key mediator of the innate immune response and is necessary for resistance to certain infections. We provide a broad overview of the beneficial and detrimental effects of MIF in sepsis. The interplay between MIF and glucocorticoids, which may play a critical role in sepsis, is also examined.","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"73 1","pages":"10-16"},"PeriodicalIF":0.0,"publicationDate":"2009-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80467087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resuscitation volume and multiple organ dysfunction syndrome 复苏量与多器官功能障碍综合征
Journal of organ dysfunction Pub Date : 2009-07-11 DOI: 10.1080/17471060701324301
K. Asehnoune
{"title":"Resuscitation volume and multiple organ dysfunction syndrome","authors":"K. Asehnoune","doi":"10.1080/17471060701324301","DOIUrl":"https://doi.org/10.1080/17471060701324301","url":null,"abstract":"Patients with severe infections and major trauma often develop multiple organ dysfunction syndrome (MODS). Aggressive fluid resuscitation can be involved in such a process and several lines of evidence have demonstrated the detrimental effects of large crystalloid-based resuscitation strategies on MODS. Additionally, fluid-restrictive strategies have been associated with a decreased frequency of acute respiratory distress syndrome (and a shorter time to recover from it) and with trends toward a shorter length of hospital stay and lower mortality. Recent knowledge of the pathophysiology of septic shock and severe trauma indicates that a release of inflammatory mediators occurs early in the course of the disease. These mediators, especially pro-inflammatory cytokines as well as hypopituitary adrenal axis dysfunction, are involved in cardiac dysfunction and vasodilatation-induced hypotension. Taking into account this combination of severe inflammation and secondary changes in endocrine profile through an ear...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"1 1","pages":"91-100"},"PeriodicalIF":0.0,"publicationDate":"2009-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82490162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatic dysfunction after shock: Clinical parameters and biological pathways for therapeutic intervention 休克后肝功能障碍:治疗干预的临床参数和生物学途径
Journal of organ dysfunction Pub Date : 2009-07-11 DOI: 10.1080/17471060802449353
Roop Gill, T. Billiar
{"title":"Hepatic dysfunction after shock: Clinical parameters and biological pathways for therapeutic intervention","authors":"Roop Gill, T. Billiar","doi":"10.1080/17471060802449353","DOIUrl":"https://doi.org/10.1080/17471060802449353","url":null,"abstract":"The prevalence of hepatic dysfunction was thought to be ≈ 1% in intensive care unit (ICU) patients, but is now being recognized to be > 10%. Mortality and length of ICU stay are directly affected by hepatic dysfunction, raising the need for a better understanding of this disorder in order to develop therapeutic options that go beyond the current practice of supportive care. The etiologies of hypoxic hepatitis are discussed, together with their differentiating physiological parameters. The liver's compensatory mechanisms are examined at the level of the microcirculation. The cytokine milieu and cells responsible are considered. Survival versus cell death by means of necrosis, apoptosis, or autophagy is determined by the interplay of intracellular pathways. Specific pathways discussed involve reactive oxygen species, Toll-like receptor 4, heme oxygenase, transcription factors such as nuclear factor-κB, mitogen-activated protein kinase and protein kinase B. From this basis, current and future therapeutic str...","PeriodicalId":89424,"journal":{"name":"Journal of organ dysfunction","volume":"4 1","pages":"26-37"},"PeriodicalIF":0.0,"publicationDate":"2009-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78797982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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