{"title":"Warping and alignment technologies for inter-sample feature correspondence in 1D H-NMR, chromatography-, and capillary electrophoresis-mass spectrometry data","authors":"R. Torgrip, E. Alm, K. Åberg","doi":"10.1007/S12566-010-0008-8","DOIUrl":"https://doi.org/10.1007/S12566-010-0008-8","url":null,"abstract":"","PeriodicalId":88396,"journal":{"name":"Bioanalytical reviews","volume":"140 1","pages":"105-116"},"PeriodicalIF":0.0,"publicationDate":"2010-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88735374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of Endogenous D-Amino Acid-Containing Peptides in Metazoa.","authors":"Lu Bai, Sarah Sheeley, Jonathan V Sweedler","doi":"10.1007/s12566-009-0001-2","DOIUrl":"10.1007/s12566-009-0001-2","url":null,"abstract":"<p><p>Peptides are chiral molecules with their structure determined by the composition and configuration of their amino acid building blocks. The naturally occurring amino acids, except glycine, possess two chiral forms. This allows the formation of multiple peptide diastereomers that have the same sequence. Although living organisms use L-amino acids to make proteins, a group of D-amino acid-containing peptides (DAACPs) has been discovered in animals that have at least one of their residues isomerized to the D-form via an enzyme-catalyzed process. In many cases, the biological functions of these peptides are enhanced due to this structural conversion. These DAACPs are different from those known to occur in bacterial cell wall and antibiotic peptides, the latter of which are synthesized in a ribosome-independent manner. DAACPs have now also been identified in a number of distinct groups throughout the Metazoa. Their serendipitous discovery has often resulted from discrepancies observed in bioassays or in chromatographic behavior between natural peptide fractions and peptides synthesized according to a presumed all-L sequence. Because this L-to-D post-translational modification is subtle and not detectable by most sequence determination approaches, it is reasonable to suspect that many studies have overlooked this change; accordingly, DAACPs may be more prevalent than currently thought. Although diastereomer separation techniques developed with synthetic peptides in recent years have greatly aided in the discovery of natural DAACPs, there is a need for new, more robust methods for naturally complex samples. In this review, a brief history of DAACPs in animals is presented, followed by discussion of a variety of analytical methods that have been used for diastereomeric separation and detection of peptides.</p>","PeriodicalId":88396,"journal":{"name":"Bioanalytical reviews","volume":"1 1","pages":"7-24"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871709/pdf/nihms171692.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29006347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bioanalytical reviewsPub Date : 2009-12-01Epub Date: 2009-06-03DOI: 10.1007/s12566-009-0003-0
Adam Heller
{"title":"The need for monitoring the actual nitric oxide concentration in tumors.","authors":"Adam Heller","doi":"10.1007/s12566-009-0003-0","DOIUrl":"https://doi.org/10.1007/s12566-009-0003-0","url":null,"abstract":"<p><p>The significance of the role of nitric oxide (NO) in cancer is evident from 1,100 publications on the subject; its triggering of apoptosis at high concentrations is documented in 300 publications. While aspects of the rate of generation of NO in tumors have been extensively studied, the rate of its removal from tumors has not been considered, even though it is the difference between the two rates that determines the all important steady-state NO concentration, and thus the likelihood of apoptosis-triggering. The rate of transport of NO scales with its concentration gradient at the interface between a neoplasm and the phase to which it diffuses, which can be air, fat, or blood. Diffusional loss of NO to air would explain the initial two-dimensionality of neoplasms of the skin and lung. The greater solubility of NO in lipids than in aqueous phases should cause its extraction by nearby fat, and would account for the positive correlation between obesity and the incidence of some cancers, such as cancers of the breast. And the rapid consumption of NO by red blood cells implies depletion of excess NO in tumors after they are vascularized: angiogenesis should blunt any apoptosis-triggering NO attack of the immune system. Thus, cancer research and the practice of oncology may benefit of in-tumor monitoring of the actual NO concentration. Miniature NO monitoring electrodes, that might serve the purpose, are reviewed.</p>","PeriodicalId":88396,"journal":{"name":"Bioanalytical reviews","volume":"1 1","pages":"3-6"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12566-009-0003-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28781662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Toxin immunosensors and sensor arrays for food quality control","authors":"Simone S. Moises, M. Schäferling","doi":"10.1007/S12566-009-0006-X","DOIUrl":"https://doi.org/10.1007/S12566-009-0006-X","url":null,"abstract":"","PeriodicalId":88396,"journal":{"name":"Bioanalytical reviews","volume":"84 1","pages":"73-104"},"PeriodicalIF":0.0,"publicationDate":"2009-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85234970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of biological samples using solid-phase microextraction","authors":"Ashwini Kumar, Gaurav, A. Malik, F. Matysik","doi":"10.1007/S12566-009-0004-Z","DOIUrl":"https://doi.org/10.1007/S12566-009-0004-Z","url":null,"abstract":"","PeriodicalId":88396,"journal":{"name":"Bioanalytical reviews","volume":"41 17","pages":"35-55"},"PeriodicalIF":0.0,"publicationDate":"2009-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S12566-009-0004-Z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72408252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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