Basal ganglia最新文献

{"title":"Phenomenology and gender characteristics of hobbyism and punding in Parkinson’s disease: A self-report study","authors":"Mette Buhl Callesen ,&nbsp;Malene Flensborg Damholdt","doi":"10.1016/j.baga.2017.06.002","DOIUrl":"10.1016/j.baga.2017.06.002","url":null,"abstract":"<div><h3>Objectives</h3><p>Dopamine replacement therapy administered to alleviate motor symptoms of Parkinson’s disease (PD) has been linked to a range of impulsive and compulsive behaviors (ICBs). The objective of the current study is to describe the phenomenology and delineate gender characteristics of hobbyism and punding in PD based on self-report.</p></div><div><h3>Materials and methods</h3><p>We applied two self-report questionnaires. A clinical and demographic questionnaire assessing motor symptomatology and the short-version of the Questionnaire for impulsive-compulsive behaviors in PD assessing symptoms of current and past ICBs in PD.</p></div><div><h3>Results</h3><p>Results suggest that hobbyism and punding are very common among Danish patients with PD with 27.5% of patients reporting symptoms hereof in the current sample. Furthermore, findings indicate that male and female patients engage differently in hobbyism and punding showing different preferences for specific compulsive activities. In addition, hobbyism and punding appear to be very time consuming with up to 10.6% of patients spending more than five hours each day on these behaviors. We found no significant gender differences in time consumption nor in the subjective experience of being pre-occupied with and feeling loss of control over the behavior. However, unlike men only very few female patients (12.1%) addressed a healthcare professional about ICB symptoms overall, and none when considering hobbyism and punding alone. Finally, findings suggest that age at PD onset and advanced motor symptomatology are significantly associated with hobbyism and punding, respectively, in both male and female patients with PD, whereas non-cardinal motor symptoms, only predict ICBs in male patients.</p></div><div><h3>Conclusions</h3><p>Findings may have important clinical implications in early identification of ICBs in male and female patients with PD by emphasizing the need for healthcare professionals to explicitly ask patients about behavioral alterations and taking motor symptomatology into account when screening for ICBs in PD.</p></div>","PeriodicalId":89327,"journal":{"name":"Basal ganglia","volume":"9 ","pages":"Pages 1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.baga.2017.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45852446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic analysis of botulinum neurotoxin type A immunogenicity in clinical studies","authors":"Sebastien Lacroix-Desmazes ,&nbsp;Stephane Mouly ,&nbsp;Michel-Robert Popoff ,&nbsp;Carlo Colosimo","doi":"10.1016/j.baga.2017.06.001","DOIUrl":"10.1016/j.baga.2017.06.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Controversy exists around the immunogenicity of the various formulations of botulinum neurotoxin type A (BoNT-A).</p></div><div><h3>Methods</h3><p>A systematic review of the literature (1968–2013) was performed, including review of materials from the FDA. Neutralizing antibody rates were calculated for overall BoNT-A and for each commercially available BoNT-A (abobotulinumtoxinA, incobotulinumtoxinA, onabotulinumtoxinA), and were compared by using the Chi-squared test. Two different onabotulinumtoxinA products were identified during the specified time-frame and classed as ‘old’ and ‘new’ versions.</p></div><div><h3>Results</h3><p>A total of 31 studies involving 5811 subjects met inclusion criteria and were analyzed. Therapeutic indications included: cervical dystonia, blepharospasm, spasticity, glabellar lines, hyperactive detrusor/sphincter dysfunction. The overall rate of development for neutralizing antibodies to BoNT-A was 2.1%. Individual rates were 1.4% for abobotulinumtoxinA, 0.8 to 1.1% for incobotulinumtoxinA, 7.2% for old onabotulinumtoxinA and 3.6% for new onabotulinumtoxinA. No significant differences were found between abobotulinumtoxinA and incobotulinumtoxinA rates (OR 1.82 [95%CI] [0.96–3.43], p<!--> <!-->=<!--> <!-->0.066; OR 1.30 [0.69–2.46], p<!--> <!-->=<!--> <!-->0.415). Rates of neutralizing antibodies were significantly lower with abobotulinumtoxinA and incobotulinumtoxinA versus either onabotulinumtoxinA formulations.</p></div><div><h3>Conclusions</h3><p>The overall neutralizing antibody rate for BoNT-A was low (≤2.1%). The rate of developing neutralizing antibodies was similar between abobotulinumtoxinA and incobotulinumtoxinA, both significantly lower when compared with onabotulinumtoxinA.</p></div>","PeriodicalId":89327,"journal":{"name":"Basal ganglia","volume":"9 ","pages":"Pages 12-17"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.baga.2017.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47213436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients’ perspective on current treatment options for Parkinson’s Disease","authors":"Wolfgang H. Jost ,&nbsp;Jennifer Bausch","doi":"10.1016/j.baga.2017.05.001","DOIUrl":"10.1016/j.baga.2017.05.001","url":null,"abstract":"<div><p><span>To date, current data on the treatment situation of patients with Parkinson’s disease (PD) are limited. Therefore </span>cross sectional surveys in 4485 patients and in addition, in office based neurologists, were performed. Patients were questioned about their disease history and current treatment, as well as their therapy satisfaction.</p><p>The mean lag time between first diagnosis of PD and the first prescription of medication was in 68.9% of patients less than 3 months, in 15.6% between 3 and 6 months, in 7.1% 7 to 12 months, in 3.3% up to 2 years, and in 3.1% more than 2 years. Patient rated themselves in 9.7% to be in the initial course of PD, 44.3% in a progressed stage and 41.3% in an advanced stage. The success of therapy rated 4.9% as very good, 22.6% as good, 43.4% as satisfactory, 23.0% as unsatisfactory, and 2.1% as poor (4.1% no response).