MedChemComm最新文献_第4页

The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif† 具有 1,2-二硫环戊-3-基基团的 ROCK2 抑制剂的合成及其生物活性

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MedChemComm Pub Date : 2024-08-01 DOI: 10.1039/D4MD00438H

Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao and Guoliang Chen

{"title":"The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif†","authors":"Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao and Guoliang Chen","doi":"10.1039/D4MD00438H","DOIUrl":"10.1039/D4MD00438H","url":null,"abstract":"Rho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation. Herein, a series of compounds were designed and synthesized as ROCK inhibitors based on the structure-based drug design (SBDD) strategy and were evaluated for cytotoxicity, antioxidant activity and anti-inflammatory activity. Among them, compound DC24 was identified as the optimal hit in enzymatic screening with an IC50 value of 0.124 μM against ROCK2 and 50-fold selectivity over ROCK1. DC24 has a novel lipid amide scaffold with a bis(4-fluorophenyl)methyl substituent, and DC24 is the first ROCK2 inhibitor interacting with the hinge region of ROCK2 via the 1,2-dithiolan-3-yl motif, which has been confirmed by the binding model of DC24 with ROCK2. In a complete Freund's adjuvant (CFA) induced acute inflammation model, DC24 at a dose of 5 mg kg−1 exhibited an anti-inflammatory effect better than that of belumosudil. Furthermore, DC24 exhibits good safety in vivo.","PeriodicalId":88,"journal":{"name":"MedChemComm","volume":" 10","pages":" 3576-3596"},"PeriodicalIF":3.597,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold(i) and gold(iii) carbene complexes from the marine betaine norzooanemonin: inhibition of thioredoxin reductase, antiproliferative and antimicrobial activity† 来自海洋甜菜碱 norzooanemonin 的金（i）和金（iii）碳烯配合物：抑制硫氧还原酶、抗增殖和抗菌活性。

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MedChemComm Pub Date : 2024-07-31 DOI: 10.1039/D4MD00358F

Seyedeh Mahbobeh Mahdavi, Dirk Bockfeld, Igor V. Esarev, Petra Lippmann, René Frank, Mark Brönstrup, Ingo Ott and Matthias Tamm

{"title":"Gold(i) and gold(iii) carbene complexes from the marine betaine norzooanemonin: inhibition of thioredoxin reductase, antiproliferative and antimicrobial activity†","authors":"Seyedeh Mahbobeh Mahdavi, Dirk Bockfeld, Igor V. Esarev, Petra Lippmann, René Frank, Mark Brönstrup, Ingo Ott and Matthias Tamm","doi":"10.1039/D4MD00358F","DOIUrl":"10.1039/D4MD00358F","url":null,"abstract":"The natural marine betaine norzooanemonin (1,3-dimethylimidazolim-4-carboxylate) and its methyl and ethyl esters were used as ligand precursors to prepare a systematic series (12 members) of neutral monocarbene gold(I/III) and cationic dicarbene gold(I/III) complexes. The complexes were evaluated as inhibitors of bacterial thioredoxin reductase and for their antiproliferative and antimicrobial activities. While gold complexes with the parent norzooanemonin scaffold resulted in overall poor performance, the more lipophilic esters proved to be highly bioactive agents, related to their higher cellular uptake. The monocarbene gold(I/III) complexes showed significant potency as inhibitors of bacterial thioredoxin reductase. In most assays, the efficacy of both gold(I) and gold(III) analogues was found to be comparable. The cytotoxicity of dicarbene gold(I/III) complexes against cancer cells was strong, in some cases exceeding that of the standard reference auranofin.","PeriodicalId":88,"journal":{"name":"MedChemComm","volume":" 9","pages":" 3248-3255"},"PeriodicalIF":3.597,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and antiproliferative potency of 1,3,4-thiadiazole and 1,3-thiazolidine-4-one based new binary heterocyclic molecules: in vitro cell-based anticancer studies† 基于 1,3,4-噻二唑和 1,3-噻唑烷-4-酮的新二元杂环分子的合成和抗增殖效力：体外细胞抗癌研究

