SAS journal最新文献

{"title":"Kineflex lumbar artificial disc versus Charité lumbar total disc replacement for the treatment of degenerative disc disease: A randomized non-inferiority trial with minimum of 2 years' follow-up","authors":"Kenneth Pettine MD ,&nbsp;Andrew Hersh MD","doi":"10.1016/j.esas.2011.07.003","DOIUrl":"10.1016/j.esas.2011.07.003","url":null,"abstract":"<div><h3>Background</h3><p>The Kineflex lumbar artificial disc replacement device (SpinalMotion, Mountain View, California) is a semiconstrained, posterior center of rotation, metal-on-metal intervertebral disc prosthesis. We performed a prospective, randomized, non-inferiority trial comparing the Kineflex Disc with the Food and Drug Administration (FDA)–approved Charité device (DePuy Spine, Raynham, Massachusetts). Our objective was to evaluate the Kineflex Disc's safety and efficacy using validated outcomes measures—the visual analog scale (VAS) and the Oswestry Disability Index (ODI).</p></div><div><h3>Methods</h3><p>Sixty-four patients were randomized to receive either the Kineflex Disc or Charité device and were then followed up for up to 3 years. Patients completed VAS and ODI questionnaires and were evaluated clinically and radiologically for complication or device failure. Results were analyzed in terms of change in mean VAS score and ODI from baseline, as well as with a comparison of clinical success as defined by FDA investigational device exemption criteria. Non-inferiority was defined as a difference of less than 18 points in the VAS score and difference of less than 10 units on the ODI scale, in keeping with a previously established minimum clinically important difference.</p></div><div><h3>Results</h3><p>The mean improvement for the Kineflex Disc group at 24 months was 56.80 for the VAS score and 37.30 for the ODI. Similarly, the mean improvement in the Charité group was 54.43 for the VAS score and 38.40 for the ODI. At 2 years of follow-up, no difference was found in VAS scores between the two groups. The Kineflex Disc group was therefore found to be non-inferior (mean difference, 2.37; 95% confidence interval, –12.5 to 17.3; <em>P</em> = .004). In addition, at 24 months, 83% of patients in the Kineflex Disc group and 85% of patients in the Charité group met FDA-defined criteria for clinical success, with no difference between groups (<em>P</em> = .802).</p></div><div><h3>Conclusions</h3><p>This level I evidence shows the Kineflex Disc to be non-inferior to the Charité device in terms of pain reduction (VAS score) and FDA-defined clinical success at 24 months' follow-up. Both devices showed a high degree of safety.</p></div>","PeriodicalId":88695,"journal":{"name":"SAS journal","volume":"5 4","pages":"Pages 108-113"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.esas.2011.07.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33155356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of preoperative education on spinal surgery patients","authors":"Ioannis Papanastassiou MD ,&nbsp;Roberta Anderson RNC, ONC ,&nbsp;Nicole Barber RN, BSN ,&nbsp;Cathleen Conover RN, BSN ,&nbsp;Antonio E. Castellvi MD","doi":"10.1016/j.esas.2011.06.003","DOIUrl":"10.1016/j.esas.2011.06.003","url":null,"abstract":"<div><h3>Background</h3><p>Preoperative patient education (PE) has been used by many institutions to deal with patient anxiety, pain control, and overall satisfaction. Although the literature suggests PE's effectiveness in joint reconstruction, data are missing in spinal surgery.</p></div><div><h3>Methods</h3><p>We retrospectively analyzed patients having elective spinal surgery who underwent PE (spine pre-care class) from October 2009 to March 2010. Of the 155 patients surveyed, 77 (49.7%) attended the class whereas 78 (50.3%) did not.</p></div><div><h3>Results</h3><p>Of the participants in the pre-care class, 96% were satisfied with their pain management versus 83% in the control group (<em>P</em> = .02). There was also a trend for better overall satisfaction in the pre-care class group (91% vs 85%; <em>P</em> &gt; .05, multiple regression analysis). Elderly women tend to be less satisfied with pain management and overall treatment.