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Bioorganic and Medicinal Chemistry Reports最新文献

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Synthesis and biological evaluation of 1,3,5-triazine-substituted ureido benzenesulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors 1,3,5-三嗪取代脲基苯磺酰胺类抗氧化、乙酰胆碱酯酶和丁基胆碱酯酶抑制剂的合成及生物学评价
Bioorganic and Medicinal Chemistry Reports Pub Date : 2020-12-12 DOI: 10.25135/acg.bmcr.22.20.07.1706
Nebih Lolak, Muhammed Tuneğ, Asli E Dogan, M. Boğa, Suleyman Akocak
{"title":"Synthesis and biological evaluation of 1,3,5-triazine-substituted ureido benzenesulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors","authors":"Nebih Lolak, Muhammed Tuneğ, Asli E Dogan, M. Boğa, Suleyman Akocak","doi":"10.25135/acg.bmcr.22.20.07.1706","DOIUrl":"https://doi.org/10.25135/acg.bmcr.22.20.07.1706","url":null,"abstract":"A series of twenty 1,3,5-triazine-substituted ureido benzenesulfonamides 2 (a-e) and 3 (a-o) were re-synthesized and assayed for antioxidant properties by using several different methods including 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging assay, 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation radical decolarization assay, metal chelating and cupric reducing antioxidant capacity (CUPRAC) methods. The inhibitory effects of compounds on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes have been also demonstrated. All compounds showed a greater antioxidant capacity against ABTS assay by having a more potent activity than the standards BHT, BHA and α-TOC. In general, all compounds were non susceptible to against AChE enzyme. On the other hand, several lead compounds were obtained from the current series against BChE enzyme. More specifically, compound 3m showed great inhibition profile against BChE with % inhibition value of 93.77, which is better than the standard drug galantamine (% inhibition value of 87.86).","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81472521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Analyzing of Some Drugable Properties of Hydrazono-pyridazinones 肼腙-吡嗪酮类药物的一些药性分析
Bioorganic and Medicinal Chemistry Reports Pub Date : 2018-12-31 DOI: 10.25135/bmcr.10.18.12.1104
B. Kuzu, Nurettin Menges
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引用次数: 0
Citric acid synthesis efficiency of Aspergillus niger in carob molasses based media 黑曲霉在角豆糖蜜培养基中柠檬酸合成效率的研究
Bioorganic and Medicinal Chemistry Reports Pub Date : 2018-12-31 DOI: 10.25135/BMCR.15.18.12.1124
B. Dur, R. Ozen, Furkan Ayaz
{"title":"Citric acid synthesis efficiency of Aspergillus niger in carob molasses based media","authors":"B. Dur, R. Ozen, Furkan Ayaz","doi":"10.25135/BMCR.15.18.12.1124","DOIUrl":"https://doi.org/10.25135/BMCR.15.18.12.1124","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84201309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Welcome to the first issue of BioorgMedChemRep for 2018! 欢迎来到BioorgMedChemRep 2018年第一期!
Bioorganic and Medicinal Chemistry Reports Pub Date : 2018-12-31 DOI: 10.25135/bmcr.09.18.01.001
Oztekin Algul
{"title":"Welcome to the first issue of BioorgMedChemRep for 2018!","authors":"Oztekin Algul","doi":"10.25135/bmcr.09.18.01.001","DOIUrl":"https://doi.org/10.25135/bmcr.09.18.01.001","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77216628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The synthesis of two novel bicyclic haloketones and measurement of their biological activity 两种新型双环卤酮的合成及其生物活性的测定
Bioorganic and Medicinal Chemistry Reports Pub Date : 2018-12-31 DOI: 10.25135/BMCR.12.18.11.1035
Esen Yıldız Bekfelavi, Pınar Çevik, Ö. Yılmaz, N. S. Kus, G. Coral, A. Çelik
{"title":"The synthesis of two novel bicyclic haloketones and measurement of their biological activity","authors":"Esen Yıldız Bekfelavi, Pınar Çevik, Ö. Yılmaz, N. S. Kus, G. Coral, A. Çelik","doi":"10.25135/BMCR.12.18.11.1035","DOIUrl":"https://doi.org/10.25135/BMCR.12.18.11.1035","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81460197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Immunomodulation of macrophages for bone formation 巨噬细胞对骨形成的免疫调节
Bioorganic and Medicinal Chemistry Reports Pub Date : 2018-12-31 DOI: 10.25135/BMCR.11.18.09.899
Furkan Ayaz
{"title":"Immunomodulation of macrophages for bone formation","authors":"Furkan Ayaz","doi":"10.25135/BMCR.11.18.09.899","DOIUrl":"https://doi.org/10.25135/BMCR.11.18.09.899","url":null,"abstract":"Especially in elderly women osteoporosis leads to decline in the strength of the bone tissue by erosion of its mass. Weakened bone tissue is more prone to breaks. Patients mostly realize this situation after having a bone breakage especially with the wrist and hip fractures. There has not been an effective way of improving this debilitating condition. A new approach aiming to regulate the activities of the immune system cells in order to reverse osteoporosis and push the tissue for the formation of the bone structure gained attention due to its promising potential. In this review, I will be focusing on this approach by regulation of the macrophage activity, the major immune cell type that is involved in the bone formation. Immunomodulation of the macrophages enable formation and healing of the bone tissue in the patients and conducting more studies in this area would certainly improve the quality of the applicable medicines.","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"67 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83075341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Electrochemical studies of regorafenib in non-aqueous media 瑞非尼在非水介质中的电化学研究
Bioorganic and Medicinal Chemistry Reports Pub Date : 2018-12-31 DOI: 10.25135/BMCR.10.18.12.110486
Z. Kudaş
{"title":"Electrochemical studies of regorafenib in non-aqueous media","authors":"Z. Kudaş","doi":"10.25135/BMCR.10.18.12.110486","DOIUrl":"https://doi.org/10.25135/BMCR.10.18.12.110486","url":null,"abstract":"","PeriodicalId":8932,"journal":{"name":"Bioorganic and Medicinal Chemistry Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84232870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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