Arab journal of nephrology and transplantation最新文献_第8页

The global role of kidney transplantation. 肾移植的全球作用。

Arab journal of nephrology and transplantation Pub Date : 2012-01-01

Guillermo Garcia Garcia, Paul Harden, Jeremy Chapman

{"title":"The global role of kidney transplantation.","authors":"Guillermo Garcia Garcia, Paul Harden, Jeremy Chapman","doi":"","DOIUrl":"","url":null,"abstract":"World Kidney Day on March 8th 2012 provides a chance to reflect on the success of kidney transplantation as a therapy for end stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost effectiveness. Anything that is both cheaper and better, but is not actually the dominant therapy, must have other drawbacks that prevent replacement of all dialysis treatment by transplantation. The barriers to universal transplantation as the therapy for end stage kidney disease include the economic limitations which, in some countries place transplantation, appropriately, at a lower priority than public health fundamentals such as clean water, sanitation and vaccination. Even in high income countries the technical challenges of surgery and the consequences of immunosuppression restrict the number of suitable recipients, but the major finite restrictions on kidney transplantation rates are the shortage of donated organs and the limited medical, surgical and nursing workforces with the required expertise. These problems have solutions which involve the full range of societal, professional, governmental and political environments. World Kidney Day is a call to deliver transplantation therapy to the one million people a year who have a right to benefit.","PeriodicalId":89079,"journal":{"name":"Arab journal of nephrology and transplantation","volume":"5 1","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30418146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aminophylline improves urine flow rates but not survival in childhood oliguric/anuric acute kidney injury. 氨茶碱改善尿流率，但不能改善儿童少尿/无尿急性肾损伤的生存率。

Arab journal of nephrology and transplantation Pub Date : 2012-01-01

Wasiu A Olowu, Olufemi Adefehinti

{"title":"Aminophylline improves urine flow rates but not survival in childhood oliguric/anuric acute kidney injury.","authors":"Wasiu A Olowu, Olufemi Adefehinti","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Acute kidney injury (AKI) morbidity and mortality rates remain high. Variable AKI outcomes have been reported in association with aminophylline treatment. This study evaluated AKI outcome in a group of Nigerian children treated with aminophylline.Methods: This is a retrospective study of AKI in children treated with (N=9) and without (N=8) aminophylline. Studied outcome indices comprised urine flow rate (UFR), duration of oliguria/anuria, progression through AKI stages, number of patients requiring dialysis and mortality.Results: Mean ages for the control and aminophylline arms were 4.6±2.7 and 4.9±2.1 years (P=0.7), respectively. All patients progressed to stage-3 AKI. Baseline median UFRs in the aminophylline and control arms were similar (0.13 Vs 0.04 ml/kg/hour respectively, P=0.5). The median UFR was significantly higher on day-5 (0.8 Vs 0.1; P=0.03), day-6 (1.0 Vs 0.2; P=0.02), and day-7 (1.2 Vs 0.2; P=0.03) in the aminophylline than the control arm, respectively. Short duration of oliguria/anuria (≤ 6 days) was more frequently observed in aminophylline- treated patients compared to controls (77.8% Vs 25.0%; odds ratio 0.09; 95% CI: 0.01-0.89; P=0.04). Only the aminophylline group maintained steady serum creatinine levels. Four out of five patients in the control group were dialyzed compared to only one out of eight patients in the aminophylline group (odds ratio 0.16; 95% CI: 0.04-0.71; P=0.03). Mortality rates were similar in aminophylline- treated and control patients (33% Vs 25%; hazard ratio 0.8; 95% CI: 0.1-5.5; P=0.8).Conclusion: Aminophylline therapy was beneficial for patients with AKI in terms of improved UFR and reduced need for dialysis, but failed to impact positively on survival.","PeriodicalId":89079,"journal":{"name":"Arab journal of nephrology and transplantation","volume":"5 1","pages":"35-9"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30418150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucocorticoid receptors and the pattern of steroid response in idiopathic nephrotic syndrome. 特发性肾病综合征中糖皮质激素受体和类固醇反应模式。