</p></div><div><h3>Conclusions</h3><p>Implementation of PE has had a positive impact on patient satisfaction, especially in terms of pain management.</p></div>","PeriodicalId":88695,"journal":{"name":"SAS journal","volume":"5 4","pages":"Pages 120-124"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.esas.2011.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33156355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An attempt at clinically defining and assessing minimally invasive surgery compared with traditional “open” spinal surgery","authors":"Paul C. McAfee MD, MBA ,&nbsp;Steven R. Garfin MD ,&nbsp;W. Blake Rodgers MD ,&nbsp;R. Todd Allen MD ,&nbsp;Frank Phillips MD ,&nbsp;Choll Kim MD","doi":"10.1016/j.esas.2011.06.002","DOIUrl":"10.1016/j.esas.2011.06.002","url":null,"abstract":"<div><h3>Background</h3><p>The goal of this editorial and literature review is to define the term “minimally invasive surgery” (MIS) as it relates to the spine and characterize methods of measuring parameters of a spine MIS technique.</p></div><div><h3>Methods</h3><p>This report is an analysis of 105,845 cases of spinal surgery in unmatched series and 95,161 cases in paired series of open compared with MIS procedures performed by the same surgeons to develop quantitative criteria to analyze the success of MIS.</p></div><div><h3>Results</h3><p>A lower rate of deep infection proved to be a key differentiator of spinal MIS. In unmatched series the infection rate for 105,845 open traditional procedures ranged from 2.9% to 4.3%, whereas for MIS, the incidence of infection ranged from 0% to 0.22%. For matched paired series with the open and MIS procedures performed by the same surgeons, the rate of infection in open procedures ranged from 1.5% to 10%, but for spine MIS, the rate of deep infection was much lower, at 0% to 0.2%. The published ranges for open versus MIS infection rates do not overlap or even intersect, which is a clear indication of the superiority of MIS for one specific clinical outcome measure (MIS proves superior to open spine procedures in terms of lower infection rate).</p></div><div><h3>Conclusions</h3><p>It is difficult, if not impossible, to validate that an operative procedure is “less invasive” or “more minimally invasive” than traditional surgical procedures unless one can establish a commonly accepted definition of MIS. Once a consensus definition or precise definition of MIS is agreed upon, the comparison shows a higher infection rate with traditional spinal exposures versus MIS spine procedures.</p></div>","PeriodicalId":88695,"journal":{"name":"SAS journal","volume":"5 4","pages":"Pages 125-130"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.esas.2011.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33156356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical and clinical experience with a viscoelastic total disc replacement","authors":"Burkhard Rischke MD, PhD ,&nbsp;Raymond S. Ross MD ,&nbsp;Boris A. Jollenbeck MD ,&nbsp;Kari B. Zimmers BS ,&nbsp;Neal D. Defibaugh BS","doi":"10.1016/j.esas.2011.08.001","DOIUrl":"10.1016/j.esas.2011.08.001","url":null,"abstract":"<div><h3>Background</h3><p>The purpose of this study is to describe the mechanical durability and the clinical and radiographic outcomes of a viscoelastic total disc replacement (VTDR). The human intervertebral disc is a complex, viscoelastic structure, permitting and constraining motion in 3 axes, thus providing stability. The ideal disc replacement should be viscoelastic and deformable in all directions, and it should restore disc height and angle.</p></div><div><h3>Methods</h3><p>Mechanical testing was conducted to validate the durability of the VTDR, and a clinical study was conducted to evaluate safety and performance. Fifty patients with single-level, symptomatic lumbar degenerative disc disease at L4-5 or L5-S1 were enrolled in a clinical trial at 3 European sites. Patients were assessed clinically and radiographically for 2 years by the Oswestry Disability Index (ODI), a visual analog scale (VAS), and independent radiographic analyses.