{"title":"NMDA Receptors and Colitis: Basic Science and Clinical Implications.","authors":"Qiqi Zhou, G Nicholas Verne","doi":"10.3727/154296108783994013","DOIUrl":"10.3727/154296108783994013","url":null,"abstract":"<p><p>During the last decade, research focusing primarily on alterations in the peripheral and central nervous system has improved our understanding of the pathophysiological mechanisms of chronic visceral pain. These studies have demonstrated significant physiological changes following injury to the viscera in the firing patterns of both primary afferent neurons that transmit nociceptive information from the viscera and in central neurons that process the nociceptive information. A number of receptors, neurotransmitters, cytokines, and second messenger systems in these neurons have been implicated in the enhancement of visceral nociception. N-methyl-d-aspartic acid (NMDA) receptors play an important role in chronic visceral pain and hypersensitivity that is present in the setting of colonic inflammation. NMDA receptors are found in the peripheral nervous system as well as the central terminal of primary afferent neurons and have been shown to play an important role in regulating the release of nociceptive neurotransmitters. Recent work has demonstrated the presence of NMDA receptors in the enteric nervous system. In this article, we will discuss more recent evidence of the role of NMDA receptors in visceral pain associated with colitis.</p>","PeriodicalId":88985,"journal":{"name":"Reviews in analgesia","volume":"10 1","pages":"33-43"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889709/pdf/nihms168078.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29079607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of personality traits in pain perception and disability.","authors":"M. Peters, L. Vancleef","doi":"10.3727/154296108783994022","DOIUrl":"https://doi.org/10.3727/154296108783994022","url":null,"abstract":"According to the biopsychosocial model of chronic pain and disability, the experience of pain is the result of a dynamic interaction between physiological, psychological, and social factors. Fear-avoidance beliefs have been identified as being among the most prominent psychological factors influencing the development and persistence of chronic pain. This article reviews the evidence that personality traits contribute to the process of pain chronification by making people more vulnerable to respond to physical threat in an anxious and avoidant manner. We will consider three potential vulnerability factors: negative affectivity, anxiety sensitivity, and injury/illness sensitivity. For all three factors evidence has been found that they may indeed contribute to maladaptive ways of dealing with pain. Recently researchers have also begun to consider the role of resilience factors that may protect people against maladaptive cognitive and behavioral reactions to acute and chronic pain. We will review the evidence for three of these potential resilience factors: optimism, hope, and (generalized) self-efficacy. It is concluded that there is at least some evidence pointing towards a role of these three factors in chronic pain and disability, but the evidence for trait characteristics acting as resilience factors in chronic pain is less compelling than that for traits acting as vulnerability factors.","PeriodicalId":88985,"journal":{"name":"Reviews in analgesia","volume":"10 1","pages":"11-21"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69738273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multilevel Genomic Approach in Pain Research: Basic Science and Clinical Implications","authors":"Z. Luo, Katherine W. Figueroa","doi":"10.3727/154296108783994059","DOIUrl":"https://doi.org/10.3727/154296108783994059","url":null,"abstract":"","PeriodicalId":88985,"journal":{"name":"Reviews in analgesia","volume":"10 1","pages":"45-58"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69738327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antinociceptive Effects of Botulinum Toxin A for the Treatment of Neuropathic Pain","authors":"H. Park, D. Moon","doi":"10.3727/154296108783994040","DOIUrl":"https://doi.org/10.3727/154296108783994040","url":null,"abstract":"","PeriodicalId":88985,"journal":{"name":"Reviews in analgesia","volume":"10 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69738318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Descending Control of Pain During Persistent Peripheral Damage","authors":"H. Vanegas","doi":"10.3727/000000007783992816","DOIUrl":"https://doi.org/10.3727/000000007783992816","url":null,"abstract":"","PeriodicalId":88985,"journal":{"name":"Reviews in analgesia","volume":"9 1","pages":"55-70"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3727/000000007783992816","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69696871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Wasner, S. Fleetwood-Walker, E. Garry, C. Abbadie, Robert W. Johnson, R. Baron
{"title":"Postherpetic Neuralgia: Basic Research and Clinical Implications","authors":"G. Wasner, S. Fleetwood-Walker, E. Garry, C. Abbadie, Robert W. Johnson, R. Baron","doi":"10.3727/000000007783992799","DOIUrl":"https://doi.org/10.3727/000000007783992799","url":null,"abstract":"","PeriodicalId":88985,"journal":{"name":"Reviews in analgesia","volume":"9 1","pages":"71-86"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3727/000000007783992799","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69697270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cytokine-Induced Pain: Basic Science and Clinical Implications","authors":"N. Üçeyler, C. Sommer","doi":"10.3727/000000007783992807","DOIUrl":"https://doi.org/10.3727/000000007783992807","url":null,"abstract":"","PeriodicalId":88985,"journal":{"name":"Reviews in analgesia","volume":"9 1","pages":"87-103"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3727/000000007783992807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69697330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Whiplash Injury Pain: Basic Science and Current/Future Therapeutics","authors":"M. Sterling","doi":"10.3727/000000007783992825","DOIUrl":"https://doi.org/10.3727/000000007783992825","url":null,"abstract":"Whiplash is a common and often disabling condition that incurs both significant personal and economic costs. While many people recover, up to 40% develop persistent symptoms. There is now considerable evidence that demonstrates whiplash to be a complex condition, particularly in those with poor recovery. This group is characterized by widespread sensory and motor hypersensitivity indicative of central hyperexcitability, motor dysfunction, psychological distress, and report higher initial levels of pain. There is some relationship between the sensory hypersensitivity and certain psychological substrates but these relationships are not consistent. Furthermore, both physical and psychological factors are predictors of poor functional recovery, indicating a complex interplay between these factors exists. Most intervention studies have considered whiplash as a homogenous condition and this may account for only modest effects offered by most interventions. Future research should account for the heterogeneity of the whiplash condition. The challenge will be to improve treatment strategies for the management of both physical and psychological aspects of whiplash, particularly in the important early acute stage postinjury.","PeriodicalId":88985,"journal":{"name":"Reviews in analgesia","volume":"9 1","pages":"105-116"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3727/000000007783992825","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69696883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
