Biomedical Engineering / Biomedizinische Technik最新文献_第4页

Development and verification of a novel blood viscoelastic monitoring method based on reciprocating motion of magnetic bead. 基于磁珠往复运动的血液粘弹性监测新方法的研制与验证。

IF 1.7 4区医学

Biomedical Engineering / Biomedizinische Technik Pub Date : 2023-04-25 DOI: 10.1515/bmt-2022-0225

Xinyu Du, Fupan Chen, Lijin Gan, Yong Liu, Yu Zheng, Linghua Xing, Qi Zhou

{"title":"Development and verification of a novel blood viscoelastic monitoring method based on reciprocating motion of magnetic bead.","authors":"Xinyu Du, Fupan Chen, Lijin Gan, Yong Liu, Yu Zheng, Linghua Xing, Qi Zhou","doi":"10.1515/bmt-2022-0225","DOIUrl":"https://doi.org/10.1515/bmt-2022-0225","url":null,"abstract":"Blood coagulation function is an essential index in clinical examination, and it is of great significance to evaluate blood coagulation function comprehensively. Based on the blood viscoelasticity theory and hydrodynamics, we proposed a method to monitor the whole blood coagulation process based on the reciprocating motion of the magnetic bead (magnetic bead method for short). We have established a mathematical model between the moment acting on the magnetic bead and the viscoelasticity of blood in the process of blood coagulation. The change of blood viscoelasticity acks on the magnetic bead in the form of moment changes, which shows that the amplitude of the motion of the magnetic bead varies with the change of blood viscoelasticity. Designed and verified a blood coagulation monitoring device based on the reciprocating movement of the magnetic bead and discussed the device's parameters through the orthogonal experiment. Lastly, the TEG5000 was used as the control group to test the thromboelasticity of four groups of thromboelastography quality control products in the same batch and 10 groups of human whole blood. It verified that our device has good repeatability, and has good consistency with TEG5000, it has particular application potential as a new blood coagulation monitoring method.","PeriodicalId":8900,"journal":{"name":"Biomedical Engineering / Biomedizinische Technik","volume":"68 2","pages":"211-223"},"PeriodicalIF":1.7,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9190235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variational mode decomposition and binary grey wolf optimization-based automated epilepsy seizure classification framework. 基于变分模分解和二值灰狼优化的癫痫发作自动分类框架。

IF 1.7 4区医学

Biomedical Engineering / Biomedizinische Technik Pub Date : 2023-04-25 DOI: 10.1515/bmt-2022-0098

Vipin Prakash Yadav, Kamlesh Kumar Sharma

引用次数: 0

Concurrent validity and reliability of a smartphone-based application for the head repositioning and cervical range of motion. 基于智能手机的头部复位和颈椎活动范围应用程序的并发有效性和可靠性。

IF 1.7 4区医学

Biomedical Engineering / Biomedizinische Technik Pub Date : 2023-04-25 DOI: 10.1515/bmt-2021-0229

Natalia Romero-Franco, Ángel Oliva-Pascual-Vaca, Juan Carlos Fernández-Domínguez

{"title":"Concurrent validity and reliability of a smartphone-based application for the head repositioning and cervical range of motion.","authors":"Natalia Romero-Franco, Ángel Oliva-Pascual-Vaca, Juan Carlos Fernández-Domínguez","doi":"10.1515/bmt-2021-0229","DOIUrl":"https://doi.org/10.1515/bmt-2021-0229","url":null,"abstract":"Objectives: To evaluate the validity and reliability of a smartphone-based application against inertial sensors to measure head repositioning (by using joint position sense -JPS) and cervical range of motion (ROM).Methods: JPS and cervical ROM were evaluated for neck flexion, extension and both-sides lateral flexion in thirty-one volunteers. Participants were simultaneously evaluated with inertial sensors and the smartphone application. A total of 248 angles were compared for concurrent validity. Inter-tester and intra-tester reliability were evaluated through scoring of images with the smartphone application by two testers, and re-scoring images by the same tester.Results: Very high correlation was observed between both methods for ROM in all neck movements and JPS in left-side lateral flexion (r>0.9), and high for JPS in the rest of movements (r>0.8). Bland-Altman plots always demonstrated absolute agreement. Inter-and intra-tester reliability was perfect for JPS and ROM in all the neck movements (ICC>0.81).Conclusions: This smartphone-based application is valid and reliable for evaluating head repositioning and cervical ROM compared with inertial sensors in healthy and young adults. Health professionals could use it in an easier and portable way in field conditions.","PeriodicalId":8900,"journal":{"name":"Biomedical Engineering / Biomedizinische Technik","volume":"68 2","pages":"125-132"},"PeriodicalIF":1.7,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9249135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An integrated and automated testing approach on Inception Restnet-V3 based on convolutional neural network for leukocytes image classification. 基于卷积神经网络的Inception Restnet-V3白细胞图像分类集成自动化测试方法。