</p></div><div><h3>Results</h3><p>The VTDR showed a fatigue life in excess of 50 million cycles (50-year equivalent) and a physiologically appropriate level of stiffness, motion, geometry, and viscoelasticity. We enrolled 28 men and 22 women in the clinical study, with a mean age of 40 years. Independent quantitative radiographic assessment indicated that the VTDR restored and maintained disc height and lordosis while providing physiologic motion. Mean ODI scores decreased from 48% preoperatively to 23% at 2 years' follow-up. Mean VAS low-back pain scores decreased from 7.1 cm to 2.9 cm. Median scores indicated that half of the patient population had ODI scores below 10% and VAS low-back pain scores below 0.95 cm at 2 years.</p></div><div><h3>Conclusions</h3><p>The VTDR has excellent durability and performs clinically and radiographically as intended for the treatment of symptomatic lumbar degenerative disc disease.</p></div><div><h3>Clinical Relevance</h3><p>The VTDR is intended to restore healthy anatomic properties and stability characteristics to the spinal segment. This study is the first to evaluate a VTDR in a 50-patient, multicenter European study.</p></div>","PeriodicalId":88695,"journal":{"name":"SAS journal","volume":"5 4","pages":"Pages 97-107"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.esas.2011.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33155355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to editorial regarding a novel surgical treatment option in which posterior dynamic stabilization is used to correct coronal plane tilt of a lumbar total disc replacement","authors":"Wayne K. Cheng MD,&nbsp;Daniel K. Palmer BS","doi":"10.1016/j.esas.2011.07.002","DOIUrl":"10.1016/j.esas.2011.07.002","url":null,"abstract":"","PeriodicalId":88695,"journal":{"name":"SAS journal","volume":"5 4","pages":"Page 131"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.esas.2011.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33156357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vertebral augmentation treatment of painful osteoporotic compression fractures with the Kiva VCF Treatment System","authors":"Luis M. Rosales Olivarez MD ,&nbsp;Juan M. Dipp MD ,&nbsp;Ricardo Flores Escamilla MD ,&nbsp;Guillermo Bajares MD ,&nbsp;Alejandro Perez MD ,&nbsp;Harrison A. Stubbs PhD ,&nbsp;Jon E. Block PhD","doi":"10.1016/j.esas.2011.06.001","DOIUrl":"10.1016/j.esas.2011.06.001","url":null,"abstract":"<div><h3>Background</h3><p>Vertebral compression fractures (VCFs) can cause significant pain and functional impairment, and their cumulative effect can lead to progressive morbidity. This single-arm, prospective feasibility trial, conducted at 4 clinical sites, was undertaken to evaluate the clinical outcomes associated with the use of an innovative vertebral augmentation device, the Kiva VCF Treatment System (Benvenue Medical, Santa Clara, California), in the management of symptomatic VCFs associated with osteoporosis.</p></div><div><h3>Methods</h3><p>Vertebral augmentation treatment was performed for persistent back pain symptoms in 57 patients (mean age, 71.9 ± 10.4 years), including 46 women, with radiologically confirmed VCFs; 36 of these patients (63%) had reached 12 months of follow-up at this data analysis. There were 51 one-level cases, 5 two-level cases, and 1 three-level case, representing 64 treated levels. Back pain severity and condition-specific functional impairment were evaluated with a standard 100-mm visual analog scale and the Oswestry Disability Index (ODI), respectively, before device implantation as well as at 6 weeks, 3 months, and 12 months.</p></div><div><h3>Results</h3><p>Marked clinical improvements were realized in back pain severity and functional impairment through 12 months of follow-up. The mean back pain score on the visual analog scale improved from 79.3 ± 17.2 before treatment to 21.9 ± 21.3, 21.9 ± 24.6, and 23.2 ± 23.3 at 6 weeks, 3 months, and 12 months, respectively. The mean decrease at 12 months was 49.9 ± 30.3 mm, or approximately 66% (<em>P</em> &lt; .0001). Similarly, the mean ODI score improved from 68.1% ± 16.9% before treatment to 27.4% ± 17.2%, 23.8% ± 18.7%, and 23.3% ± 15.5% at 6 weeks, 3 months, and 12 months, respectively, representing a mean change of 39.2 ± 19.6 percentage points, or approximately 63%, at 12 months. Overall clinical success rates based on a 30% improvement in pain severity or greater and maintenance or improvement in the ODI were 91%, 88%, and 89% at 6 weeks, 3 months, and 12 months, respectively. The vertebral augmentation procedure required injection of a mean of 2.2 ± 0.12 mL of cement per vertebral body. There were 5 levels (8%) where cement extravasation was identified radiographically, and none were related to clinical symptoms.