Arab journal of nephrology and transplantation Pub Date : 2012-01-01

Sherein A Shalaby, Howidah M El Idrissy, Ramziah A Safar, Samar T Hussein

{"title":"Glucocorticoid receptors and the pattern of steroid response in idiopathic nephrotic syndrome.","authors":"Sherein A Shalaby, Howidah M El Idrissy, Ramziah A Safar, Samar T Hussein","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Little is known about the relationships between the T lymphocytes (CD3+) expression of glucocorticoid receptors (GCR) and the response to glucocorticoid treatment in children with idiopathic nephrotic syndrome (NS). The aim of the current study is to determine whether steroid responsiveness is dependent on the amount of T lymphocytes GCR expression.Methods: We studied 60 children with idiopathic NS in the age group from 2-10 years. According to the response to steroids we classified our patients into early responders (ER; n = 46) and late responders (LR; n = 14). Sixty age and gender matched healthy children represented the control group. The clinical and laboratory findings at baseline and GCR expression by T lymphocytes (CD3+) as determined by flow cytometry were compared between the three groups.Results: The T lymphocytes (CD3+) expression of GCR was significantly lower in the LR than that in the control group (P < 0.01), whereas it was similar in the ER and control groups. GCR expression was also decreased in the LR group compared to the ER group (P < 0.01). Furthermore, the T lymphocytes (CD3+) expression of GCR correlated inversely with the time to complete remission (CR) (r = -0.54, P < 0.05), but not with urinary protein excretion at baseline.Conclusion: The levels of T lymphocytes (CD3+) expression of GCR may be a useful predictor of steroid responsiveness in children presenting with idiopathic NS.","PeriodicalId":89079,"journal":{"name":"Arab journal of nephrology and transplantation","volume":"5 1","pages":"13-7"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30418147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed graft function, allograft and patient srvival in kidney transplantation. 肾移植中移植物功能延迟、同种异体移植物与患者存活。

Arab journal of nephrology and transplantation Pub Date : 2012-01-01

Mohammad Hassan Ghadiani, Said Peyrovi, Seyed Nouraddin Mousavinasab, Mojgan Jalalzadeh

{"title":"Delayed graft function, allograft and patient srvival in kidney transplantation.","authors":"Mohammad Hassan Ghadiani, Said Peyrovi, Seyed Nouraddin Mousavinasab, Mojgan Jalalzadeh","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Delayed Graft Function (DGF) is a common complication of renal transplants and the long-term relation between DGF and survival of patients and grafts is not well established.Methods: This is a historical cohort study of transplanted patients in Taleghani Hospital of Shahid Beheshti University in Iran between 1994 and 2010. Patients who required dialysis during the first week after transplantation were considered to have DGF. The patients' conditions were updated to determine existing graft function, graft loss or patients' death at one year and five years post transplantation in relation to the presence or absence of DGF.Results: DGF complicated 67/385 transplants (17.4%). Causes included acute tubular necrosis (58.2%), accelerated rejection (29.9%), transplant renal artery thrombosis (9%) and renal vein thrombosis (3%). More kidneys in the DGF group were procured from cadaveric donors (6% versus 0.9%, P = 0.02). At hospital discharge, patients with DGF had significantly higher mean creatinine level (4.4 ± 2.8 versus 2.0 ± 1.7; P = 0.001) compared to other patients. They also had more early acute rejection episodes and more late acute rejection episodes (34.3% versus 2% and 16.4% versus 3%, respectively; P = 0.0001) compared to other patients. The proportion of functioning grafts was significantly lower in the DGF group at 1-year (53.7% versus 95.3%, P = 0.0001) and 5-years (22.4% versus 61.6%, P = 0.001) compared to patients without DGF.Conclusion: The DGF group had a significantly higher acute rejection rate and an increased risk of graft loss at one and five years.","PeriodicalId":89079,"journal":{"name":"Arab journal of nephrology and transplantation","volume":"5 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30418148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucocorticoid receptors and the pattern of steroid response in idiopathic nephrotic syndrome. 特发性肾病综合征中糖皮质激素受体和类固醇反应模式。

