Cardiovascular psychiatry and neurology最新文献_第9页

P2X(7) Receptors in Neurological and Cardiovascular Disorders. P2X(7)受体在神经和心血管疾病中的作用。

Cardiovascular psychiatry and neurology Pub Date : 2009-01-01 Epub Date: 2009-06-24 DOI: 10.1155/2009/861324

Stephen D Skaper, Patrizia Debetto, Pietro Giusti

{"title":"P2X(7) Receptors in Neurological and Cardiovascular Disorders.","authors":"Stephen D Skaper, Patrizia Debetto, Pietro Giusti","doi":"10.1155/2009/861324","DOIUrl":"https://doi.org/10.1155/2009/861324","url":null,"abstract":"P2X receptors are ATP-gated cation channels that mediate fast excitatory transmission in diverse regions of the brain and spinal cord. Several P2X receptor subtypes, including P2X(7), have the unusual property of changing their ion selectivity during prolonged exposure to ATP, which results in a channel pore permeable to molecules as large as 900 daltons. The P2X(7) receptor was originally described in cells of hematopoietic origin, and mediates the influx of Ca(2+) and Na(+) and Ca(2+) and Na(+) ions as well as the release of proinflammatory cytokines. P2X(7) receptors may affect neuronal cell death through their ability to regulate the processing and release of interleukin-1beta, a key mediator in neurodegeneration, chronic inflammation, and chronic pain. Activation of P2X(7), a key mediator in neurodegeneration, chronic inflammation, and chronic pain. Activation of P2X(7) receptors provides an inflammatory stimulus, and P2X(7) receptor-deficient mice have substantially attenuated inflammatory responses, including models of neuropathic and chronic inflammatory pain. Moreover, P2X(7) receptor activity, by regulating the release of proinflammatory cytokines, may be involved in the pathophysiology of depression. Apoptotic cell death occurs in a number of vascular diseases, including atherosclerosis, restenosis, and hypertension, and may be linked to the release of ATP from endothelial cells, P2X(7) receptor activation, proinflammatory cytokine production, and endothelial cell apoptosis. In this context, the P2X(7) receptor may be viewed as a gateway of communication between the nervous, immune, and cardiovascular systems.","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2009 ","pages":"861324"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2009/861324","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28610219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) in Cardiovascular Diseases (CVDs) and Depression: The Missing Link? Omega-3多不饱和脂肪酸(n-3 PUFAs)与心血管疾病(cvd)和抑郁症:缺失的环节?

Cardiovascular psychiatry and neurology Pub Date : 2009-01-01 Epub Date: 2009-09-27 DOI: 10.1155/2009/725310

Jane Pei-Chen Chang, Yi-Ting Chen, Kuan-Pin Su

{"title":"Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) in Cardiovascular Diseases (CVDs) and Depression: The Missing Link?","authors":"Jane Pei-Chen Chang, Yi-Ting Chen, Kuan-Pin Su","doi":"10.1155/2009/725310","DOIUrl":"https://doi.org/10.1155/2009/725310","url":null,"abstract":"Background. Based on epidemiological data, clinical trials, and meta-analytic reviews, omega-3 polyunsaturated fatty acids (n-3 PUFAs) seem to be a biological link between depression and cardiovascular diseases (CVDs). Presentation. Involvement of n-3 PUFAs in depression and CVDs may be associated with a chronic, low-grade, inflammation. We hypothesize that n-3 PUFAs link depression and CVDs via \"PUFA-prostaglandin E2 (PGE2) cascade.\" Testing. To further support our hypothesis, case-control studies are needed to test the role of COX2 and PLA2 functions in depression and in CVDs. In addition, the effects of n-3 PUFAs on cardiovascular markers in depression and on depressive symptoms in CVDs should be investigated in clinical trials. Finally, the effects of manipulating COX2 and PLA2 functions on depression-like behaviors and cardiovascular functions could be explored in animal studies. Implications. n-3 PUFAs might be a promising treatment for both cardiovascular diseases and depression via its anti-inflammatory, cardioprotective, and neuroprotective effects.","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2009 ","pages":"725310"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2009/725310","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28610281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Interleukin-10: a key cytokine in depression? 白细胞介素-10:抑郁症的关键细胞因子?

Cardiovascular psychiatry and neurology Pub Date : 2009-01-01 Epub Date: 2009-08-16 DOI: 10.1155/2009/187894

Susana Roque, Margarida Correia-Neves, Ana Raquel Mesquita, Joana Almeida Palha, Nuno Sousa

引用次数: 74

Do Neural Cells Communicate with Endothelial Cells via Secretory Exosomes and Microvesicles? 神经细胞是否通过分泌外泌体和微泡与内皮细胞沟通?