</p><p>Treatment success was dependent on motor symptoms in the view of 51.3% of patients, on non-motor symptoms in 6.5%, in 23.4% with cognitive ability, in 57.0% with quality of life<span> and in 21.5% with impairment caused by medication. With respect to current therapy 41.8% of patients were affected by frequency of drug intake, 3.2% by type of administration, 12.3% by number of drugs, 27.7% by unsatisfactory efficacy, and 41.3% by side effects (several answers possible).</span></p><p>Overall, only 27.5% of patients rated their current PD medication as very good or a good, in contrast to the physicians (treatment success very good or good in 75.8%). Physicians named control of motor symptoms (89.7%) and quality of life (86.7%) as key criteria for successful therapy.</p><p>In summary, PD patients report deficits in drug treatment. There is a clear need for action with regard to the information transfer to patients (including the explanation of side effects or differentiation of symptoms of the PD) and possibly for a change of the medication schedules including other drugs or combination therapies.</p></div>","PeriodicalId":89327,"journal":{"name":"Basal ganglia","volume":"9 ","pages":"Pages 7-11"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.baga.2017.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46001250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term essential tremor recovery after stroke thalamotomy","authors":"Marianna Sarchioto ,&nbsp;Anna Nicolina Manca ,&nbsp;Maurizio Melis ,&nbsp;Giovanni Cossu","doi":"10.1016/j.baga.2017.06.003","DOIUrl":"10.1016/j.baga.2017.06.003","url":null,"abstract":"<div><p>Thalamic stroke can be the cause of acute or delayed onset of movement disorders but it may also constitute their treatment. We report the case of an 89-year-old man with essential tremor in whom a right thalamic stroke caused long-term remission of severe contralateral tremor.</p></div>","PeriodicalId":89327,"journal":{"name":"Basal ganglia","volume":"9 ","pages":"Pages 18-19"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.baga.2017.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49105172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Device-based assessment through a mobile application in the Luxembourg Parkinson Cohort","authors":"Christian Stallinger,&nbsp;Venkata Satagopam,&nbsp;Peter Banda,&nbsp;Pierre Kolber,&nbsp;Christine Suver,&nbsp;Andrew Trister,&nbsp;Stephen Friend,&nbsp;Rejko Krüger","doi":"10.1016/j.baga.2017.02.006","DOIUrl":"10.1016/j.baga.2017.02.006","url":null,"abstract":"","PeriodicalId":89327,"journal":{"name":"Basal ganglia","volume":"8 ","pages":"Page 2"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.baga.2017.02.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47859744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putaminal iron dyshomeostasis in X-linked Dystonia-Parkinsonism","authors":"Henrike Hanßen,&nbsp;Marcus Heldmann,&nbsp;Cid C.E. Diesta,&nbsp;Raymond L. Rosales,&nbsp;Aloysius Domingo,&nbsp;Thomas F. Münte,&nbsp;Christine Klein,&nbsp;Norbert Brüggemann","doi":"10.1016/j.baga.2017.02.039","DOIUrl":"10.1016/j.baga.2017.02.039","url":null,"abstract":"","PeriodicalId":89327,"journal":{"name":"Basal ganglia","volume":"8 ","pages":"Page 13"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.baga.2017.02.039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46201859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep in patients with Parkinson's disease: Differences in two groups of 219 patients with and without sleep disturbances","authors":"Matthias Hahne,&nbsp;Dietrich Hartmann,&nbsp;Matthias Keidel,&nbsp;Heinz Reichmann,&nbsp;Wolfgang Jost","doi":"10.1016/j.baga.2017.02.010","DOIUrl":"10.1016/j.baga.2017.02.010","url":null,"abstract":"","PeriodicalId":89327,"journal":{"name":"Basal ganglia","volume":"8 ","pages":"Page 4"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.baga.2017.02.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46916497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volumetry of substantia nigra hyperechogenity in Parkinson's disease","authors":"Norbert Brüggemann,&nbsp;Julia Graf,&nbsp;Marco Maaß,&nbsp;Achim Schweikard,&nbsp;Philipp Jauer,&nbsp;Sophia Lammers","doi":"10.1016/j.baga.2017.02.020","DOIUrl":"10.1016/j.baga.2017.02.020","url":null,"abstract":"","PeriodicalId":89327,"journal":{"name":"Basal ganglia","volume":"8 ","pages":"Page 7"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.baga.2017.02.020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43955617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired empathy: A non-motor symptom associated with advanced stages of Parkinson's disease","authors":"Nele Schmidt,&nbsp;Laura Paschen,&nbsp;Günther Deuschl,&nbsp;Karsten Witt","doi":"10.1016/j.baga.2017.02.012","DOIUrl":"10.1016/j.baga.2017.02.012","url":null,"abstract":"","PeriodicalId":89327,"journal":{"name":"Basal ganglia","volume":"8 ","pages":"Page 4"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.baga.2017.02.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47254665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to explain patient's unsatisfaction with deep brain stimulation with great overall results in studies? A vivid example of multi-dimensional aspects in quality of life","authors":"Lars Timmermann","doi":"10.1016/j.baga.2017.02.053","DOIUrl":"10.1016/j.baga.2017.02.053","url":null,"abstract":"","PeriodicalId":89327,"journal":{"name":"Basal ganglia","volume":"8 ","pages":"Page 18"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.baga.2017.02.053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45750044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}