Pathology research international最新文献_第6页

What We Have Learned about Autism Spectrum Disorder from Valproic Acid. 我们从丙戊酸中了解到的自闭症谱系障碍。

Pathology research international Pub Date : 2013-01-01 Epub Date: 2013-12-17 DOI: 10.1155/2013/712758

Taylor Chomiak, Nathanael Turner, Bin Hu

引用次数: 88

A Comparison of Hemoglobin A2 Levels in Untreated and Treated Groups of HIV Patients on ART Including Zidovudine. 齐多夫定抗逆转录病毒治疗组与未治疗组的血红蛋白A2水平比较

Pathology research international Pub Date : 2013-01-01 Epub Date: 2013-12-26 DOI: 10.1155/2013/828214

Jitendra Singh Nigam, Jyotsna Naresh Bharti, Dinker Kumar, Ankit Sharma

{"title":"A Comparison of Hemoglobin A2 Levels in Untreated and Treated Groups of HIV Patients on ART Including Zidovudine.","authors":"Jitendra Singh Nigam, Jyotsna Naresh Bharti, Dinker Kumar, Ankit Sharma","doi":"10.1155/2013/828214","DOIUrl":"https://doi.org/10.1155/2013/828214","url":null,"abstract":"Objective. To assess the level of haemoglobin A2 in HIV patients on antiretroviral therapy (ART) including zidovudine with untreated HIV patients. Material and Methods. The study was a case control study. A total of 185 patients were included in the study; the case group included 125 HIV patients who were on antiretroviral therapy (ART) including zidovudine and 60 were in the control group who were not receiving ART. The high-performance liquid chromatography (HPLC) was done and hemoglobin A2 level was observed; value more than 3.5% was considered significant. The Hb A2 percentages of HIV patients were compared with those of control using an unpaired t-test. Results. The mean of Hb A2 in case group was 3.462% (SD 0.675) and in control group it was 2.815% (SD0.246). The higher Hb A2 value was seen in significant number of treated patients than control group (P < 0.0001). Conclusion. The clinicians, pathologists, haematologists, and genetic counsellors should be aware of effects of nutritional anaemia and ART on Hb A2 to reduce the chances of misdiagnosis of β -thalassaemia especially in developing countries and for centres for antenatal screening. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2013 ","pages":"828214"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/828214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32059972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Outcomes in Ovarian Cancer among Hispanic Women Living in the United States: A Population-Based Analysis. 生活在美国的西班牙裔女性卵巢癌的结局:基于人群的分析

Pathology research international Pub Date : 2013-01-01 Epub Date: 2013-02-20 DOI: 10.1155/2013/672710

Okechukwu A Ibeanu, Teresa P Díaz-Montes

{"title":"Outcomes in Ovarian Cancer among Hispanic Women Living in the United States: A Population-Based Analysis.","authors":"Okechukwu A Ibeanu, Teresa P Díaz-Montes","doi":"10.1155/2013/672710","DOIUrl":"https://doi.org/10.1155/2013/672710","url":null,"abstract":"Introduction. Ovarian cancer is the deadliest gynecologic cancer in the United States. There is limited data on presentation and outcomes among Hispanic women with ovarian cancer. Objective. To investigate how ovarian cancer presents among Hispanic women in the USA and to analyze differences in presentation, staging, and survival between Hispanic and non-Hispanic women with ovarian cancer. Methods. Data from January 1, 2000 to December 31, 2004 were extracted from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) database. Results. The study sample comprised 1215 Hispanics (10%), 10 652 non-Hispanic whites (83%), and 905 non-Hispanic blacks (7%). Hispanic women were diagnosed with ovarian cancer at a younger age and earlier stage when compared to non-Hispanic whites, non-Hispanic blacks; P < 0.001. Similar proportion of Hispanics (33%), non-Hispanic whites (32%), and non-Hispanic blacks (24%) underwent lymphadenectomy; P < 0.001. Hispanics with epithelial ovarian cancer histology had longer five-year survival of 30.6 months compared to non-Hispanic whites (22.8 months) and non-Hispanic blacks (23.3 months); P = 0.001. Conclusion. Hispanic women with ovarian cancer have a statistically significantly longer median survival compared to whites and blacks. This survival difference was most apparent in patients with epithelial cancers and patients with stage IV disease.","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2013 ","pages":"672710"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/672710","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31412368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Clinicopathological study of 25 cases of diverticular disease of the appendix: experience from farwaniya hospital. 法瓦尼亚医院阑尾憩室病25例临床病理分析。

Pathology research international Pub Date : 2013-01-01 Epub Date: 2013-10-02 DOI: 10.1155/2013/404308

