Clinical ovarian cancer and other gynecologic malignancies最新文献

{"title":"2022-RA-686-ESGO Paradigm shift in surgical approach in the management of advanced ovarian cancer in the university hospitals of LEICESTER","authors":"Anas Barakat, Ae Ismail, S. Chattopadhyay","doi":"10.1136/ijgc-2022-esgo.545","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.545","url":null,"abstract":"","PeriodicalId":89343,"journal":{"name":"Clinical ovarian cancer and other gynecologic malignancies","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81688197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-1464-ESGO Clinical behavior of high-grade ovarian cancer (HGOC) patients with non contributive GIS results (NA) by Myriad","authors":"F. Blanc-Durand, S. Cotteret, C. Genestie, E. Rouleau, J. Michels, E. Colomba-Blameble, M. Kfoury, P. Pautier, A. Leary","doi":"10.1136/ijgc-2022-esgo.722","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.722","url":null,"abstract":"2022-RA-1456-ESGO Figure 1 Conclusion Our classification represents a useful and reliable tool, able to stratify patients with OC metastases in the liver area in Classes with different surgical outcomes and different postoperative complication profile. 2022-RA-1459-ESGO MALIGNANT STRUMA OVARII IN AN ASYMPTOMATIC NULLIPAROUS 20-YEAROLD PATIENT: A CASE REPORT Eleftherios G Klonos, CH Zimperdikas, G Pados, G Grimbizis, T Theodoridis, S Tsaipakidou, A Tolkos, T Karalis. st. Department of Ob/Gyn Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece 10.1136/ijgc-2022-ESGO.72","PeriodicalId":89343,"journal":{"name":"Clinical ovarian cancer and other gynecologic malignancies","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87529382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-1176-ESGO Borderline ovarien tumor management in a tunisian hospital","authors":"R. Bouhmida, H. Bettaieb, Meriem Ouederni, N. Souayeh, Hadhami Rouiss, A. Chermiti, Hadir Lamiri, Wael Mbarki, H. Oueslati, C. Mbarki","doi":"10.1136/ijgc-2022-esgo.657","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.657","url":null,"abstract":"","PeriodicalId":89343,"journal":{"name":"Clinical ovarian cancer and other gynecologic malignancies","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90164214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-1347-ESGO The impact of the induction of anaesthesia and the opening of the abdominal cavity on haemodynamic parameters in cytoreductive debulking surgery","authors":"Charlotte Middel, Matthias Stetzuhn, Nadine Sander, Björn Kalkbrenner, Timo Tigges, Alexandru-Gabriel Pielmus, C. Spies, K. Pietzner, Michael Klum, C. Haefen, O. Hunsicker, J. Sehouli, F. Konietschke, Aarne Feldheiser","doi":"10.1136/ijgc-2022-esgo.695","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.695","url":null,"abstract":"","PeriodicalId":89343,"journal":{"name":"Clinical ovarian cancer and other gynecologic malignancies","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85084415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-1623-ESGO Effect of bevacizumab and complete cytoreductive surgery in advanced low grade serous ovarian cancer: a secondary analysis of MITO 22","authors":"L. Musacchio, M. Turinetto, M. Bartoletti, L. Arenare, D. Califano, V. Tuninetti, G. Cormio, C. Pisano, G. Valabrega, C. Marchetti, S. Cecere, S. Greggi, F. Raspagliesi, F. Perrone, A. Fagotti, D. Lorusso, G. Scambia, S. Pignata","doi":"10.1136/ijgc-2022-esgo.759","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.759","url":null,"abstract":"","PeriodicalId":89343,"journal":{"name":"Clinical ovarian cancer and other gynecologic malignancies","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85256149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-865-ESGO Oncologic and fertility outcomes in advanced stage immature teratomas","authors":"G. Marino, T. Grassi, Serena Negri, Filippo Testa, E. De Ponti, D. Giuliani, M. D. Marchette, F. Sina, D. Vicini, Diletta Fumagalli, Liliana Marchetta, Maria Cristina Bonazzi, F. Landoni, R. Fruscio","doi":"10.1136/ijgc-2022-esgo.579","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.579","url":null,"abstract":"","PeriodicalId":89343,"journal":{"name":"Clinical ovarian cancer and other gynecologic malignancies","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83502179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-941-ESGO CEBOC, a single-arm phase II trial to evaluate the safety of cediranib in the prevention of bowel perforation in platinum resistant ovarian cancer","authors":"A. Murphy, Catharine Porter, A. White, Alys Irving, R. Ray, A. Casbard, Tracie-Ann Madden, Reem D. Mahmood, R. Morgan, J. Pugh, Chelsey Wheeler, Victoria Roberts, Giorgio Arnetoli, Z. Salih, J. Hasan, C. Mitchell, A. Clamp, G. Jayson","doi":"10.1136/ijgc-2022-esgo.599","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.599","url":null,"abstract":"2022-RA-939-ESGO Figure 1 Relative mRNA expression of HO-1, IL-1b, IL-4, IL-6, PD-1, PD-L1 genes in PBMCs from ovarian cancer patients on the 1st, 3rd and 5th day after surgery compared to the expression before the treatment. Bar graphs show median value and interquartile range *p<0.05 Results Median age of controls and cancer patients were 