The open nuclear medicine journal最新文献_第3页

Multimodality Imaging of Angiogenesis 血管生成的多模态成像

The open nuclear medicine journal Pub Date : 2010-12-14 DOI: 10.2174/1876388X01002010166

Ho-Yyoung Lee, J. Jeong

引用次数: 2

The open nuclear medicine journal Pub Date : 2010-12-14 DOI: 10.2174/1876388X01002010171

Chun-lei Zhao, M. Tian, Hong Zhang

引用次数: 11

The Utility of Tc-99m MDP Bone Scintigraphy for the Detection of Articular Involvement in Behçet's Disease Tc-99m MDP骨显像检测beharet病关节受累的应用

The open nuclear medicine journal Pub Date : 2010-10-21 DOI: 10.2174/1876388X01002010138

A. Amin, H. Darweesh, Heba Attia

{"title":"The Utility of Tc-99m MDP Bone Scintigraphy for the Detection of Articular Involvement in Behçet's Disease","authors":"A. Amin, H. Darweesh, Heba Attia","doi":"10.2174/1876388X01002010138","DOIUrl":"https://doi.org/10.2174/1876388X01002010138","url":null,"abstract":"Introduction: Behcet's disease (BD) is a chronic relapsing inflammatory disease. 40-70% of BD patients display rheumatic features with a 9% incidence as an initial presentation. However, there are no pathognomonic laboratory tests in BD and the diagnosis depends on the occurrence and grouping of sufficient clinical manifestations to allow the physician to either suspect, or definitely diagnose the condition. Our aim was to assess the utility of Tc-99m methylene diphosphonate (Tc-99m MDP) bone scintigraphy for the detection of articular involvement in BD patients and its impact on disease activity & severity scoring. Methods: 25 BD patients diagnosed according to the international study group criteria for BD diagnosis (ISG) (18 �, 7 �, mean age 32.44±7.78, disease duration 6.98±4.61year) were included and subjected to selected joint x-ray and bone scintigraphy. Results: 25/25 was scintigraphically positive for arthritis (100%, 64%, 44%, 40%, 36%& 20% in wrist, Metacarpophalangeal, proximal interphalangeal (PIPs), distal interphalangeal (DIPs), Knees & ankles respectively). 13/25 were clinically negative while scintigraphically positive for arthritis. 11/25 (44%) and 8/25 (32%) turned from inactive to active BD and from mild to moderate disease severity, based on their positive hand scintigraphy with treatment modification. 4/25 (16%) had recurrent oral ulcers with normal laboratory data and only positive hand scintigraphy; with follow-up they met ISG criteria. Conclusion: skeletal scintigraphy is a simple diagnostic modality with a low radiation burden, when compared to conventional radiology. Hence, when used appropriately in the diagnostic algorithm of BD, bone scintigraphy can be used for detection of early joint involvement, assessment of the extent and activity status with guidance for the selected therapy.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"2 1","pages":"138-142"},"PeriodicalIF":0.0,"publicationDate":"2010-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68126440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial-Lung Imaging in the Acute Respiratory Distress Syndrome 编辑-急性呼吸窘迫综合征的肺部影像学

The open nuclear medicine journal Pub Date : 2010-10-12 DOI: 10.2174/1876388X01002010071

C. Guérin

引用次数: 0

Lung Imaging in Acute Lung Injury and Acute Respiratory DistressSyndrome with PET PET在急性肺损伤和急性呼吸窘迫综合征中的肺显像

The open nuclear medicine journal Pub Date : 2010-10-12 DOI: 10.2174/1876388X01002010099

J. Richard, C. Pouzot, C. Guérin

引用次数: 0

Electrical Impedance Tomography in Acute Respiratory Distress Syndrome 急性呼吸窘迫综合征的电阻抗断层扫描

The open nuclear medicine journal Pub Date : 2010-10-12 DOI: 10.2174/1876388X01002010110

I. Frerichs, S. Pulletz, G. Elke, G. Zick, N. Weiler

{"title":"Electrical Impedance Tomography in Acute Respiratory Distress Syndrome","authors":"I. Frerichs, S. Pulletz, G. Elke, G. Zick, N. Weiler","doi":"10.2174/1876388X01002010110","DOIUrl":"https://doi.org/10.2174/1876388X01002010110","url":null,"abstract":"Electrical impedance tomography (EIT) is an emerging new imaging modality not yet routinely used in a clinical setting. The generation of EIT scans is based on the non-invasive measurement of electrical properties of tissues which does not require the use of radiation. Thoracic EIT examinations have been shown to track changes in regional lung volumes at scan rates of up to 40-50 scans/s. Experimental and clinical studies indicate the potential of EIT in monitoring regional lung ventilation and aeration at the bedside. Mechanically ventilated patients with acute lung injury and acute respiratory distress syndrome (ARDS) might benefit from possible continuous monitoring of their regional lung function by EIT which could be used to optimise the ventilator settings and minimise the ventilator-induced lung injury. This review explains the measuring principle of EIT and the analysis of regional EIT signals which allow the assessment of regional lung ventilation, aeration and potentially also lung perfusion. Protective lung ventilation using low tidal volumes and adequate positive end-expiratory pressures, recruitment manoeuvres, surfactant administration, prone posture, restricted fluid administration, assisted ventilation allowing spontaneous breathing, partial liquid ventilation, administration of pulmonary vasoactive, anti-inflammatory and antioxidant agents are used or considered in the management of ARDS patients. EIT is capable of monitoring the pulmonary effects of many of these therapeutic procedures. This is documented by examples from experimental and clinical EIT studies and by references to relevant EIT literature. The perspectives and limitations of EIT monitoring are also addressed.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"2 1","pages":"110-118"},"PeriodicalIF":0.0,"publicationDate":"2010-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68126367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