Nabeel Al-Brahim, Ibrahim Al-Kandari, Musaad Munahai, Prem Sharma

{"title":"Clinicopathological study of 25 cases of diverticular disease of the appendix: experience from farwaniya hospital.","authors":"Nabeel Al-Brahim, Ibrahim Al-Kandari, Musaad Munahai, Prem Sharma","doi":"10.1155/2013/404308","DOIUrl":"https://doi.org/10.1155/2013/404308","url":null,"abstract":"Background. Diverticular disease of the appendix (DDA) is a rare disease and it has been shown to be associated with locoregional neoplasms. This study was conducted to characterize clinicopathological features and to investigate its association with appendiceal neoplasms. Methods. We searched the records of the Department of Pathology at Farwaniya Hospital for cases of diverticular disease of the appendix between 2003 and 2011. Histological slides and patient charts were reviewed for relevant information. Consecutive cases of acute appendicitis were selected as a control group. Results. We identified 25 cases of DDA, 24 of which occurred in men. Mean age of DDA patients was 35 ± 10.1 years and was significantly greater than that of appendicitis patients (P = 0.027). The mean temperature of cases (37.9°) was significantly higher (P = 0.012) than that of the controls (37.3°). The cases had lower white blood cell (WBC) counts compared to controls (13.6 versus 16.7, P = 0.04). Pathological diagnosis identified 4 cases of diverticulosis, 5 cases of diverticulitis, 6 cases of diverticulosis with acute appendicitis, and 10 cases of diverticulitis and appendicitis. None of the cases was associated with any type of neoplasm. Conclusions. DDA is a rare disease, and clinicians and radiologists should be aware of it. Male sex and adult age seem to be risk factors associated with DDA. The disease may not have any direct association with any neoplasm. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2013 ","pages":"404308"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/404308","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31859400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 49

A compendium of urinary biomarkers indicative of glomerular podocytopathy. 肾小球足细胞病的尿液生物标志物摘要。

Pathology research international Pub Date : 2013-01-01 Epub Date: 2013-11-13 DOI: 10.1155/2013/782395

Miroslav Sekulic, Simona Pichler Sekulic

{"title":"A compendium of urinary biomarkers indicative of glomerular podocytopathy.","authors":"Miroslav Sekulic, Simona Pichler Sekulic","doi":"10.1155/2013/782395","DOIUrl":"https://doi.org/10.1155/2013/782395","url":null,"abstract":"It is well known that glomerular podocyte injury and loss are present in numerous nephropathies and that the pathophysiologic consecution of disease hinges upon the fate of the podocyte. While multiple factors play a hand in glomerulopathy progression, basic logic lends that if one monitors the podocyte's status, that may reflect the status of disease. Recent investigations have focused on what one can elucidate from the noninvasive collection of urine, and have proven that certain, specific biomarkers of podocytes can be readily identified via varying techniques. This paper has brought together all described urinary biomarkers of podocyte injury and is made to provide a concise summary of their utility and testing in laboratory and clinical theatres. While promising in the potential that they hold as tools for clinicians and investigators, the described biomarkers require further comprehensive vetting in the form of larger clinical trials and studies that would give their value true weight. These urinary biomarkers are put forth as novel indicators of glomerular disease presence, disease progression, and therapeutic efficacy that in some cases may be more advantageous than the established parameters/measures currently used in practice. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2013 ","pages":"782395"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/782395","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31945886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

A naturally occurring feline model of head and neck squamous cell carcinoma. 自然发生的猫头颈部鳞状细胞癌模型。

Pathology research international Pub Date : 2013-01-01 Epub Date: 2013-07-16 DOI: 10.1155/2013/502197

Jackie M Wypij

{"title":"A naturally occurring feline model of head and neck squamous cell carcinoma.","authors":"Jackie M Wypij","doi":"10.1155/2013/502197","DOIUrl":"https://doi.org/10.1155/2013/502197","url":null,"abstract":"Despite advances in understanding cancer at the molecular level, timely and effective translation to clinical application of novel therapeutics in human cancer patients is lacking. Cancer drug failure is often a result of toxicity or inefficacy not predicted by preclinical models, emphasizing the need for alternative animal tumor models with improved biologic relevancy. Companion animals (dogs and cats) provide an opportunity to capitalize on an underutilized and biologically relevant translational research model which allows spontaneous disease modeling of human cancer. Head and neck squamous cell carcinoma (HNSCC) is a common cancer with a poor prognosis and limited clinical advancements in recent years. One potential novel spontaneous animal tumor model is feline oral squamous cell carcinoma (FOSCC). FOSCC and HNSCC share similar etiopathogenesis (tobacco and papillomavirus exposure) and molecular markers (EGFR, VEGF, and p53). Both human and feline SCCs share similar tumor biology, clinical outcome, treatment, and prognosis. Future clinical trials utilizing FOSCC as a tumor model may facilitate translation of preclinical cancer research for human cancer patients. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2013 ","pages":"502197"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/502197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31679761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58

