Open structure magnetic particle imaging by nonlinear back projection tomography reconstruction.

Objectives: In open structure MPI systems, the nonlinear variation of the field free lines in the large region of interest scanning process distorts the x-space image reconstruction. In this study, we propose a nonlinear field free line projection reconstruction algorithm to solve the edge distortion problem of open structure MPI imaging.

Methods: First, we calculate the curvature change law of the field free line in the scanning process. Then, we design a nonlinear back projection reconstruction algorithm according to the nonlinear characteristics of the field free line in the scanning process. Finally, the nonlinear back projection reconstruction algorithm is used to complete the tomography of blood vessels.

Results: The numerical calculation and simulation results show that the open structure MPI combined with a nonlinear back projection reconstruction algorithm can accomplish vascular fault reconstruction. The reconstruction algorithm proposed in this paper suppresses the edge distortion of the image and improves the positioning accuracy of the image. The size of the region of interest where distortions are low is increased 16 times by allowing 10.9% degradation in the gradient.

Conclusions: We provide a non-linear inverse projection reconstruction algorithm to reduce the structural artefacts caused by FFL distortion. It provides a reconstruction scheme for a large region of interest fine imaging of open structure FFL-MPI.