Clinical medicine. Oncology最新文献_第2页

Hospital costs of colorectal cancer care. 结直肠癌治疗的住院费用。

Clinical medicine. Oncology Pub Date : 2009-03-20 DOI: 10.4137/cmo.s2362

D A L Macafee, J West, J H Scholefield, D K Whynes

{"title":"Hospital costs of colorectal cancer care.","authors":"D A L Macafee, J West, J H Scholefield, D K Whynes","doi":"10.4137/cmo.s2362","DOIUrl":"https://doi.org/10.4137/cmo.s2362","url":null,"abstract":"Objective: In a hospital based setting, identify factors which influence the cost of colorectal cancer care?Design: Retrospective case note reviewSetting: Nottingham, United KingdomParticipants: 227 patients treated for colorectal cancerMethods: Retrospective review of the hospital records provided the primary data for the costing study and included all CRC related resource consumption over the study period.Results: Of 700 people identified, 227 (32%) sets of hospital notes were reviewed. The median age of the study group was 70.3 (IQR 11.3) years and there were 128 (56%) males. At two years, there was a significant difference in costs between Dukes D cancers ( pound3641) and the other stages ( pound3776 Dukes A; pound4921 Dukes B). Using univariate and multivariate regression, the year of diagnosis, Dukes stage of disease, intensive nursing care, stoma requirements and recurrent disease all significantly affected the total cost of care.Conclusions: CRC remains costly with no significant difference in costs if diagnosed before compared to after 1992. Very early and very late stage cancers remain the least costly stage of cancers to treat. Other significant effectors of hospital costs were the site of cancer (rectal), intensive nursing care, recurrent disease and the need for a stoma.","PeriodicalId":88451,"journal":{"name":"Clinical medicine. Oncology","volume":"3 ","pages":"27-37"},"PeriodicalIF":0.0,"publicationDate":"2009-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/cmo.s2362","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29174095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Anticancer conjugates and cocktails based on methotrexate and nucleoside synergism. 基于甲氨蝶呤和核苷协同作用的抗癌共轭物和鸡尾酒。

Clinical medicine. Oncology Pub Date : 2009-03-20 DOI: 10.4137/cmo.s2113

Anthony R Vortherms, Hester N Dang, Robert P Doyle

引用次数: 0

Treatment of early childhood medulloblastoma by postoperative chemotherapy alone-a critical review. 术后化疗治疗早期儿童髓母细胞瘤-一项重要综述。

Clinical medicine. Oncology Pub Date : 2009-03-04 DOI: 10.4137/cmo.s392

Ricardo J Komotar, Marc L Otten, Matthew C Garrett, Richard C E Anderson

引用次数: 12

A Challenging Picture of Cancer-and Inflammation-Related Changes. 癌症和炎症相关变化的挑战性图景。

Clinical medicine. Oncology Pub Date : 2009-03-02 DOI: 10.4137/cmo.s2104

Carsten Nieder, Rolf E Steen, Astrid Dalhaug

引用次数: 0

Recurrent pneumonia due to an appendiceal mucinous cystadenocarcinoma: a rare presentation of a rare malignancy. 阑尾粘液囊腺癌引起的复发性肺炎:一种罕见恶性肿瘤的罕见表现。

Clinical medicine. Oncology Pub Date : 2009-03-02 DOI: 10.4137/cmo.s1178

Karin G Gerritsen, Peter H Slee, Thomas L Bollen, Wim van Hecke, Cornelis A Seldenrijk, Ruth G Keijsers, Vincent A Duurkens

