Cardiovascular psychiatry and neurology最新文献_第3页

Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics: A Study with the General Practice Research Database. 奥氮平和其他抗精神病药物使用者的死亡风险(包括心源性猝死)和主要心血管事件:一项基于全科实践研究数据库的研究

Cardiovascular psychiatry and neurology Pub Date : 2013-01-01 Epub Date: 2013-12-14 DOI: 10.1155/2013/647476

Meghan E Jones, Giedra Campbell, Deven Patel, Elizabeth Brunner, Chetan C Shatapathy, Tarita Murray-Thomas, Tjeerd P van Staa, Stephen Motsko

{"title":"Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics: A Study with the General Practice Research Database.","authors":"Meghan E Jones, Giedra Campbell, Deven Patel, Elizabeth Brunner, Chetan C Shatapathy, Tarita Murray-Thomas, Tjeerd P van Staa, Stephen Motsko","doi":"10.1155/2013/647476","DOIUrl":"https://doi.org/10.1155/2013/647476","url":null,"abstract":"Objective. Assess risk of cardiac events and mortality among users of olanzapine and other antipsychotics relative to nonusers. Methods. The General Practice Research Database was used to identify cohorts of antipsychotic users and nonusers with psychiatric illness. Outcomes included cardiac mortality, sudden cardiac death (SCD), all-cause mortality (excluding suicide), coronary heart disease (CHD), and ventricular arrhythmias (VA). Results. 183,392 antipsychotic users (including 20,954 olanzapine users) and 193,920 psychiatric nonusers were identified. There was a significantly higher rate of cardiac mortality (adjusted RR [aRR]: 1.53, CI, 1.12-2.09) in olanzapine users relative to psychiatric nonusers, consistent with findings for both atypical and typical antipsychotics. Relative to psychiatric nonusers, no increased risk of all-cause mortality was observed among olanzapine users (aRR: 1.04, CI, 0.93-1.17), but elevated all-cause mortality risk was observed when compared to all antipsychotic users (aRR: 1.75, CI, 1.64-1.87). There was no increased risk of CHD or VA among olanzapine users relative to psychiatric nonusers, consistent with findings for atypical but not typical antipsychotics. SCD cases were uncommon. Conclusions. Use of antipsychotic agents was associated with increased risk of all-cause and cardiac mortality. Patients treated with olanzapine were found to be at increased risk of cardiac mortality versus psychiatric nonusers. ","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2013 ","pages":"647476"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/647476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32023639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Risk of mortality (including sudden cardiac death) and major cardiovascular events in atypical and typical antipsychotic users: a study with the general practice research database. 非典型和典型抗精神病药物使用者的死亡风险（包括心源性猝死）和主要心血管事件：一项利用全科医学研究数据库进行的研究。

Cardiovascular psychiatry and neurology Pub Date : 2013-01-01 Epub Date: 2013-12-26 DOI: 10.1155/2013/247486

Tarita Murray-Thomas, Meghan E Jones, Deven Patel, Elizabeth Brunner, Chetan C Shatapathy, Stephen Motsko, Tjeerd P Van Staa

