The open nuclear medicine journal最新文献

Imaging of Pulmonary Tuberculosis with 18F-Fluoro-Deoxy-Glucose and 18F-Ethylcholine 18f -氟脱氧葡萄糖和18f -乙基胆碱对肺结核的显像

The open nuclear medicine journal Pub Date : 2014-11-28 DOI: 10.2174/1876388X01406010017

M. Vorster, A. Stoltz, A. Jacobs, M. Sathekge

引用次数: 9

Low FDG Metabolic Activity of Loco-Regional Recurrence in ThyroidCancer Patients; Is Iodine-131 has a Potentiality? 低FDG代谢活性与甲状腺癌局部复发的关系碘-131有潜力吗?

The open nuclear medicine journal Pub Date : 2014-06-27 DOI: 10.2174/1876388X01406010012

A. Amin, Mahasen Amin, E. Ahmed

{"title":"Low FDG Metabolic Activity of Loco-Regional Recurrence in ThyroidCancer Patients; Is Iodine-131 has a Potentiality?","authors":"A. Amin, Mahasen Amin, E. Ahmed","doi":"10.2174/1876388X01406010012","DOIUrl":"https://doi.org/10.2174/1876388X01406010012","url":null,"abstract":"Purpose: To investigate the impact of quantitative FDG-Metabolic activity of non-iodine avid Loco-regional recurrence (LRR; thyroid recurrence and/or cervical node metastasis) on therapy selection in thyroid cancer patients with elevated thyroglobulin (TG). Methods: Forty thyroid cancer (33 papillary and 7 follicular) patients who underwent FDG PET/CT were studied (with TSH>30 mU/L). Those with only LRR were classified according to maxSUV (cut-off level 5) into high and low metabolic activity lesions (HMA L their therapy outcome was compared with histopathologic findings and/or follow-up routine evaluation. Results: Only LRRs was found in 20 patients (17 papillary and 3 follicular) with diagnostic accuracy of FDG PET/CT of 100 %. 14/20 patients belonged to HMA where surgical neck exploration was done while in the remaining 6 patients with LMA empirical high dose of radioactive iodine-131 was given based on the assumption of the presence of a mixture of undifferentiated and differentiated thyroid cancer cells; though their post-therapy scan was negative but declined TG- levels were elicited in their follow-up (base-line 27.7±2.4 and at follow-up 6.8±1.4 ng/ml; P 0.02). Conclusion: Max-SUV based classification of non-iodine avid LRR might improve the diagnostic accuracy FDG PET/CT in a therapeutically relevant way in DTC-patients by precisely localizing them with subsequent surgical guidance in HMA lesions while those with LMA could benefit from further RA-131 therapy.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"6 1","pages":"12-16"},"PeriodicalIF":0.0,"publicationDate":"2014-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68128104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spinal Tuberculosis Evaluated by Means of 18F-FDG PET/CT: Pilot Study 用18F-FDG PET/CT评价脊柱结核:初步研究

The open nuclear medicine journal Pub Date : 2014-04-04 DOI: 10.2174/1876388X01406010006

Christa Zinn, M. Vorster, M. Sathekge

{"title":"Spinal Tuberculosis Evaluated by Means of 18F-FDG PET/CT: Pilot Study","authors":"Christa Zinn, M. Vorster, M. Sathekge","doi":"10.2174/1876388X01406010006","DOIUrl":"https://doi.org/10.2174/1876388X01406010006","url":null,"abstract":"Results: Only 4 patients had one spinal lesion, while 12 (75%) patients had 2 or more lesions. Those patients that had three or more lesions demonstrated intense FDG uptake with a median of 11.34 (3.8-20.9). Ten (62%) of the patients had both spinal and extraspinal lesions. In most of the cases (75%), the lumbar spine was involved as opposed to the thoracic vertebrae. 18F-FDG PET detected all 39/39 (100%) clinically (sites of disease that resulted in symptoms or signs such as pain, swelling, neurological fallout etc.) and histologically (as reported by the laboratory) observed spinal sites. The median of the SUVmax for spinal lesions was 6.06 (ranging from 2.63 to 16.78). Diagnostic CT reported corresponding morphological changes in only 27 (69%) of the spinal sites identified on 18F-FDG PET/CT. 18F-FDG PET/CT detected 60 of 60 (100%) clinically observed extraspinal sites including pulmonary TB, nodal disease and other musculoskeletal sites versus the 43 of 60 (71%) detected by diagnostic CT only. The median of the SUVmax was 3.61 for nodal sites (ranging from 1.71 to 10.79) and 3.38 for pulmonary sites (ranging from 1.23 to 5.93). Conclusion: The results suggest that 18F-FDG PET/CT is more effective compared to diagnostic CT only in the identification of sites of active disease and contributes to a better evaluation of extraspinal involvement in TB patients. It also appears to be a very promising imaging modality for the identification of the most appropriate biopsy site, staging disease, predicting multi-drug resistance and monitoring response to therapy.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"6 1","pages":"6-11"},"PeriodicalIF":0.0,"publicationDate":"2014-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68128037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Differential Diagnosis Between Neurodegenerative Dementia Disorders and Parkinson’s Disease Using 99mTc-HMPAO SPECT 用99mTc-HMPAO SPECT鉴别诊断神经退行性痴呆和帕金森病

