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Force spectroscopy of streptavidin conjugated lipid coated microbubbles 链霉亲和素共轭脂质包被微泡的力谱分析
Bubble science engineering and technology Pub Date : 2010-05-01 DOI: 10.1179/175889610X12865266108541
J. McKendry, C. Grant, Benjamin R G Johnson, P. Coletta, J. A. Evans, S. Evans
{"title":"Force spectroscopy of streptavidin conjugated lipid coated microbubbles","authors":"J. McKendry, C. Grant, Benjamin R G Johnson, P. Coletta, J. A. Evans, S. Evans","doi":"10.1179/175889610X12865266108541","DOIUrl":"https://doi.org/10.1179/175889610X12865266108541","url":null,"abstract":"AbstractForce microscopy has been used to investigate the mechanical properties of phospholipid coated microbubbles and to quantify their stiffness. The mechanical properties were investigated using tipless cantilevers to compress microbubbles attached to a gold surface under aqueous conditions. The phospholipid microbubbles were produced by microfluidic flow focusing and were found to have stiffness of 25 mN m–1. The attachment of a streptavidin coating increased the microbubble stiffness by a factor of 30 to ∼750 mN m–1. Further, estimation of the frequency response based on values of stiffness obtained by force spectroscopy seems reasonable in comparison with those of an uncoated bubble and a polyethylene glycol coated Bracco SonoVue BR14 bubble, suggesting that the present approach may provide useful information for the development of novel microbubble coatings.","PeriodicalId":88410,"journal":{"name":"Bubble science engineering and technology","volume":"113 1","pages":"48-54"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79242695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Stirring and electric field assisted microbubble preparation 搅拌和电场辅助微泡制备
Bubble science engineering and technology Pub Date : 2010-03-01 DOI: 10.1179/175889709X12615681946485
H. Zhang, J. Li
{"title":"Stirring and electric field assisted microbubble preparation","authors":"H. Zhang, J. Li","doi":"10.1179/175889709X12615681946485","DOIUrl":"https://doi.org/10.1179/175889709X12615681946485","url":null,"abstract":"AbstractIn this paper, a stirring and electric field assisted microbubble preparation (SEFAMP) method for the preparation of microbubble ultrasound contrast agents is reported. Microbubbles with a narrow size distribution were obtained. The coalescence of microbubbles, which often happens in the stirring method, was eliminated. Addition of polyethylene glycol (PEG) 400 further optimised microbubble size distribution profile. This new method shed a light on realising the microbubble ultrasound agents as drug delivery vehicle and gene therapy for a potential clinical use.","PeriodicalId":88410,"journal":{"name":"Bubble science engineering and technology","volume":"13 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75367484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Biota of fecal bacteria concentrated in stable foam formed along water's edge in coastal zones 在沿海地区，粪便细菌的生物群集中在沿水边形成的稳定泡沫中
Bubble science engineering and technology Pub Date : 2010-03-01 DOI: 10.1179/175889709X12615681946449
T. Furukawa, T. Yoshida, Y. Suzuki
{"title":"Biota of fecal bacteria concentrated in stable foam formed along water's edge in coastal zones","authors":"T. Furukawa, T. Yoshida, Y. Suzuki","doi":"10.1179/175889709X12615681946449","DOIUrl":"https://doi.org/10.1179/175889709X12615681946449","url":null,"abstract":"Abstract Since the coastal zone plays an important role in recreation, humans might be directly or indirectly exposed to pathogenic bacteria. Along the water's edge at the coast, stable yellowish brown foam generated by breaking waves is observed frequently. We examined the foam, and determined the fecal bacteria count in coastal water, sand and the foam on the Miyazaki coast, Japan. Fecal coliform and fecal streptococcus counts in the foam were markedly higher than those in the coastal water and sand. Furthermore, the concentration of dissolved organic carbon in the foam was much higher than that in the coastal water. We concluded that the fecal bacteria were concentrated in the foam formed by bubbles generated in the water and that the dissolved organic substances exhibit surface activity. In addition, the main species of fecal streptococcus in the foam was enterococcus faecium, which is often used as an indicator of fecal pollution.","PeriodicalId":88410,"journal":{"name":"Bubble science engineering and technology","volume":"129 1","pages":"25-30"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80248864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Growth and collapse of vapour bubble and shockwave emission around holmium laser beam: theory and experiments 钬激光周围气泡的生长、坍缩和冲击波发射:理论与实验
Bubble science engineering and technology Pub Date : 2010-03-01 DOI: 10.1179/175889610X12730566149146
B. Krasovitski, A. Goldring, A. Harari, E. Kimmel