{"title":"Risk of mortality (including sudden cardiac death) and major cardiovascular events in atypical and typical antipsychotic users: a study with the general practice research database.","authors":"Tarita Murray-Thomas, Meghan E Jones, Deven Patel, Elizabeth Brunner, Chetan C Shatapathy, Stephen Motsko, Tjeerd P Van Staa","doi":"10.1155/2013/247486","DOIUrl":"10.1155/2013/247486","url":null,"abstract":"Objective. Antipsychotics have been associated with increased cardiac events including mortality. This study assessed cardiac events including mortality among antipsychotic users relative to nonusers. Methods. The General Practice Research Database (GPRD) was used to identify antipsychotic users, matched general population controls, and psychiatric diseased nonusers. Outcomes included cardiac mortality, sudden cardiac death (SCD), all-cause mortality (excluding suicide), coronary heart disease (CHD), and ventricular arrhythmias (VA). Sensitivity analyses were conducted for age, dose, duration, antipsychotic type, and psychiatric disease. Results. 183,392 antipsychotic users (115,491 typical and 67,901 atypical), 544,726 general population controls, and 193,920 psychiatric nonusers were identified. Nonusers with schizophrenia, dementia, or bipolar disorder had increased risks of all-cause mortality compared to general population controls, while nonusers with major depression had comparable risks. Relative to psychiatric nonusers, the adjusted relative ratios (aRR) of all-cause mortality in antipsychotic users was 1.75 (95% CI: 1.64-1.87); cardiac mortality 1.72 (95% CI: 1.42-2.07); SCD primary definition 5.76 (95% CI: 2.90-11.45); SCD secondary definition 2.15 (95% CI: 1.64-2.81); CHD 1.16 (95% CI: 0.94-1.44); and VA 1.16 (95% CI: 1.02-1.31). aRRs of the various outcomes were lower for atypical versus typical antipsychotics (all-cause mortality 0.83 (95% CI: 0.80-0.85); cardiac mortality 0.89 (95% CI: 0.82-0.97); and SCD secondary definition 0.76 (95% CI: 0.55-1.04). Conclusions. Antipsychotic users had an increased risk of cardiac mortality, all-cause mortality, and SCD compared to a psychiatric nonuser cohort. ","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2013 ","pages":"247486"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32054316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive Performance following Carotid Endarterectomy or Stenting in Asymptomatic Patients with Severe ICA Stenosis. 无症状严重颈动脉狭窄患者颈动脉内膜切除术或支架置入术后的认知表现。

Cardiovascular psychiatry and neurology Pub Date : 2013-01-01 Epub Date: 2013-12-21 DOI: 10.1155/2013/342571

Livio Picchetto, Gianfranco Spalletta, Barbara Casolla, Claudia Cacciari, Michele Cavallari, Cristiano Fantozzi, Alessandro Ciuffoli, Maurizia Rasura, Francesca Imperiale, Giuliano Sette, Carlo Caltagirone, Maurizio Taurino, Francesco Orzi

{"title":"Cognitive Performance following Carotid Endarterectomy or Stenting in Asymptomatic Patients with Severe ICA Stenosis.","authors":"Livio Picchetto, Gianfranco Spalletta, Barbara Casolla, Claudia Cacciari, Michele Cavallari, Cristiano Fantozzi, Alessandro Ciuffoli, Maurizia Rasura, Francesca Imperiale, Giuliano Sette, Carlo Caltagirone, Maurizio Taurino, Francesco Orzi","doi":"10.1155/2013/342571","DOIUrl":"https://doi.org/10.1155/2013/342571","url":null,"abstract":"Background. Endarterectomy (CEA) or stenting (CAS) of a stenotic carotid artery is currently undertaken to reduce stroke risk. In addition removal of the arterial narrowing has been hypothesized to improve cerebral hemodynamics and provide benefits in cognitive functions, by supposedly resolving a “hypoperfusion” condition. Methods. In this study we sought to test whether resolution of a carotid stenosis is followed by measurable changes in cognitive functions in 22 subjects with “asymptomatic” stenosis. Results. A main finding of the study was the statistically significant pre-post difference observed in the performance of phonological verbal fluency and Rey's 15-word immediate recall. Remarkably, there was a significant interaction between phonological verbal fluency performance and side of the carotid intervention, as the improvement in the verbal performance, a typical “lateralized” skill, was associated with resolution of the left carotid stenosis. Conclusion. The results reflect a substantial equivalence of the overall performance at the before- and after- CEA or CAS tests. In two domains, however, the postintervention performance resulted improved. The findings support the hypothesis that recanalization of a stenotic carotid could improve brain functions by resolving hypothetical “hypoperfusion” states, associated with the narrowing of the vessels.","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2013 ","pages":"342571"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/342571","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32054317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

A systematic review of depression and anxiety in patients with atrial fibrillation: the mind-heart link. 心房颤动患者抑郁和焦虑的系统回顾:心-心联系。

Cardiovascular psychiatry and neurology Pub Date : 2013-01-01 Epub Date: 2013-04-27 DOI: 10.1155/2013/159850

Dimpi Patel, Nathaniel D Mc Conkey, Ryann Sohaney, Ashley Mc Neil, Andy Jedrzejczyk, Luciana Armaganijan

