Chimerism最新文献

Microchimerism of male origin in a cohort of Danish girls 丹麦女孩群体中男性起源的微嵌合现象

Chimerism Pub Date : 2015-10-02 DOI: 10.1080/19381956.2016.1218583

A. C. Müller, M. Jakobsen, T. Barington, A. Vaag, L. Grunnet, S. Olsen, M. Kamper-Jørgensen

{"title":"Microchimerism of male origin in a cohort of Danish girls","authors":"A. C. Müller, M. Jakobsen, T. Barington, A. Vaag, L. Grunnet, S. Olsen, M. Kamper-Jørgensen","doi":"10.1080/19381956.2016.1218583","DOIUrl":"https://doi.org/10.1080/19381956.2016.1218583","url":null,"abstract":"ABSTRACT Male microchimerism, the presence of a small number of male cells, in women has been attributed to prior pregnancies. However, male microchimerism has also been reported in women with only daughters, in nulliparous women and prepubertal girls suggesting that other sources of male microchimerism must exist. The aim of the present study was to examine the presence of male microchimerism in a cohort of healthy nulliparous Danish girls aged 10–15 y using DNA extracted from cells from whole blood (buffy coats) and report the association with potential sources of male cells. A total of 154 girls were studied of which 21 (13.6%) tested positive for male microchimerism. There was a tendency that girls were more likely to test positive for male microchimerism if their mothers previously had received transfusion, had given birth to a son or had had a spontaneous abortion. Furthermore, the oldest girls were more likely to test positive for male microchimerism. However, less than half of microchimerism positivity was attributable to these factors. In conclusion, data suggest that male microchimerism in young girls may originate from an older brother either full born or from a discontinued pregnancy or from transfusion during pregnancy. We speculate that sexual intercourse may be important but other sources of male cells likely exist in young girls.","PeriodicalId":89114,"journal":{"name":"Chimerism","volume":"6 1","pages":"65 - 71"},"PeriodicalIF":0.0,"publicationDate":"2015-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381956.2016.1218583","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59984590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Lost in translation? Microchimersim detection in experimental and clinical transplantation 迷失在翻译中?微嵌合体在实验和临床移植中的检测

Chimerism Pub Date : 2015-10-02 DOI: 10.1080/19381956.2016.1241373

J. Woodall, M. Uluer, Matthew T. Chrencik, A. Nam, S. Bartlett, R. Barth

引用次数: 0

Mixed chimerism renders residual host dendritic cells incapable of alloimmunization of the marrow donor in the canine model of allogeneic marrow transplantation 在犬同种异体骨髓移植模型中，混合嵌合使残余宿主树突状细胞不能对骨髓供体进行同种免疫

Chimerism Pub Date : 2015-10-02 DOI: 10.1080/19381956.2016.1270483

S. Rosinski, S. Graves, Deborah A Higginbotham, R. Storb

{"title":"Mixed chimerism renders residual host dendritic cells incapable of alloimmunization of the marrow donor in the canine model of allogeneic marrow transplantation","authors":"S. Rosinski, S. Graves, Deborah A Higginbotham, R. Storb","doi":"10.1080/19381956.2016.1270483","DOIUrl":"https://doi.org/10.1080/19381956.2016.1270483","url":null,"abstract":"ABSTRACT This study tested whether an alloimmune response can occur in the marrow donor when infused or injected with leukocytes from their mixed chimeric transplant recipient. Two mixed chimeras were produced after conditioning with three Gray total body irradiation, donor marrow infusion, and post-grafting immunosuppression. The marrow donors were then repeatedly infused and injected with leukocytes from their respective chimeric recipient. A donor lymphocyte infusion (DLI) into their mixed chimeras had no effect, even after the experiments were repeated. The presence of blood dendritic cells (DCs) of recipient origin was confirmed in chimeric recipients, as well as the presence of microchimerism in the marrow donors. Donor sensitization did occur following placement of a recipient skin graft that was confirmed following DLI into recipients that changed the mixed chimeras into full donor chimeras. These observations suggest that mixed chimerism renders recipient peripheral blood DCs incapable of inducing a donor T cell response.","PeriodicalId":89114,"journal":{"name":"Chimerism","volume":"97 1","pages":"54 - 64"},"PeriodicalIF":0.0,"publicationDate":"2015-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381956.2016.1270483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59984639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Deep-sequencing of the T-cell receptor repertoire in patients with haplo-cord and matched-donor transplants 单倍脐带和匹配供体移植患者t细胞受体库的深度测序

Chimerism Pub Date : 2015-07-03 DOI: 10.1080/19381956.2015.1128624

Houda Alachkar, Yusuke Nakamura

引用次数: 7

Ray Owen and the history of naturally acquired chimerism. 雷·欧文和自然获得嵌合的历史。

Chimerism Pub Date : 2015-04-03 Epub Date: 2016-04-19 DOI: 10.1080/19381956.2016.1168561

