Journal of allergy最新文献_第6页

Insulin and the lung: connecting asthma and metabolic syndrome. 胰岛素和肺:哮喘和代谢综合征之间的联系。

Journal of allergy Pub Date : 2013-01-01 Epub Date: 2013-09-24 DOI: 10.1155/2013/627384

Suchita Singh, Y S Prakash, Allan Linneberg, Anurag Agrawal

{"title":"Insulin and the lung: connecting asthma and metabolic syndrome.","authors":"Suchita Singh, Y S Prakash, Allan Linneberg, Anurag Agrawal","doi":"10.1155/2013/627384","DOIUrl":"https://doi.org/10.1155/2013/627384","url":null,"abstract":"Obesity, metabolic syndrome, and asthma are all rapidly increasing globally. Substantial emerging evidence suggests that these three conditions are epidemiologically and mechanistically linked. Since the link between obesity and asthma appears to extend beyond mechanical pulmonary disadvantage, molecular understanding is necessary. Insulin resistance is a strong, independent risk factor for asthma development, but it is unknown whether a direct effect of insulin on the lung is involved. This review summarizes current knowledge regarding the effect of insulin on cellular components of the lung and highlights the molecular consequences of insulin-related metabolic signaling cascades that could adversely affect lung structure and function. Examples include airway smooth muscle proliferation and contractility and regulatory signaling networks that are associated with asthma. These aspects of insulin signaling provide mechanistic insight into the clinical evidence for the links between obesity, metabolic syndrome, and airway diseases, setting the stage for novel therapeutic avenues targeting these conditions. ","PeriodicalId":88910,"journal":{"name":"Journal of allergy","volume":"2013 ","pages":"627384"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/627384","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31844084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 81

Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control. 肥胖和非肥胖哮喘学龄儿童血清瘦素和脂联素水平与哮喘控制的关系

Journal of allergy Pub Date : 2013-01-01 Epub Date: 2013-12-17 DOI: 10.1155/2013/654104

Atqah Abdul Wahab, Muna M Maarafiya, Ashraf Soliman, Noura B M Younes, Prem Chandra

{"title":"Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control.","authors":"Atqah Abdul Wahab, Muna M Maarafiya, Ashraf Soliman, Noura B M Younes, Prem Chandra","doi":"10.1155/2013/654104","DOIUrl":"https://doi.org/10.1155/2013/654104","url":null,"abstract":"There is growing evidence of a positive correlation between asthma and obesity in children and adults. Leptin and adiponectin regulate several metabolic and inflammatory functions. This study aims to evaluate serum leptin and adiponectin concentrations in asthmatic school children to investigate their association with obesity and the degree of asthma control. Obese asthmatic (OA) and nonobese asthmatic (NOA) children, aged 7 to 14, were randomly enrolled in this prospective study. Data on demographic, anthropometric, serum lipids, and spirometric measures and allergy status were collected and analyzed. Serum leptin was significantly higher (25.8 ± 11.1 versus 8.7 ± 11.1; P < 0.0001) and adiponectin levels were lower (2.5 ± 1.2 versus 5.4 ± 2.9; P < 0.0001) in OA compared to NOA children. The uncontrolled group had higher leptin and lower adiponectin levels compared to well and partially controlled asthma. BMI was positively correlated with leptin (r = 0.79; P < 0.001) and negatively with adiponectin (r = -0.73; P < 0.001). Mean BMI and leptin levels were observed to be higher in girls compared to boys. Stepwise multiple linear regression analysis showed that higher BMI and female gender had significant effect on serum leptin levels. Among asthmatic children higher serum leptin and lower adiponectin levels were significantly associated with obesity and showed no significant association with degree of asthma controls. ","PeriodicalId":88910,"journal":{"name":"Journal of allergy","volume":"2013 ","pages":"654104"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/654104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32055327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Airway smooth muscle hypercontractility in asthma. 哮喘气道平滑肌过度收缩。

Journal of allergy Pub Date : 2013-01-01 Epub Date: 2013-03-18 DOI: 10.1155/2013/185971