引用次数: 83

Adult medication-free schizophrenic patients exhibit long-chain omega-3 Fatty Acid deficiency: implications for cardiovascular disease risk. 成人无药物精神分裂症患者表现出长链omega-3脂肪酸缺乏:对心血管疾病风险的影响

Cardiovascular psychiatry and neurology Pub Date : 2013-01-01 Epub Date: 2013-02-27 DOI: 10.1155/2013/796462

Robert K McNamara, Ronald Jandacek, Therese Rider, Patrick Tso, Yogesh Dwivedi, Ghanshyam N Pandey

{"title":"Adult medication-free schizophrenic patients exhibit long-chain omega-3 Fatty Acid deficiency: implications for cardiovascular disease risk.","authors":"Robert K McNamara, Ronald Jandacek, Therese Rider, Patrick Tso, Yogesh Dwivedi, Ghanshyam N Pandey","doi":"10.1155/2013/796462","DOIUrl":"https://doi.org/10.1155/2013/796462","url":null,"abstract":"Deficiency in long-chain omega-3 (LCn - 3) fatty acids, eicosapentaenoic acid (EPA, 20:5n - 3) and docosahexaenoic acid (DHA, 22:6n - 3), has been implicated in the pathoetiology of cardiovascular disease, a primary cause of excess premature mortality in patients with schizophrenia (SZ). In the present study, we determined erythrocyte EPA + DHA levels in adult medication-free patients SZ (n = 20) and age-matched healthy controls (n = 24). Erythrocyte EPA + DHA composition exhibited by SZ patients (3.5%) was significantly lower than healthy controls (4.5%, -22%, P = 0.007). The majority of SZ patients (72%) exhibited EPA+DHA levels ≤4.0% compared with 37% of controls (Chi-square, P = 0.001). In contrast, the omega-6 fatty acid arachidonic acid (AA, 20:4n - 6) (+9%, P = 0.02) and the AA:EPA + DHA ratio (+28%, P = 0.0004) were significantly greater in SZ patients. Linoleic acid (18:2n - 6) was significantly lower (-12%, P = 0.009) and the erythrocyte 20:3/18:2 ratio (an index of delta6-desaturase activity) was significantly elevated in SZ patients. Compared with same-gender controls, EPA + DHA composition was significantly lower in male (-19%, P = 0.04) but not female (-13%, P = 0.33) SZ patients, whereas the 20:3/18:2 ratio was significantly elevated in both male (+22%, P = 0.008) and female (+22%, P = 0.04) SZ patients. These results suggest that the majority of SZ patients exhibit low LCn - 3 fatty acid levels which may place them at increased risk for cardiovascular morbidity and mortality.","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":" ","pages":"796462"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/796462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40229761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Effects of age and cardiovascular disease on selective attention. 年龄和心血管疾病对选择性注意的影响。

Cardiovascular psychiatry and neurology Pub Date : 2013-01-01 Epub Date: 2013-12-25 DOI: 10.1155/2013/185385

Sylvie Chokron, Gérard Helft, Céline Perez

{"title":"Effects of age and cardiovascular disease on selective attention.","authors":"Sylvie Chokron, Gérard Helft, Céline Perez","doi":"10.1155/2013/185385","DOIUrl":"https://doi.org/10.1155/2013/185385","url":null,"abstract":"In order to study the effect of normal aging and cardiovascular disease on selective attention, a letter-identification task was proposed to younger and older healthy adults as well as patients with a recent myocardial infarction or a recent coronary artery bypass grafting. Participants had to detect either a big stimulus or a small one surrounded by flanking letters. The stimuli were displayed horizontally, either in the left (LVF) or in the right visual field (RVF). The interaction between the type of stimulus and the hemifield of presentation reached significance in all groups except in patients who underwent a coronary artery bypass. Only young normal adults showed the expected significant RVF advantage when detecting big stimuli and an LVF advantage when detecting small stimuli surrounded by flankers. In older control adults and in patients with myocardial infarction, the RVF advantage for the condition with selective attention vanished. In patients who underwent a coronary artery bypass, reaction times were increased and no hemispheric specialization for selective attention emerged. The results are discussed with regard to the hypothesis of a Hemispheric Asymmetry Reduction in Older Adults (HAROLD model) and to the presence of cognitive dysfunction consecutive to cardiovascular disease. ","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2013 ","pages":"185385"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/185385","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32054315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Depression and cardiac disease: epidemiology, mechanisms, and diagnosis. 抑郁症和心脏病:流行病学、机制和诊断。