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MedChemComm Pub Date : 2024-07-31 DOI: 10.1039/D4MD00279B

Avik Maji, Ambati Himaja, Sripathi Nikhitha, Soumitra Rana, Abhik Paul, Ajeya Samanta, Uday Shee, Chhanda Mukhopadhyay, Balaram Ghosh and Tapan Kumar Maity

{"title":"Synthesis and antiproliferative potency of 1,3,4-thiadiazole and 1,3-thiazolidine-4-one based new binary heterocyclic molecules: in vitro cell-based anticancer studies†","authors":"Avik Maji, Ambati Himaja, Sripathi Nikhitha, Soumitra Rana, Abhik Paul, Ajeya Samanta, Uday Shee, Chhanda Mukhopadhyay, Balaram Ghosh and Tapan Kumar Maity","doi":"10.1039/D4MD00279B","DOIUrl":"10.1039/D4MD00279B","url":null,"abstract":"Herein, we report the synthesis and anticancer properties of 21 new 1,3,4-thiadiazole-2-yl-imino-thiazolidine-4-one containing binary heterocyclic molecules. Cytotoxicity of the synthesized molecules was evaluated on various in vitro cancer cell lines (MCF-7, PC3, 4T1, MDA-MB-231, and MOC2) and normal human embryonic cell lines (HEK-293) via MTT assay. The cytotoxicity data of developed compounds was compared with the reference anticancer molecule BG45, a selective inhibitor of the HDAC3 enzyme. All compounds showed a significant cytotoxic effect higher than BG45 on tested cancer cell lines. Moreover, the compounds exhibited better selectivity on cancer cells than on normal cells. Among the molecules, compound 6e is the most potent in cytotoxic activity on MCF-7 cell lines (IC50 value of 3.85 μM). Additional mechanistic investigation revealed that compound 6e promotes apoptosis (25.3%) and G0/G1 phase cell cycle arrest of MCF-7 cells. Also, compound 6e induces intracellular ROS accumulation and subsequent nuclear fragmentation. Hence, this research finds new hybrid molecules active against in vitro cancer cells.","PeriodicalId":88,"journal":{"name":"MedChemComm","volume":" 9","pages":" 3057-3069"},"PeriodicalIF":3.597,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141872883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies† 将氨基酸整合到 Bcr-Abl 抑制剂中：设计、合成、生物评估和硅学研究。

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MedChemComm Pub Date : 2024-07-24 DOI: 10.1039/D4MD00417E

Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang and Xiaoyan Pan

{"title":"Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies†","authors":"Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang and Xiaoyan Pan","doi":"10.1039/D4MD00417E","DOIUrl":"10.1039/D4MD00417E","url":null,"abstract":"Bcr-Abl is successfully applied to drug discovery as a CML therapeutic target, but point mutation resistance has become a major challenge in the clinical treatment of CML. Our previous studies have shown that the introduction of amino acids as flexible linkers and heterocyclic structures as HBMs can achieve potent inhibition of Bcr-AblT315I. In continuation of these studies, we further enriched the linker types by developing a library of compounds with tert-leucine or serine as a linker. Biological results showed that these compounds exhibited enhanced inhibition against Bcr-AblWT and Bcr-AblT315I kinases as well as improved antiproliferative activity in leukemia cell assays compared to previously disclosed compounds. In particular, compounds TL8, TL10, BS4, BS10, SR5 and SR11 exhibited potent inhibitory activities against Ba/F3 cells bearing a T315I mutant. Additionally, compounds TL8, BS4 and SR5 effectively induced K562 cell apoptosis, arrested the cell cycle at the S or G2/M phase, and inhibited the phosphorylation of Bcr-Abl and STAT5 in a dose-dependent manner. Docking studies verified the rationality of tert-leucine or serine as a flexible linker and indicated that phenylpyridine with an amide side chain favored the potency of these inhibitors. Moreover, ADME prediction suggested that the tested compounds had a favorable safety profile. Thus, tert-leucine or serine can be used as a promising class of flexible linkers for Bcr-Abl inhibitors with heterocyclic structures as HBMs, and compounds BS4, SR5, and especially TL8, can be used as starting points for further optimization.","PeriodicalId":88,"journal":{"name":"MedChemComm","volume":" 10","pages":" 3507-3528"},"PeriodicalIF":3.597,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An analysis of the physicochemical properties of oral drugs from 2000 to 2022† 2000 至 2022 年口服药物理化特性分析