IF 1.7 4区医学

Biomedical Engineering / Biomedizinische Technik Pub Date : 2023-04-25 DOI: 10.1515/bmt-2022-0297

Silambarasi Palanivel, Viswanathan Nallasamy

{"title":"An integrated and automated testing approach on Inception Restnet-V3 based on convolutional neural network for leukocytes image classification.","authors":"Silambarasi Palanivel, Viswanathan Nallasamy","doi":"10.1515/bmt-2022-0297","DOIUrl":"https://doi.org/10.1515/bmt-2022-0297","url":null,"abstract":"Objectives: The leukocyte is a specialized immune cell that functions as the foundation of the immune system and keeps the body healthy. The WBC classification plays a vital role in diagnosing various disorders in the medical area, including infectious diseases, immune deficiencies, leukemia, and COVID-19. A few decades ago, Machine Learning algorithms classified WBC types required for image segmentation, and the feature extraction stages, but this new approach becomes automatic while existing models can be fine-tuned for specific classifications.Methods: The inception architecture and deep learning model-based Resnet connection are integrated into this article. Our proposed method, inception Resnet-v3, was used to classify WBCs into five categories using 15.7k images. Pathologists made diagnoses of all images so a model could be trained to classify five distinct types of cells.Results: After implementing the proposed architecture on a large dataset of 5 categories of human peripheral white blood cells, it achieved high accuracy than VGG, U-Net and Resnet. We tested our model with WBC images from additional public datasets such as the Kaagel data sets and Raabin data sets of which the accuracy was 98.80% and 98.95%.Conclusions: Considering the large sample sizes, we believe the proposed method can be used for improving the diagnostic performance of clinical blood examinations as well as a promising alternative for machine learning. Test results obtained with the system have been satisfying, with outstanding values for Accuracy, Precision, Recall, Specificity and F1 Score.","PeriodicalId":8900,"journal":{"name":"Biomedical Engineering / Biomedizinische Technik","volume":"68 2","pages":"165-174"},"PeriodicalIF":1.7,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9248622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Analysis of EEG brain connectivity of children with ADHD using graph theory and directional information transfer. 应用图论和定向信息传递分析ADHD儿童脑电连通性。

IF 1.7 4区医学

Biomedical Engineering / Biomedizinische Technik Pub Date : 2023-04-25 DOI: 10.1515/bmt-2022-0100

Ali Ekhlasi, Ali Motie Nasrabadi, Mohammadreza Mohammadi

{"title":"Analysis of EEG brain connectivity of children with ADHD using graph theory and directional information transfer.","authors":"Ali Ekhlasi, Ali Motie Nasrabadi, Mohammadreza Mohammadi","doi":"10.1515/bmt-2022-0100","DOIUrl":"https://doi.org/10.1515/bmt-2022-0100","url":null,"abstract":"Research shows that Attention Deficit Hyperactivity Disorder (ADHD) is related to a disorder in brain networks. The purpose of this study is to use an effective connectivity measure and graph theory to examine the impairments of brain connectivity in ADHD. Weighted directed graphs based on electroencephalography (EEG) signals of 61 children with ADHD and 60 healthy children were constructed. The edges between two nodes (electrodes) were calculated by Phase Transfer Entropy (PTE). PTE is calculated for five frequency bands: delta, theta, alpha, beta, and gamma. The graph theory measures were divided into two categories: global and local. Statistical analysis with global measures indicates that in children with ADHD, the segregation of brain connectivity increases while the integration of the brain connectivity decreases compared to healthy children. These brain network differences were identified in the delta and theta frequency bands. The classification accuracy of 89.4% is obtained for both in-degree and strength measures in the theta band. Our result indicated local graph measures classified ADHD and healthy subjects with accuracy of 91.2 and 90% in theta and delta bands, respectively. Our analysis may provide a new understanding of the differences in the EEG brain network of children with ADHD and healthy children.","PeriodicalId":8900,"journal":{"name":"Biomedical Engineering / Biomedizinische Technik","volume":"68 2","pages":"133-146"},"PeriodicalIF":1.7,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9248626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Open structure magnetic particle imaging by nonlinear back projection tomography reconstruction. 开放结构磁粒子的非线性反投影层析成像。

