Current medicinal chemistry. Anti-inflammatory & anti-allergy agents最新文献

In the Crosshairs: NF-κB Targets the JNK Signaling Cascade. 十字准星：NF-κB靶向JNK信号级联。

Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-12-01 DOI: 10.2174/156801405774933188

Can G Pham, Salvatore Papa, Concetta Bubici, Francesca Zazzeroni, Guido Franzoso

{"title":"In the Crosshairs: NF-κB Targets the JNK Signaling Cascade.","authors":"Can G Pham, Salvatore Papa, Concetta Bubici, Francesca Zazzeroni, Guido Franzoso","doi":"10.2174/156801405774933188","DOIUrl":"10.2174/156801405774933188","url":null,"abstract":"<p><p>NF-κB/Rel transcription factors are well-known for their roles in the regulation of inflammation and immunity. NF-κB also blocks programmed cell death (PCD) or apoptosis triggered by proinflammatory cytokine, tumor necrosis factor (TNF)α. Through transcriptional induction of distinct subsets of cyto-protective target genes, NF-κB inhibits the execution of apoptosis activated by this cytokine. This protective action is mediated, in part, by factors (such as A20, GADD45β, and XIAP) that downregulate the pro-apoptotic c-Jun-N-terminal (JNK) pathway. A suppression of reactive oxygen species (ROS), which are themselves major cell death-inducing elements activated by TNFα, is an additional protective function recently ascribed to NF-κB. This function of NF-κB involves an induction of mitochondrial anti-oxidant enzyme, manganese superoxide dismutase (Mn-SOD), and a control of cellular iron availability through upregulation of Ferritin heavy chain - one of two subunits of Ferritin, the major iron storage protein complex of the cell. An emerging view of NF-κB is that, while integrated, its actions in immunity and in promoting cell survival are executed through upregulation of distinct subsets of target genes. Thus, these inducible blockers of apoptosis may provide potential new targets to inhibit specific functions of NF-κB. In the future, this might allow for a better treatment of complex human diseases involving dysregulated NF-κB activity, including chronic inflammatory conditions and cancer.</p>","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"4 6","pages":"569-576"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760982/pdf/nihms110480.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28437519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TNF and TNF Receptors in TRAPS 陷阱中的TNF和TNF受体

Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-11-30 DOI: 10.2174/156801405774933160

I. Todd, P. Tighe, R. Powell

引用次数: 7

Inhibition of Type 1 Diabetes Development by Vitamin D Receptor Agonists 维生素D受体激动剂对1型糖尿病发展的抑制作用

Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-11-30 DOI: 10.2174/156801405774933197

L. Adorini, G. Penna, N. Giarratana, R. Mariani, M. Uskoković

引用次数: 6

Editorial [Hot Topic: Interface between the Immune and Metabolic Regulation (Guest Editor: Giuseppe Matarese)] 社论[热门话题:免疫和代谢调节之间的接口(特邀编辑:Giuseppe Matarese)]

Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-11-30 DOI: 10.2174/156801405774933142

G. Matarese

引用次数: 0

Histamine in Immune Regulation: Possible Roles in Autoimmune Demyelinating Disease of the Central Nervous System 免疫调节中的组胺:在中枢神经系统自身免疫性脱髓鞘疾病中的可能作用

Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-11-30 DOI: 10.2174/156801405774933151

R. Pedotti, L. Steinman

引用次数: 3

Transcriptional Control of Metabolism, Inflammation and the Immune Response: The Role of PPARs 代谢、炎症和免疫反应的转录控制:ppar的作用

Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-11-30 DOI: 10.2174/156801405774933115

D. Savage

引用次数: 0

Adipokines, Metabolism and the Immune Response in the Regulation of Inflammation 脂肪因子、代谢和免疫反应在炎症调节中的作用

Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-11-30 DOI: 10.2174/156801405774933205

G. Matarese, V. Rosa, Daniela Aufiero, C. Procaccini, C. Alviggi, G. Placido, S. Fontana, S. Zappacosta

引用次数: 1

Neuro-Hormonal Regulation of Immune and Metabolic Function 免疫和代谢功能的神经激素调节

Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-11-30 DOI: 10.2174/156801405774933223

S. Farooqi

引用次数: 0

All in the Family: The TNF-TNFR Superfamily in the Pathogenesis and Treatment of Rheumatoid Arthritis and other Inflammatory Diseases 全家福:TNF-TNFR超家族在类风湿关节炎和其他炎症性疾病的发病和治疗中的作用

Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-11-30 DOI: 10.2174/156801405774933133

N. Siegel

引用次数: 0

Viral Inhibition of Tumour Necrosis Factor-α (TNFα) and TNF-Receptor Induced Apoptosis and Inflammation 病毒抑制肿瘤坏死因子-α (TNFα)及tnf受体诱导的细胞凋亡和炎症

Current medicinal chemistry. Anti-inflammatory & anti-allergy agents Pub Date : 2005-11-30 DOI: 10.2174/156801405774933124

L. Sedger

{"title":"Viral Inhibition of Tumour Necrosis Factor-α (TNFα) and TNF-Receptor Induced Apoptosis and Inflammation","authors":"L. Sedger","doi":"10.2174/156801405774933124","DOIUrl":"https://doi.org/10.2174/156801405774933124","url":null,"abstract":"Apoptotic cell death can be triggered by death-inducing cytokines such and TNFα, Fas Ligand, and TRAIL, and death-receptors TNF-Rs, Fas, and TRAIL-Rs, or by mitochondrial-sensed events. The biochemical signalling pathways that lead from death receptors or mitochondria to the degradation of DNA and apoptotic cell death are wellcharacterized. Furthermore, it is clear that apoptotic cell death is important for the normal biology in all organisms. Apoptotic cell death is equally important in the context of virus infection such that the induction of apoptosis appears to be a generalised innate response to the insult of virus infection. As a consequence, viral-mediated regulation of apoptosis is crucial for the successful replication and survival of most viruses. For this reason viruses have evolved multiple strategies to subvert the apoptotic response. This review summarises the mechanisms by which viral gene products inhibit the production of TNFα, the interaction between TNFα and TNF-Rs, the expression of TNF-Rs, and inhibit virtually all aspects of TNF-R signalling, including TNF-R-mediated apoptosis and TNF-R-mediated proliferation and inflammation. Current Medicinal Chemistry – Anti-Inflammatory and Anti-Allergy Agents (2005). In press.","PeriodicalId":88233,"journal":{"name":"Current medicinal chemistry. Anti-inflammatory & anti-allergy agents","volume":"4 1","pages":"597-615"},"PeriodicalIF":0.0,"publicationDate":"2005-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/156801405774933124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67903245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2