{"title":"Growth and collapse of vapour bubble and shockwave emission around holmium laser beam: theory and experiments","authors":"B. Krasovitski, A. Goldring, A. Harari, E. Kimmel","doi":"10.1179/175889610X12730566149146","DOIUrl":"https://doi.org/10.1179/175889610X12730566149146","url":null,"abstract":"Abstract Holmium laser therapy is used in many urological applications in humans. Most important among these are ablation of prostate tissue in benign prostatic hyperplasia and stone resection in the urinary system (lithotripsy). During treatment, short pulses of high intensity laser are transmitted through a liquid (blood or urine) medium. Heating of the liquid by the laser beam was found to generate vapour bubbles; the bubbles then go through growth and collapse phases reaching internal pressure of several thousand bar. This leads to formation of a pressure shockwave that propagates outwards. A simulation is presented of growth and collapse of a vapour bubble around a Ho : YAG laser beam. Experimental results for the time evolution of a bubble induced by a holmium laser beam are presented. Results of shockwave pressure measurements are also shown. The experimental results are in fairly good agreement with the simulation.","PeriodicalId":88410,"journal":{"name":"Bubble science engineering and technology","volume":"1 1","pages":"17-24"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88908736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Microbubble Compositions, Properties and Biomedical Applications. 微泡成分、特性和生物医学应用。
Bubble science engineering and technology Pub Date : 2009-11-01 DOI: 10.1179/175889709X446507
Shashank Sirsi, Mark Borden
{"title":"Microbubble Compositions, Properties and Biomedical Applications.","authors":"Shashank Sirsi,&nbsp;Mark Borden","doi":"10.1179/175889709X446507","DOIUrl":"10.1179/175889709X446507","url":null,"abstract":"<p><p>Over the last decade, there has been significant progress towards the development of microbubbles as theranostics for a wide variety of biomedical applications. The unique ability of microbubbles to respond to ultrasound makes them useful agents for contrast ultrasound imaging, molecular imaging, and targeted drug and gene delivery. The general composition of a microbubble is a gas core stabilized by a shell comprised of proteins, lipids or polymers. Each type of microbubble has its own unique advantages and can be tailored for specialized functions. In this review, different microbubbles compositions and physiochemical properties are discussed in the context of current progress towards developing novel constructs for biomedical applications, with specific emphasis on molecular imaging and targeted drug/gene delivery.</p>","PeriodicalId":88410,"journal":{"name":"Bubble science engineering and technology","volume":"1 1-2","pages":"3-17"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1179/175889709X446507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29077495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 430
Bubble generation in microfluidic devices 微流控装置中的气泡产生
Bubble science engineering and technology Pub Date : 2009-11-01 DOI: 10.1179/175889709X446561
C. Martinez
{"title":"Bubble generation in microfluidic devices","authors":"C. Martinez","doi":"10.1179/175889709X446561","DOIUrl":"https://doi.org/10.1179/175889709X446561","url":null,"abstract":"AbstractMicrofluidics has provided a rapid and inexpensive prototyping tool for the exploration and manipulation of multiphase flow at low Reynolds numbers. This has opened up a new realm of possibilities regarding the compartmentalisation of fluids via the generation of monodispersed drops and bubbles. Bubble formation is an area of growing interest in the microfluidic community and the aim of this article is to review the latest advances in bubble generation in microfluidic devices. The review starts with a full description of axisymmetric and asymmetric flow focusing devices. Details on the mechanism of bubble formation and the dependence of bubble size as a function of gas and liquid flow rates are provided. T junction and parallel channel bubble generators are also discussed and compared to the other flow focusing configurations. The last section provides an overview of different applications of bubbles in microfluidic channels.","PeriodicalId":88410,"journal":{"name":"Bubble science engineering and technology","volume":"120 1","pages":"40-52"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85704744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Physical chemistry of experimental models for lipid shells of medical microbubbles 医用微泡脂质壳实验模型的物理化学
Bubble science engineering and technology Pub Date : 2009-11-01 DOI: 10.1179/175889709X446534
M. Longo, Mónica M. Lozano, M. Borden
{"title":"Physical chemistry of experimental models for lipid shells of medical microbubbles","authors":"M. Longo, Mónica M. Lozano, M. Borden","doi":"10.1179/175889709X446534","DOIUrl":"https://doi.org/10.1179/175889709X446534","url":null,"abstract":"Micrometre scale gas in liquid bubbles (microbubbles) can be stabilised by a thin shell composed of proteins, surfactants, lipopolymers, and/or lipids. The objective of this paper is to review a number of the physical chemical properties of microbubble shells, primarily composed of semi-ordered or ordered alkyl chains such as lipids, we have systematically investigated. These properties include shell collapse and shedding, resistance to gas mass transfer, and phase behaviour (phase diagrams). We relate our investigations and findings to the most closely relevant literature and practical use and design principles of shells for medical microbubbles.","PeriodicalId":88410,"journal":{"name":"Bubble science engineering and technology","volume":"17 1","pages":"18-30"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83762636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Frequencies of acoustically interacting bubbles 气泡声相互作用的频率