IF 1.7 4区医学

Biomedical Engineering / Biomedizinische Technik Pub Date : 2023-04-25 DOI: 10.1515/bmt-2021-0319

Wanni Zu, Li Ke, Qiang Du

{"title":"Open structure magnetic particle imaging by nonlinear back projection tomography reconstruction.","authors":"Wanni Zu, Li Ke, Qiang Du","doi":"10.1515/bmt-2021-0319","DOIUrl":"https://doi.org/10.1515/bmt-2021-0319","url":null,"abstract":"Objectives: In open structure MPI systems, the nonlinear variation of the field free lines in the large region of interest scanning process distorts the x-space image reconstruction. In this study, we propose a nonlinear field free line projection reconstruction algorithm to solve the edge distortion problem of open structure MPI imaging.Methods: First, we calculate the curvature change law of the field free line in the scanning process. Then, we design a nonlinear back projection reconstruction algorithm according to the nonlinear characteristics of the field free line in the scanning process. Finally, the nonlinear back projection reconstruction algorithm is used to complete the tomography of blood vessels.Results: The numerical calculation and simulation results show that the open structure MPI combined with a nonlinear back projection reconstruction algorithm can accomplish vascular fault reconstruction. The reconstruction algorithm proposed in this paper suppresses the edge distortion of the image and improves the positioning accuracy of the image. The size of the region of interest where distortions are low is increased 16 times by allowing 10.9% degradation in the gradient.Conclusions: We provide a non-linear inverse projection reconstruction algorithm to reduce the structural artefacts caused by FFL distortion. It provides a reconstruction scheme for a large region of interest fine imaging of open structure FFL-MPI.","PeriodicalId":8900,"journal":{"name":"Biomedical Engineering / Biomedizinische Technik","volume":"68 2","pages":"199-210"},"PeriodicalIF":1.7,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9564688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safe design of surgical robots - a systematic approach to comprehensive hazard identification. 手术机器人的安全设计——一种综合危险识别的系统方法。

IF 1.7 4区医学

Biomedical Engineering / Biomedizinische Technik Pub Date : 2023-04-25 DOI: 10.1515/bmt-2022-0202

Lukas Theisgen, Florian Strauch, Matías de la Fuente Klein, Klaus Radermacher

{"title":"Safe design of surgical robots - a systematic approach to comprehensive hazard identification.","authors":"Lukas Theisgen, Florian Strauch, Matías de la Fuente Klein, Klaus Radermacher","doi":"10.1515/bmt-2022-0202","DOIUrl":"https://doi.org/10.1515/bmt-2022-0202","url":null,"abstract":"Objectives: Since the 1980s, robotic arms have been transferred from industrial applications to orthopaedic surgical robotics. Adverse events are frequent and often associated with the adopted powerful and oversized anthropomorphic arms. The FDA's 510(k) pathway encourages building on such systems, leading to the adoption of hazards, which is known as \"predicate creep\". Additionally, the methodology of hazard identification for medical device development needs improvement.Methods: We present an approach to enhance general hazard identification and prevent hazards of predicate creep by using the integrative, scenario-based and multi-perspective Point-of-View (PoV) approach. We also present the Catalogue of Hazards (CoH) as an approach for collecting and systematising hazards for future risk analysis and robot development.Results: We applied seven predefined PoVs to the use case of robotic laminectomy and identified 133 hazards, mainly coming from HMI analysis and literature. By analysing the MAUDE and recalls databases of the FDA, we were able to classify historical hazards and adopt them into the use case.Conclusions: The combination of PoV approach and CoH is suitable for integrating multiple established hazard identification methods, increasing comprehensiveness, and supporting the systematic and hazard-based development of surgical robots.","PeriodicalId":8900,"journal":{"name":"Biomedical Engineering / Biomedizinische Technik","volume":"68 2","pages":"117-123"},"PeriodicalIF":1.7,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9195931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A novel deep learning approach for sickle cell anemia detection in human RBCs using an improved wrapper-based feature selection technique in microscopic blood smear images. 一种新的深度学习方法，用于人类红细胞镰状细胞贫血检测，使用改进的基于包装的特征选择技术在显微镜下的血液涂片图像。

