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A brief review on metabolic evasion mechanisms of tumor cells against T cells 肿瘤细胞对T细胞的代谢逃避机制综述
Forum on immunopathological diseases and therapeutics Pub Date : 2021-01-01 DOI: 10.1615/forumimmundisther.2021040911
S. Romero‐Garcia, Ángeles Carlos-Reyes, H. Prado-Garcia
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引用次数: 0
Gene Regulation During the Enzootic Cycle of the Lyme Disease Spirochete. 莱姆病螺旋体在地方性循环中的基因调控。
Forum on immunopathological diseases and therapeutics Pub Date : 2016-01-01 DOI: 10.1615/ForumImmunDisTher.2017019469
D Scott Samuels, Leah R N Samuels
{"title":"Gene Regulation During the Enzootic Cycle of the Lyme Disease Spirochete.","authors":"D Scott Samuels,&nbsp;Leah R N Samuels","doi":"10.1615/ForumImmunDisTher.2017019469","DOIUrl":"https://doi.org/10.1615/ForumImmunDisTher.2017019469","url":null,"abstract":"<p><p><i>Borrelia burgdorferi</i>, the spirochete that causes Lyme disease, exists in an enzootic cycle, alternating between a tick vector and a vertebrate host. To adapt to and survive the environmental changes associated with its enzootic cycle, including nutrient availability, <i>B. burgdorferi</i> uses three different systems to regulate the expression of genes: RpoN-RpoS, histidine kinase (Hk)1/response regulator 1 (Rrp1), and Rel<sub>Bbu</sub>. The RpoN-RpoS alternative sigma factor cascade activates genes required for transmission from the tick to the vertebrate, maintenance of the vertebrate infection, and persistence in the tick. Rel<sub>Bbu</sub> controls the levels of the alarmones guanosine pentaphosphate and guanosine tetraphosphate, which are necessary for surviving the nutrient-deficient conditions in the midgut of the tick following absorption of the blood meal and the subsequent molt. The Hk1/Rrp1 two-component system produces cyclic dimeric guanosine monophosphate that regulates the genes required for the transitions between the tick and vertebrate as well as protective responses to the blood meal.</p>","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"7 3-4","pages":"205-212"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985821/pdf/nihms970534.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36199570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Activation of Natural Killer Cells by Probiotics. 益生菌对自然杀伤细胞的激活作用
Forum on immunopathological diseases and therapeutics Pub Date : 2016-01-01 DOI: 10.1615/ForumImmunDisTher.2016017095
Nabil Aziz, Benjamin Bonavida
{"title":"Activation of Natural Killer Cells by Probiotics.","authors":"Nabil Aziz,&nbsp;Benjamin Bonavida","doi":"10.1615/ForumImmunDisTher.2016017095","DOIUrl":"https://doi.org/10.1615/ForumImmunDisTher.2016017095","url":null,"abstract":"<p><p>During the last decade, probiotics have been established to be important mediators of host immunity. Their effects on both innate and adaptive immunity have been documented in the literature. Although several reports have correlated different strains of bacteria as probiotics, their effects on immunity vary. Clearly, there is a complex interplay between various constituents of probiotics and the immune response in humans. The role of probiotics on natural killer (NK) cells in the gut has been the subject of a few reports. In this review, we summarize the reported findings on the role of probiotics in the activation of gut-associated NK cells and the response of NK cells to stimuli elicited by probiotics and their microenvironment. The effects of probiotics on the activation of NK cells and their secretion of immune factors (e.g., interferon-γ, tumor necrosis factor-α, interleukin-2, etc.) are discussed in regard to their clinical significance in various diseases. Current investigations are being pursued, in particular, on the role of probiotics-activated NK cells in promoting the adaptive immune response against pathogens.</p>","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"7 1-2","pages":"41-55"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1615/ForumImmunDisTher.2016017095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35090003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
The University of California at Los Angeles and James Miller: A Powerhouse 加州大学洛杉矶分校和詹姆斯·米勒:一个发电站
Forum on immunopathological diseases and therapeutics Pub Date : 2016-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.2017020223
N. Charon
{"title":"The University of California at Los Angeles and James Miller: A Powerhouse","authors":"N. Charon","doi":"10.1615/FORUMIMMUNDISTHER.2017020223","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2017020223","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"7 1","pages":"161"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67440722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Immune-Cell−Expressing Kruppel-Like Factor 4 in Cancer Development 表达kruppel样因子4的免疫细胞−在癌症发展中的作用
