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Autophagy and Autophagy-Related Proteins in the Immunity against Mycobacterium Tuberculosis 自噬和自噬相关蛋白在抗结核分枝杆菌免疫中的作用
Forum on immunopathological diseases and therapeutics Pub Date : 2015-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.V6.I3-4.110
Aïcha Bah, I. Vergne
{"title":"Autophagy and Autophagy-Related Proteins in the Immunity against Mycobacterium Tuberculosis","authors":"Aïcha Bah, I. Vergne","doi":"10.1615/FORUMIMMUNDISTHER.V6.I3-4.110","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.V6.I3-4.110","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"6 1","pages":"217-226"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67441637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Homologous Recombination and Non-Homologous Ends Joining Systems in M. Tuberculosis Survival inside Macrophages 同源重组和非同源末端连接系统在巨噬细胞内结核分枝杆菌存活中的作用
Forum on immunopathological diseases and therapeutics Pub Date : 2015-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.V6.I3-4.130
Izabela Szulc-Kielbik, Michal Kielbik, M. Klink
{"title":"The Role of Homologous Recombination and Non-Homologous Ends Joining Systems in M. Tuberculosis Survival inside Macrophages","authors":"Izabela Szulc-Kielbik, Michal Kielbik, M. Klink","doi":"10.1615/FORUMIMMUNDISTHER.V6.I3-4.130","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.V6.I3-4.130","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"6 1","pages":"237-249"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67441710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Brief Chronicle of CD4 as a Biomarker for HIV/AIDS: A Tribute to the Memory of John L. Fahey. 作为艾滋病毒/艾滋病生物标志物的 CD4 简史：缅怀约翰-L-法黑（John L. Fahey）。
Forum on immunopathological diseases and therapeutics Pub Date : 2015-01-01 DOI: 10.1615/ForumImmunDisTher.2016014169
Jonathan M Kagan, Ana M Sanchez, Alan Landay, Thomas N Denny
{"title":"A Brief Chronicle of CD4 as a Biomarker for HIV/AIDS: A Tribute to the Memory of John L. Fahey.","authors":"Jonathan M Kagan, Ana M Sanchez, Alan Landay, Thomas N Denny","doi":"10.1615/ForumImmunDisTher.2016014169","DOIUrl":"10.1615/ForumImmunDisTher.2016014169","url":null,"abstract":"<p><p>Foundational cellular immunology research of the 1960s and 1970s, together with the advent of monoclonal antibodies and flow cytometry, provided the knowledge base and the technological capability that enabled the elucidation of the role of CD4 T cells in HIV infection. Research identifying the sources and magnitude of variation in CD4 measurements, standardized reagents and protocols, and the development of clinical flow cytometers all contributed to the feasibility of widespread CD4 testing. Cohort studies and clinical trials provided the context for establishing the utility of CD4 for prognosis in HIV-infected persons, initial assessment of <i>in vivo</i> antiretroviral drug activity, and as a surrogate marker for clinical outcome in antiretroviral therapeutic trials. Even with sensitive HIV viral load measurement, CD4 cell counting is still utilized in determining antiretroviral therapy eligibility and time to initiate therapy. New point of care technologies are helping both to lower the cost of CD4 testing and enable its use in HIV test and treat programs around the world.</p>","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"6 1-2","pages":"55-64"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864990/pdf/nihms783462.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34550264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Worms and Humans: A Happy Divorce? 蠕虫与人类幸福的离婚？
Forum on immunopathological diseases and therapeutics Pub Date : 2015-01-01 DOI: 10.1615/ForumImmunDisTher.2015015300
Hannah Akuffo, Sven Britton, Thomas Schön
{"title":"Worms and Humans: A Happy Divorce?","authors":"Hannah Akuffo, Sven Britton, Thomas Schön","doi":"10.1615/ForumImmunDisTher.2015015300","DOIUrl":"10.1615/ForumImmunDisTher.2015015300","url":null,"abstract":"<p><p>Chronic asymptomatic worm infection, often in combination with tuberculosis (TB), is common in low-income countries. Indeed, a life without worm infestation, as is now the case in most high-income countries, is a recent condition for humankind. Worms and <i>Mycobacterium tuberculosis</i> give rise to different immune response patterns (Th2 vs. Th1 driven), and we have studied whether chronic worm infection affects the susceptibility to and control of TB in the low income country of Ethiopia. Our results, as well of those in the general literature, are inconclusive, although we have some rather strong data in support of adult deworming in relation to vaccination with bacillus Calmette-Guérin (BCG) against TB. In addition, we discuss briefly the putative relationship between chronic worm infestation and autoimmunity/allergy.</p>","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"6 1-2","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381959/pdf/nihms847431.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34898969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental Approaches for Eliminating Latent HIV. 消除潜伏性HIV的实验方法。
Forum on immunopathological diseases and therapeutics Pub Date : 2015-01-01 DOI: 10.1615/forumimmundisther.2016015242
Matthew D Marsden, Jerome A Zack
