Francesca Rodino, Myriam Briki, Thierry Buclin, Monia Guidi, Sandro Carrara
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引用次数: 0
Abstract
Abstract: The increasing demand for precision medicine, particularly in oncology, requires innovative solutions to address patient-specific inter-individual variability in drug response. Therapeutic drug monitoring (TDM) is crucial for optimizing treatment efficacy and minimizing toxic side effects, enabling precise dosage adjustments tailored to the patient's individual metabolic profile. Electrochemical biosensors offer a cost-effective, simple, and portable solution with rapid response times, making them ideal for point-of-care applications. In this work, we propose a novel dual-biosensor platform for TDM, designed to simultaneously detect multiple chemotherapeutic agents-cyclophosphamide, ifosfamide, etoposide, methotrexate, and 5-fluorouracil-for precision oncology. Following real clinical treatment scenarios, the system uses only two working electrodes integrated into a single electrochemical sensing platform, significantly reducing complexity and cost. By integrating MWCNTs with cytochrome P450 enzymes (CYP3A4 and CYP2B6), our platform achieves enhanced electron transfer and substrate specificity, enabling sensitive and selective detection of the five chemotherapeutic drugs, individually and in combination, within clinically relevant ranges. Designed for portability and rapid analysis, this dual-biosensor platform enables real-time, cost-effective drug monitoring at the point-of-care, advancing personalized cancer treatment with greater precision and accessibility.
期刊介绍：
BioNanoScience is a new field of research that has emerged at the interface of nanoscience and biology, aimed at integration of nano-materials into engineered systems, for new applications in biology and medicine. The aim of BioNanoScience is to provide a forum for the rapidly growing area of bionanoscience, emphasizing the link between structure, properties and processes of nanoscale phenomena in biological and bioinspired structures and materials for a variety of engineered systems. The journal promotes fundamental research in bionanoscience and engineering to advance nanoscience, nanotechnology and engineering, toward application in biology and medicine. This new journal will provide a forum for this interdisciplinary community by publishing highest quality peer-reviewed publications.
Methods covered in this journal include experimental (including but not limited to imaging, via SEM/AFM/optical microscopy and tweezers; x-ray scattering and diffraction tools, electrical/magnetic characterizations; design, and synthesis via self-assembly, layer-by-layer, Langmuir films; biotechnology, via recombinant DNA methods, and protein engineering, etc.), theoretical (e.g. statistical mechanics, nanomechanics, quantum mechanics, etc.) and computational (bottom-up multi-scale simulation, first principles methods, supercomputing, etc.) research.
Areas of applications of interest include all relevant physical, chemical, and biological phenomena and their engineering into integrated systems: mechanical (e.g. deformation, adhesion, failure), electrical and electronic (e.g. electromechanical stimulation, capacitors, energy storage, batteries), optical (e.g. absorption, luminescence, photochemistry), thermal (e.g. thermomutability, thermal management), biological (e.g. how cells interact with nanomaterials, molecular flaws and defects, biosensing, biological mechanisms s.a. mechanosensing), nanoscience of disease (e.g. genetic disease, cancer, organ/tissue fa ilure), as well as information science (e.g. DNA computing). The journal covers fundamental structural and mechanistic analyses of biological processes at nanoscale and their translation into synthetic applications. Studies of interfaces (e.g. between dissimilar structures, organic-inorganic) are of particular interest. In the area of interface between dissimilar structures, papers are also welcome on hybrid systems, including CMOS integrated circuits embedding organic nanostructures as well as biological components.
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