Cardiovascular psychiatry and neurology Pub Date : 2013-01-01 Epub Date: 2013-04-07 DOI: 10.1155/2013/695925

Jeff C Huffman, Christopher M Celano, Scott R Beach, Shweta R Motiwala, James L Januzzi

{"title":"Depression and cardiac disease: epidemiology, mechanisms, and diagnosis.","authors":"Jeff C Huffman, Christopher M Celano, Scott R Beach, Shweta R Motiwala, James L Januzzi","doi":"10.1155/2013/695925","DOIUrl":"https://doi.org/10.1155/2013/695925","url":null,"abstract":"In patients with cardiovascular disease (CVD), depression is common, persistent, and associated with worse health-related quality of life, recurrent cardiac events, and mortality. Both physiological and behavioral factors-including endothelial dysfunction, platelet abnormalities, inflammation, autonomic nervous system dysfunction, and reduced engagement in health-promoting activities-may link depression with adverse cardiac outcomes. Because of the potential impact of depression on quality of life and cardiac outcomes, the American Heart Association has recommended routine depression screening of all cardiac patients with the 2- and 9-item Patient Health Questionnaires. However, despite the availability of these easy-to-use screening tools and effective treatments, depression is underrecognized and undertreated in patients with CVD. In this paper, we review the literature on epidemiology, phenomenology, comorbid conditions, and risk factors for depression in cardiac disease. We outline the associations between depression and cardiac outcomes, as well as the mechanisms that may mediate these links. Finally, we discuss the evidence for and against routine depression screening in patients with CVD and make specific recommendations for when and how to assess for depression in this high-risk population.","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2013 ","pages":"695925"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/695925","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31507817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 308

Multiple sclerosis and the blood-central nervous system barrier. 多发性硬化症和血液-中枢神经系统屏障。

Cardiovascular psychiatry and neurology Pub Date : 2013-01-01 Epub Date: 2013-01-15 DOI: 10.1155/2013/530356

Alan M Palmer

{"title":"Multiple sclerosis and the blood-central nervous system barrier.","authors":"Alan M Palmer","doi":"10.1155/2013/530356","DOIUrl":"https://doi.org/10.1155/2013/530356","url":null,"abstract":"The central nervous system (CNS) is isolated from the blood system by a physical barrier that contains efflux transporters and catabolic enzymes. This blood-CNS barrier (BCNSB) plays a pivotal role in the pathophysiology of multiple sclerosis (MS). It binds and anchors activated leukocytes to permit their movement across the BCNSB and into the CNS. Once there, these immune cells target particular self-epitopes and initiate a cascade of neuroinflammation, which leads to the breakdown of the BCNSB and the formation of perivascular plaques, one of the hallmarks of MS. Immunomodulatory drugs for MS are either biologics or small molecules, with only the latter having the capacity to cross the BCNSB and thus have a propensity to cause CNS side effects. However, BCNSB penetration is a desirable feature of MS drugs that have molecular targets within the CNS. These are nabiximols and dalfampridine, which target cannabinoid receptors and potassium channels, respectively. Vascular cell adhesion molecule-1, present on endothelial cells of the BCNSB, also serves as a drug discovery target since it interacts with α4-β1-integrin on leucocytes. The MS drug natalizumab, a humanized monoclonal antibody against α4-β1-integrin, blocks this interaction and thus reduces the movement of immune cells into the CNS. This paper further elaborates on the role of the BCNSB in the pathophysiology and pharmacotherapy of MS.","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2013 ","pages":"530356"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/530356","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31231075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Fatty Acid desaturase gene polymorphisms and metabolic measures in schizophrenia and bipolar patients taking antipsychotics. 服用抗精神病药物的精神分裂症和双相情感障碍患者脂肪酸去饱和酶基因多态性和代谢测定。

