Frontiers of medicine in China最新文献

{"title":"Comparing the effects of Bassini versus tension-free hernioplasty: 3 years' follow-up.","authors":"Yulong Shi,&nbsp;Zhongxue Su,&nbsp;Leping Li,&nbsp;Hongjun Liu,&nbsp;Changqing Jing","doi":"10.1007/s11684-010-0050-5","DOIUrl":"https://doi.org/10.1007/s11684-010-0050-5","url":null,"abstract":"<p><p>In order to compare the effects of Bassini and tension-free mesh hernioplasty, a total of 552 patients with inguinal hernia who were subjected to surgical treatment in our hospital were randomly divided into the following two groups: the Bassini group (n = 269) and the tension-free mesh group (n = 283). The recurrence rates, pain, discomfort, and other complications were recorded, and the causes of the complications were explored. The recurrence rate in the Bassini group was 8.9% (24/269), significantly higher than that in the tension-free repair group (2.8%, 8/283). In addition, the recurrence rates in the Bassini and tension-free groups before 2004 were 12.6% and 5.6%, respectively, which were markedly higher than the rates after 2004 (5.3% and 0.7%, respectively). The rate of postoperative discomfort and pain within the first three months was higher in the Bassini group compared to the tensionfree group (25.7% vs 18.5%, respectively). However, there was no difference after three months in the rate of postoperative discomfort and pain, incidence of infection, or scrotal edema between the two groups. The average hospital stay in the Bassini group was longer than that in the tension-free repair group (7.6±1.2 vs 4.5±2.2 days, respectively), but the cost was lower (4518.0±510 vs 6221.3±578 yuan, respectively). Thus, tension-free mesh hernioplasty is indicated for most inguinal hernia patients due to the low recurrence rate, rapid recovery time, and treatment success, but the traditional Bassini procedure has lower cost and other beneficial effects and is still suitable for some patients.</p>","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"463-8"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0050-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29495370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational medicine promising personalized therapy in oncology.","authors":"Yi-Xin Zeng,&nbsp;Xiao-Shi Zhang,&nbsp;Qiang Liu","doi":"10.1007/s11684-010-0320-2","DOIUrl":"https://doi.org/10.1007/s11684-010-0320-2","url":null,"abstract":"","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"351-5"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0320-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29493796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol and tea consumption in relation to the risk of nasopharyngeal carcinoma in Guangdong, China.","authors":"Hong-Lian Ruan,&nbsp;Feng-Hua Xu,&nbsp;Wen-Sheng Liu,&nbsp;Qi-Sheng Feng,&nbsp;Li-Zhen Chen,&nbsp;Yi-Xin Zeng,&nbsp;Wei-Hua Jia","doi":"10.1007/s11684-010-0280-6","DOIUrl":"https://doi.org/10.1007/s11684-010-0280-6","url":null,"abstract":"<p><p>To investigate whether alcohol and tea consumption has an etiological association with nasopharyngeal carcinoma (NPC) in a high-incident population, a large scale case-control study was conducted. The study included 2846 individuals in Guangdong Province, China, with 1387 newly diagnosed cases of NPC and 1459 frequency-matched controls. Exposure histories of alcohol and tea consumption were obtained via personal interviews. Information regarding socio-demographic characteristics (age, sex, education, dialect and household type), family history of NPC, Epstein-Barr virus (EBV) infection, dietary habits and other potential confounding factors was also studied. An analysis was performed using unconditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI). The risk of NPC was found to be associated with habitual alcohol consumption and tea consumption. Tea consumption has been associated with a decreased occurrence of NPC (OR = 0.62), while consumption of alcohol was associated with a complex effect. Specifically, moderate consumption of alcohol was associated with decreased risk of NPC, while overuse, especially strong distillate spirits, appeared to be a risk factor.</p>","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"448-56"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0280-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29495371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectively cultivate the next generation of competent Chinese physicians: a perspective from a physician trained in both Chinese and US medical institutions.","authors":"Zongyu John Chen","doi":"10.1007/s11684-010-0290-4","DOIUrl":"https://doi.org/10.1007/s11684-010-0290-4","url":null,"abstract":"","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"473-6"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0290-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29489859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma.","authors":"Xi-Yan Wang,&nbsp;Hai-Jun Li,&nbsp;Hao Wen,&nbsp;Dong Yan,&nbsp;Shu-Yong Peng","doi":"10.1007/s11684-010-0700-7","DOIUrl":"https://doi.org/10.1007/s11684-010-0700-7","url":null,"abstract":"<p><p>This study aimed to investigate the effect of adjuvant therapy on the treatment of stage II pancreatic carcinomas. The