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Current medicinal chemistry. Anti-inflammatory & anti-allergy agents最新文献

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Antihistamines as Important Tools for Regulating Inflammation 抗组胺药是调节炎症的重要工具
Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-01-31 DOI: 10.2174/1568014053005372
E. Nettis, M. C. Colanardi, A. Ferrannini, A. Tursi
{"title":"Antihistamines as Important Tools for Regulating Inflammation","authors":"E. Nettis, M. C. Colanardi, A. Ferrannini, A. Tursi","doi":"10.2174/1568014053005372","DOIUrl":"https://doi.org/10.2174/1568014053005372","url":null,"abstract":"Allergic disorders are characterized by typical symptoms and an infiltrate of cells, including Th2 lymphocytes, eosinophils and mast cells. Activated mast cell mediators cause the early appearance of symptoms, and cytokines induce a cascade of inflammatory events. Both resident and infiltrating cells are important sources of those mediators and cytokines which maintain and enhance the allergic inflammatory response. The predominant preformed mediator released by mast cells and basophils is histamine, which binds to specific cell receptors to produce its clinical effects. Therapeutic intervention in allergic disease has thus commonly focused on blocking the action of histamine. Ever since Arunlakshana demonstrated, in 1953, the ability of antihistamines to inhibit histamine release by mast cells, numerous studies have been conducted, both in vivo and in vitro , to determine the H1 antihistamines additional properties which contribute to their clinical efficacy in the treatment of allergic disease. It has been reported that some antihistamines can also regulate the expression and/or release of cytokines, chemokines, adhesion molecules, and or/inflammatory mediators. Such properties make these agents important tools for the continuous long- term regulation of both early and late-phase allergic reactions. It appears likely that antihistamines exert these anti- inflammatory effects by means of both receptor-dependent and receptor-independent mechanisms. The receptor- dependent mechanisms seem to involve inhibition of the generation of NF-kB dependent cytokines and adhesion proteins. The latter mechanisms, which require higher drug concentrations, appear to include the release by inflammatory cells of pre-formed mediators, such as histamine and eosinophil proteins as well as eicosanoid generation and oxygen free radicals production. Herein, we review the current state of knowledge of the anti-inflammatory properties of antihistamine s and their mechanisms.","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"4 1","pages":"81-89"},"PeriodicalIF":0.0,"publicationDate":"2005-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568014053005372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67902538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Innate Immune Receptors and IRF Family Transcription Factors 先天免疫受体和IRF家族转录因子
Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-01-31 DOI: 10.2174/1568014053005291
T. Yoneyama
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引用次数: 0
Novel Therapeutic Targets for Somatostatin in Inflammatory Chronic Diseases 生长抑素治疗炎症性慢性疾病的新靶点
Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-01-31 DOI: 10.2174/1568014053005354
N. Vaysse, H. Lahlou, Géraldine Ferjoux, C. Susini
{"title":"Novel Therapeutic Targets for Somatostatin in Inflammatory Chronic Diseases","authors":"N. Vaysse, H. Lahlou, Géraldine Ferjoux, C. Susini","doi":"10.2174/1568014053005354","DOIUrl":"https://doi.org/10.2174/1568014053005354","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"4 1","pages":"91-104"},"PeriodicalIF":0.0,"publicationDate":"2005-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568014053005354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67902489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
SIGIRR/TIR8: A negative regulator of Toll-IL-1R signaling SIGIRR/TIR8: Toll-IL-1R信号的负调控因子
Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-01-31 DOI: 10.2174/1568014053005309
Xiaoxia Li, J. Qin
{"title":"SIGIRR/TIR8: A negative regulator of Toll-IL-1R signaling","authors":"Xiaoxia Li, J. Qin","doi":"10.2174/1568014053005309","DOIUrl":"https://doi.org/10.2174/1568014053005309","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"4 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2005-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568014053005309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67902466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemokines in Allergic Inflammation: Human Disease and Animal Models 变应性炎症中的趋化因子:人类疾病和动物模型
Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2004-11-30 DOI: 10.2174/1568014043355203
H. Hogenesch
{"title":"Chemokines in Allergic Inflammation: Human Disease and Animal Models","authors":"H. Hogenesch","doi":"10.2174/1568014043355203","DOIUrl":"https://doi.org/10.2174/1568014043355203","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"3 1","pages":"351-361"},"PeriodicalIF":0.0,"publicationDate":"2004-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67901668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Lymphocyte Homing to the Liver 淋巴细胞归巢到肝脏
Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2004-11-30 DOI: 10.2174/1568014043355258
Tohru Sato, H. Thorlacius, E. Butcher
{"title":"Lymphocyte Homing to the Liver","authors":"Tohru Sato, H. Thorlacius, E. Butcher","doi":"10.2174/1568014043355258","DOIUrl":"https://doi.org/10.2174/1568014043355258","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"3 1","pages":"331-339"},"PeriodicalIF":0.0,"publicationDate":"2004-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67901845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Small-Molecule Chemokine Receptor Antagonists: Potential Targets for Inflammatory and Allergic Disorders 小分子趋化因子受体拮抗剂:炎症和过敏性疾病的潜在靶点
Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2004-11-30 DOI: 10.2174/1568014043355230
T. Saeki
{"title":"Small-Molecule Chemokine Receptor Antagonists: Potential Targets for Inflammatory and Allergic Disorders","authors":"T. Saeki","doi":"10.2174/1568014043355230","DOIUrl":"https://doi.org/10.2174/1568014043355230","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"3 1","pages":"363-375"},"PeriodicalIF":0.0,"publicationDate":"2004-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67901725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Stromal cell derived factor-1/CXCL12, CXCR4 and CD26 in the mobilization and homing of hematopoietic stem and progenitor cells 造血干细胞和祖细胞的动员和归巢中的基质细胞衍生因子-1/CXCL12、CXCR4和CD26
Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2004-11-30 DOI: 10.2174/1568014043355249
H. Broxmeyer, K. Christopherson
{"title":"Stromal cell derived factor-1/CXCL12, CXCR4 and CD26 in the mobilization and homing of hematopoietic stem and progenitor cells","authors":"H. Broxmeyer, K. Christopherson","doi":"10.2174/1568014043355249","DOIUrl":"https://doi.org/10.2174/1568014043355249","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"3 1","pages":"303-311"},"PeriodicalIF":0.0,"publicationDate":"2004-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67901805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Preface [Hot Topic: Chemokines (Guest Editor: Chang H. Kim)] 前言[热门话题:趋化因子(客座编辑:Chang H. Kim)]
Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2004-11-30 DOI: 10.2174/1568014043355212
C. Kim
{"title":"Preface [Hot Topic: Chemokines (Guest Editor: Chang H. Kim)]","authors":"C. Kim","doi":"10.2174/1568014043355212","DOIUrl":"https://doi.org/10.2174/1568014043355212","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2004-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1568014043355212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67901714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trafficking Potentials of Unconventional T Cell Subsets 非常规T细胞亚群的转运潜力
Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2004-11-30 DOI: 10.2174/1568014043355267
C. Johnson
{"title":"Trafficking Potentials of Unconventional T Cell Subsets","authors":"C. Johnson","doi":"10.2174/1568014043355267","DOIUrl":"https://doi.org/10.2174/1568014043355267","url":null,"abstract":"","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"3 1","pages":"321-330"},"PeriodicalIF":0.0,"publicationDate":"2004-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67901856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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