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MedChemComm Pub Date : 2024-07-22 DOI: 10.1039/D4MD00160E

Rachael Pirie, Harriet A. Stanway-Gordon, Hannah L. Stewart, Kirsty L. Wilson, Summer Patton, Jack Tyerman, Daniel J. Cole, Katherine Fowler and Michael J. Waring

{"title":"An analysis of the physicochemical properties of oral drugs from 2000 to 2022†","authors":"Rachael Pirie, Harriet A. Stanway-Gordon, Hannah L. Stewart, Kirsty L. Wilson, Summer Patton, Jack Tyerman, Daniel J. Cole, Katherine Fowler and Michael J. Waring","doi":"10.1039/D4MD00160E","DOIUrl":"10.1039/D4MD00160E","url":null,"abstract":"Calculable physicochemical descriptors are a useful guide to assist compound design in medicinal chemistry. It is well established that controlling size, lipophilicity, hydrogen bonding, flexibility and shape, guided by descriptors that approximate to these properties, can greatly increase the chances of successful drug discovery. Many therapeutic targets and new modalities are incompatible with the optimal ranges of these properties and thus there is much interest in approaches to find oral drug candidates outside of this space. These considerations have been a focus for a while and hence we analysed the physicochemical properties of oral drugs approved by the FDA from 2000 to 2022 to assess if such concepts had influenced the output of the drug-discovery community. Our findings show that it is possible to find drug molecules that lie outside of the optimal descriptor ranges and that large molecules in particular (molecular weight >500 Da) can be oral drugs. The analysis suggests that this is more likely if lipophilicity, hydrogen bonding and flexibility are controlled. Crude physicochemical descriptors are useful in that regard but more accurate and robust means of understanding substructural classes, shape and conformation are likely to be required to improve the chances of success in this space.","PeriodicalId":88,"journal":{"name":"MedChemComm","volume":" 9","pages":" 3125-3132"},"PeriodicalIF":3.597,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/md/d4md00160e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141944950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiosynthesis of [18F]brequinar for in vivo PET imaging of hDHODH for potential studies of acute myeloid leukemia and cancers† 用于 hDHODH 体内 PET 成像的[18F]brequinar 的放射合成，可用于急性髓性白血病和癌症的潜在研究。

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MedChemComm Pub Date : 2024-07-22 DOI: 10.1039/D4MD00433G

Vinay Kumar Banka, Stefano Sainas, Elena Martino, Jiacheng Wang, Marco Lucio Lolli and Yu-Shin Ding