clinical data of 139 cases of stage II pancreatic carcinoma were analyzed retrospectively. The overall 1-, 3-, and 5-year cumulative survival rates of 139 patients were 40%, 6%, and 3%, respectively, and the median survival time (MST) was 279 days. The MST was 399 days for those with adjuvant therapy, 210 days for those without adjuvant therapy, 390 days for the radical resection group, 270 days for the bypass operation and laparotomy group, and 132 days for the nonsurgical group. The adjuvant therapy could not prolong the survival time and decrease the liver metastasis rate of the patients with stage II carcinoma significantly in radical resection group (P>0.05). In the bypass operation and laparotomy group and nonsurgical group, the adjuvant therapy could improve the survival of the patients significantly (P<0.05); however, the survival rate was not significantly different among systemic venous chemotherapy, radiation therapy, interventional therapy, and combination therapy (P>0.05); or between gemcitabine (GEM) regimen and 5-fluorouracil regimen (P>0.05); or between GEM monotherapy and GEM combined with platinum/capecitabine (P>0.05). The proper adjuvant therapy can be suggested according to the general condition of the patients after radical resection for stage II pancreatic carcinoma. Chemotherapy combined with radiation should be applied actively for the patients whose cancerous tissues were not radically resected. The clinical efficacy of GEM combined with platinum/capecitabine is relatively better than GEM.</p>","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"430-5"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0700-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29563972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graft versus host disease after liver transplantation: a case report.","authors":"Peng-Ji Gao,&nbsp;Xi-Sheng Leng,&nbsp;Dong Wang,&nbsp;Guang-Ming Li,&nbsp;Lei Huang,&nbsp;Jie Gao,&nbsp;Ji-Ye Zhu","doi":"10.1007/s11684-010-0120-8","DOIUrl":"https://doi.org/10.1007/s11684-010-0120-8","url":null,"abstract":"<p><p>In documenting clinical experience in the diagnosis and treatment of graft versus host disease (GVHD), we retrospectively analyzed data of one case that has developed GVHD after liver transplantation. This patient exhibited fever, skin rash, and diarrhea on day 9 after liver transplantation. His liver function was normal. Skin biopsy showed scattered keratinocytes accompanied by satellite-like lymphocyte infiltration and basal cell liquefaction degeneration. After carefully analyzing the complications, we took the strategy of decreasing the dose of tacrolimus. Thereafter, the patient's temperature decreased to normal, his skin rashes subsided, and his diarrhea was relieved. This case suggests that reducing the dosage of immunosuppressive agents can be an effective strategy for GVHD after liver transplantation.</p>","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"469-72"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0120-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29507300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell lines.","authors":"Junfang Ji,&nbsp;Kun Wu,&nbsp;Min Wu,&nbsp;Qimin Zhan","doi":"10.1007/s11684-010-0260-x","DOIUrl":"https://doi.org/10.1007/s11684-010-0260-x","url":null,"abstract":"<p><p>p53 mutations have been found in many esophageal squamous cell carcinoma (ESCC) clinical specimens and cell lines. We reasoned that functional inactivation of wild-type p53 or the functional activation of mutant-type p53 might exist in these specimens and cell lines. In this study, we identified the correlation between p53 functional activation and its genotype in five different ESCC cell lines. To examine the potential p53 activation in a certain ESCC cell line, DNA damage methods including X-ray exposure and cisplatin treatment were employed to treat cells. Further, the expression of p53 protein and four transcripts of well-known p53 target genes were investigated using Western blot and reverse transcriptionpolymerase chain reaction (RT-PCR) after cell exposure to DNA damage. The results showed that in KYSE 30 cell line with mutant p53 and KYSE 150 with wild-type p53, p53 could be activated by DNA damages. However, p53 could not be activated following the DNA damages in YES 2 with wild-type p53, KYSE 70 with mutant p53, and EC9706 with unknown p53 genotype. All our data indicated that p53 function in certain cells is not closely correlated with its genotype. To judge p53 function in a particular cell line, it is important to examine the p53 functional activation, but not to simply rely on the p53 genotype.</p>","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"412-8"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0260-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29563971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first year follow-up after colorectal adenoma polypectomy is important: a multiple-center study in symptomatic hospital-based individuals in China.","authors":"Qin-Yan Gao,&nbsp;Hui-Min Chen,&nbsp;Jian-Qiu Sheng,&nbsp;Ping Zheng,&nbsp;Cheng-Gong Yu,&nbsp;Bo Jiang,&nbsp;Jing-Yuan Fang","doi":"10.1007/s11684-010-0200-9","DOIUrl":"https://doi.org/10.1007/s11684-010-0200-9","url":null,"abstract":"<p><p>The recurrence of colorectal adenoma (CRA) is high. Although there are guidelines for colonoscopy surveillance after polypectomy in other countries, little is known about its recurrence rate and recurrence peak, especially in China. The aim of the present research is to investigate how long after polypectomy follow-up should take and to analyze risk factors of recurrence. 