Rachid Berair, Fay Hollins, Christopher Brightling

{"title":"Airway smooth muscle hypercontractility in asthma.","authors":"Rachid Berair, Fay Hollins, Christopher Brightling","doi":"10.1155/2013/185971","DOIUrl":"10.1155/2013/185971","url":null,"abstract":"In recent years, asthma has been defined primarily as an inflammatory disorder with emphasis on inflammation being the principle underlying pathophysiological characteristic driving airway obstruction and remodelling. Morphological abnormalities of asthmatic airway smooth muscle (ASM), the primary structure responsible for airway obstruction seen in asthma, have long been described, but surprisingly, until recently, relatively small number of studies investigated whether asthmatic ASM was also fundamentally different in its functional properties. Evidence from recent studies done on single ASM cells and on ASM-impregnated gel cultures have shown that asthmatic ASM is intrinsically hypercontractile. Several elements of the ASM contraction apparatus in asthmatics and in animal models of asthma have been found to be different from nonasthmatics. These differences include some regulatory contractile proteins and also some components of both the calcium-dependent and calcium-independent contraction signalling pathways. Furthermore, oxidative stress was also found to be heightened in asthmatic ASM and contributes to hypercontractility. Understanding the abnormalities and mechanisms driving asthmatic ASM hypercontractility provides a great potential for the development of new targeted drugs, other than the conventional current anti-inflammatory and bronchodilator therapies, to address the desperate unmet need especially in patients with severe and persistent asthma.","PeriodicalId":88910,"journal":{"name":"Journal of allergy","volume":"2013 ","pages":"185971"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31351653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population Studies. 哮喘中的脂肪连接素、瘦素和抗组蛋白：通过人群研究了解基本机制

Journal of allergy Pub Date : 2013-01-01 Epub Date: 2013-10-30 DOI: 10.1155/2013/785835

Akshay Sood, Stephanie A Shore

{"title":"Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population Studies.","authors":"Akshay Sood, Stephanie A Shore","doi":"10.1155/2013/785835","DOIUrl":"10.1155/2013/785835","url":null,"abstract":"Adipokines, factors produced by adipose tissue, may be proinflammatory (such as leptin and resistin) or anti-inflammatory (such as adiponectin). Effects of these adipokines on the lungs have the potential to evoke or exacerbate asthma. This review summarizes basic mechanistic data through population-based and clinical studies addressing the potential role of adipokines in asthma. Augmenting circulating concentrations of adiponectin attenuates allergic airway inflammation and airway hyperresponsiveness in mice. Murine data is supported by human data that suggest that low serum adiponectin is associated with greater risk for asthma among women and peripubertal girls. Further, higher serum total adiponectin may be associated with lower clinical asthma severity among children and women with asthma. In contrast, exogenous administration of leptin results in augmented allergic airway hyperresponsiveness in mice. Alveolar macrophages obtained from obese asthmatics are uniquely sensitive to leptin in terms of their potential to augment inflammation. Consistent with this basic mechanistic data, epidemiologic studies demonstrate that higher serum leptin is associated with greater asthma prevalence and/or severity and that these associations may be stronger among women, postpubertal girls, and prepubertal boys. The role of adipokines in asthma is still evolving, and it is not currently known whether modulation of adipokines may be helpful in asthma prevention or treatment. ","PeriodicalId":88910,"journal":{"name":"Journal of allergy","volume":"2013 ","pages":"785835"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31913720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of IL-22 in Allergic Airway Inflammation. IL-22在变应性气道炎症中的作用

Journal of allergy Pub Date : 2013-01-01 Epub Date: 2013-02-21 DOI: 10.1155/2013/260518

Koichi Hirose, Kentaro Takahashi, Hiroshi Nakajima

引用次数: 19

An important role of blood and lymphatic vessels in inflammation and allergy. 血液和淋巴管在炎症和过敏中起重要作用。

Journal of allergy Pub Date : 2013-01-01 Epub Date: 2013-01-31 DOI: 10.1155/2013/672381

Silvana Zgraggen, Alexandra M Ochsenbein, Michael Detmar

引用次数: 61

Swimming and Asthma: Differences between Women and Men. 游泳与哮喘：游泳与哮喘：男女之间的差异

Journal of allergy Pub Date : 2013-01-01 Epub Date: 2013-02-20 DOI: 10.1155/2013/520913

Marja Kristiina Päivinen, Kari Lasse Keskinen, Heikki Olavi Tikkanen

{"title":"Swimming and Asthma: Differences between Women and Men.","authors":"Marja Kristiina Päivinen, Kari Lasse Keskinen, Heikki Olavi Tikkanen","doi":"10.1155/2013/520913","DOIUrl":"10.1155/2013/520913","url":null,"abstract":"Background and Aim. Asthma is common in endurance athletes including swimmers. Our aim was to study gender differences in asthma, allergy, and asthmatic symptoms in swimmers and investigate the effects of varying intensities of physical exercise on competitive swimmers with asthma. Methods. Three hundred highly trained swimmers (156 females and 144 males) were studied by a questionnaire. Their mean (±SD) ages were 17 ± 3 and 19 ± 3 years, and they had training history of 7 ± 2 and 7 ± 3 years in females and males, respectively. Gender differences in asthma, allergy, and respiratory symptoms were examined. Special attention was focused on asthmatic swimmers, their allergies and respiratory symptoms during swimming at different intensities. Results. The prevalence of physician-diagnosed asthma was 19% for females and males. No gender differences in asthma or respiratory symptoms were found. Males reported allergies significantly more often than females (P = 0.007). Gender difference was found in respiratory symptoms among swimmers with physician-diagnosed asthma because females reported symptoms significantly more often (P = 0.017) than males. Asthmatic females also reported symptoms significantly more often at moderate intensity swimming (P = 0.003) than males especially for coughing. Discussion. Gender difference in prevalence of asthma was not found in swimmers. However, allergy was reported significantly more by male swimmers. Male swimmers with asthma reported significantly more cases having family history of asthma, which may be a sign of selection of asthma-friendly sport. Moderate intensity swimming seemed to induce significantly more symptoms especially coughing in asthmatic females.","PeriodicalId":88910,"journal":{"name":"Journal of allergy","volume":"2013 ","pages":"520913"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31351655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Airway Smooth Muscle Dynamics and Hyperresponsiveness: In and outside the Clinic. 气道平滑肌动力学和高反应性:诊所内外。

