Asian Journal of Organic & Medicinal Chemistry最新文献_第4页

Microwave Assisted Envirocat EPZ-10 Catalyzed Multi-componentSynthesis of 1-Amidoalkyl-2-naphthols 微波辅助环境EPZ-10催化多组分合成1-氨基烷基-2-萘酚

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-01-01 DOI: 10.14233/ajomc.2021.ajomc-p335

Kanchan S. Joshi-Kulkarni, T. Chhowala, B. Ajalkar

引用次数: 0

Synthesis and Biological Properties of New Piperidine Substituted Benzothiazole Derivatives 新型哌啶取代苯并噻唑衍生物的合成及其生物学性质

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-01-01 DOI: 10.14233/ajomc.2021.ajomc-p333

S. Shafi, R. Rajesh, S. Senthilkumar

引用次数: 0

Synthesis, Characterization and Docking Studies ofSome New Alkyne Containing Thiazole Derivatives 几种新型含噻唑烷衍生物的合成、表征及对接研究

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-01-01 DOI: 10.14233/ajomc.2021.ajomc-p319

Navneet P. Mori, Priti K. Parmar, Vijay M. Khedker, Gaurav Sanghavi, R. Khunt

{"title":"Synthesis, Characterization and Docking Studies of\u0000Some New Alkyne Containing Thiazole Derivatives","authors":"Navneet P. Mori, Priti K. Parmar, Vijay M. Khedker, Gaurav Sanghavi, R. Khunt","doi":"10.14233/ajomc.2021.ajomc-p319","DOIUrl":"https://doi.org/10.14233/ajomc.2021.ajomc-p319","url":null,"abstract":"Thiazole derivatives are potential candidates for drug development. They can be efficiently synthesized and are extremely active against several diseases, including antimicrobial screening. A series of 2-(2-(3-methoxy-4-(prop-2-yn-1-yloxy)benzylidene)hydrazinyl)-4-(p-tolyl)-4,5-dihydrothiazole (5a-f) and 2-((2-(4-(4-bromophenyl)-thiazol-2-yl)hydrazono)methyl)-5-(diethylamino)phenol (8g-j). The synthesized compounds’ have been characterized by spectral analysis, such as mass, FT-IR, 1H & 13C NMR. All the synthesized compounds were screened for in vitro antibacterial activity against some Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and Gram-negative (Escherichia coli, Klebsila) bacteria. The thiazole derivatives with a pharmacologically potent group provide the valued therapeutic involvement in the treatment of microbial diseases, especially against bacterial and fungal infections. Furthermore, to gauze their plausible mechanism of action and thermodynamic interaction governing these molecules’ binding, a molecular docking study was carried out against crucial target bacterial DNA, Gyrase.","PeriodicalId":8846,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73169221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A CuAAC Based Click Chemistry Approach for Synthesis of Quinoxaline-1,2,3-TriazoleHybrid Molecular Library and Its Antimicrobial Evaluation 基于CuAAC的点击化学方法合成喹啉-1,2,3-三唑杂化分子文库及其抗菌评价

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-01-01 DOI: 10.14233/ajomc.2021.ajomc-p342

Bhoomi M. Makwana, Y. Naliapara

引用次数: 0

Spectral Characterization, DNA Binding and Antibacterial Studies of Heterolyptic MetalComplexes with 2-Acetylthiophene-4-phenyl-3-thiosemicarbazone and 2,2′-Bipyridyl 2-乙酰基噻吩-4-苯基-3-硫代氨基脲和2,2′-联吡啶杂多金属配合物的光谱表征、DNA结合及抗菌研究

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-01-01 DOI: 10.14233/ajomc.2021.ajomc-p318

K. Srinivasulu, K. Reddy, D. Dhanalakshmi, K. Anuja, Y.B. Nagamani

{"title":"Spectral Characterization, DNA Binding and Antibacterial Studies of Heterolyptic Metal\u0000Complexes with 2-Acetylthiophene-4-phenyl-3-thiosemicarbazone and 2,2′-Bipyridyl","authors":"K. Srinivasulu, K. Reddy, D. Dhanalakshmi, K. Anuja, Y.B. Nagamani","doi":"10.14233/ajomc.2021.ajomc-p318","DOIUrl":"https://doi.org/10.14233/ajomc.2021.ajomc-p318","url":null,"abstract":"Heterolyptic metal complexes having the composition M(Bpy)Cl2 (where, M = Cu(II), Ni(II) and Co(II); Bpy = 2,2′-bipyridyl) were reacted with 2-acetylthiophene-4-phenyl-3-thiosemicarbazone (ATPT) to produce bivalent metal complexes with molecular formula M(Bpy)(ATPT)Cl·H2O. The complexes were characterized using physical (molar conductivity) and spectral (mass spectra, infrared and electronic spectroscopies) methods. Electrochemical behaviour of the complexes was revealed using cyclic voltammetry. The Cu(II)/Cu(I) couple complexes show a quasi-reversible cyclic voltammetric responses. The DNA binding properties of complexes were determined through absorption UV-visible spectrophotometry. Furthermore, the agar well diffusion method was used to screen the metal(II) complexes for their antibacterial activity against pathogenic bacterial strains, namely Gram negative strains such as Escherichia coli and Klebsiella pneumonia and Gram positve strains such as Staphylococcus aureus and Bacillus cereus. The synthesized Cu(Bpy)(ATPT)]Cl·H2O complex strongly inhibits bacteria compared with other complexes.","PeriodicalId":8846,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77728269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient Green Synthesis, Molecular Modeling and AntimicrobialInvestigations of Novel Chloroflavone Libraries 新型氯黄酮文库的高效绿色合成、分子模拟及抗菌研究