Arab journal of nephrology and transplantation Pub Date : 2012-01-01 DOI: 10.4314/AJNT.V5I1

S. Shalaby, Howidah M El Idrissy, R. Safar, Samar Hussein

{"title":"Glucocorticoid receptors and the pattern of steroid response in idiopathic nephrotic syndrome.","authors":"S. Shalaby, Howidah M El Idrissy, R. Safar, Samar Hussein","doi":"10.4314/AJNT.V5I1","DOIUrl":"https://doi.org/10.4314/AJNT.V5I1","url":null,"abstract":"INTRODUCTION Little is known about the relationships between the T lymphocytes (CD3+) expression of glucocorticoid receptors (GCR) and the response to glucocorticoid treatment in children with idiopathic nephrotic syndrome (NS). The aim of the current study is to determine whether steroid responsiveness is dependent on the amount of T lymphocytes GCR expression. METHODS We studied 60 children with idiopathic NS in the age group from 2-10 years. According to the response to steroids we classified our patients into early responders (ER; n = 46) and late responders (LR; n = 14). Sixty age and gender matched healthy children represented the control group. The clinical and laboratory findings at baseline and GCR expression by T lymphocytes (CD3+) as determined by flow cytometry were compared between the three groups. RESULTS The T lymphocytes (CD3+) expression of GCR was significantly lower in the LR than that in the control group (P < 0.01), whereas it was similar in the ER and control groups. GCR expression was also decreased in the LR group compared to the ER group (P < 0.01). Furthermore, the T lymphocytes (CD3+) expression of GCR correlated inversely with the time to complete remission (CR) (r = -0.54, P < 0.05), but not with urinary protein excretion at baseline. CONCLUSION The levels of T lymphocytes (CD3+) expression of GCR may be a useful predictor of steroid responsiveness in children presenting with idiopathic NS.","PeriodicalId":89079,"journal":{"name":"Arab journal of nephrology and transplantation","volume":"5 1 1","pages":"13-7"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70471174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Renal transplantation and pregnancy. 肾移植与妊娠。

Arab journal of nephrology and transplantation Pub Date : 2012-01-01

Padam Hirachan, Sadip Pant, Ramesh Chhetri, Aditya Joshi, Tirtha Kharel

{"title":"Renal transplantation and pregnancy.","authors":"Padam Hirachan, Sadip Pant, Ramesh Chhetri, Aditya Joshi, Tirtha Kharel","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Although pregnancy after kidney transplantation is feasible, complications are relatively common and this needs to be considered in patient counseling and clinical decision making.Review: Fertility generally returns after renal transplantation. Approximately 74% of pregnancies in kidney transplant recipients end successfully in life births. Published reports suggest that pregnancy has no adverse affects on graft survival although patients with higher pre-pregnancy serum creatinine have a trend toward increased post-pregnancy serum creatinine. There is, however, a significantly increased risk of preeclampsia, gestational diabetes, cesarean section and preterm delivery compared to the general population. Almost half life births are preterm, and low birth weight is very common. Immunosuppressive medications are required to be continued during pregnancy in transplant recipients to prevent graft rejection, except for sirolimus and mycophenolate mofetil (MMF) which are contraindicated during pregnancy. The incidence of birth defects in the live born is similar to the general population, except for pregnancies exposed to MMF which have a high incidence of birth defects. Every female in the reproductive age group should be counseled regarding pregnancy including the potential risks to the graft, to the mother and to the child. Timing pregnancy should be based upon whether graft function is optimal, but the general recommendation is to wait one year post transplantation before conception.Conclusion: Pregnancy in renal transplant patients should be planned with combined care from surgeons, nephrologists, obstetricians, pediatricians and dietitians which offers the best chance of a favorable outcome in the mother and the fetus.","PeriodicalId":89079,"journal":{"name":"Arab journal of nephrology and transplantation","volume":"5 1","pages":"41-6"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30418151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soluble TWEAK and cardiovascular morbidity and mortality in chronic kidney disease patients. 可溶性TWEAK与慢性肾病患者心血管发病率和死亡率的关系