Correlation of various techniques in diagnosis of tuberculous lymphadenitis on fine needle aspiration cytology. 细针穿刺细胞学诊断结核性淋巴结炎各项技术的相关性分析。

Pathology research international Pub Date : 2013-01-01 Epub Date: 2013-09-19 DOI: 10.1155/2013/824620

Brijesh Thakur, Ravi Mehrotra, Jitendra Singh Nigam

{"title":"Correlation of various techniques in diagnosis of tuberculous lymphadenitis on fine needle aspiration cytology.","authors":"Brijesh Thakur, Ravi Mehrotra, Jitendra Singh Nigam","doi":"10.1155/2013/824620","DOIUrl":"https://doi.org/10.1155/2013/824620","url":null,"abstract":"Objective. To study the correlation of cytomorphological features in fine needle aspiration smears from patients suspected of having tuberculous lymphadenitis with Ziehl-Neelsen staining (ZN), auramine-rhodamine staining (ARS), and autofluorescence (AF). Methods. A total of 145 lymph nodes were aspirated, 3 air-dried smears were stained with Giemsa, Ziehl-Neelsen, and auramine-rhodamine stains, and 1 smear was wet fixed for Papanicolaou staining. Needle washes were incubated in Lowenstein-Jensen medium for culture. Papanicolaou and auramine-rhodamine stained smears were examined under fluorescent microscope using a blue excitation filter (450-480 nm). Results. Ninety aspirates were reported on cytomorphology as suggestive of tuberculous lymphadenitis. Smear positivity for Mycobacteria by Ziehl-Neelsen method was 26.67% (24/90), while positivity increased to 34.44% (31/90) by auramine-rhodamine and 42.22% (38/90) on autofluorescence. Culture was positive in 27.78% (25/90) aspirates. Using culture as the reference method, the statistical values of ZN, ARS, and AF were as follows: sensitivity 80.0%, 88.0%, 96.0%; specificity 93.85%, 86.15%, 78.46%; positive predictive values 83.33%, 70.97%, 63.16%; and negative predictive values 92.42%, 94.92%, 98.08%, respectively. Conclusion. There is a definite advantage of autofluorescence over Ziehl-Neelsen and auramine-rhodamine which is to detect Mycobacteria, being more sensitive as well as an inexpensive technique. Autofluorescence can be a useful addition to routine cytology for early diagnosis and effective treatment. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":" ","pages":"824620"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/824620","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40276856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Evidences suggesting involvement of viruses in oral squamous cell carcinoma. 有证据表明口腔鳞状细胞癌与病毒有关。

Pathology research international Pub Date : 2013-01-01 Epub Date: 2013-12-19 DOI: 10.1155/2013/642496

Kanupriya Gupta, Rashmi Metgud

{"title":"Evidences suggesting involvement of viruses in oral squamous cell carcinoma.","authors":"Kanupriya Gupta, Rashmi Metgud","doi":"10.1155/2013/642496","DOIUrl":"10.1155/2013/642496","url":null,"abstract":"Oral cancer is one of the most common cancers and it constitutes a major health problem particularly in developing countries. Oral squamous cell carcinoma (OSCC) represents the most frequent of all oral neoplasms. Several risk factors have been well characterized to be associated with OSCC with substantial evidences. The etiology of OSCC is complex and involves many factors. The most clearly defined potential factors are smoking and alcohol, which substantially increase the risk of OSCC. However, despite this clear association, a substantial proportion of patients develop OSCC without exposure to them, emphasizing the role of other risk factors such as genetic susceptibility and oncogenic viruses. Some viruses are strongly associated with OSCC while the association of others is less frequent and may depend on cofactors for their carcinogenic effects. Therefore, the exact role of viruses must be evaluated with care in order to improve the diagnosis and treatment of OSCC. Although a viral association within a subset of OSCC has been shown, the molecular and histopathological characteristics of these tumors have yet to be clearly defined. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2013 ","pages":"642496"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32054060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Modalities of Precancerous and Cancerous Cervical Lesions with Special Emphasis on CD31 Angiogenesis Factor as a Marker. 宫颈癌前病变和癌性病变的诊断模式，特别强调CD31血管生成因子作为标志物。