The open nuclear medicine journal Pub Date : 2014-01-24 DOI: 10.2174/1876388X01406010001

B. Palumbo, D. Siepi, S. Amici, H. Sinzinger

{"title":"Differential Diagnosis Between Neurodegenerative Dementia Disorders and Parkinson’s Disease Using 99mTc-HMPAO SPECT","authors":"B. Palumbo, D. Siepi, S. Amici, H. Sinzinger","doi":"10.2174/1876388X01406010001","DOIUrl":"https://doi.org/10.2174/1876388X01406010001","url":null,"abstract":"Introduction and Objective: To investigate perfusion in dementia and Parkinson's disease (PD) we performed 99m Tc-HMPAO brain SPECT with semiquantitative analysis of Brodmann areas in different aged patients. Materials and Methods: We retrospectively evaluated 104 patients, 30 with Alzheimer's disease (AD), 26 with frontotemporal dementia (FTD), 25 with mild cognitive impairment (MCI), 23 with PD, undergoing 99m Tc-HMPAO brain SPECT. SPECT data of 3D ROIs of predefined Brodmann's area templates were compared with those of a database of age and sex-matched healthy subjects. Median values and inter-quartile ranges were used to summarize ROIs of Brodmann areas (L= left, R= right) in the different groups; Kruskal-Wallis test evaluated difference between medians (p< 0.05 as level of significance). Results: Different Brodmann areas were significantly hypoperfused in the different pathological categories. Both Areas 37 (temporal gyrus) and 39 (angular gyrus) of AD patients were hypoperfused (p<0.05) compared with MCI and FTD, both Areas 40 (supramarginal gyrus) and Area 39 L of AD patients were (p<0.01) hypoperfused comparing with PD; in FTD both Areas 47 (frontal association cortex) showed significantly decreased (p<0.05) perfusion compared with MCI and Area 11 R (frontal-orbital gyrus) comparing with PD. Conclusion: Perfusion impairment of specific parietal and temporal areas characterized AD, while frontal area hypoperfusion was present in FTD. No specific hypoperfusion pattern was evident for MCI and PD.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"9 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2014-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68127962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

123I-Vascular Endothelial Growth Factor-165 (123I-VEGF165) Scintigraphyfor Visualisation of Extranodal Marginal Zone B-Cell Lymphoma of theMucosa-Associated Lymphoid Tissue (MALT) Type 123i -血管内皮生长因子-165 (123I-VEGF165)闪烁显像显示粘膜相关淋巴组织(MALT)型结外边缘区b细胞淋巴瘤

The open nuclear medicine journal Pub Date : 2013-07-12 DOI: 10.2174/1876388X01305010001

P. Ubl, R. Sareshgi, A. Schiefer, D. Lai, B. Kiesewetter, X. Liu, M. Raderer, S. Li

{"title":"123I-Vascular Endothelial Growth Factor-165 (123I-VEGF165) Scintigraphyfor Visualisation of Extranodal Marginal Zone B-Cell Lymphoma of theMucosa-Associated Lymphoid Tissue (MALT) Type","authors":"P. Ubl, R. Sareshgi, A. Schiefer, D. Lai, B. Kiesewetter, X. Liu, M. Raderer, S. Li","doi":"10.2174/1876388X01305010001","DOIUrl":"https://doi.org/10.2174/1876388X01305010001","url":null,"abstract":"Aim: Vascular endothelial growth factor (VEGF) and VEGF receptor are over-expressed in lymphomagenesis. The aim of this study was to evaluate the usefulness of 123 I-VEGF165 scintigraphy for imaging of B-cell lymphoma of the Mucosa-Associated Lymphoid TissueMALT lymphoma). Methods: Three Patients (age range: 52-71 years) with histopathological verified MALT lymphoma were included in the study. Two patients had disseminated MALT-lymphoma and one patient had parotid MALT-lymphoma with involvement of cervical lymph nodes. Recombinant VEGF165 was radiolabeled with 123 I by electrophilic radioiodination using the chloramine T method. Each patient received 172 MBq (<130 pmole (< 5 � g) VEGF165 per patient) of 123 I-VEGF165. Dynamic acquisition was initiated immediately after administration and carried out until 30 minutes post injection. Whole-body images were acquired in anterior and posterior views at various times points post injection (p.i.). SPECT was performed 1 hour p.i. Results: None of the patients with MALT lymphoma showed pathologically increased focal 123 I-VEGF uptake in verified tumor lesions. No clinical adverse reaction and no side-effects after intravenous application of 123 I-VEGF165 were found. Conclusions: Our results suggest that 123 I-VEGF165 scintigraphy does not visualize B-cell lymphomas of MALT type.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"5 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2013-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68127947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eleven-year experience with the avidin-biotin pretargeting system in glioblastoma: Toxicity, efficacy and survival 在胶质母细胞瘤中使用亲和素-生物素预靶向系统的11年经验:毒性、疗效和生存率

