BioNanoScience最新文献

Dual-Biosensor for Five Drugs Detection in Precision Oncology. 双生物传感器用于精准肿瘤五种药物检测。

IF 3.2

BioNanoScience Pub Date : 2026-01-01 Epub Date: 2026-03-19 DOI: 10.1007/s12668-026-02506-8

Francesca Rodino, Myriam Briki, Thierry Buclin, Monia Guidi, Sandro Carrara

{"title":"Dual-Biosensor for Five Drugs Detection in Precision Oncology.","authors":"Francesca Rodino, Myriam Briki, Thierry Buclin, Monia Guidi, Sandro Carrara","doi":"10.1007/s12668-026-02506-8","DOIUrl":"https://doi.org/10.1007/s12668-026-02506-8","url":null,"abstract":"Abstract: The increasing demand for precision medicine, particularly in oncology, requires innovative solutions to address patient-specific inter-individual variability in drug response. Therapeutic drug monitoring (TDM) is crucial for optimizing treatment efficacy and minimizing toxic side effects, enabling precise dosage adjustments tailored to the patient's individual metabolic profile. Electrochemical biosensors offer a cost-effective, simple, and portable solution with rapid response times, making them ideal for point-of-care applications. In this work, we propose a novel dual-biosensor platform for TDM, designed to simultaneously detect multiple chemotherapeutic agents-cyclophosphamide, ifosfamide, etoposide, methotrexate, and 5-fluorouracil-for precision oncology. Following real clinical treatment scenarios, the system uses only two working electrodes integrated into a single electrochemical sensing platform, significantly reducing complexity and cost. By integrating MWCNTs with cytochrome P450 enzymes (CYP3A4 and CYP2B6), our platform achieves enhanced electron transfer and substrate specificity, enabling sensitive and selective detection of the five chemotherapeutic drugs, individually and in combination, within clinically relevant ranges. Designed for portability and rapid analysis, this dual-biosensor platform enables real-time, cost-effective drug monitoring at the point-of-care, advancing personalized cancer treatment with greater precision and accessibility.Graphical abstract: ","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"16 4","pages":"258"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Computational Modeling for Reconfigurable Biosensors. 可重构生物传感器的计算建模。

IF 3.2

BioNanoScience Pub Date : 2026-01-01 Epub Date: 2026-03-17 DOI: 10.1007/s12668-026-02504-w

Roberta Grasso, Jose M Gonzalez-Medina, Gian Luca Barbruni, Sandro Carrara

{"title":"A Computational Modeling for Reconfigurable Biosensors.","authors":"Roberta Grasso, Jose M Gonzalez-Medina, Gian Luca Barbruni, Sandro Carrara","doi":"10.1007/s12668-026-02504-w","DOIUrl":"https://doi.org/10.1007/s12668-026-02504-w","url":null,"abstract":"For the first time ever reported, we present a multiscale modeling approach combining molecular dynamics simulations of probe-target binding with TCAD simulations of Reconfigurable Field Effect Transistors (RFETs). Field-effect transistor biosensors detect biomolecules by channel surface potential as affected by analyte charge. However, fixed channel doping limits them to sense either positive or negative targets. RFETs, based on doping-free nanowires, overcome this limitation by switching dynamically between n- and p-type modes. Recently proposed as a novel class of reconfigurable devices, RFETs remain almost unexplored as biosensors. Their intrinsic reconfigurability and high surface-to-volume ratio make them ideal for dual-polarity and high-sensitivity detection. To demonstrate RFET adaptability, we use both negatively and positively charged analytes, with two distinct recognition elements - aptamer and enzyme - highlighting the device's ability to detect targets of opposite polarity through different binding mechanisms. The proposed multiscale framework establishes a direct link between molecular-scale binding phenomena and device-level electrical response, providing mechanistic insight into the sensing process and supporting the rational design of RFET-based biosensors. More broadly, the proposed methodology applies to a wide range of charge-based field-effect biosensors and supports device optimization and the prediction of experimentally observable trends.","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"16 4","pages":"248"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13068709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On Emergence of Spontaneous Oscillations in Kombucha and Proteinoids. 康普茶和类蛋白中自发振荡的出现。

IF 3

BioNanoScience Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1007/s12668-024-01678-5

Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky

{"title":"On Emergence of Spontaneous Oscillations in Kombucha and Proteinoids.","authors":"Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky","doi":"10.1007/s12668-024-01678-5","DOIUrl":"10.1007/s12668-024-01678-5","url":null,"abstract":"An important part of studying living systems is figuring out the complicated steps that lead to order from chaos. Spontaneous oscillations are a key part of self-organisation in many biological and chemical networks, including kombucha and proteinoids. This study examines the spontaneous oscillations in kombucha and proteinoids, specifically exploring their potential connection to the origin of life. As a community of bacteria and yeast work together, kombucha shows remarkable spontaneous oscillations in its biochemical parts. This system can keep a dynamic balance and organise itself thanks to metabolic processes and complex chemical reactions. Similarly, proteinoids, which may have been primitive forms of proteins, undergo spontaneous fluctuations in their structure and function periodically. Because these oscillations happen on their own, they may play a very important part in the development of early life forms. This paper highlights the fundamental principles governing the transition from chaos to order in living systems by examining the key factors that influence the frequency and characteristics of spontaneous oscillations in kombucha and proteinoids. Looking into these rhythms not only helps us understand where life came from but also shows us ways to make self-organising networks in synthetic biology and biotechnology. There is significant discussion over the emergence of biological order from chemical disorder. This article contributes to the ongoing discussion by examining at the theoretical basis, experimental proof, and implications of spontaneous oscillations. The results make it clear that random oscillations are an important part of the change from nonliving to living matter. They also give us important information about what life is all about.","PeriodicalId":8939,"journal":{"name":"BioNanoScience","volume":"15 1","pages":"65"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenol-Loaded Nano-carriers for Breast Cancer Therapy: A Comprehensive Review 用于乳腺癌治疗的多酚载体纳米载体：全面综述

IF 3

BioNanoScience Pub Date : 2024-01-10 DOI: 10.1007/s12668-023-01288-7

A. Bhat, Gaurav Gupta, Muhammad Afzal, Riya Thapa, Haider Ali, Safar M. Alqahtani, W. Almalki, Imran Kazmi, S. Alzarea, Shakir Saleem, Vetriselvan Subramaniyan