Forum on immunopathological diseases and therapeutics Pub Date : 2016-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.2016018247
W. Ai
{"title":"Role of Immune-Cell−Expressing Kruppel-Like Factor 4 in Cancer Development","authors":"W. Ai","doi":"10.1615/FORUMIMMUNDISTHER.2016018247","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2016018247","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"7 1","pages":"61-75"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67440504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probiotics in Human Health 人体健康中的益生菌
Forum on immunopathological diseases and therapeutics Pub Date : 2016-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.2016018570
A. Goyal, T. Garg, Goutam Rath
{"title":"Probiotics in Human Health","authors":"A. Goyal, T. Garg, Goutam Rath","doi":"10.1615/FORUMIMMUNDISTHER.2016018570","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2016018570","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"7 1","pages":"17-31"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1615/FORUMIMMUNDISTHER.2016018570","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67440566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Tribute to James N. Miller: Colleague−Friend− Mentor 致敬詹姆斯·n·米勒:同事-朋友-导师
Forum on immunopathological diseases and therapeutics Pub Date : 2016-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.2017020106
B. Bonavida
{"title":"A Tribute to James N. Miller: Colleague−Friend− Mentor","authors":"B. Bonavida","doi":"10.1615/FORUMIMMUNDISTHER.2017020106","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2017020106","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"7 1","pages":"165"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67440637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Tribute to James N. Miller 致敬詹姆斯·n·米勒
Forum on immunopathological diseases and therapeutics Pub Date : 2016-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.2017020474
L. Bockenstedt
{"title":"A Tribute to James N. Miller","authors":"L. Bockenstedt","doi":"10.1615/FORUMIMMUNDISTHER.2017020474","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2017020474","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"7 1","pages":"163-164"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67440796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dr. James N. Miller: Virtuoso of All Spirochetes 詹姆斯·n·米勒博士:所有螺旋体的大师
Forum on immunopathological diseases and therapeutics Pub Date : 2016-01-01 DOI: 10.1615/FORUMIMMUNDISTHER.2017020504
J. Nally
{"title":"Dr. James N. Miller: Virtuoso of All Spirochetes","authors":"J. Nally","doi":"10.1615/FORUMIMMUNDISTHER.2017020504","DOIUrl":"https://doi.org/10.1615/FORUMIMMUNDISTHER.2017020504","url":null,"abstract":"","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"7 1","pages":"159"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67440813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Miller Hypothesis. 米勒假说。
Forum on immunopathological diseases and therapeutics Pub Date : 2016-01-01 DOI: 10.1615/ForumImmunDisTher.2017020293
David A Haake
{"title":"The Miller Hypothesis.","authors":"David A Haake","doi":"10.1615/ForumImmunDisTher.2017020293","DOIUrl":"https://doi.org/10.1615/ForumImmunDisTher.2017020293","url":null,"abstract":"<p><p>The immune response is a cornerstone in the body's struggle against microbial pathogens. In ways that we do not yet completely understand, the mammalian immune response has evolved to identify proteins of pathogens that are either important virulence factors or key immunoprotective targets. Professor James N. Miller suggested that one way to discover such proteins is to harness the power of the immune system in the laboratory.This general concept, referred to here as the Miller Hypothesis, took several different manifestations in the discovery of some of the best known and widely studied leptospiral proteins: The porin OmpL1 was identified by surface immunoprecipitation, leptospiral immunoglobulin-like proteins were uncovered by screening a genomic library with sera from leptospirosis patients, and the major outer-membrane lipoprotein LipL32 was recognized through immunoblot studies. Such approaches will continue to bear fruit for both the leptospiral research field and research on other invasive pathogens.</p>","PeriodicalId":89370,"journal":{"name":"Forum on immunopathological diseases and therapeutics","volume":"7 3-4","pages":"167-174"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1615/ForumImmunDisTher.2017020293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36913455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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