The open nuclear medicine journal Pub Date : 2012-06-01 DOI: 10.2174/1876388X01204010014

C. Grana, M. Chinol, C. Cicco, M. Bartolomei, M. Cremonesi, L. Bodei, P. Rocca, M. Pacifici, Simone Tiberini, S. Baio, G. Broggi, S. Severi, G. Paganelli

{"title":"Eleven-year experience with the avidin-biotin pretargeting system in glioblastoma: Toxicity, efficacy and survival","authors":"C. Grana, M. Chinol, C. Cicco, M. Bartolomei, M. Cremonesi, L. Bodei, P. Rocca, M. Pacifici, Simone Tiberini, S. Baio, G. Broggi, S. Severi, G. Paganelli","doi":"10.2174/1876388X01204010014","DOIUrl":"https://doi.org/10.2174/1876388X01204010014","url":null,"abstract":"Background: The 3-step avidin-biotin pretargeting approach is applied in patients with recurrent glioblastoma (GBM), using biotinylated anti-tenascin monoclonal antibody as the first step of pretargeting followed by avidin and 90 Y- biotin. Methods: The present study reviews objective response and overall survival rates in 502 glioblastoma patients treated with 3-step radioimmunotherapy in our institute from December 1994 to December 2005. Patients underwent standard treatment before receiving Pretargeted Antibody-Guided Radionuclide Therapy with 90 Y-biotin (PAGRIT ® ). Results: Of the 502 patients, 272 (54%) were evaluable for response and 375 (75%) for overall survival. 174 patients (64%) continued to progress after PAGRIT ® , 77 (28%) obtained disease stabilization, and 21 (8%) showed objective tumor regression. Survival of the 375 evaluable patients was 98.4% at 6 months, 79.2% at 12 months, 51.7% at 18 months, and 30.7% at 24 months after the first cycle of PAGRIT ® . All 375 received 3-step PAGRIT ® at recurrence of GBM. The median survival time from diagnosis was 19 months. Conclusion: The results from this retrospective analysis suggest that 90 Y-biotin PAGRIT ® interferes with the progression of glioblastoma, prolonging survival in a larger number of patients. Our analysis forms the basis for further prospective trials, where radioimmunotherapy, which is known to be more effective in minimal residual disease, could be offered immediately after surgery.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"4 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68127869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Sentinel Lymph Node Identification in Breast Cancer - Comparison of Planar Scintigraphy and SPECT/CT 乳腺癌前哨淋巴结的鉴别——平面闪烁成像与SPECT/CT的比较

The open nuclear medicine journal Pub Date : 2012-04-13 DOI: 10.2174/1876388X01204010005