Bubble science engineering and technology Pub Date : 2009-11-01 DOI: 10.1179/175889709X446552
R. Manasseh, A. Ooi
{"title":"Frequencies of acoustically interacting bubbles","authors":"R. Manasseh, A. Ooi","doi":"10.1179/175889709X446552","DOIUrl":"https://doi.org/10.1179/175889709X446552","url":null,"abstract":"AbstractWork on the frequencies of mutual acoustic oscillation of finite numbers of bubbles is reviewed. In many applications in medicine, industry and nature, multiple bubbles create multiple modes of oscillation. We focus only on the linear modes established transiently on acoustic excitation. The self-consistent coupled-oscillator theory is adopted. Progressively larger numbers of bubbles are described, examining both the natural frequency, and the damping of the system. Even a single bubble has interesting behaviour when close to a wall: the wall creates a mirror image coupled to the real bubble. As more bubbles are introduced, the number of modes of mutual oscillation increases, permitting increasingly more complex behaviour. A large number of bubbles in a chain gives rise to a preferred direction for the propagation of sound, owing to the re-distribution of energy to bubbles along the chain. Finally, some applications of these phenomena are discussed.","PeriodicalId":88410,"journal":{"name":"Bubble science engineering and technology","volume":"1 1","pages":"58-74"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88546533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
Coalescence of bubbles in liquid 液体中气泡的结合
Bubble science engineering and technology Pub Date : 2009-11-01 DOI: 10.1179/175889709X446543
P. Ghosh
{"title":"Coalescence of bubbles in liquid","authors":"P. Ghosh","doi":"10.1179/175889709X446543","DOIUrl":"https://doi.org/10.1179/175889709X446543","url":null,"abstract":"AbstractCoalescence of bubbles is important for the destabilisation of gas–liquid dispersions. The theories of coalescence used at present are reviewed. The film drainage theory and the stochastic theory of coalescence have been discussed with their merits and drawbacks. The influence of van der Waals, electrostatic double layer, steric and solvation forces on the coalescence process has been discussed. The importance of adsorption of surfactant molecules at the air/water interface in presence and in absence of salt on coalescence time has been explained. Difference between the experimental conditions under which the foam films collapse and the bubble coalescence experiments has been pointed out. Possible reasons behind the failure of the film drainage models in predicting the coalescence time have been explained. Some directions for future research have also been discussed.","PeriodicalId":88410,"journal":{"name":"Bubble science engineering and technology","volume":"15 1","pages":"75-87"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81128568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Microbubble Generation in Phase-Shift Nanoemulsions used as Anticancer Drug Carriers. 用作抗癌药物载体的相移纳米乳液中的微泡生成。
Bubble science engineering and technology Pub Date : 2009-01-01 DOI: 10.1179/175889709X446516
Natalya Y Rapoport, Alexey L Efros, Douglas A Christensen, Anne M Kennedy, Kweon-Ho Nam
{"title":"Microbubble Generation in Phase-Shift Nanoemulsions used as Anticancer Drug Carriers.","authors":"Natalya Y Rapoport, Alexey L Efros, Douglas A Christensen, Anne M Kennedy, Kweon-Ho Nam","doi":"10.1179/175889709X446516","DOIUrl":"10.1179/175889709X446516","url":null,"abstract":"<p><p>The paper describes droplet-to-bubble transition in block copolymer stabilized perfluoropentane nanoemulsions. Three physical factors that trigger droplet-to-bubble transition in liquid emulsions and gels were evaluated, namely heat, ultrasound, and injections through fine-gauge needles. Among those listed, ultrasound irradiation was found the most efficient factor. Possible mechanisms of bubble generation and growth discussed in the paper include liquid-to-gas transition inside the individual bubble; bubble coalescence; and diffusion of dissolved air and/or perfluoropentane from small bubbles into larger bubbles (i.e., Oswald ripening). The last two factors result in irreversibility of the droplet-to-bubble transition. In gel matrices, ultrasound-induced droplet-to-bubble transition was substantially inhibited but was catalyzed by large (hundred micron) pre-existing bubbles irradiated by low frequency (hundred kilohertz) ultrasound. The dependence of the droplet-to-bubble transition on initial bubble size is theoretically treated and the role of increase of surface area in promoting bubble coalescence is discussed. Therapeutic implications of observed effects are discussed.</p>","PeriodicalId":88410,"journal":{"name":"Bubble science engineering and technology","volume":"1 1-2","pages":"31-39"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777721/pdf/nihms110690.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28624667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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