Imaging of Pulmonary Tuberculosis with 18F-Fluoro-Deoxy-Glucose and 18F-Ethylcholine

The open nuclear medicine journal Pub Date : 2014-11-28 DOI:10.2174/1876388X01406010017

M. Vorster, A. Stoltz, A. Jacobs, M. Sathekge

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引用次数: 9

Abstract

Introduction: A 37-year-old man was referred for PET/CT with the following diagnostic challenge: a longstanding smoking history, histologically confirmed TB and sarcoidosis with worsening chest-related symptoms and a non-responsive right upper lobe lung lesion (as detected on CT). Materials and Methods: PET/CT imaging was performed with 18 F-FDG and followed by imaging with 18 F-fluoroethyl- choline in an attempt to better characterize the lung lesion. This was followed by biopsies of the right upper lobe nodule, the pleura and a brain lesion. Results: Both tracers demonstrated increased uptake in the lung lesion and in multiple lymph node groups. Histology revealed the presence of a granulomatous disease in the lung lesion, the pleura and in the brain. Follow-up evaluation with 18 F-fluoroethyl-choline PET/CT demonstrated some improvement, which correlated with clinical improvement. Conclusion: Tuberculous lesions demonstrate increased accumulation of 18 F-fluoroethyl-choline on PET/CT, which may be useful in the evaluation of treatment response. When used in combination with 18 F-FDG, it could be of value in

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18f -氟脱氧葡萄糖和18f -乙基胆碱对肺结核的显像

简介:一名37岁男性因以下诊断挑战被转介PET/CT:长期吸烟史，组织学证实结核病和结节病，胸部相关症状恶化，右上肺无反应性病变(CT上发现)。材料和方法:采用18 F-FDG进行PET/CT成像，然后用18 f -氟乙基胆碱成像，试图更好地表征肺部病变。随后对右上肺叶结节、胸膜和脑病变进行活检。结果:两种示踪剂在肺病变和多淋巴结组均显示摄取增加。组织学显示肺部病变、胸膜和脑部有肉芽肿性病变。随访评价18f -氟乙基胆碱PET/CT显示有一定改善，与临床改善相关。结论:结核病变在PET/CT上表现为18 f -氟乙基胆碱积累增加，可用于评价治疗效果。当与18f - fdg结合使用时，它可以在

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The open nuclear medicine journal

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