Audiological medicine最新文献

{"title":"Referees","authors":"","doi":"10.3109/1651386x.2012.736195","DOIUrl":"https://doi.org/10.3109/1651386x.2012.736195","url":null,"abstract":"","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"3 1","pages":"188 - 188"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90101589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ménière's disorder: A short history","authors":"D. Stephens, A. Mudry","doi":"10.3109/1651386X.2012.718858","DOIUrl":"https://doi.org/10.3109/1651386X.2012.718858","url":null,"abstract":"The authors discuss early reports probably related to Ménière's disorder, a short account of the contribution and life of Prosper Menière and the developments and terminological confusions following that time. We consider various approaches that have been made to the treatment of the condition and briefly mention some famous people who have suffered from the condition.","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"1 1","pages":"153 - 159"},"PeriodicalIF":0.0,"publicationDate":"2012-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83024087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Betahistine for Menière's disease","authors":"M. Strupp, E. Krause, F. Lezius, M. Canis, F. Ihler, R. Gürkov","doi":"10.3109/1651386X.2012.726767","DOIUrl":"https://doi.org/10.3109/1651386X.2012.726767","url":null,"abstract":"Betahistine, a histamine H1 agonist and H3 antagonist, has been used for the pharmacotherapy of Menière's disease for many decades. Earlier its mode of action and efficacy, in particular in low dosages, were the subject of controversy mainly because valid experimental or clinical data were not available. Recent animal studies, however, showed that betahistine increases cochlear blood flow in a sigmoid dose-dependent way, thus supporting the hypothesis that it may act by improving cochlear microcirculation. In terms of its clinical efficacy, two studies demonstrated that a high-dose (at least 48 mg t.i.d.) and long-term treatment (at least six to 12 months) have a significant prophylactic effect on the occurrence of attacks in Menière's disease.","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"12 1","pages":"167 - 170"},"PeriodicalIF":0.0,"publicationDate":"2012-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85967615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and functional structure of the inner ear: Its relation to Ménière's disease","authors":"Elena Olivetto, E. Simoni, V. Guaran, L. Astolfi, A. Martini","doi":"10.3109/1651386X.2012.714192","DOIUrl":"https://doi.org/10.3109/1651386X.2012.714192","url":null,"abstract":"Ménière's disease is a disabling disorder presenting with crises of aural fullness, tinnitus, hearing loss and vertigo. The hallmark of the pathology is a labyrinthine hydrops, but its pathogenesis remains unclear. This unknown aetiology explains the lack of a good pharmacological treatment. Here, we wish to evaluate the different parameters that can be involved in the progression of the disease, focusing on vascular disorders, production of reactive oxygen species and the relationship between the endolymph and haematic perfusion. We know that the blood supply must be adequate to guarantee the establishment of the endocochlear potential and the production of endolymph, so aberrant microcirculation may be an aetiological factor for Ménière's disease.","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"7 1","pages":"160 - 166"},"PeriodicalIF":0.0,"publicationDate":"2012-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73618618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it possible to consider non-conventional proposals for treating Ménière's disease?","authors":"A. Pirodda, C. Borghi","doi":"10.3109/1651386X.2012.718583","DOIUrl":"https://doi.org/10.3109/1651386X.2012.718583","url":null,"abstract":"According to our model, the primum movens for the onset of Ménière's disease should be represented by a haemodynamic imbalance. From this starting point, the principal therapeutic approach should concern the necessity of achieving and maintaining a stable blood perfusion to the inner ear; this involves a number of different factors ranging from cardiac pump activity to vasomotor regulation that in turn exert an influence on membrane and cell integrity. A simple, alternative or coadjuvant and almost risk-free treatment can thus be represented by antioxidants such as melatonin, especially through its modulating activity on the autonomic nervous system, and mostly by omega-3 polyunsaturated fatty acids (omega-3 PUFAs); the latter, owing to their capability of improving myocardial function and arterial compliance, modulating blood pressure, and stabilizing cell and organelle membrane structure and function could theoretically fulfil all the requirements. When considering a resort to more strictly pharmacological principles, the hypothesis of some possible benefit deriving from commercially available proton pump inhibitors has been advanced. Moreover, an aspect that in our opinion deserves some interest, is the role of angiogenesis; a series of analogies permits the hypothesis of a similar role for the eye and the ear, thus opening a matter of debate on the possibility to apply to the labyrinth the same principles that have proved useful in treating degenerative retinopathy.","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"7 1","pages":"182 - 185"},"PeriodicalIF":0.0,"publicationDate":"2012-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85755983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simon Dafydd Glyn Stephens, Professor of Audiological Medicine","authors":"R. Davies","doi":"10.3109/1651386X.2012.736248","DOIUrl":"https://doi.org/10.3109/1651386X.2012.736248","url":null,"abstract":"","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"29 1","pages":"186 - 187"},"PeriodicalIF":0.0,"publicationDate":"2012-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80855467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ménière's disease: Is it time to approach it from another point of