Journal of allergy Pub Date : 2012-01-01 Epub Date: 2012-10-17 DOI: 10.1155/2012/157047

Peter B Noble, Thomas K Ansell, Alan L James, Peter K McFawn, Howard W Mitchell

{"title":"Airway Smooth Muscle Dynamics and Hyperresponsiveness: In and outside the Clinic.","authors":"Peter B Noble, Thomas K Ansell, Alan L James, Peter K McFawn, Howard W Mitchell","doi":"10.1155/2012/157047","DOIUrl":"https://doi.org/10.1155/2012/157047","url":null,"abstract":"The primary functional abnormality in asthma is airway hyperresponsiveness (AHR)-excessive airway narrowing to bronchoconstrictor stimuli. Our understanding of the underlying mechanism(s) producing AHR is incomplete. While structure-function relationships have been evoked to explain AHR (e.g., increased airway smooth muscle (ASM) mass in asthma) more recently there has been a focus on how the dynamic mechanical environment of the lung impacts airway responsiveness in health and disease. The effects of breathing movements such as deep inspiration reveal innate protective mechanisms in healthy individuals that are likely mediated by dynamic ASM stretch but which may be impaired in asthmatic patients and thereby facilitate AHR. This perspective considers the evidence for and against a role of dynamic ASM stretch in limiting the capacity of airways to narrow excessively. We propose that lung function measured after bronchial provocation in the laboratory and changes in lung function perceived by the patient in everyday life may be quite different in their dependence on dynamic ASM stretch.","PeriodicalId":88910,"journal":{"name":"Journal of allergy","volume":"2012 ","pages":"157047"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/157047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31022291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Dendritic cells, viruses, and the development of atopic disease. 树突状细胞、病毒和特应性疾病的发展。

Journal of allergy Pub Date : 2012-01-01 Epub Date: 2012-10-15 DOI: 10.1155/2012/936870

Jonathan S Tam, Mitchell H Grayson

引用次数: 2

A randomised, double-blind pilot study of enzyme-potentiated desensitisation for prophylaxis of large local reactions to mosquito bites. 酶促脱敏法预防蚊虫叮咬引起的大面积局部反应的随机双盲试验研究。

Journal of allergy Pub Date : 2012-01-01 Epub Date: 2012-03-22 DOI: 10.1155/2012/106069

S Berkovitz, N Hill, M Radcliffe, G Ambler

{"title":"A randomised, double-blind pilot study of enzyme-potentiated desensitisation for prophylaxis of large local reactions to mosquito bites.","authors":"S Berkovitz, N Hill, M Radcliffe, G Ambler","doi":"10.1155/2012/106069","DOIUrl":"10.1155/2012/106069","url":null,"abstract":"Primary Objective. To test the hypothesis that two injections of enzyme-potentiated mosquito antigen significantly reduce the size of experimental mosquito bites in participants with LLR-MB. Design. Randomised, double-blind, placebo-controlled, parallel group comparison over 3 months. Setting. Hospital outpatient clinic. Participants. Fifty adult participants of both sexes. Interventions. Two injections of mosquito antigen or matching placebo, 6 weeks apart. Main Outcome Measures. Early (1 hour) and late (24 hours) mean square root of erythema area (SREA) following controlled mosquito bite with the second bite given at least 6 weeks following the final injection. Results. At 1 hour, mean SREA was slightly higher in the EPD group compared to placebo after adjusting for baseline values (0.46, 95% CI -6.11 to 7.03), but this was not statistically significant (P = 0.89, ANCOVA analysis); neither were the results at 24 hours (-2.58, 95% CI -11.73 to 6.57) (P = 0.57). The proportion of participants experiencing a decrease in wheal size at 1 or 24 hours was similar between groups. Conclusions. EPD was not demonstrated to be effective for immediate or delayed LLR-MB. Methodological problems included a high variability in LLR-MB between subjects, suggesting that a crossover design should be used in future.","PeriodicalId":88910,"journal":{"name":"Journal of allergy","volume":" ","pages":"106069"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40185829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0