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Use of averaged norbeck social support questionnaire scores. 使用平均诺贝克社会支持问卷得分。
ISRN nursing Pub Date : 2011-01-01 Epub Date: 2011-06-07 DOI: 10.5402/2011/567280
Eileen Gigliotti, William Ellery Samuels
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引用次数: 11
Genomics and pain research in sickle cell disease: an explanation of heterogeneity? 镰状细胞病的基因组学和疼痛研究:异质性的解释?
ISRN nursing Pub Date : 2011-01-01 Epub Date: 2011-04-20 DOI: 10.5402/2011/672579
Maxine Adegbola
{"title":"Genomics and pain research in sickle cell disease: an explanation of heterogeneity?","authors":"Maxine Adegbola","doi":"10.5402/2011/672579","DOIUrl":"10.5402/2011/672579","url":null,"abstract":"<p><p>Sickle cell disease (SCD) is a chronic illness, and the major complication, pain, results in complex multidimensional problems that affect an individual's ability to maintain adequate quality of life in multiple areas. Chronic SCD pain is inadequately treated, because it is not well understood, and the degree of chronic pain, clinical presentation, and sequela complications can vary from patient to patient, even among individuals with the same SCD genotype. The reason for this variation is unknown, but the underlying cause might be genetic. Researchers have not explored the contribution of a genomic variable to the occurrence of heterogeneous chronic SCD pain. Previous research on the guanosine triphosphate cyclohydrolase (GCH1) gene suggests that in some cases, phenotypic heterogeneity in human sensitivity to pain correlates with underlying genotypic variations in the GCH1 gene. These findings imply that genotypic variations might also explain why some SCD patients experience more chronic pain than others.</p>","PeriodicalId":89398,"journal":{"name":"ISRN nursing","volume":"2011 ","pages":"672579"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30049396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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