{"title":"Radiosynthesis of [18F]brequinar for in vivo PET imaging of hDHODH for potential studies of acute myeloid leukemia and cancers†","authors":"Vinay Kumar Banka, Stefano Sainas, Elena Martino, Jiacheng Wang, Marco Lucio Lolli and Yu-Shin Ding","doi":"10.1039/D4MD00433G","DOIUrl":"10.1039/D4MD00433G","url":null,"abstract":"Dihydroorotate dehydrogenase (DHODH), an enzyme that plays a critical role in the de novo pyrimidine biosynthesis, has been recognized as a promising target for the treatment of diseases that involve cellular proliferation, such as autoimmune diseases and cancers. Pharmacological inhibition of human DHODH (hDHODH) that offers a potential therapeutic strategy for the treatment in adult subjects with acute myeloid leukemia (AML) has recently been supported by phase I/II clinical trials for the treatment of patients with relapsed/refractory AML. To facilitate the development of optimized hDHODH inhibitors, the presence of an in vivo imaging probe that is able to demonstrate in vivo target engagement is critical and desirable. Brequinar is one of the most potent hDHODH inhibitors so far discovered. In this work, we use a copper-mediated radiofluorination (CMRF) strategy and compare the chemical design and radiosynthesis starting from either pinacole boronate p-nitrobenzyl ester (4) or tributylstannate (tin) p-nitrobenzyl ester (5), chosen for their suitability as a precursor to [18F]brequinar. We report here the design, synthesis, radiolabeling and characterization of [18F]brequinar, and a preliminary PET imaging study of DHODH in vivo. This study provides the strategies to create [18F]brequinar, the first hDHODH inhibitor PET radiotracer, which will facilitate its use as a tool (theranostics) for hDHODH drug development and for diagnosis and monitoring therapeutic efficacy in AML and cancers.","PeriodicalId":88,"journal":{"name":"MedChemComm","volume":" 9","pages":" 3147-3161"},"PeriodicalIF":3.597,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of di-arylated 1,2,4-triazole-based derivatives as therapeutic agents against breast cancer: synthesis and biological evaluation† 开发作为乳腺癌治疗药物的二芳基化 1,2,4 三唑基衍生物：合成与生物学评价

IF 3.597

MedChemComm Pub Date : 2024-07-22 DOI: 10.1039/D4MD00285G

Mousumi Deb, Hoshiyar Singh, Diksha Manhas, Utpal Nandi, Santosh K. Guru and Parthasarathi Das

{"title":"Development of di-arylated 1,2,4-triazole-based derivatives as therapeutic agents against breast cancer: synthesis and biological evaluation†","authors":"Mousumi Deb, Hoshiyar Singh, Diksha Manhas, Utpal Nandi, Santosh K. Guru and Parthasarathi Das","doi":"10.1039/D4MD00285G","DOIUrl":"10.1039/D4MD00285G","url":null,"abstract":"The synthesis, anticancer activity, and metabolic stability of di-arylated 1,2,4-triazole molecules have been reported. Utilizing an efficient programmed arylation technique which starts from commercially available 3-bromo-1H-1,2,4-triazole, a series of therapeutic agents have been synthesized and screened against three human breast cancer cell lines, MDA-MB-231, MCF-7, and ZR-75-1, via an in vitro growth inhibition assay. At 10 μM concentration, 4k, 4m, 4q, and 4t have displayed good anticancer potency in the MCF-7 cell line, among which 4q has shown the best efficacy (IC50 = 4.8 μM). Mechanistic investigations of 4q have indicated the elevation of the pro-apoptotic BAX protein in the malignant cells along with mitochondrial outer membrane permeabilization which are hallmarks of apoptosis. Further metabolic stability studies in diverse liver microsomes have provided insights into the favorable pharmacokinetic properties of 4q in humans, establishing it as a promising lead compound of this series that deserves further investigation.","PeriodicalId":88,"journal":{"name":"MedChemComm","volume":" 9","pages":" 3097-3113"},"PeriodicalIF":3.597,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141944952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trehalose in cryopreservation. Applications, mechanisms and intracellular delivery opportunities 低温保存中的妥拉糖。应用、机制和细胞内输送机会

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MedChemComm Pub Date : 2024-07-19 DOI: 10.1039/D4MD00174E