Aryn Martin

引用次数: 9

Tolerance to noninherited maternal antigens, reproductive microchimerism and regulatory T cell memory: 60 years after 'Evidence for actively acquired tolerance to Rh antigens'. 对非遗传性母体抗原的耐受性，生殖微嵌合和调节性T细胞记忆:“对Rh抗原主动获得性耐受性的证据”60年后。

Chimerism Pub Date : 2015-04-03 Epub Date: 2015-10-30 DOI: 10.1080/19381956.2015.1107253

Jeremy M Kinder, Tony T Jiang, James M Ertelt, Lijun Xin, Beverly S Strong, Aimen F Shaaban, Sing Sing Way

{"title":"Tolerance to noninherited maternal antigens, reproductive microchimerism and regulatory T cell memory: 60 years after 'Evidence for actively acquired tolerance to Rh antigens'.","authors":"Jeremy M Kinder, Tony T Jiang, James M Ertelt, Lijun Xin, Beverly S Strong, Aimen F Shaaban, Sing Sing Way","doi":"10.1080/19381956.2015.1107253","DOIUrl":"https://doi.org/10.1080/19381956.2015.1107253","url":null,"abstract":"Compulsory exposure to genetically foreign maternal tissue imprints in offspring sustained tolerance to noninherited maternal antigens (NIMA). Immunological tolerance to NIMA was first described by Dr. Ray D. Owen for women genetically negative for erythrocyte rhesus (Rh) antigen with reduced sensitization from developmental Rh exposure by their mothers. Extending this analysis to HLA haplotypes has uncovered the exciting potential for therapeutically exploiting NIMA-specific tolerance naturally engrained in mammalian reproduction for improved clinical outcomes after allogeneic transplantation. Herein, we summarize emerging scientific concepts stemming from tolerance to NIMA that includes postnatal maintenance of microchimeric maternal origin cells in offspring, expanded accumulation of immune suppressive regulatory T cells with NIMA-specificity, along with teleological benefits and immunological consequences of NIMA-specific tolerance conserved across mammalian species. ","PeriodicalId":89114,"journal":{"name":"Chimerism","volume":"6 1-2","pages":"8-20"},"PeriodicalIF":0.0,"publicationDate":"2015-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19381956.2015.1107253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34131910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Transient mixed chimerism for allograft tolerance. 用于异体移植耐受的瞬时混合嵌合体

Chimerism Pub Date : 2015-04-03 Epub Date: 2015-10-30 DOI: 10.1080/19381956.2015.1111975

Tetsu Oura, Kiyohiko Hotta, A B Cosimi, Tatsuo Kawai

{"title":"Transient mixed chimerism for allograft tolerance.","authors":"Tetsu Oura, Kiyohiko Hotta, A B Cosimi, Tatsuo Kawai","doi":"10.1080/19381956.2015.1111975","DOIUrl":"10.1080/19381956.2015.1111975","url":null,"abstract":"Mixed chimerism discovered in Freemartin cattle by Ray Owen 70 years ago paved the way for research on immune tolerance. Since his discovery, significant progress has been made in the effort to induce allograft tolerance via mixed chimerism in various murine models. However, induction of persistent mixed chimerism has proved to be extremely difficult in major histocompatibility complex mismatched humans. Chimerism induced in humans tends to either disappear or convert to full donor chimerism, depending on the intensity of the conditioning regimen. Nevertheless, our studies in both NHPs and humans have clearly demonstrated that renal allograft tolerance can be induced by transient mixed chimerism. Our studies have shown that solid organ allograft tolerance via transient mixed chimerism 1) requires induction of multilineage hematologic chimerism, 2) depends on peripheral regulatory mechanisms, rather than thymic deletion, for long-term maintenance, 3) is organ specific (kidney and lung but not heart allograft tolerance are feasible). A major advantage of tolerance induction via transient mixed chimerism is exclusion of the risk of graft-versus-host disease. Our ongoing studies are directed toward improving the consistency of tolerance induction, reducing the morbidity of the conditioning regimen, substituting clinically available agents, such as Belatacept for the now unavailable anti-CD2 monoclonal antibody, and extending the protocol to recipients of deceased donor allografts. ","PeriodicalId":89114,"journal":{"name":"Chimerism","volume":"6 1-2","pages":"21-6"},"PeriodicalIF":0.0,"publicationDate":"2015-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064472/pdf/kchm-06-1-2-1111975.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34131931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stable mixed chimerism and tolerance to human organ transplants 稳定的混合嵌合和对人体器官移植的耐受性

Chimerism Pub Date : 2015-04-03 DOI: 10.1080/19381956.2015.1115584

S. Strober

引用次数: 4

Facilitating cells: Translation of hematopoietic chimerism to achieve clinical tolerance 促进细胞:翻译造血嵌合实现临床耐受

Chimerism Pub Date : 2015-04-03 DOI: 10.1080/19381956.2015.1130780

S. Ildstad, J. Leventhal, Y. Wen, E. Yolcu

引用次数: 10

Foreword. 前言。

Chimerism Pub Date : 2015-04-03 Epub Date: 2016-04-22 DOI: 10.1080/19381956.2015.1176759

Dixon B Kaufman

引用次数: 1