{"title":"Experimental Approaches for Eliminating Latent HIV.","authors":"Matthew D Marsden, Jerome A Zack","doi":"10.1615/forumimmundisther.2016015242","DOIUrl":"10.1615/forumimmundisther.2016015242","url":null,"abstract":"<p><p>Antiretroviral therapy (ART) can reduce HIV viral loads to undetectable levels and prevent disease progression. However, HIV persists in rare cellular reservoirs within ART-treated patients and rapidly reemerges if ART is stopped. Latently infected CD4<sup>+</sup> T cells represent a major reservoir of HIV that persists during ART. Therefore, a cure for HIV must include methods that either permanently inactivate or eliminate latent virus. Experimental methods under investigation for eliminating latently infected cells include transplantation/gene therapy approaches intended to deplete the infected cells and replace them with HIV-resistant ones, and DNA editing strategies that are capable of damaging or excising non-expressing HIV proviruses. Alternatively, \"activation-elimination,\" also known as \"shock and kill,\" approaches aim to induce expression of latent virus, allowing the virus to be eliminated by viral cytopathic effects, immune effector mechanisms, or additional cells/antibodies that specifically target and kill cells expressing HIV proteins. Here, we describe these experimental approaches for eliminating latent HIV along with other recent advances in HIV cure research.</p>","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"19 1","pages":"91-99"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67440065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Memories of John L. Fahey, M.D.'s Clinical Immunology Society Years 回忆约翰·法伊，医学博士美国临床免疫学学会年会
Forum on immunopathological diseases and therapeutics Pub Date : 2015-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.2015014920
S. Kanowith-Klein
{"title":"Memories of John L. Fahey, M.D.'s Clinical Immunology Society Years","authors":"S. Kanowith-Klein","doi":"10.1615/FORUMIMMUNDISTHER.2015014920","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2015014920","url":null,"abstract":"John L. Fahey, M.D. headed a team of researchers, clinicians, and other academic staff throughout his career at the University of California, Los Angeles, working with them in various capacities. Here, I recount my memories of working with Dr. Fahey during the early years of the Clinical Immunology Society.","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"6 1","pages":"25-26"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1615/FORUMIMMUNDISTHER.2015014920","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67439935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circular RNAs and Exosomes: The New Frontier of Cancer Diagnosis 环状rna和外泌体:癌症诊断的新前沿
Forum on immunopathological diseases and therapeutics Pub Date : 2015-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.2016016641
Flavia Scoyni, R. Giugno
{"title":"Circular RNAs and Exosomes: The New Frontier of Cancer Diagnosis","authors":"Flavia Scoyni, R. Giugno","doi":"10.1615/FORUMIMMUNDISTHER.2016016641","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2016016641","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"6 1","pages":"181-186"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67440273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Indian HIV-1 Subtype C Vaccine Candidates 印度HIV-1亚型C候选疫苗的研制
Forum on immunopathological diseases and therapeutics Pub Date : 2015-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.2016014508
P. Seth, S. Yadav
{"title":"Development of Indian HIV-1 Subtype C Vaccine Candidates","authors":"P. Seth, S. Yadav","doi":"10.1615/FORUMIMMUNDISTHER.2016014508","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2016014508","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"6 1","pages":"101-107"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67440053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular Vesicles as Potential Mediators of Epigenetic Reprogramming 细胞外囊泡作为表观遗传重编程的潜在介质
Forum on immunopathological diseases and therapeutics Pub Date : 2015-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.2016016526
A. L. Ronnegren
{"title":"Extracellular Vesicles as Potential Mediators of Epigenetic Reprogramming","authors":"A. L. Ronnegren","doi":"10.1615/FORUMIMMUNDISTHER.2016016526","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2016016526","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"42 1","pages":"133-141"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67440187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
PREFACE: Manipulation of Macrophage Functions by Mycobacterium Tuberculosis 前言:结核分枝杆菌对巨噬细胞功能的操纵
Forum on immunopathological diseases and therapeutics Pub Date : 2015-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.V6.I3-4.80
M. Klink
{"title":"PREFACE: Manipulation of Macrophage Functions by Mycobacterium Tuberculosis","authors":"M. Klink","doi":"10.1615/FORUMIMMUNDISTHER.V6.I3-4.80","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.V6.I3-4.80","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"25 1","pages":"189"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1615/FORUMIMMUNDISTHER.V6.I3-4.80","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67441784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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