</p></div><div><h3>Conclusions</h3><p>These pilot findings are encouraging, suggesting robust and durable clinical improvement after this novel vertebral augmentation procedure in patients with painful VCFs.</p></div>","PeriodicalId":88695,"journal":{"name":"SAS journal","volume":"5 4","pages":"Pages 114-119"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.esas.2011.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33155357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motion-preserving technologies for degenerative lumbar spine: The past, present, and future horizons","authors":"Hassan Serhan PhD ,&nbsp;Devdatt Mhatre MS ,&nbsp;Henri Defossez PhD ,&nbsp;Christopher M. Bono MD","doi":"10.1016/j.esas.2011.05.001","DOIUrl":"10.1016/j.esas.2011.05.001","url":null,"abstract":"<div><p>Over the past few decades, remarkable advancements in the understanding of the origin of low-back pain and lumbar spinal disorders have been achieved. Spinal fusion is generally considered the “gold standard” in the treatment of low-back pain; however, fusion is also associated with accelerated degeneration of adjacent levels. Spinal arthroplasty and dynamic stabilization technologies, as well as the continuous improvement in diagnosis and surgical interventions, have opened a new era of treatment options. Recent advancements in nonfusion technologies such as motion-preservation devices and posterior dynamic stabilization may change the gold standard. These devices are designed with the intent to provide stabilization and eliminate pain while preserving motion of the functional spinal unit. The adaption of nonfusion technologies by the surgical community and payers for the treatment of degenerative spinal conditions will depend on the long-term clinical outcome of controlled randomized clinical studies. Although the development of nonfusion technology has just started and the adoption is very slow, it may be considered a viable option for motion preservation in coming years. This review article provides technical and surgical views from the past and from the present, as well as a glance at the future endeavors and challenges in instrumentation development for lumbar spinal disorders.</p></div>","PeriodicalId":88695,"journal":{"name":"SAS journal","volume":"5 3","pages":"Pages 75-89"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.esas.2011.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33155352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications with axial presacral lumbar interbody fusion: A 5-year postmarketing surveillance experience","authors":"Mukund I. Gundanna MD ,&nbsp;Larry E. Miller PhD ,&nbsp;Jon E. Block PhD","doi":"10.1016/j.esas.2011.03.002","DOIUrl":"10.1016/j.esas.2011.03.002","url":null,"abstract":"<div><h3>Background</h3><p>Open and minimally invasive lumbar fusion procedures have inherent procedural risks, with posterior and transforaminal approaches resulting in significant soft-tissue injury and the anterior approach endangering organs and major blood vessels. An alternative lumbar fusion technique uses a small paracoccygeal incision and a presacral approach to the L5-S1 intervertebral space, which avoids critical structures and may result in a favorable safety profile versus open and other minimally invasive fusion techniques. The purpose of this study was to evaluate complications associated with axial interbody lumbar fusion procedures using the Axial Lumbar Interbody Fusion (AxiaLIF) System (TranS1, Wilmington, North Carolina) in the postmarketing period.