Functional MRI of the Lung 肺功能MRI

The open nuclear medicine journal Pub Date : 2010-10-12 DOI: 10.2174/1876388X01002010125

Y. Berthezène

引用次数: 0

Real Time Lung Imaging for the Detection of Lung Injury and Alveolar Fluid Movement During Mechanical Ventilation 实时肺成像检测机械通气过程中肺损伤和肺泡液运动

The open nuclear medicine journal Pub Date : 2010-10-12 DOI: 10.2174/1876388X01002010079

N. Prost, J. Ricard, G. Saumon, D. Dreyfuss

{"title":"Real Time Lung Imaging for the Detection of Lung Injury and Alveolar Fluid Movement During Mechanical Ventilation","authors":"N. Prost, J. Ricard, G. Saumon, D. Dreyfuss","doi":"10.2174/1876388X01002010079","DOIUrl":"https://doi.org/10.2174/1876388X01002010079","url":null,"abstract":"Experimental ventilator-induced lung injury (VILI) is characterized by alterations in alveolar epithelial and microvascular permeability that favors the systemic dissemination of lung borne cytokines or bacteria. Animal models of VILI have been shown relevant to patient care and outcome and help explaining why most patients with the acute respiratory distress syndrome do not die from respiratory failure but from multiple organ dysfunction. Recent experimental studies also showed that adverse ventilator patterns may propel airway secretions and bacteria to previously healthy lung regions. Noninvasive imaging techniques were used for years to study the net rate of protein flow across the pulmonary microvascular endothelium and the alveolar epithelium in vivo, during normal breathing and lung inflation. More recently, the two-way protein fluxes across the alveolo-capillary barrier and the intra-pulmonary dispersion of alveolar edema have been monitored during mechanical ventilation. These experiments have provided new insights on the mechanisms of experimental VILI that may be of clinical value. This review will describe the evolution of these techniques and their main physiological and pharmacological applications in the era of VILI.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"2 1","pages":"79-85"},"PeriodicalIF":0.0,"publicationDate":"2010-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68126837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is and how to Manage the Acute Respiratory Distress Syndrome 什么是急性呼吸窘迫综合征，如何处理

The open nuclear medicine journal Pub Date : 2010-10-12 DOI: 10.2174/1876388X01002010072

C. Guérin, J. Richard

{"title":"What is and how to Manage the Acute Respiratory Distress Syndrome","authors":"C. Guérin, J. Richard","doi":"10.2174/1876388X01002010072","DOIUrl":"https://doi.org/10.2174/1876388X01002010072","url":null,"abstract":"Acute respiratory distress syndrome (ARDS) is an acute hypoxemic respiratory failure with lung oedema of non cardiac origin. Its primary treatment is mechanical ventilation. ARDS is under the spotlights with influenza A pandemic flu. An operating definition has been set out by an experts-consensus conference in order to include patients in clinical trials. However, this definition lacks diagnostic accuracy when compared with lung pathology. The conventional mechanical ventilation has two main objectives: firstly, preservation of arterial blood oxygenation, and secondly, protection of the lung from excessive volume or pressure at the end of inspiration. It has been demonstrated that high tidal volume can increase mortality as compared to low tidal volume. The setting of positive end-expiratory pressure (PEEP) is still not solved. Three large randomized controlled trials failed to demonstrate any benefit between a high and a low level of PEEP. A fascinating strategy of mechanical ventilation is lung recruitment, which is defined as an increase in aerated lung mass by reducing non-aerated or poorly aerated lung mass. Recruiting the lung is useful because it can improve oxygenation and limit ventilator-induced lung injury. Lung recruitment depends not only on the ventilatory settings but also on lung and patient. Several adjunct treatments can be used, as prone position or various pharmacological interventions (inhaled nitric oxide). There are several non conventional methods to deliver mechanical ventilation, such as non invasive mechanical ventilation, liquid ventilation, none of them being recommended to date. Finally, the use of extracorporeal lung support is gaining further interest.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"2 1","pages":"72-78"},"PeriodicalIF":0.0,"publicationDate":"2010-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68126827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Where the Future Goes: What do we Need to Know in the ARDS and how Lung Imaging Can Deal with this? 未来走向:在ARDS中我们需要知道什么以及肺部成像如何处理这一点?

The open nuclear medicine journal Pub Date : 2010-10-12 DOI: 10.2174/1876388X01002010133

J. Richard, C. Pouzot, C. Guérin

引用次数: 0