Frontiers of medicine in China最新文献

Realization of word-final taps in Spanish infinitive verbs 西班牙语不定式动词词尾轻敲的实现

Frontiers of medicine in China Pub Date : 2021-08-16 DOI: 10.7939/R3-FMED-6H82

Ashley Dugarte, S. J. Perry, Benjamin V. Tucker

引用次数: 0

Erratum to: Polycystic ovary syndrome 对多囊卵巢综合征的勘误

Frontiers of medicine in China Pub Date : 2010-12-30 DOI: 10.1007/S11684-010-0330-0

Zi-jiang Chen, Yuhua Shi

引用次数: 0

Serum carbohydrate antigen (CA) 19-9 as a prognostic factor in cholangiocarcinoma: a meta-analysis. 血清碳水化合物抗原(CA) 19-9作为胆管癌预后因素:一项荟萃分析

Frontiers of medicine in China Pub Date : 2010-12-01 Epub Date: 2010-11-16 DOI: 10.1007/s11684-010-0240-1

Shang-Long Liu, Zi-Fang Song, Qing-Gang Hu, Duo Shan, Shao-Bo Hu, Jun Li, Qi-Chang Zheng

{"title":"Serum carbohydrate antigen (CA) 19-9 as a prognostic factor in cholangiocarcinoma: a meta-analysis.","authors":"Shang-Long Liu, Zi-Fang Song, Qing-Gang Hu, Duo Shan, Shao-Bo Hu, Jun Li, Qi-Chang Zheng","doi":"10.1007/s11684-010-0240-1","DOIUrl":"https://doi.org/10.1007/s11684-010-0240-1","url":null,"abstract":"This study was performed to determine the prognostic role of preoperative serum carbohydrate antigen (CA) 19-9 levels in the survival of patients with cholangiocarcinoma. Articles published up to June 1(st), 2010 that evaluated preoperative CA19-9 levels and the prognosis of cholangiocarcinoma were collected for meta-analysis. The required information for calculating individual relative risk (RR) was extracted from the studies, and a combined overall RR was estimated. Nine eligible studies were included. One study dealt with extra-hepatic cholangiocarcinoma, while the other eight studies analyzed intra-hepatic cholangiocarcinoma. The mean methodological quality score was 74.1%, ranging from 65.5% to 82.5%. The overall RR for the nine studies was 1.28 (95% confidence interval = 1.10-1.46), and the Z-score for overall effect was 13.83 (P<0.001). The association between serum CA19-9 level and lymph node involvement was also assessed. The combined RR was 1.471 (95% confidence interval = 0.411-5.264) and Z-score for overall effect was 0.59 (P = 0.553). CA19-9 levels were associated significantly with the prognosis of patients with cholangiocarcinoma. This meta-analysis shows that elevation of preoperative CA19-9 levels is correlated with a poor prognosis of patients with cholangiocarcinoma. However, larger scale and randomized studies are needed to draw a more substantive conclusion.","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"457-62"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0240-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29563973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Hilar cholangiocarcinoma: pathology and tumor biology. 肝门胆管癌:病理学和肿瘤生物学。

Frontiers of medicine in China Pub Date : 2010-12-01 Epub Date: 2010-11-25 DOI: 10.1007/s11684-010-0130-6

Dong Kuang, Guo-Ping Wang

引用次数: 18

The liver tissue bank and clinical database in China. 中国肝组织库和临床数据库。

Frontiers of medicine in China Pub Date : 2010-12-01 Epub Date: 2010-11-19 DOI: 10.1007/s11684-010-0190-7

Yuan Yang, Yi-Min Liu, Ming-Yue Wei, Yi-Fei Wu, Jun-Hui Gao, Lei Liu, Wei-Ping Zhou, Hong-Yang Wang, Meng-Chao Wu

引用次数: 9

Molecular mechanisms of leukemia-associated protein degradation. 白血病相关蛋白降解的分子机制。

Frontiers of medicine in China Pub Date : 2010-12-01 Epub Date: 2010-11-19 DOI: 10.1007/s11684-010-0210-7

Ying-Li Wu, Hu-Chen Zhou, Guo-Qiang Chen

{"title":"Molecular mechanisms of leukemia-associated protein degradation.","authors":"Ying-Li Wu, Hu-Chen Zhou, Guo-Qiang Chen","doi":"10.1007/s11684-010-0210-7","DOIUrl":"https://doi.org/10.1007/s11684-010-0210-7","url":null,"abstract":"Chemical biology, using small molecules as probes to study the cellular signaling network, has developed rapidly in recent years. The interaction between chemistry and biology not only provides new insight into the understanding of cellular activities, but also generates new lead compounds for the treatment of diseases. Transcription factors and kinases such as retinoic acid receptor-alpha (RARα), acute myeloid leukemia 1 (AML1), CAAT/enhancer-binding protein α (C/EBPα), c-myc, and c-abl play important roles in the differentiation of hematopoietic stem/progenitor cells. Abnormalities in these proteins may cause the dysregulation of hematopoiesis and even the occurrence of leukemia. Ubiquitin-mediated protein degradation represents a critical mechanism in regulating the cellular levels and functions of these proteins. Thus, targeting protein degradation has been emerging as an important strategy to conquer malignant diseases. In this review, we will summarize the recent advances in the understanding of the roles of protein degradation in leukemia, with an emphasis on the mechanisms revealed by small molecules.","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"363-70"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0210-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29490551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Association of novel mutations and haplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma. 乙型肝炎病毒前s区新突变和单倍型与肝细胞癌的关系