</p></div><div><h3>Methods</h3><p>Between March 2005 and March 2010, 9,152 patients underwent interbody fusion with the AxiaLIF System through an axial presacral approach. A single-level L5-S1 fusion was performed in 8,034 patients (88%), and a 2-level (L4-S1) fusion was used in 1,118 (12%). A predefined database was designed to record device- or procedure-related complaints via spontaneous reporting. The complications that were recorded included bowel injury, superficial wound and systemic infections, transient intraoperative hypotension, migration, subsidence, presacral hematoma, sacral fracture, vascular injury, nerve injury, and ureter injury.</p></div><div><h3>Results</h3><p>Complications were reported in 120 of 9,152 patients (1.3%). The most commonly reported complications were bowel injury (n = 59, 0.6%) and transient intraoperative hypotension (n = 20, 0.2%). The overall complication rate was similar between single-level (n = 102, 1.3%) and 2-level (n = 18, 1.6%) fusion procedures, with no significant differences noted for any single complication.</p></div><div><h3>Conclusions</h3><p>The 5-year postmarketing surveillance experience with the AxiaLIF System suggests that axial interbody lumbar fusion through the presacral approach is associated with a low incidence of complications. The overall complication rates observed in our evaluation compare favorably with those reported in trials of open and minimally invasive lumbar fusion surgery.</p></div>","PeriodicalId":88695,"journal":{"name":"SAS journal","volume":"5 3","pages":"Pages 90-94"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.esas.2011.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33155353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Novel indication for posterior dynamic stabilization: correction of disc tilt after lumbar total disc replacement","authors":"Ali Araghi DO,&nbsp;Lisa Ferrara PhD","doi":"10.1016/j.esas.2011.07.001","DOIUrl":"10.1016/j.esas.2011.07.001","url":null,"abstract":"","PeriodicalId":88695,"journal":{"name":"SAS journal","volume":"5 3","pages":"Page 95"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.esas.2011.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33155354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical results of dynamic nonfusion stabilization with the Segmental Spinal Correction System for degenerative lumbar spinal diseases with instability: Minimum 2-year follow-up","authors":"Hideki Ohta MD,&nbsp;Yoshiyuki Matsumoto MD,&nbsp;Yuichirou Morishita MD, PhD,&nbsp;Tsubasa Sakai MD,&nbsp;George Huang MD,&nbsp;Hirotaka Kida MD,&nbsp;Yoshiharu Takemitsu MD, PhD","doi":"10.1016/j.esas.2011.02.003","DOIUrl":"10.1016/j.esas.2011.02.003","url":null,"abstract":"<div><h3>Background</h3><p>When spinal fusion is applied to degenerative lumbar spinal disease with instability, adjacent segment disorder will be an issue in the future. However, decompression alone could cause recurrence of spinal canal stenosis because of increased instability on operated segments and lead to revision surgery. Covering the disadvantages of both procedures, we applied nonfusion stabilization with the Segmental Spinal Correction System (Ulrich Medical, Ulm, Germany) and decompression.</p></div><div><h3>Methods</h3><p>The surgical results of 52 patients (35 men and 17 women) with a minimum 2-year follow-up were analyzed: 10 patients with lumbar spinal canal stenosis, 15 with lumbar canal stenosis with disc herniation, 20 with degenerative spondylolisthesis, 6 with disc herniation, and 1 with lumbar discopathy.</p></div><div><h3>Results</h3><p>The Japanese Orthopaedic Association score was improved, from 14.4 ± 5.3 to 25.5 ± 2.8. The improvement rate was 76%. Range of motion of the operated segments was significantly decreased, from 9.6° ± 4.2° to 2.0° ± 1.8°. Only 1 patient had adjacent segment disease that required revision surgery. There was only 1 screw breakage, but the patient was asymptomatic.</p></div><div><h3>Conclusions</h3><p>Over a minimum 2-year follow-up, the results of nonfusion stabilization with the Segmental Spinal Correction System for unstable degenerative lumbar disease were good. It is necessary to follow up the cases with a focus on adjacent segment disorders in the future.</p></div>","PeriodicalId":88695,"journal":{"name":"SAS journal","volume":"5 3","pages":"Pages 69-74"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.esas.2011.02.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33155351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}