Audiological medicine最新文献_第9页

Exploring hearing and ear disease in a non-literate society: The use of historical linguistics 探索听力和耳部疾病在一个不识字的社会:使用历史语言学

Audiological medicine Pub Date : 2010-01-01 DOI: 10.3109/16513861003608037

D. Stephens, R. Stephens

引用次数: 0

Aquaporin-2 and -4: Single nucleotide polymorphisms in Ménière's disease patients 水通道蛋白-2和-4:在m懊悔病患者中的单核苷酸多态性

Audiological medicine Pub Date : 2010-01-01 DOI: 10.3109/16513860903574232

P. Mallur, A. Weisstuch, M. Pfister, A. Mhatre, A. Lalwani

{"title":"Aquaporin-2 and -4: Single nucleotide polymorphisms in Ménière's disease patients","authors":"P. Mallur, A. Weisstuch, M. Pfister, A. Mhatre, A. Lalwani","doi":"10.3109/16513860903574232","DOIUrl":"https://doi.org/10.3109/16513860903574232","url":null,"abstract":"Abstract The endolymphatic hydrops seen in Ménière's disease (MD) results from an inner ear fluid disequilibrium that has a suspected inherited component. Aquaporin-2 and aquaporin-4 (AQP2 and AQP4) water transport proteins may contribute to abnormal fluid homeostasis seen in MD. Our objective was to screen for sequence alterations in AQP2 and AQP4 genes in a northern European population with MD. Amplification for AQP2 (n = 18) and AQP4 (n = 30) was performed for patients with MD. Sequences were screened with denaturing high powered liquid chromatography (DHPLC) and confirmed with sequencing. Allele frequencies were compared with previously reported normal populations. We found that DHPLC failed to identify sequence alterations in any sample. Sequencing identified three intronic and one 3’ untranslated region polymorphism in AQP2, and one polymorphism upstream from the start codon in AQP4. Two of the AQP2 intronic allele frequencies showed an A and C allele enrichment, respectively, compared with a reported mixed population (0.389 A vs. 0.00 A; 0.389 C vs. 0.00 C, p<0.001). The remaining polymorphism showed statistical difference from three non-Caucasian populations (0.611 A vs. 0.389 A, 0.375 A, and 0.280 A, p<0.05). The AQP4 allele frequency in the MD population was statistically different from a previously published Japanese population (0.800 G vs. 0.620 G, p = 0.0053) but not from a reported Caucasian population. We concluded that aquaporin polymorphisms may contribute to MD. Additional studies are needed to confirm these findings in well-defined population isolates and to determine if these polymorphisms lead to altered AQP protein function or levels.","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"3 1","pages":"18 - 23"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90081959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

A different modulation of vascular endothelial growth factor (VEGF) activation in response to hypoxia could cause different clinical pictures in inner ear disorders 缺氧对血管内皮生长因子(VEGF)激活的不同调节可能导致内耳疾病的不同临床表现

Audiological medicine Pub Date : 2010-01-01 DOI: 10.3109/16513861003647043

A. Pirodda, C. Borghi, G. Ferri

{"title":"A different modulation of vascular endothelial growth factor (VEGF) activation in response to hypoxia could cause different clinical pictures in inner ear disorders","authors":"A. Pirodda, C. Borghi, G. Ferri","doi":"10.3109/16513861003647043","DOIUrl":"https://doi.org/10.3109/16513861003647043","url":null,"abstract":"Abstract When envisaging inner ear damage, the general tendency is to classify the damage into separate entities, according to the differences in clinical presentation, regardless of the frequent absence of a completely satisfactory explanation for the damage and, consequently, absence of a specific therapy. Nevertheless, a common ground can be found in haemodynamic changes and subsequent abnormal vasomotor reaction, which can be responsible for various kinds of labyrinthine effects depending on the extent, the duration and the severity of the consequent ischaemia. A key to a better understanding of the different effects of the resulting ischaemia and hypoxia could be found by considering the regulation of vascular endothelial growth factor (VEGF), which is known as a protective factor for inner ear structures under threat. If the haemodynamic change is mild, the possibility of VEGF up-regulation, which despite its finality could be a trigger for an imbalance of labyrinthine hair cells or fluids, could be a reliable indicator of damage. In contrast, if the vasoconstriction leads to a more severe hypoxia, this could directly lead to an acute, more or less transient damage according to a more direct mechanism. This damage could not, or could only partially, permit a useful activation of VEGF, and the total or partial recovery could therefore depend on the entity of the damage itself and on the efficacy of other, less specific protective endogenous or exogenous factors.","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"27 1","pages":"33 - 35"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78086448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Sensorineural hearing loss and congenital diaphragmatic hernia 感音神经性听力损失与先天性膈疝

Audiological medicine Pub Date : 2010-01-01 DOI: 10.3109/16513861003647035

R. Masi

引用次数: 2

Functional and structural changes in the chinchilla cochlea and vestibular system following round window application of carboplatin. 卡铂圆窗应用后鼠耳蜗和前庭系统功能和结构的改变。