IF 1.7 4区医学

Biomedical Engineering / Biomedizinische Technik Pub Date : 2023-04-25 DOI: 10.1515/bmt-2021-0127

Alagu S, Kavitha Ganesan, Bhoopathy Bagan K

{"title":"A novel deep learning approach for sickle cell anemia detection in human RBCs using an improved wrapper-based feature selection technique in microscopic blood smear images.","authors":"Alagu S, Kavitha Ganesan, Bhoopathy Bagan K","doi":"10.1515/bmt-2021-0127","DOIUrl":"https://doi.org/10.1515/bmt-2021-0127","url":null,"abstract":"Sickle Cell Anemia (SCA) is a disorder in Red Blood Cells (RBCs) of human blood. Children under five years and pregnant women are mostly affected by SCA. Early diagnosis of this ailment can save lives. In recent years, the computer aided diagnosis of SCA is preferred to resolve this issue. A novel and effective deep learning approach for identification of sickle cell anemia is proposed in this work. Around nine hundred microscopic images of human red blood cells are obtained from the public database 'erythrocytes IDB'. All the images are resized uniformly. About 2048 deep features are extracted from the fully connected layer of pre-trained model InceptionV3. These features are further subjected to classification using optimization-based methods. An improved wrapper-based feature selection technique is implemented using Multi- Objective Binary Grey Wolf Optimization (MO-BGWO) approach with KNN and SVM for classification. The detection of sickle cell is also performed using typical InceptionV3 model by using SoftMax layer. It is observed that the performance of the proposed system seems to be high when compared to the classification using the original InceptionV3 model. The results are validated by various evaluation metrics such as accuracy, precision, sensitivity, specificity and F1-score. The SVM classifier yields high accuracy of about 96%. The optimal subset of deep features along with SVM enhances the system performance in the proposed work. Thus, the proposed approach is appropriate for pathologists to take early clinical decisions on detection of sickle cells.","PeriodicalId":8900,"journal":{"name":"Biomedical Engineering / Biomedizinische Technik","volume":"68 2","pages":"175-185"},"PeriodicalIF":1.7,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9548653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Frontmatter 头版头条

4区医学

Biomedical Engineering / Biomedizinische Technik Pub Date : 2023-03-29 DOI: 10.1515/bmt-2023-frontmatter2

引用次数: 0

Development of a microfluidic electroosmosis pump on a chip for steady and continuous fluid delivery. 芯片微流控电渗透泵的研制。

IF 1.7 4区医学

Biomedical Engineering / Biomedizinische Technik Pub Date : 2023-02-23 DOI: 10.1515/bmt-2022-0051

Vania Silverio, Patricia A G Canane, Tomas A Martins, Ruben Afonso, Susana Cardoso, Elsa Batista

{"title":"Development of a microfluidic electroosmosis pump on a chip for steady and continuous fluid delivery.","authors":"Vania Silverio, Patricia A G Canane, Tomas A Martins, Ruben Afonso, Susana Cardoso, Elsa Batista","doi":"10.1515/bmt-2022-0051","DOIUrl":"https://doi.org/10.1515/bmt-2022-0051","url":null,"abstract":"Infusion therapy is the most common form of therapy used in health care. However, the existing infusion devices show higher flow discrepancies as flow rates decrease to a few nL min-1. As a result, dosing errors can contribute to the morbidity and mortality of patients. In the scope of project 18HLT08 MeDD II - Metrology for drug delivery, this investigation aims at the development of a silicon microchip flow pump capable of steadily and continuously dispense very low flow rates of a few nL min-1. The fabrication methodologies explored here use a combination of typical cleanroom micro/nanofabrication techniques and off-the-shelf equipment. Preliminary tests show flow rates as low as 45 nL min-1 can be obtained in this microfluidic electroosmotic pump. The experimental flow rates are in good agreement with results predicted by multiphysics simulation, with less than 8% deviation ratio. This cost effective electroosmotic micropump has the potential to act as a steady and continuous drug delivery system to neonatal patients as well as to organs on chip (OoC), determining the stability of the shear stress imposed on the cells or the right cell culture medium conditions.","PeriodicalId":8900,"journal":{"name":"Biomedical Engineering / Biomedizinische Technik","volume":"68 1","pages":"79-90"},"PeriodicalIF":1.7,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10642969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1