59 (26) and 58 (14) years respectively (p>0.05). The mRNA expression of all markers in PBMCs were significantly downregulated in cancer patients before surgery comparing to controls (p<0.05). Relative median expression of HO-1, IL1b, IL-4, IL-6, PD-1 and PD-L1 in controls and cancer patients respectively were 0.97 (0.33) vs 0.66 (0.5), 0.87 (1.95) vs 0.07 (0.16), 0.86 (1.39) vs 0.43 (0.61), 0.98 (1.15) vs 0.03 (0.03), 0.99 (0.94) vs 0.32 (0.50), 1.18 (0.66) vs 0.26 (0.36). Significant post-surgical changes in IL-6 and PD-L1 expression were observed along with not significant fluctuations of other targets expression (figure 1). Conclusion Investigated components of anticancer immunity and immunosuppression mechanisms are affected by cancer and surgical treatment. Therefore, PBMCs are worthy targets for detailed investigation in this field. 2022-RA-941-ESGO CEBOC, A SINGLE-ARM PHASE II TRIAL TO EVALUATE THE SAFETY OF CEDIRANIB IN THE PREVENTION OF BOWEL PERFORATION IN PLATINUM RESISTANT OVARIAN CANCER Alexander Murphy, Catharine Porter, Ann White, Alys Irving, Ruby Ray, Angela Casbard, Tracie-Ann Madden, Reem Mahmood, Robert Morgan, Julia Pugh, Chelsey Wheeler, Victoria Roberts, Giorgio Arnetoli, Zena Salih, Jurjees Hasan, Claire Mitchell, Andrew Clamp, Gordon Jayson. The Christie NHS Foundation Trust, Manchester, UK; Centre for Trials Research, Cardiff University, Cardiff, UK 10.1136/ijgc-2022-ESGO.599 Introduction/Background Systemic treatment of platinum-resistant advanced ovarian cancers (PROC) utilises cytotoxic chemotherapy and vascular endothelial growth factor receptor (VEGFR) inhibitors. However, patients at risk for malignant bowel obstruction (MBO) are excluded from this efficacious combination due to risk of bowel perforation. Methodology We conducted a Simon’s two-stage trial combining oral VEGFR inhibitor cediranib (20 mg/day) with weekly paclitaxel (70 mg/m), in participants with recurrent PROC and clinical and/or radiological features indicating an increased risk of developing MBO. Primary endpoint was number of patients free of grade 3–5 gastrointestinal perforation (GIP) or fistula, from those who received 5 days and £18 weeks cediranib, causally related to cediranib. With 90% power and 5% significance, 24 evaluable patients were required, with 22 free of GIP or fistula to demonstrate safety. Cediranib could start with chemotherapy, or at cycle 2 or 3, once bowel symptoms were CTCAE grade £2. Previous bevacizumab exposure and prior MBO were permitted. Patients were continued on cediranib maintenance after paclitaxel completion, and optionally proceeded to cediranib plus olaparib (300 mg bd) at ","PeriodicalId":89343,"journal":{"name":"Clinical ovarian cancer and other gynecologic malignancies","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79299393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-1451-ESGO Critical care management following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: not routinely indicated","authors":"S. Aronson, RM van Stein, FJ Hendriks, K. Sikorska, Api Houwink, Pfe Schutte, C. D. de Kroon, G. Sonke, W. van Driel","doi":"10.1136/ijgc-2022-esgo.718","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.718","url":null,"abstract":"","PeriodicalId":89343,"journal":{"name":"Clinical ovarian cancer and other gynecologic malignancies","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81358116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-1459-ESGO Malignant struma ovarii in an asymptomatic nulliparous 20-year-old patient: a case report","authors":"Eleftherios Klonos, CH Zimperdikas, G. Pados, G. Grimbizis, T. Theodoridis, S. Tsaipakidou, A. Tolkos, T. Karalis","doi":"10.1136/ijgc-2022-esgo.721","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.721","url":null,"abstract":"2022-RA-1456-ESGO Figure 1 Conclusion Our classification represents a useful and reliable tool, able to stratify patients with OC metastases in the liver area in Classes with different surgical outcomes and different postoperative complication profile. 2022-RA-1459-ESGO MALIGNANT STRUMA OVARII IN AN ASYMPTOMATIC NULLIPAROUS 20-YEAROLD PATIENT: A CASE REPORT Eleftherios G Klonos, CH Zimperdikas, G Pados, G Grimbizis, T Theodoridis, S Tsaipakidou, A Tolkos, T Karalis. st. Department of Ob/Gyn Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece 10.1136/ijgc-2022-ESGO.72","PeriodicalId":89343,"journal":{"name":"Clinical ovarian cancer and other gynecologic malignancies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79861849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-1441-ESGO Epithelial ovarian cancers during pregnancy: the results of a large retrospective study from the INCIP network","authors":"R. Fruscio, R. Trozzi, K. Van Calsteren, M. D. Marchette, A. Fagotti, F. Mascilini, E. Cardonick, M. Halaska, C. Lok, J. Farthmann, N. Ottevanger, S. Galimberti, J. Heimovaara, F. Amant","doi":"10.1136/ijgc-2022-esgo.715","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.715","url":null,"abstract":"","PeriodicalId":89343,"journal":{"name":"Clinical ovarian cancer and other gynecologic malignancies","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78689604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}