Audiological medicine Pub Date : 2009-12-01 DOI: 10.3109/16513860903335795

Yide Zhou, Dalian Ding, Kari Suzanne Kraus, Dongzhen Yu, Richard J Salvi

{"title":"Functional and structural changes in the chinchilla cochlea and vestibular system following round window application of carboplatin.","authors":"Yide Zhou, Dalian Ding, Kari Suzanne Kraus, Dongzhen Yu, Richard J Salvi","doi":"10.3109/16513860903335795","DOIUrl":"https://doi.org/10.3109/16513860903335795","url":null,"abstract":"<p><p>OBJECTIVE: In chinchillas, moderate doses of carboplatin administered systemically selectively destroy inner hair cells and type I vestibular hair cells; however, it is unclear whether this unique damage pattern persists if carboplatin is applied directly to the cochlea, how quickly the damage develops and what cell death pathways are involved. STUDY DESIGN: To address these questions, carboplatin (5 mg/ml, 50 µl) was applied to the round window. RESULTS: Carboplatin caused a rapid decline in distortion product otoacoustic emissions, significantly increased compound action potential thresholds and caused massive inner hair cell loss and less severe outer hair cell loss. Hair cell loss was initially more severe in the base than the apex of the cochlea, but by 28 days post-treatment most cochlear hair cells were missing and hair cell density in the utricle, saccule and lateral crista was greatly reduced. At one day post-treatment, many hair cell nuclei were condensed or fragmented indicative of apoptosis, and expressed initiator caspase-8 and executioner caspase-3, but not initiator caspase-9. Carboplatin-treated animals circled towards the treated ear and during the swim test rolled towards the treated ear. CONCLUSION: These results indicate that local application of carboplatin causes loss of hair cells that begins near the base of the cochlea and spreads towards the apex with increasing survival time. Hair cell loss is initiated by caspase-8 followed by executioner caspase-3.</p>","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"7 4","pages":"189-199"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/16513860903335795","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28625982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Advances in Auditory and Vestibular Medicine. 听觉和前庭医学进展》。

Audiological medicine Pub Date : 2009-12-01 DOI: 10.3109/02841860903364076

Mohamed A Hamid, Dennis R Trune, Mayank B Dutia

引用次数: 0

PET study of auditory plasticity: Helping to address decision making for cochlear implantation of adults 听觉可塑性的PET研究:帮助解决成人人工耳蜗植入的决策

Audiological medicine Pub Date : 2009-01-01 DOI: 10.1080/16513860802628233

F. J. Cervera-paz, J. Arbizu, E. Prieto, M. Manrique

{"title":"PET study of auditory plasticity: Helping to address decision making for cochlear implantation of adults","authors":"F. J. Cervera-paz, J. Arbizu, E. Prieto, M. Manrique","doi":"10.1080/16513860802628233","DOIUrl":"https://doi.org/10.1080/16513860802628233","url":null,"abstract":"The study of regional cerebral metabolism by positron emission tomography (PET) can be applied to the primary and associative auditory cortices, providing important information about normal hearing, hearing loss, and the neuroplasticity processes of the auditory system. We have reviewed the pertinent literature to provide the most significant facts that may help clinicians in the selection phase of a cochlear implant programme. PET-scan studies offer vital information concerning the time process for hearing restoration in cases of severe-profound hearing impairment. Additionally, we report a short case series of eight patients with long-lasting unilateral profound hearing loss combined with the contralateral ear having some functional hearing. These patients are quite difficult to counsel in the process of selection for cochlear implantation, as there is a lack of functional information on neural plasticity. PET-scan studies permit an evaluation of activation of both primary auditory cortices in patients with profound hearing impairment in one ear and contralateral functional hearing. This helps us to settle the question of a possible indication for a cochlear implant in the deaf ear.","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"30 1","pages":"47 - 54"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76660308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Estimation of the degree of inner and outer hair cell dysfunction from distortion product otoacoustic emission input/output functions 从畸变产物耳声发射输入/输出函数估计内外部毛细胞功能障碍程度

Audiological medicine Pub Date : 2009-01-01 DOI: 10.1080/16513860802622491

E. Lopez-Poveda, P. T. Johannesen, M. Merchán

引用次数: 12

The effects of a pre-fitting intervention on hearing aid benefit: A randomized controlled trial 预配干预对助听器效益的影响:一项随机对照试验

Audiological medicine Pub Date : 2009-01-01 DOI: 10.3109/16513860903309790

M. Öberg, G. Andersson, Gunilla Wänström, T. Lunner

{"title":"The effects of a pre-fitting intervention on hearing aid benefit: A randomized controlled trial","authors":"M. Öberg, G. Andersson, Gunilla Wänström, T. Lunner","doi":"10.3109/16513860903309790","DOIUrl":"https://doi.org/10.3109/16513860903309790","url":null,"abstract":"Abstract Objective: The aim of this study was to investigate the effect of pre-fitting user-controlled hearing aid adjustments. Study design: Thirty-nine first time hearing aid users with mild to moderate hearing losses were randomly assigned to a pre-fitting intervention group (n = 19) or a control group (n = 20). The pre-fitting intervention consisted of three weekly visits, where the hearing aid candidate adjusted the amplification of an experimental hearing aid to preferred settings, and wore the aid between the visits. After the pre-fitting intervention phase, both groups received conventional hearing aid fittings. Standardized questionnaires (HHIE, ECHO, SADL, HADS) were administered before and after the pre-fitting intervention, after the conventional hearing aid fittings, and at a one-year follow-up. In addition, the IOI-HA questionnaire was administered immediately after the conventional hearing aid fitting and at the one-year follow-up. Hearing aid success was evaluated by an independent audiologist at the one-year follow-up appointment. Results: The pre-fitting intervention phase showed positive effects for the intervention group but not for the control group on activity limitation, participation restriction and expectations. However, the intervention in its current version had no lasting effects beyond the control group after conventional hearing aid fitting or after a year. Both groups showed mostly successful hearing aid fittings, improved psychosocial well-being and quality of life, and reduced participation restriction. Conclusion: Only short-term effects were found and further research is needed to investigate for which individuals the intervention could be effective.","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"13 1","pages":"211 - 225"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82042506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Acknowledgement to our referees 向我们的推荐人致谢

Audiological medicine Pub Date : 2009-01-01 DOI: 10.3109/16513860903350711

引用次数: 0