Reviews in analgesia最新文献

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Purinergic Modulation of Pain 嘌呤能调节疼痛
Reviews in analgesia Pub Date : 2003-01-01 DOI: 10.3727/000000003783993035
M. Jarvis
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引用次数: 4
Critical Evaluation of Reported Plant Sources of Possibly Novel Analgesic Compounds 对可能的新型镇痛化合物的植物来源的批判性评价
Reviews in analgesia Pub Date : 2003-01-01 DOI: 10.3727/000000003783992973
N. Bassi, Andrea R. Cohen, Shyam Desai, M. G. Espinosa, E. Flynn, Keith E. Franchetti, Anu Kuriakose, Stephany-Kieu T. Lam, Kin S. Ly, M. J. McGraw, Niloufar N. Namazi, George A. Nemeh, Cynthia D Oliva, S. Pastakia, Kathleen M. Riley, O. Tairu, R. Raffa
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引用次数: 1
Placebo-Induced Analgesia: Methodology, Neurobiology, Clinical Use, and Ethics 安慰剂诱导的镇痛:方法学、神经生物学、临床应用和伦理学
Reviews in analgesia Pub Date : 2003-01-01 DOI: 10.3727/000000003783992955
F. Benedetti, L. Colloca
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引用次数: 18
Analgesic Effects of Cannabinoids: Sites and Mechanisms of Action 大麻素的镇痛作用:部位和作用机制
Reviews in analgesia Pub Date : 2003-01-01 DOI: 10.3727/000000003783992991
V. Chapman, D. Finn
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引用次数: 11
The Formalin Test: Characteristics and Usefulness of the Model 福尔马林检验:模型的特征和有用性
Reviews in analgesia Pub Date : 2003-01-01 DOI: 10.3727/000000003783992982
J. Sawynok, X. Liu
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引用次数: 73
Opioid Research in Amphibians: A Unique Perspective on Mechanisms of Opioid Analgesia and the Evolution of Opioid Receptors 两栖动物的阿片研究:阿片镇痛机制和阿片受体进化的独特视角
Reviews in analgesia Pub Date : 2003-01-01 DOI: 10.3727/000000003783993044
C. Stevens
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引用次数: 11
Modulation of Guanosine-5′- O -(3-[ 35 S]thio)triphosphate ([ 35 S]GTP-γ-S) Binding by Opioid Agonists and Antagonists 阿片激动剂和拮抗剂对鸟苷-5′- O -(3-[35 S]硫代)三磷酸([35 S]GTP-γ-S)结合的调节
Reviews in analgesia Pub Date : 2003-01-01 DOI: 10.3727/000000003783993017
Heng Xu, R. Rothman
{"title":"Modulation of Guanosine-5′- O -(3-[ 35 S]thio)triphosphate ([ 35 S]GTP-γ-S) Binding by Opioid Agonists and Antagonists","authors":"Heng Xu, R. Rothman","doi":"10.3727/000000003783993017","DOIUrl":"https://doi.org/10.3727/000000003783993017","url":null,"abstract":"","PeriodicalId":88985,"journal":{"name":"Reviews in analgesia","volume":"30 1","pages":"83-96"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3727/000000003783993017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69694542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
New Breakthroughs in the Regulation of G-Protein Signaling: Implications in Mu and Delta Opioid Receptor-Mediated Analgesia g蛋白信号调控的新突破:在阿片受体介导的镇痛中的意义
Reviews in analgesia Pub Date : 2003-01-01 DOI: 10.3727/000000003783993026
J. Garzón, P. Sánchez-Blázquez
{"title":"New Breakthroughs in the Regulation of G-Protein Signaling: Implications in Mu and Delta Opioid Receptor-Mediated Analgesia","authors":"J. Garzón, P. Sánchez-Blázquez","doi":"10.3727/000000003783993026","DOIUrl":"https://doi.org/10.3727/000000003783993026","url":null,"abstract":"The present understanding of opioid pharmacology has been influenced by discoveries relating to the mechanisms that operate on G-protein-coupled receptor (GPCR) signaling. Over the last decade, new concepts have been gradually substantiated, such as receptor preference for the regulation of certain classes of G-proteins in cells, agonists’ selection of G-protein classes for internalizing their effects, and the regulation of the functional state of Gα subunits and Gβγ dimers shuttling between activated receptors and effectors during agonist signal propagation. Current research is providing new information on how transduction regulated by mu and delta receptors influences the analgesic efficacy of their agonists. This includes aspects such as the Gβγ binding phosducin-like proteins (PhLP) and the Gα-GTP binding regulators of G-protein signaling (RGS) proteins. These regulatory proteins emerge as being involved in controlling opioid receptor phosphorylation uncoupling, modulating the potency and duration of agonist analgesic effects, and the development of tachyphylaxis and acute tolerance to opioid analgesia.","PeriodicalId":88985,"journal":{"name":"Reviews in analgesia","volume":"7 1","pages":"41-60"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3727/000000003783993026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69694598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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