Arab journal of nephrology and transplantation Pub Date : 2012-01-01

Seham Bakry Hassan, Ahmed Bahgat El-demery, Asmaa Ismail Ahmed, Reham Emad Abukhalil

{"title":"Soluble TWEAK and cardiovascular morbidity and mortality in chronic kidney disease patients.","authors":"Seham Bakry Hassan, Ahmed Bahgat El-demery, Asmaa Ismail Ahmed, Reham Emad Abukhalil","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in chronic kidney patients (CKD). The aim of this study was to demonstrate the role of soluble tumor necrosis factor (TNF) weak inducer of apoptosis (sTWEAK) as a marker of cardiovascular morbidity and mortality in CKD patients.Methods: The study included 75 CKD patients classified according to eGFR into three groups; group-1 included 15 patients with stage-1 CKD, group-2 included 30 patients with stage-2 and stage-3 CKD, and group-3 included 30 patients with stage-4 and stage-5 CKD. The three groups were compared to 20 matched controls. Interleukin-6 (IL-6) and sTWEAK were measured using ELISA and chemiluminescent techniques respectively. Carotid intima-media thickness (IMT) was also measured.Results: We found that IL-6 showed significant difference between patient groups and controls, being highest in stage 4 and 5 CKD patients and lowest in controls. Soluble TWEAK showed significant difference between patient groups and controls, being lowest in stage 4 and 5 CKD patients and highest in controls. Soluble TWEAK level showed significant negative correlation with IL-6 (r = -0.68; P < 0.01) and carotid IMT (r = -0.95; P < 0.01). After two years follow up, nine out of 75 CKD patients developed ischemic heart disease (IHD). Two patients developed cerebrovascular stroke and another patient developed peripheral arterial disease. These patients had significantly lower levels of sTWEAK at baseline compared to other patients (160.5 ± 60.2 versus 274.8 ± 90 pg/mL; P < 0.05).Conclusion: Soluble TWEAK can be a novel biomarker of atherosclerosis and endothelial dysfunction as well as cardiovascular outcome in CKD patients.","PeriodicalId":89079,"journal":{"name":"Arab journal of nephrology and transplantation","volume":"5 1","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30418149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Informed consent for inclusion into clinical trials: a serious subject to note in the developing world. 纳入临床试验的知情同意:发展中国家需要注意的一个严肃问题。

Arab journal of nephrology and transplantation Pub Date : 2012-01-01 DOI: 10.4314/AJNT.V5I2

M. Izadi, M. Fazel, Taha Nasiri-Vanashi, S. Saadat, S. Taheri

{"title":"Informed consent for inclusion into clinical trials: a serious subject to note in the developing world.","authors":"M. Izadi, M. Fazel, Taha Nasiri-Vanashi, S. Saadat, S. Taheri","doi":"10.4314/AJNT.V5I2","DOIUrl":"https://doi.org/10.4314/AJNT.V5I2","url":null,"abstract":"INTRODUCTION Informed consent is a critical issue especially in conducting clinical trials that expose human life to medical or surgical interventions. It necessitates a long and complex process through which the participant is presented with all potential favorable and non-favorable consequences upon getting enrolled in the study. REVIEW The process of taking informed consent is well-understood in developed countries, with every effort taken to enhance and maintain the autonomy of patients and their right to make an informed choice of whether to participate or not. This may not be the case in the developing world.The information given to patients before the trial might not be properly developed and presented, an issue that can result in serious threat to the decision-making process. On the other hand, investigators should remember that enrolling people into a trial with no potential benefit for themselves cannot be considered ethical. In the current debate, we aim to address the issue of how respectfully and ethically clinical research trials can be done on human subjects and what we can do to enhance the practice in an ethical context. CONCLUSION Development of a system through which we could warrant all rights of study participants in all cases around the world seems far from view. However, if we are in doubt about the ethics of a clinical trial, we can ask ourselves: \"what would we do, if we were in the same position our patients are in now?\"","PeriodicalId":89079,"journal":{"name":"Arab journal of nephrology and transplantation","volume":"8 1","pages":"97-100"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70471913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Bradycardia following oral corticosteroid use: case report and literature review. 口服皮质类固醇后的心动过缓:病例报告和文献回顾。