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-01-01 DOI: 10.14233/ajomc.2021.ajomc-p330

S. S. Chobe, N. Mali, Charushila K. Nerkar, Savita S. Chobe, Arvind M. Patil, Trupti Tated

引用次数: 0

Synthesis, Characterization and Antimicrobial Evaluation of Novel DimethylTriazene Incorporated Phenylamino Pyrimidine Derivatives 新型二甲基三氮苯基氨基嘧啶衍生物的合成、表征及抗菌评价

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-01-01 DOI: 10.14233/ajomc.2021.ajomc-p336

Vidhya V. Jadvani, Y. Naliapara

引用次数: 0

Natural Product Inspired Synthesis of Tryptanthrin Analogues as Potential Antimalarial Agents 天然产物启发合成色氨酸类似物作为潜在的抗疟剂

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2020-12-31 DOI: 10.14233/ajomc.2020.ajomc-p302

V. Tripathi

{"title":"Natural Product Inspired Synthesis of Tryptanthrin Analogues as Potential Antimalarial Agents","authors":"V. Tripathi","doi":"10.14233/ajomc.2020.ajomc-p302","DOIUrl":"https://doi.org/10.14233/ajomc.2020.ajomc-p302","url":null,"abstract":"A new series of tryptanthrin analogues have been synthesized as\u0000potential antimalarial molecules. Synthesis of tryptanthrin aminoalkyl\u0000derivatives have been achieved via alkylation of oxime functionality\u0000of tryptanthrin derivatives by various alkyl amino pharmacophoric\u0000chains. 21-Membered small library of tryptanthrin aminoalkyl analogues\u0000were synthesized with variation in both parent natural alkaloid\u0000and in amino alkyl side chains. Synthesized compounds were fully\u0000characterized with 1H & 13C NMR, IR spectroscopy. Further all the\u0000members were screened for their antimalarial potential against Plasmoum\u0000falciparum in both sensitive (3D7) and in resistant (k1) strains. Most\u0000of the screened compounds were exhibited potent antimalarial activity\u0000in both strains. Compounds (5m, 3c and 5l) having nitro group at the\u00008 position in tryptanthrin framework were most promising compounds\u0000in series (IC50 = 10 nm) with IC50 value as low as 10 nm comparable to\u0000chloroquine. These compounds were also tested for their toxic effect\u0000and found to be highly safe with very high value of SI index.","PeriodicalId":8846,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80656895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Docking and Molecular Dynamic Simulation ofTemozolomide with Carbonic Anhydrase XIII 替莫唑胺与碳酸酐酶xii的对接及分子动力学模拟

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2020-12-31 DOI: 10.14233/ajomc.2020.

R. Meenashi, K. Selvaraju, P. Jayalakshmi, P. Nidhin, A. D. Stephen

引用次数: 0

Structural Studies on Different Ligand Binding Ability of Sialoadhesin Using Molecular Modeling Techniques 基于分子模拟技术的唾液粘附素不同配体结合能力的结构研究

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2020-12-31 DOI: 10.14233/ajomc.2020.ajomc-p279

M. Patra

{"title":"Structural Studies on Different Ligand Binding Ability of Sialoadhesin Using Molecular Modeling Techniques","authors":"M. Patra","doi":"10.14233/ajomc.2020.ajomc-p279","DOIUrl":"https://doi.org/10.14233/ajomc.2020.ajomc-p279","url":null,"abstract":"Siglecs are the major homologous subfamily of I-type lectins with an ability to recognize sialylated glycans. Siglecs are attractive therapeutic targets because of their endocytic properties, ability to modulate receptor signaling and cell-type specific expression pattern. Sialoadhesin (Sn/ Siglec-1/ CD169), a member of the Siglec family expressed on subsets of resident and inflammatory macrophages and involves in modulation of inflammation and immunity. In this work, 3-D structure of human Siglec-1 (hSiglec-1) was predicted based on X-ray crystallo-graphically determined structure of mouse Siglec-1[mSiglec-1(PDB ID: 1QFP)] using molecular modeling techniques. The structure of complexes in solution of hSiglec-1 with ligands, glycopeptide and 3′-sialyllactose were predicted using a novel docking technique comprising of repeated cycles of molecular dynamics and energy minimization. Calculation of the free energies of binding of complexes suggested that glycopeptide can form stable complex with dissociation constant value of 3.31 μM whereas complex formation of 3′-sialyllactose with the protein in aqueous medium is thermodynamically unfavorable. The structural analysis of theses complexes represent the functional recognition interactions of this protein with the bound sugar molecule and as such provide detailed information about functional roles of such sugar binding protein.","PeriodicalId":8846,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88351330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0