O. Kraft, M. Havel

{"title":"Sentinel Lymph Node Identification in Breast Cancer - Comparison of Planar Scintigraphy and SPECT/CT","authors":"O. Kraft, M. Havel","doi":"10.2174/1876388X01204010005","DOIUrl":"https://doi.org/10.2174/1876388X01204010005","url":null,"abstract":"Aim: Assess the role of planar lymphoscintigraphy and fusion imaging of SPECT/CT in sentinel lymph node (SLN) identification in patients with breast cancer. Methods: Planar scintigraphy and hybrid modality SPECT/CT were performed in 223 consecutive women with breast cancer (mean age 59,5 yrs with range 25 - 82 years). In 190 women with a palpable mass radiocolloid was injected in four peritumoral sites and one subdermal injection above the tumour (GROUP A), in 33 women with nonpalpable tumour radiotracer was injected in four subareolar sites (GROUP B). Planar and SPECT/CT images were interpreted separately by two nuclear medicine physicians. Ability of these two techniques to image SLN was compared. Results: In GROUP A the overall hot LN detection rate by planar and SPECT-CT lymphoscintigraphy was 87,9 % (167 patients). In 10 patients (5,3 %), hot LNs were detected only by SPECT-CT. 18 (5,3 %) foci of uptake in 13 (6,8 %) patients interpreted on planar images as hot LNs were found to be false positive non-nodal sites of uptake when further assessed on SPECT/CT. In GROUP B the overall hot LN detection rate on planar and SPECT-CT was 97 % (32 patients). In one (3,0 %) patient hot LNs were identified only on SPECT/CT. Four (6,6 %) foci of uptake in four (12,1 %) patients were found to be false positive when further correlated with SPECT/CT. Differences in detection of SLNs between planar and SPECT/CT imaging in all 223 patients were statistically significant (P< 0.001). Conclusion: In some patients with breast cancer SPECT/CT improves the detection of sentinel lymph nodes. It can image nodes not visible on planar scintigrams, exclude false positive uptake and exactly localize axillary and non-axillary SLN.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"4 1","pages":"5-13"},"PeriodicalIF":0.0,"publicationDate":"2012-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68127860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Gallium-67 Uptake in Histological Variants of Non-Hodgkin's Lymphoma - A Correlative Study 非霍奇金淋巴瘤组织学变异中镓-67摄取的相关研究

The open nuclear medicine journal Pub Date : 2012-03-09 DOI: 10.2174/1876388X01204010001

B. Iqbal, G. Currie, H. Bashir, U. Afzal, M. Nawaz, S. Mansoor, Janelle Wheat, M. Younis

引用次数: 1

18FFDG Labelled Leukocytes In Vitro Functional Tests: Viability,Chemotaxis and Phagocytosis Assays 18FFDG标记的白细胞体外功能试验:活力、趋化性和吞噬试验

The open nuclear medicine journal Pub Date : 2011-11-11 DOI: 10.2174/1876388X01103010025

P. Lafont, I. Morelec, M. Fraysse, P. Got, C. Houzard, Antoine Confavreux, Antoine Foucher, F. Giammarile

{"title":"18FFDG Labelled Leukocytes In Vitro Functional Tests: Viability,Chemotaxis and Phagocytosis Assays","authors":"P. Lafont, I. Morelec, M. Fraysse, P. Got, C. Houzard, Antoine Confavreux, Antoine Foucher, F. Giammarile","doi":"10.2174/1876388X01103010025","DOIUrl":"https://doi.org/10.2174/1876388X01103010025","url":null,"abstract":"Purpose: 18 F-FDG labelled leukocytes using PET/CT have been suggested as a radiotracer that offer specificity and high quality images for localization of inflammation and infection. The purpose of this in vitro study was to determine the functional integrity of leukocytes after labelling with 18 F-FDG. Materials and Methods: Leukocytes were separated from whole blood donated by 6 healthy volunteers and labelled with 18 F-FDG. The tests included viability, chemotaxis and phagocytosis of the cells. Trypan Blue was used for viability test. Directional migration was done using chemotaxis under agarose technique. Opsonised zymosan particles were used for phagocytosis assay. Results: Average labelling efficiency (LE) was 90.8%. Viability of 18 F-FDG labelled leukocytes one hour after labelling was superior to 99%. Chemotaxis assay showed cells were attracted by chemoattractant after 4 hours of incubation. Labelled cells were found to continue further migration after 24 hours with approximately the same pattern and distance as those of unlabelled cells. Zymosan particles were phagocytosed by the labelled leukocytes. Conclusion: Our study showed that 18 F-FDG labelled leukocytes preserved their functional integrity. The labelled cells were viable, responded to inflammatory signals and reacted by engulfing zymosan particles. The results of these in vitro tests suggest that 18 F-FDG labelled leukocytes could be used for localization of infections and inflammations.","PeriodicalId":88754,"journal":{"name":"The open nuclear medicine journal","volume":"3 1","pages":"25-29"},"PeriodicalIF":0.0,"publicationDate":"2011-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68127805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

125I-Iododeoxyuridine for the Treatment of a Brain Tumor Model:Selection of Conditions for Optimal Effectiveness 125i -碘脱氧尿苷治疗脑肿瘤模型:最佳疗效条件的选择

The open nuclear medicine journal Pub Date : 2011-10-07 DOI: 10.2174/1876388X01103010019

S. Lehnert, Yongbiao Li, E. Bump, Bill Riddoch, A. Chenite, M. Shive

引用次数: 2