Arab journal of nephrology and transplantation Pub Date : 2012-01-01

Amar Al Shibli, Ibrahim Al Attrach, Mohammad A Hamdan

{"title":"Bradycardia following oral corticosteroid use: case report and literature review.","authors":"Amar Al Shibli, Ibrahim Al Attrach, Mohammad A Hamdan","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Corticosteroids are used in various clinical conditions that include many immune-mediated inflammatory diseases. Different side effects were described including cardiac arrhythmias. Most of those arrhythmias were in the form of bradycardia which usually occurs with high intravenous steroid doses. More significant arrhythmias and cardiac arrest were also described. In this report we describe a case of bradycardia that developed after the use of oral corticosteroids.Case report: We report a case of bradycardia that developed in a 14 year-old male after receiving oral prednisone. The patient had steroid-sensitive nephrotic syndrome and presented with anasarca that started to develop few days prior to hospitalization. He had no underlying heart disease. Vitals was normal. Investigations confirmed a new nephrotic relapse. Oral prednisone 80 mg / day divided into three doses was started. Albumin infusions were initially given with intravenous furosemide to control the edema. Seven days after hospitalization, he developed bradycardia with a pulse rate of 50-60 per minute, which was less than 50% of the baseline heart rate. He didn't develop significant symptoms and he had no other apparent corticosteroids side effects. Cardiac evaluation and echocardiography were normal. Electrocardiogram revealed only sinus bradycardia.The bradycardia recovered after decreasing the dose of steroids to 60 mg PO every other day and he was discharged in stable condition a few days later.Conclusion: Cardiac arrhythmias may develop with all forms of steroids including oral prednisone. Bradyarrhythmias can occur even with standard doses of oral prednisone.","PeriodicalId":89079,"journal":{"name":"Arab journal of nephrology and transplantation","volume":"5 1","pages":"47-9"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30418152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term use of cinacalcet in children on regular hemodialysis. 定期血液透析的儿童短期使用cinacalcet。

Arab journal of nephrology and transplantation Pub Date : 2012-01-01

Doaa Youssef

{"title":"Short-term use of cinacalcet in children on regular hemodialysis.","authors":"Doaa Youssef","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Therapy with vitamin D3 analogs suppress the parathyroid hormone (PTH) secretion in chronic kidney disease (CKD) patients suffering from secondary hyperparathyroidism (sHPT). The concurrent administration of calcium-containing phosphate binders further increases the likelihood of developing hypercalcemia. Calcimimetics, such as cinacalcet, lower PTH level while limiting the risks of hyperphosphatemia and/or hypercalcemia. In adults, clinical experience with calcimimetics has shown significant reductions in PTH levels in cases with sHPT, but the clinical experience in children with CKD is limited.Case series: We report here the effect of short term use of cinacalcet on sHPT in two children on regular hemodialysis for CKD stage 5. Both children had very high PTH level which failed to be controlled with vitamin D3 and phosphate binders. We started cinacalcet therapy at a dose of 30 mg/day for both of them for duration of eight weeks. The first case was an 11 year-old male, his iPTH level decreased by 26% at four weeks after initiation of therapy and decreased by 39% at eight weeks. The second case was a 13 year-old female, her iPTH level decreased by 25% at four weeks after therapy and by 40% at eight weeks. There were no drug related side effects in both cases. Serum calcium and phosphorus levels remained stable in both patients.Conclusion: Cinacalcet can be effectively used in the treatment of sHPT in children in the short term, with minimal changes in the serum levels of calcium and phosphorus.","PeriodicalId":89079,"journal":{"name":"Arab journal of nephrology and transplantation","volume":"5 1","pages":"51-3"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30418153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0