Pathology research international Pub Date : 2013-01-01 Epub Date: 2013-09-17 DOI: 10.1155/2013/243168

Bandana Sharma, Neetu Singh, Neena Gupta, Pavika Lal, Shefali Pande, Shashi Chauhan

{"title":"Diagnostic Modalities of Precancerous and Cancerous Cervical Lesions with Special Emphasis on CD31 Angiogenesis Factor as a Marker.","authors":"Bandana Sharma, Neetu Singh, Neena Gupta, Pavika Lal, Shefali Pande, Shashi Chauhan","doi":"10.1155/2013/243168","DOIUrl":"https://doi.org/10.1155/2013/243168","url":null,"abstract":"Objectives. To evaluate the role of angiogenesis tumor marker CD31 in the detection of precancerous and cancerous cervical lesions and to compare its efficacy with colposcopy and histopathology. Materials and Methods. 230 patients with a suspicious looking cervix and an abnormal Pap smear attending the Outpatient Department of Obstetrics and Gynaecology of GSVM Medical College were subjected to a colposcopic examination. 180 patients with suspected colposcopic findings were subjected to a colposcopic directed biopsy. Biopsy tissues were sent for histopathological examination out of which 50 biopsied samples were sent for immunostaining of CD-31. Statistical analysis was done. Results. Comparison of microvessel density (MVD) count by haematoxylin and eosin staining (HE) and immunostaining of CD31 in preinvasive group were 4.012 ± 2.57 and 5.44 ± 2.21, respectively, and in invasive group were 9.18 ± 2.32 and 12.82 ± 4.07, respectively, which showed that MVD was higher by CD31 both in preinvasive and invasive group, and it was statistically significant. Conclusion. Angiogenesis is a marker of tumor progression, and CD31 fixes up vessel better as compared to HE, so aggressiveness of the tumor can be better predicted by MVD-CD31 as compared to MVD-HE. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":" ","pages":"243168"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/243168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40274188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Immunoreactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Primary Lymphoid Tumors and Lymph Node Metastasis. 14F7单抗对n -糖基GM3神经节苷脂在原发性淋巴肿瘤和淋巴结转移中的免疫反应性

Pathology research international Pub Date : 2013-01-01 Epub Date: 2013-11-28 DOI: 10.1155/2013/920972

Rancés Blanco, Damián Blanco, Yisel Quintana, Xiomara Escobar, Charles E Rengifo, Marta Osorio, Zailí Gutiérrez, Janet Lamadrid, Mercedes Cedeño, Milagros Frómeta, Adriana Carr, Enrique Rengifo

{"title":"Immunoreactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Primary Lymphoid Tumors and Lymph Node Metastasis.","authors":"Rancés Blanco, Damián Blanco, Yisel Quintana, Xiomara Escobar, Charles E Rengifo, Marta Osorio, Zailí Gutiérrez, Janet Lamadrid, Mercedes Cedeño, Milagros Frómeta, Adriana Carr, Enrique Rengifo","doi":"10.1155/2013/920972","DOIUrl":"https://doi.org/10.1155/2013/920972","url":null,"abstract":"The reactivity of the 14F7 Mab, a highly specific IgG1 against N-glycolyl GM3 ganglioside (NeuGcGM3) in normal tissues, lymphomas, lymph node metastasis, and other metastatic sites was assessed by immunohistochemistry. In addition, the effect of chemical fixation on the 14F7 Mab staining using monolayers of P3X63Ag.653 cells was also evaluated. Moreover, the ability of 14F7 to bind NeuGcGM3 ganglioside inducing complement-independent cytotoxicity by a flow cytometry-based assay was measured. The 14F7 Mab was reactive in unfixed, 4% paraformaldehyde, 4% formaldehyde, and acetone fixed cells. Postfixation with acetone did not alter the localization of NeuGcGM3, while the staining with 14F7 Mab was significantly eliminated in both cells fixed and postfixed with methanol but only partially reduced with ethanol. The staining with 14F7 Mab was evidenced in the 89.2%, 89.4%, and 88.9% of lymphomas, lymph node metastasis, and other metastatic sites, respectively, but not in normal tissues. The treatment with 14F7 Mab affected both morphology and membrane integrity of P3X63Ag.653 cells. This cytotoxic activity was dose-dependent and ranged from 24.0 to 84.7% (10-1000 μ g/mL) as compared to the negative control. Our data could support the possible use of NeuGcGM3 as target for both active and passive immunotherapy against malignancies expressing this molecule. ","PeriodicalId":89212,"journal":{"name":"Pathology research international","volume":"2013 ","pages":"920972"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/920972","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31992939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15