Alex Murray, Peter Kilbride and Matthew I. Gibson

{"title":"Trehalose in cryopreservation. Applications, mechanisms and intracellular delivery opportunities","authors":"Alex Murray, Peter Kilbride and Matthew I. Gibson","doi":"10.1039/D4MD00174E","DOIUrl":"10.1039/D4MD00174E","url":null,"abstract":"Cryopreservation is crucial to fields including immune and stem cell therapies, reproductive technology, blood banking, regenerative medicine and across all biotechnology. During cryopreservation, cryoprotectants are essential to protect cells from the damage caused by exposure to freezing temperatures. The most common penetrating cryoprotectants, such as DMSO and glycerol do not give full recovery and have a cytotoxicity limit on the concentration which can be applied. The non-reducing disaccharide trehalose has been widely explored and used to supplement these, inspired by its use in nature to aid survival at extreme temperatures and/or desiccation. However, trehalose has challenges to its use, particular its low membrane permeability, and how its protective role compares to other sugars. Here we review the application of trehalose and its reported benefit and seek to show where chemical tools can improve its function. In particular, we highlight emerging chemical methods to deliver (as cargo, or via selective permeation) into the intracellular space. This includes encapsulation, cell penetrating peptides or (selective) modification of hydroxyls on trehalose.","PeriodicalId":88,"journal":{"name":"MedChemComm","volume":" 9","pages":" 2980-2995"},"PeriodicalIF":3.597,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/md/d4md00174e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141742998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel aurone RNA CAG binder inhibits the huntingtin RNA–protein interaction† 一种新型 Aurone RNA CAG 结合剂可抑制亨廷汀 RNA 蛋白相互作用

IF 3.597

MedChemComm Pub Date : 2024-07-17 DOI: 10.1039/D4MD00403E

Giovanna Ballarin, Maddalena Biasiotto, Annika Reisbitzer, Marlen Hegels, Michael Bolte, Sybille Krauß and Daria V. Berdnikova

引用次数: 0

Expanding the chemical space of ester of quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives as potential antitubercular agents† 拓展喹喔啉-7-羧酸酯 1,4- 二-N-氧化物衍生物作为潜在抗结核药物的化学空间

IF 3.597

MedChemComm Pub Date : 2024-07-17 DOI: 10.1039/D4MD00221K

Alonzo González-González, Oscar Sánchez-Sánchez, Baojie Wan, Scott Franzblau, Isidro Palos, José C. Espinoza-Hicks, Adriana Moreno-Rodríguez, Ana Verónica Martínez-Vázquez, Edgar E. Lara-Ramírez, Eyra Ortiz-Pérez, Alma D. Paz-González and Gildardo Rivera

{"title":"Expanding the chemical space of ester of quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives as potential antitubercular agents†","authors":"Alonzo González-González, Oscar Sánchez-Sánchez, Baojie Wan, Scott Franzblau, Isidro Palos, José C. Espinoza-Hicks, Adriana Moreno-Rodríguez, Ana Verónica Martínez-Vázquez, Edgar E. Lara-Ramírez, Eyra Ortiz-Pérez, Alma D. Paz-González and Gildardo Rivera","doi":"10.1039/D4MD00221K","DOIUrl":"10.1039/D4MD00221K","url":null,"abstract":"Tuberculosis is a worldwide health problem that warrants attention given that the current treatment options require a long-term chemotherapeutic period and have reported the development of Mycobacterium tuberculosis (M. tuberculosis) multidrug resistant strains. In this study, n-butyl and isobutyl quinoxaline-7-carboxylate 1,4-di-N-oxide were evaluated against replicating and non-replicating H37Rv M. tuberculosis strains. The results showed that seventeen of the twenty-eight derivatives have minimum inhibitory concentration (MIC) values lower than isoniazid (2.92 μM). The most active antimycobacterial agents were T-148, T-149, T-163, and T-164, which have the lowest MIC values (0.53, 0.57, 0.53, and 0.55 μM respectively). These results confirm the potential of quinoxaline-1,4-di-N-oxide against M. tuberculosis to develop and obtain new and more safety antituberculosis drugs.","PeriodicalId":88,"journal":{"name":"MedChemComm","volume":" 8","pages":" 2785-2791"},"PeriodicalIF":3.597,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141742999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0