Cardiovascular psychiatry and neurology Pub Date : 2009-01-01 Epub Date: 2009-08-03 DOI: 10.1155/2009/383086

Neil R Smalheiser

引用次数: 33

The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease. 黄嘌呤氧化酶抑制在心脑血管疾病防治中的潜力。

Cardiovascular psychiatry and neurology Pub Date : 2009-01-01 Epub Date: 2009-11-04 DOI: 10.1155/2009/282059

Peter Higgins, Jesse Dawson, Matthew Walters

引用次数: 46

Chromatin from peripheral blood mononuclear cells as biomarkers for epigenetic abnormalities in schizophrenia. 外周血单核细胞染色质作为精神分裂症表观遗传异常的生物标志物。

Cardiovascular psychiatry and neurology Pub Date : 2009-01-01 Epub Date: 2009-07-22 DOI: 10.1155/2009/409562

David P Gavin, Rajiv P Sharma

{"title":"Chromatin from peripheral blood mononuclear cells as biomarkers for epigenetic abnormalities in schizophrenia.","authors":"David P Gavin, Rajiv P Sharma","doi":"10.1155/2009/409562","DOIUrl":"https://doi.org/10.1155/2009/409562","url":null,"abstract":"Background. Studies have implicated abnormalities in epigenetic gene regulation in schizophrenia. Presentation. We hypothesize that identifying abnormalities in chromatin structure and the epigenetic machinery in peripheral blood mononuclear cells (PBMC) from schizophrenia patients could (a) help characterize a subset of schizophrenia patients and (b) lead to targeted pharmacological interventions. Testing. Investigate the relationship between clinical symptoms, demographics, hormonal fluctuations, substance abuse, disease characteristics across the major mental illnesses, and epigenetic parameters in PBMC. In addition, examine the effects of individual antipsychotics, mood stabilizers, as well as experimental agents both as clinically prescribed as well as in cultured PBMC to understand the effects of these agents on chromatin. Implications. If PBMC could serve as a reliable model of overall epigenetic mechanisms then this could lead to a \"biomarker\" approach to revealing pathological chromatin state in schizophrenia. This approach may provide an informed method for selecting chromatin modifying agents for psychiatric disorders.","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2009 ","pages":"409562"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2009/409562","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28609774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Depression with panic episodes and coronary vasospasm. 抑郁症伴惊恐发作和冠状血管痉挛。

Cardiovascular psychiatry and neurology Pub Date : 2009-01-01 Epub Date: 2009-06-01 DOI: 10.1155/2009/453786

Mladen I Vidovich, Aneet Ahluwalia, Radmila Manev

引用次数: 8

Putative Role of MicroRNA-Regulated Pathways in Comorbid Neurological and Cardiovascular Disorders. microrna调控通路在神经和心血管疾病共病中的作用

Cardiovascular psychiatry and neurology Pub Date : 2009-01-01 Epub Date: 2009-08-24 DOI: 10.1155/2009/849519

Sébastien S Hébert

引用次数: 9

The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease. GRK2过表达是早期阿尔茨海默病线粒体病变的主要标志。

Cardiovascular psychiatry and neurology Pub Date : 2009-01-01 Epub Date: 2010-03-03 DOI: 10.1155/2009/327360

Mark E Obrenovich, Hector H Palacios, Eldar Gasimov, Jerzy Leszek, Gjumrakch Aliev

{"title":"The GRK2 Overexpression Is a Primary Hallmark of Mitochondrial Lesions during Early Alzheimer Disease.","authors":"Mark E Obrenovich, Hector H Palacios, Eldar Gasimov, Jerzy Leszek, Gjumrakch Aliev","doi":"10.1155/2009/327360","DOIUrl":"https://doi.org/10.1155/2009/327360","url":null,"abstract":"Increasing evidence points to vascular damage as an early contributor to the development of two leading causes of age-associated dementia, namely Alzheimer disease (AD) and AD-like pathology such as stroke. This review focuses on the role of G protein-coupled receptor kinases (GRKs) as they relate to dementia and how the cardio and cerebrovasculature is involved in AD pathogenesis. The exploration of GRKs in AD pathogenesis may help bridge gaps in our understanding of the heart-brain connection in relation to neurovisceral damage and vascular complications of AD. The a priori basis for this inquiry stems from the fact that kinases of this family regulate numerous receptor functions in the brain, myocardium and elsewhere. The aim of this review is to discuss the finding of GRK2 overexpression in the context of early AD pathogenesis. Also, we consider the consequences for this overexpression as a loss of G-protein coupled receptor (GPCR) regulation, as well as suggest a potential role for GPCRs and GRKs in a unifying theory of AD pathogenesis through the cerebrovasculature. Finally, we synthesize this newer information in an attempt to put it into context with GRKs as regulators of cellular function, which makes these proteins potential diagnostic and therapeutic targets for future pharmacological intervention.","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2009 ","pages":"327360"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2009/327360","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28754352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Possible treatment concepts for the levodopa-related hyperhomocysteinemia. 左旋多巴相关高同型半胱氨酸血症的可能治疗方案。

Cardiovascular psychiatry and neurology Pub Date : 2009-01-01 Epub Date: 2009-09-09 DOI: 10.1155/2009/969752

Thomas Müller

引用次数: 0