{"title":"Recurrent pneumonia due to an appendiceal mucinous cystadenocarcinoma: a rare presentation of a rare malignancy.","authors":"Karin G Gerritsen, Peter H Slee, Thomas L Bollen, Wim van Hecke, Cornelis A Seldenrijk, Ruth G Keijsers, Vincent A Duurkens","doi":"10.4137/cmo.s1178","DOIUrl":"https://doi.org/10.4137/cmo.s1178","url":null,"abstract":"Mucinous cystadenocarcinoma of the appendix is a rare malignancy. This is a report of a 74-year-old man who presented with recurrent pneumonia which turned out to be a postobstructive pneumonia complicating a large mucinous cystadenocarcinoma of the appendix with massive retroperitoneal and intrathoracic extension. Mucinous cystadenocarcinoma of the appendix is a low-grade malignancy characterized by expansive growth due to progressive accumulation of mucinous fluid produced by the cancer cells. The tendency of this tumor to expand massively is well demonstrated by this case. The unusual retroperitoneal location of appendix in this patient probably allowed the tumor to expand massively in the retroperitoneal space and the thoracic cavity. In addition to computed tomography, [(18)F]fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) was used as an ancillary method for staging in this patient. The value of (18)F-FDG PET in the diagnosis of mucinous cystadenocarcinoma of the appendix has not been determined yet, but it might be promising. The most common presentation of this tumor is abdominal pain or a palpable ileocoecal mass. To the knowledge of the authors, this is the first report of an appendiceal mucinous cystadenocarcinoma with expansion into the thoracic cavity presenting with recurrent pneumonia.","PeriodicalId":88451,"journal":{"name":"Clinical medicine. Oncology","volume":"3 ","pages":"9-12"},"PeriodicalIF":0.0,"publicationDate":"2009-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/cmo.s1178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29174091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Treated Colorectal Cancer: What is the Cost to Primary Care? 结直肠癌治疗:初级保健费用是多少?

Clinical medicine. Oncology Pub Date : 2008-12-22 DOI: 10.4137/cmo.s877

D A L Macafee, J West, J H Scholefield, D K Whynes

{"title":"Treated Colorectal Cancer: What is the Cost to Primary Care?","authors":"D A L Macafee, J West, J H Scholefield, D K Whynes","doi":"10.4137/cmo.s877","DOIUrl":"https://doi.org/10.4137/cmo.s877","url":null,"abstract":"Background: Colorectal cancer is the second commonest cause of cancer death and the cost to primary care has not been estimated.Aim: To determine the direct primary care costs of colorectal cancer care.Design: Retrospective case note review.Setting: Nottingham, United Kingdom.Methods: We identified people with colorectal cancer between 1995 and 1998, from computerised pathology records. Colorectal cancer related resources consumed in primary care, from hospital discharge to death, were identified from retrospective notes review. Outcome measures were costs incurred by the General Practitioner (GP) and the total cost to primary care. We used multiple linear regression to identify predictors of cost.Results: Of 416 people identified from pathology records, the median age at primary operation of the 135 (33%) people we selected was 74.2 (IQR 14.4) years, 75 (56%) were male. The median GP cost was: Dukes A pound61.0 (IQR 516.2) and Dukes D pound936.2 (1196.2) p < 0.01. The geometric mean ratio found Dukes D cancers to be 10 times as costly as Dukes A. The median total cost was: Dukes A pound1038.3 (IQR 5090.6) and Dukes D pound1815.2 (2092.5) p = 0.06. Using multivariate analysis, Dukes stage was the most important predictor of GP costs. For total costs, the presence of a permanent stoma was the most predictive variable, followed by adjuvant therapy and advanced Dukes stage (Dukes C and D).Conclusions: Contrary to hospital based care costs, late stage disease (Dukes D) costs substantially more to general practice than any other stage. Stoma care products are the most costly prescribable item. Costs savings may be realised in primary care by screening detection of early stage colorectal cancers.","PeriodicalId":88451,"journal":{"name":"Clinical medicine. Oncology","volume":"3 ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2008-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/cmo.s877","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29174090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Disruption of the non-canonical WNT pathway in lung squamous cell carcinoma. 肺鳞状细胞癌非典型WNT通路的破坏。

Clinical medicine. Oncology Pub Date : 2008-04-01

Eric H L Lee, Raj Chari, Andy Lam, Raymond T Ng, John Yee, John English, Kenneth G Evans, Calum Macaulay, Stephen Lam, Wan L Lam