1208 patients who received polypectomies from five clinical research centers in four regions of China (Shanghai, Guangzhou, Nanjing and Beijing) were included. They were divided into 4 groups: group A (follow-up ≤ 1 year after polypectomy), group B (follow-up 2-3 years after polypectomy), group C (follow-up 4-5 years after polypectomy), and group D (follow-up > 5 years after polypectomy). The sex, age, adenoma location, size, number, and pathological characteristics were compared. On the whole, the recurrence rate was 59.46% in group A, 61.09% in group B, 78.07% in group C, and 87.12% in group D, which indicated an increased tendency with a prolonged follow-up duration. There was a significant difference between group A and C or D, and between group B and C or D (P<0.01), but there was no statistical difference between group A and B. Additionally, the recurrent patients in the first year had a recurrence rate of 97.33% in the first three years (59.46/61.09), which means that the peak of recurrence was almost entirely concentrated in the first year. The recurrence rate was higher in males and the elder. The risk factors included multiple numbers, villous feature, high-grade dysplasia of medium or smaller size and location in the distal colon. In conclusion, the peak of recurrence was almost totally concentrated in the first year; meanwhile, the first year follow-up is of critical importance in China. It may not be necessary to do the follow-up examination during the second and third years, but after three years, another colonoscopy should be undertaken.</p>","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"436-42"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0200-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29509318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas.","authors":"Lei Chen,&nbsp;Liang Hu,&nbsp;Liang Li,&nbsp;Yuan Liu,&nbsp;Qian-Qian Tu,&nbsp;Yan-Xin Chang,&nbsp;He-Xin Yan,&nbsp;Meng-Chao Wu,&nbsp;Hong-Yang Wang","doi":"10.1007/s11684-010-0170-y","DOIUrl":"https://doi.org/10.1007/s11684-010-0170-y","url":null,"abstract":"<p><p>β-catenin is a key molecule involved in both cell-cell adhesion and Wnt signaling pathway. In our study, we found that, in the development of hepatocellular carcinoma (HCC), β-catenin was correlated with hepatitis B virus (HBV) X gene encoded protein, which is essential for HBV infectivity and is a potential cofactor in viral carcinogenesis. The expression levels of wild-type β-catenin and E-cadherin were decreased in HepG2 cells expressing hepatitis B virus X protein (HBx), accompanied by destabilization of adherens junction. Reverse transcriptase PCR (RT-PCR), Northern and Western blot showed that reduction of wild-type β-catenin expression involved degradation of the protein. However, RNA interference (RNAi) and luciferase assay indicated that HBx enhanced β-catenin mediated signaling in HepG2 cells. In addition, immunohistochemical and Western blot analysis of β-catenin revealed that a decrease in the β-catenin protein level was found in 58.3% of HBV-related HCCs versus 19.2% of non-HBV-related tumors. Our data suggest that the expression of HBx contributed to the development of HCC, in part, by repressing the wild-type β-catenin expression and enforcing β-catenin-dependent signaling pathway, thus inducing cellular changes leading to acquisition of metastatic and/or proliferation properties.</p>","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"399-411"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0170-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29493798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and management against the complications of human cystic echinococcosis.","authors":"Hao Wen,&nbsp;Tuerganaili Aji,&nbsp;Ying-Mei Shao","doi":"10.1007/s11684-010-0180-9","DOIUrl":"https://doi.org/10.1007/s11684-010-0180-9","url":null,"abstract":"<p><p>Cystic echinococcosis (CE) (hydatidosis, hydatid disease) is a zoonosis caused by the larval stage of Echinococcus granulosus, typically affecting the liver. Hepatic cystic echinococcosis (HCE) is often asymptomatic, and symptoms occur largely when complications develop. Up to one-third of HCE can be shown their complications such as rupture of the cyst, secondary infection, and anaphylactic reaction. Clinically, patients present with pain, obstructive jaundice, cholangitis, anaphylactic reaction, and shock. Early diagnosis and treatment of complications of CE must be very important, since mortality is high when obstruction of the biliary ducts occurs, leading to ascending cholangitis and septicemia, anaphylactic shock, or even life-threatening conditions.</p>","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"394-8"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0180-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29507299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}