American journal of immunology最新文献_第6页

Description of a Novel Probiotic Concept: Implications for the Modulation of the Immune System 描述一种新的益生菌概念:对免疫系统调节的影响

American journal of immunology Pub Date : 2017-01-28 DOI: 10.3844/AJISP.2017.107.113

S. Pacini, M. Ruggiero

{"title":"Description of a Novel Probiotic Concept: Implications for the Modulation of the Immune System","authors":"S. Pacini, M. Ruggiero","doi":"10.3844/AJISP.2017.107.113","DOIUrl":"https://doi.org/10.3844/AJISP.2017.107.113","url":null,"abstract":"It is estimated that the first processed food products consumed by humans pertained to the category of fermented foods and beverages such as beer, wine, sauerkraut, fermented sausage as well as fermented milk derivatives such as yogurt and kefir. Thus, fermented foods are endowed with undisputed healthy properties due to the presence of probiotic microbes that not only help supporting the healthy human microbiota, but also produce bioactive or bio-available metabolites that contribute to the host's wellbeing. It is widely acknowledged that modulation of the immune system is one of the beneficial effects associated with consuming fermented food products rich in live probiotics and this effect is being exploited in the field of natural immunotherapy. Here we describe the genesis and development of a novel, non-dairy product that may represent a novelty in the field of probiotic drinks since it combines the healthy properties of dairy-based products with the properties of non-dairy probiotic drinks. The major improvements over the existing non-dairy probiotic drinks consist in the number and diversity of probiotic strains endowed with health-promoting properties and in the presence of a glycosaminoglycan, chondroitin sulfate, that is, at the same time, a newly identified prebiotic and a supplement known to modulate the immune system.","PeriodicalId":88361,"journal":{"name":"American journal of immunology","volume":"13 1","pages":"107-113"},"PeriodicalIF":0.0,"publicationDate":"2017-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3844/AJISP.2017.107.113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42609435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Evaluation of Mast Cell Distribution in Oral Lichen Planus and Lichenoid Lesions by Immunohistochemical and Histochemical Analysis 应用免疫组织化学和组织化学方法评价口腔扁平苔藓和类苔藓病变中肥大细胞的分布

American journal of immunology Pub Date : 2016-12-11 DOI: 10.3844/AJISP.2016.99.106

Mahi Balcı, M. Erçin

{"title":"Evaluation of Mast Cell Distribution in Oral Lichen Planus and Lichenoid Lesions by Immunohistochemical and Histochemical Analysis","authors":"Mahi Balcı, M. Erçin","doi":"10.3844/AJISP.2016.99.106","DOIUrl":"https://doi.org/10.3844/AJISP.2016.99.106","url":null,"abstract":"The histopathological assessment of Oral Lichen Planus (OLP) and oral lichenoid lesions is relatively subjective. The distinguishing criteria established by WHO effectively reproducible when all selection criteria were fulfilling but sometimes fail to provide a reliable diagnosis. The aim of the present study was to evaluate mast cell counts and their distribution among OLP and lichenoid lesions. The density and localization of mast cells was examined in 22 patients with a diagnosis of OLP (11 patients) or oral lichenoid reactions (11 patients) by c-kit/CD117 immunohistochemical and toluidine blue histochemical staining. Data were analyzed using either the Kruskal-Wallis or Mann-Whitney U tests. No significant difference in the total number of mast cells was observed between the two groups (P = 0.599); however, a significant difference was observed in mast cell counts between reticular and junctional zones (P<0.05). The findings of the present study suggest that mast cells play a key role in the pathogenesis of oral inflammation; however, the ability of mast cell measurements to reliably differentiate between lichen planus and other lichenoid mimickers was limited as the number of mast cells was found to be increased in both the conditions.","PeriodicalId":88361,"journal":{"name":"American journal of immunology","volume":"12 1","pages":"99-106"},"PeriodicalIF":0.0,"publicationDate":"2016-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3844/AJISP.2016.99.106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70191105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Clinical Observation of a Novel, Complementary, Immunotherapeutic Approach based on Ketogenic Diet, Chondroitin Sulfate, Vitamin D 3 , Oleic Acid and a Fermented Milk and Colostrum Product 一种基于生酮饮食、硫酸软骨素、维生素d3、油酸和发酵乳及初乳产品的新型互补免疫治疗方法的临床观察

American journal of immunology Pub Date : 2016-11-21 DOI: 10.3844/AJISP.2016.91.98

M. Schwalb, Margit Taubmann, S. Hines, H. Reinwald, M. Ruggiero

引用次数: 16

Analyses of the Interleukin32 Transcript Variants in Breast Cancer Cell Lines 白细胞介素32在乳腺癌细胞系中的转录变异分析

American journal of immunology Pub Date : 2016-10-31 DOI: 10.3844/AJISP.2016.83.90

Kayla Burrell, A. Player

引用次数: 1

The Effect of Bovine Cartilage on the Growth of Mouse B16F10 Melanoma Cells in vitro and in vivo 牛软骨对小鼠B16F10黑色素瘤细胞体外和体内生长的影响

American journal of immunology Pub Date : 2016-10-26 DOI: 10.3844/ajisp.2016.69.76