{"title":"Disruption of the non-canonical WNT pathway in lung squamous cell carcinoma.","authors":"Eric H L Lee, Raj Chari, Andy Lam, Raymond T Ng, John Yee, John English, Kenneth G Evans, Calum Macaulay, Stephen Lam, Wan L Lam","doi":"","DOIUrl":"","url":null,"abstract":"Disruptions of beta-catenin and the canonical Wnt pathway are well documented in cancer. However, little is known of the non-canonical branch of the Wnt pathway. In this study, we investigate the transcript level patterns of genes in the Wnt pathway in squamous cell lung cancer using reverse-transcriptase (RT)-PCR. It was found that over half of the samples examined exhibited dysregulated gene expression of multiple components of the non-canonical branch of the WNT pathway. In the cases where beta catenin (CTNNB1) was not over-expressed, we identified strong relationships of expression between wingless-type MMTV integration site family member 5A (WNT5A)/ frizzled homolog 2 (FZD2), frizzled homolog 3 (FZD3) / dishevelled 2 (DVL2), and low density lipoprotein receptor-related protein 5 (LRP5)/ secreted frizzled-related protein 4 (SFRP4). This is one of the first studies to demonstrate expression of genes in the non-canonical pathway in normal lung tissue and its disruption in lung squamous cell carcinoma. These findings suggest that the non-canonical pathway may have a more prominent role in lung cancer than previously reported.","PeriodicalId":88451,"journal":{"name":"Clinical medicine. Oncology","volume":"2008 2","pages":"169-179"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28930767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should we consider cancers as embryonic diseases or as consequences of stem-cell deregulation? 我们应该将癌症视为胚胎疾病还是干细胞管制放松的后果?

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-04-29 DOI: 10.4137/cmo.s603

Jérémy Bastid, Alain Puisieux, Stéphane Ansieau

引用次数: 1

Documentation of complete response in metastatic breast cancer to liver and bone achieved with trastuzumab and pegylated liposomal Doxorubicin. 曲妥珠单抗和聚乙二醇脂质体阿霉素治疗转移性乳腺癌对肝脏和骨骼的完全缓解。

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-06-11 DOI: 10.4137/cmo.s482

Boris Kobrinsky, Eleni Andreopoulou, Karen Mourtzikos, Franco Muggia

引用次数: 1

Increased incidence of loco-regional recurrences among african american women with terminal stage breast cancer. 非洲裔美国妇女终末期乳腺癌的局部区域复发率增加。

Clinical medicine. Oncology Pub Date : 2008-01-01 Epub Date: 2008-11-03 DOI: 10.4137/cmo.s988

Gerardo Colón-Otero, Sherry King, Vandelyn Smith, Carolyn Bieber, Julia Crook, Lawrence A Solberg, Robert Shannon, Edith A Perez

{"title":"Increased incidence of loco-regional recurrences among african american women with terminal stage breast cancer.","authors":"Gerardo Colón-Otero, Sherry King, Vandelyn Smith, Carolyn Bieber, Julia Crook, Lawrence A Solberg, Robert Shannon, Edith A Perez","doi":"10.4137/cmo.s988","DOIUrl":"https://doi.org/10.4137/cmo.s988","url":null,"abstract":"Unlabelled: A prospective analysis of women with terminal breast cancer admitted to CHNE from November 2006-August 2007 evaluated anecdotal observations that African American (AA) women are likelier than Caucasian women to evidence loco-regional recurrences (LRR). Women with terminal breast cancer who were admitted to CHNE, a not-for-profit hospice serving over 90% of Northeast Florida hospice patients, were eligible for participation. 134 terminal breast cancer patients were assessed by hospice nurses for LRR presence via chest wall examination. 80% of them (107) were Caucasian, 17% (23) were AA and 3% (4) were of other ethnicities. Evidence of LRR were noted in 13% of the women (17/134). The proportion of patients with LRR was higher in AA women than Caucasian women (26% vs. 10%, 6/23 vs. 11/107, respectively), although this difference was not statistically significant (p = 0.08). The majority of Caucasian women with LRR consented to a medical record review, but a minority of AA women consented (8/11 vs. 2/6, respectively, p = 0.16).Conclusion: Evaluating disparities in breast cancer care outcomes is possible by reviewing data from patients served by hospice programs that aid a majority of patients within a community. This pilot data suggests that AA women with breast cancer have a higher incidence of loco-regional failure as a component of their terminal breast cancer disease than Caucasian women. A smaller proportion of AA patients and families agreed to participate in a medical record review study than Caucasians. Larger studies are necessary to confirm these findings, to elucidate factors contributing to disparities and to develop potential solutions.","PeriodicalId":88451,"journal":{"name":"Clinical medicine. Oncology","volume":"2 ","pages":"547-50"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/cmo.s988","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30120341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0