Cardiovascular psychiatry and neurology Pub Date : 2013-01-01 Epub Date: 2013-12-21 DOI: 10.1155/2013/596945

Kyle J Burghardt, Kristen N Gardner, Joshua W Johnson, Vicki L Ellingrod

{"title":"Fatty Acid desaturase gene polymorphisms and metabolic measures in schizophrenia and bipolar patients taking antipsychotics.","authors":"Kyle J Burghardt, Kristen N Gardner, Joshua W Johnson, Vicki L Ellingrod","doi":"10.1155/2013/596945","DOIUrl":"https://doi.org/10.1155/2013/596945","url":null,"abstract":"Atypical antipsychotics have become a common therapeutic option in both schizophrenia and bipolar disorder. However, these medications come with a high risk of metabolic side effects, particularly dyslipidemia and insulin resistance. Therefore, identification of patients who are at increased risk for metabolic side effects is of great importance. The genetics of fatty acid metabolism is one area of research that may help identify such patients. Therefore, in this present study, we aimed to determine the effect of one commonly studied genetic polymorphism from both fatty acid desaturase 1 (FADS1) and FADS2 gene on a surrogate measure of insulin resistance and lipid levels in a metabolically high-risk population of patients largely exposed to atypical antipsychotics. This study used a cross-sectional design, fasting blood draws, and genetic analysis to investigate associations between polymorphisms, haplotypes, and metabolic measures. A total of 320 subjects with schizophrenia (n = 226) or bipolar disorder (n = 94) were included in this study. The mean age of the population was 42.5 years and 45% were male. A significant association between FADS1 and FADS2 haplotypes was found with insulin resistance while controlling for confounders. Further investigation is required to replicate this finding. ","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2013 ","pages":"596945"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/596945","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32054318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Changes in heart rate variability of depressed patients after electroconvulsive therapy. 电休克治疗后抑郁症患者心率变异性的变化。

Cardiovascular psychiatry and neurology Pub Date : 2012-01-01 Epub Date: 2012-08-27 DOI: 10.1155/2012/794043

Erica B Royster, Lisa M Trimble, George Cotsonis, Brian Schmotzer, Amita Manatunga, Natasha N Rushing, Giuseppe Pagnoni, S Freda Auyeung, Angelo R Brown, Joel Schoenbeck, Smitha Murthy, William M McDonald, Dominique L Musselman

{"title":"Changes in heart rate variability of depressed patients after electroconvulsive therapy.","authors":"Erica B Royster, Lisa M Trimble, George Cotsonis, Brian Schmotzer, Amita Manatunga, Natasha N Rushing, Giuseppe Pagnoni, S Freda Auyeung, Angelo R Brown, Joel Schoenbeck, Smitha Murthy, William M McDonald, Dominique L Musselman","doi":"10.1155/2012/794043","DOIUrl":"https://doi.org/10.1155/2012/794043","url":null,"abstract":"Objective. As few, small studies have examined the impact of electroconvulsive therapy (ECT) upon the heart rate variability of patients with major depressive disorder (MDD), we sought to confirm whether ECT-associated improvement in depressive symptoms would be associated with increases in HRV linear and nonlinear parameters. Methods. After providing consent, depressed study participants (n = 21) completed the Beck Depression Index (BDI), and 15-minute Holter monitor recordings, prior to their 1st and 6th ECT treatments. Holter recordings were analyzed for certain HRV indices: root mean square of successive differences (RMSSD), low-frequency component (LF)/high-frequency component (HF) and short-(SD1) versus long-term (SD2) HRV ratios. Results. There were no significant differences in the HRV indices of RMSDD, LF/HF, and SD1/SD2 between the patients who responded, and those who did not, to ECT. Conclusion. In the short term, there appear to be no significant improvement in HRV in ECT-treated patients whose depressive symptoms respond versus those who do not. Future studies will reveal whether diminished depressive symptoms with ECT are reliably associated with improved sympathetic/parasympathetic balance over the long-term, and whether acute changes in sympathetic/parasympathetic balance predict improved mental- and cardiac-related outcomes.","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2012 ","pages":"794043"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/794043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30895268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10