A. Tanelian, D. F. Jaber, N. A. Akl, A. Abdelnoor

{"title":"The Effect of Bovine Cartilage on the Growth of Mouse B16F10 Melanoma Cells in vitro and in vivo","authors":"A. Tanelian, D. F. Jaber, N. A. Akl, A. Abdelnoor","doi":"10.3844/ajisp.2016.69.76","DOIUrl":"https://doi.org/10.3844/ajisp.2016.69.76","url":null,"abstract":"Earlier reports indicated that Bovine Cartilage (BC) had anti-tumor effects but only a few in vitro and in vivo investigations were conducted to assess its mechanism of action. The aim of this study was to investigate some of the proposed mechanisms of action of BC on mouse melanoma cells both in vitro and in vivo and to determine if its effect on tumor cells is selective. One hundred and ten mice were divided into 5 groups and received Intraperitoneal (IP) injections of melanoma cells followed by treatment with BC using different routes of administration. Following a daily treatment period of 16 days, serum levels of VEGF and IL-12 were determined by ELISA at 2, 4 and 6 h after the last treatment dose. Additionally, 10 mice from each group were monitored for survival for 20 days post-last treatment. Moreover, melanoma and mouse mononuclear cells were incubated separately with increasing BC concentrations for 48 h and percent viability was determined. A significant decrease in the serum levels of VEGF and significant increase in the serum levels of IL-12 were observed in the groups treated with BC. Moreover 20% survival rate was noted in the group treated with BC both orally and IP, whereas 10% survival was noted in the groups given BC either IP or orally. In vitro, total eradication of melanoma cells was observed with 1000 μg mL-1 of BC. BC was not toxic to mouse mononuclear cells. The in vivo anti-tumor effect of BC was best observed when combined IP and oral doses were given and it appears that two of its actions are by activating macrophages as indicated by increases in IL-12 levels and blocking angiogenesis as indicated by decreases in VEGF levels. Finally BC showed selective toxicity against melanoma cells.","PeriodicalId":88361,"journal":{"name":"American journal of immunology","volume":"12 1","pages":"69-76"},"PeriodicalIF":0.0,"publicationDate":"2016-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3844/ajisp.2016.69.76","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70190921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gc Protein-Derived Macrophage Activating Factor (GcMAF) and Autism: Do Clinical Results Require a Novel Interpretation? Gc蛋白衍生的巨噬细胞激活因子(GcMAF)与自闭症:临床结果需要新的解释吗?

American journal of immunology Pub Date : 2016-10-14 DOI: 10.3844/AJISP.2016.77.82

M. Ruggiero

引用次数: 3

What You See Is What You Get 所见即所得

American journal of immunology Pub Date : 2016-09-29 DOI: 10.3844/AJISP.2016.52.55

S. Sel, Mark A. Brown, J. Storsberg, C. Schmidt

引用次数: 0

Prevalence of Asthma Bronchiale in the Czech Republic and its Economic Burden 捷克共和国支气管哮喘患病率及其经济负担

American journal of immunology Pub Date : 2016-08-30 DOI: 10.3844/AJISP.2016.61.68

R. Josef, Král Vlastimil, Rajnohova Dobiasova Lucie, Svozil Vladimir, P. Petr, V. Vaclav

{"title":"Prevalence of Asthma Bronchiale in the Czech Republic and its Economic Burden","authors":"R. Josef, Král Vlastimil, Rajnohova Dobiasova Lucie, Svozil Vladimir, P. Petr, V. Vaclav","doi":"10.3844/AJISP.2016.61.68","DOIUrl":"https://doi.org/10.3844/AJISP.2016.61.68","url":null,"abstract":"Asthma Bronchiale (AB) is a chronic inflammatory disorder of the airways currently affecting around 350,000,000 patients in the world. A steady increase in prevalence of this disease was the incentive for our study of the prevalence of AB in the Czech Republic. Special attention was focused on possible differential regional incidence. We found that prevalence of this disease in an age group 0-14 years is 5.21%, in age group of 15-19 is 11.5%. In the 2000-2013 period, we observed a 268% increase in the 0-14 group and 685% increase in the 15-19 group. Using published materials, we used medical costs values from other European countries, which are in range of 600 to 3,200 dollars to calculate the finacial burden in the Czech Republic. When we used a conservative estimate of $1,200, the total costs of AB treatment in the 0-14 years group is $66,475,200 per year. When compared with the year 2000, the increase in financial costs is more than $50,000,000, with the anticipated increase of $30,000,000 every single year. These findings indicate that there is a necessity to increase interest in primary prevention and early diagnosis of this disease.","PeriodicalId":88361,"journal":{"name":"American journal of immunology","volume":"12 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2016-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3844/AJISP.2016.61.68","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70190805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double Application of Translocator Protein Ligands and RAW Cells Inflammatory Milieu 转运蛋白配体与RAW细胞炎症环境的双重应用

American journal of immunology Pub Date : 2016-08-28 DOI: 10.3844/AJISP.2016.56.60

M. Staykova, F. Mattner, D. Liñares, A. Katsifis

引用次数: 0

Vaccination Against Heart Attack 预防心脏病的疫苗

American journal of immunology Pub Date : 2016-08-22 DOI: 10.3844/AJISP.2016.49.51

J. Storsberg, Mark A. Brown, C. Schmidt

引用次数: 0