Frontiers of medicine in China Pub Date : 2010-12-01 Epub Date: 2010-11-19 DOI: 10.1007/s11684-010-0160-0

Jia-Xin Xie, Jun Zhao, Jian-Hua Yin, Qi Zhang, Rui Pu, Wen-Ying Lu, Hong-Wei Zhang, Hong-Yang Wang, Guang-Wen Cao

{"title":"Association of novel mutations and haplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma.","authors":"Jia-Xin Xie, Jun Zhao, Jian-Hua Yin, Qi Zhang, Rui Pu, Wen-Ying Lu, Hong-Wei Zhang, Hong-Yang Wang, Guang-Wen Cao","doi":"10.1007/s11684-010-0160-0","DOIUrl":"https://doi.org/10.1007/s11684-010-0160-0","url":null,"abstract":"The association of viral mutations and haplotypic carriages with mutations in the preS region of hepatitis B virus (HBV) genotypes B and C with hepatocellular carcinoma (HCC) is of great significance for the prediction of this malignancy, but it remains obscure. We analyzed the preS sequences of HBV genotypes B and C from 1172 HBV-infected subjects including 231 patients with HCC. As compared with the HBV-infected subjects without HCC, C2875T, G2946C, A3054C, C3060A, T3066C, C3116T, A3120C, G3191A, A1C, C7A, C10A, A31C, C76T, G105C, and G147C in both genotypes were significantly associated with increased risks of HCC. C2875A, G2950A, G2951A, A3054T, C3060T, T3066A, T3069G, A3120T, and G3191C were significantly associated with increased risks of HCC in genotype C, whereas these mutations were inversely associated with HCC in genotype B. Multivariate regression analyses showed that C76A/T was a novel factor independently associated with an increased risk of HCC, as compared with those without HCC. The frequencies of haplotypes 2964A-3116T-preS2 start codon wild-type-7C, 2964C-3116T-7A-76C, and 2964A-3116T-7C-76A/T were significantly higher in the patients with HCC (P<0.001), whereas a haplotypic carriage with a single mutation and another three wildtypes were inversely associated with HCC. Conclusively, the association of HBV mutations in the preS region with HCC depends on HBV genotype and haplotypic carriage with two or more mutations that are each associated with an increased risk of HCC independently.","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"419-29"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0160-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29490552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Molecular pathogenesis of acute myeloid leukemia: a diverse disease with new perspectives. 急性髓系白血病的分子发病机制:一种具有新视角的多样化疾病。

Frontiers of medicine in China Pub Date : 2010-12-01 DOI: 10.1007/s11684-010-0220-5

Felicitas Thol, Arnold Ganser

{"title":"Molecular pathogenesis of acute myeloid leukemia: a diverse disease with new perspectives.","authors":"Felicitas Thol, Arnold Ganser","doi":"10.1007/s11684-010-0220-5","DOIUrl":"https://doi.org/10.1007/s11684-010-0220-5","url":null,"abstract":"Acute myeloid leukemia (AML) is a very heterogeneous neoplasm of the hematopoietic stem cell. Despite important achievements in the treatment of AML, the long term survival of patients with the disease remains poor. Understanding the pathogenesis of AML better is crucial for finding new treatment approaches. During AML development, hematopoietic precursor cells undergo clonal transformation in a multistep process through acquisition of chromosomal rearrangements and/or different gene mutations. Over recent years, novel gene mutations have been found in patients with AML. These mutations can be divided into two important categories, class I mutations that confer a proliferation advantage and class II mutations that inhibit myeloid differentiation. Screening for some of these mutations is now part of the initial diagnostic workup in newly diagnosed AML patients. Information about the mutation status of specific genes is useful for risk-stratification, minimal residual disease (MRD) monitoring and increasingly also for targeted therapy, especially for patients with cytogenetically normal AML (CN-AML). Besides chromosomal rearrangements and gene mutations, epigenetic regulation of genes - meaning changes in gene expression by mechanisms other than changes in the underlying DNA sequence - also represents an important mechanism of leukemogenesis. This article reviews some of the most common mutations in CN-AML and gives a perspective of the translation of these discoveries from bench to bedside.","PeriodicalId":89138,"journal":{"name":"Frontiers of medicine in China","volume":"4 4","pages":"356-62"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11684-010-0220-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29507298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Toll-like receptors in innate immunity and infectious diseases. toll样受体在先天免疫和传染病中的作用。

Frontiers of medicine in China Pub Date : 2010-12-01 Epub Date: 2010-12-02 DOI: 10.1007/s11684-010-0600-x

Min-Hao Wu, Ping Zhang, Xi Huang

引用次数: 20

The value of epigenetic markers in esophageal cancer. 表观遗传标记在食管癌中的价值。

Frontiers of medicine in China Pub Date : 2010-12-01 Epub Date: 2010-11-24 DOI: 10.1007/s11684-010-0230-3

Xiao-Mei Zhang, Ming-Zhou Guo

引用次数: 30