view?","authors":"A. Pirodda, C. Borghi","doi":"10.3109/1651386X.2012.717794","DOIUrl":"https://doi.org/10.3109/1651386X.2012.717794","url":null,"abstract":"Since it was fi rst described in the 19th century, M é ni è re ’ s disease (MD) has presented with a series of fundamental aspects the basis of which still remain unclear. It is commonly accepted that an endolymphatic hydrops occurs; the modalities and mostly the causes of this alteration are still under debate despite numerous attempts at an explanation over the decades. A review of the suggested aetiopathogenetic explanations (1) reveals that these range from genetic abnormalities to viral infections, autoimmune alterations, Eustachian tube dysfunction, disorders of the transport and regulation of water, dietary factors, hormonal changes and psychological triggers. As a consequence of the uncertainties concerning MD, various medical and surgical therapeutic strategies have been proposed but none has proved universally acceptable to date. Although a number of supposed causes of MD involve systemic alterations, there is a tendency to focus attention on local treatment, thus scarcely considering the link between the homeostasis of the inner ear and the systemic changes. As all the surgical proposals are clearly aimed at fi nding a ‘ local ’ solution, the medical therapies tend toward producing an effect that only involves the inner ear; however, even in this case the match between the labyrinthine circulation and fl uids, on one hand, and the systemic plasmatic volume, on the other, is often poorly emphasized. In our opinion, however, the key to a better understanding of the behaviour of the inner ear is to consider it as a very sensitive terminal that works in accordance with the changes occurring in the whole organism and infl uencing circulation. A very recent explanation that has been advanced by our group, stresses the possible role of the inner ear proton pumps working under ischaemia in the genesis of the fl uid imbalance, leading to a series of unexplained inner ear alterations including hydrops (1). The possible infl uence of a more or less transient ischaemia, that can even be due to functional and transitory causes (2), is not negligible when considering the terminal type of the labyrinthine blood supply, its interaction with inner ear fl uid pressure (3), and the occurrence of mild auditory fl uctuations even under physiological hormonal changes such as those occurring in the ovarian cycle (4). Moreover, the presence of cochlear sympathetic efferent fi bres, that are reported to infl uence susceptibility to noise (5), further supports the importance of vasomotor changes in the inner ear. Briefl y, a haemodynamic imbalance that can be represented by an abrupt lowering of blood pressure values followed by an exaggerated peripheral vasoconstriction could have adverse effects of different kinds on the labyrinth (1); this could reliably explain various labyrinthine disorders of unexplained origin and, as stated above, be extended to MD. This orientation is given important support when considering the role of a specialized central nervous sy","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"20 1","pages":"151 - 152"},"PeriodicalIF":0.0,"publicationDate":"2012-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84889541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proton pump inhibitors: A possible effect on Ménière's disease?","authors":"A. Pirodda, M. C. Raimondi, G. Ferri, A. Sammartano, R. Albera","doi":"10.3109/1651386X.2012.718412","DOIUrl":"https://doi.org/10.3109/1651386X.2012.718412","url":null,"abstract":"Background: The model of explanation for the pathogenesis of Ménière's disease (MD) proposed by our group postulates a crucial role for the maintained activity of the labyrinthine gastric-type proton pump under ischaemic conditions. Thus, the administration of the common proton pump inhibitors (PPI) could exert a favourable influence on MD symptoms. Method: In order to help assess the validity of this hypothesis a questionnaire was administered to a selected population of sufferers from MD; the aim was to verify the percentage of PPI users and the incidence of MD symptoms among users and non-users. Results: These showed a higher prevalence of PPI users in the selected sample compared to an unselected large series in the literature; the difference was statistically significant in all cases. In contrast, no statistically significant differences between users and non-users were found regarding the incidence of symptoms in the previous six months, even though the group of PPI users had a slightly better performance. Conclusion: Despite these inconclusive findings and the consequent need for further studies to eventually propose PPI as a therapy for MD, some physiological and pharmacological aspects seem to support a possible positive influence of this category of drugs on the inner ear.","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"10 1","pages":"178 - 181"},"PeriodicalIF":0.0,"publicationDate":"2012-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89282418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical therapy in Ménière's disease","authors":"Sammartano Azia Maria, C. Claudia, Giordano Pamela, C. Andrea, A. Roberto","doi":"10.3109/1651386X.2012.718413","DOIUrl":"https://doi.org/10.3109/1651386X.2012.718413","url":null,"abstract":"Objective: This article describes the current clinical treatment approaches for MD. Study design: Acute and chronic current pharmacological treatments in Ménière's disease (MD) are reviewed. Results: All treatments for MD are focused on treating the symptoms and are prophylactic to prevent further attacks. Medical management includes sodium restriction and the avoidance of caffeine, alcohol and nicotine. An evidence base for the management of patients with MD is still lacking. Conclusion: The outcome of treatment of MD is difficult to assess. The medical management of MD is still empiric and based on lifestyle changes and pharmacotherapy that remain the primary therapy in definite MD, while ablative and transtympanic therapies represent the treatment of second choice.","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"38 1","pages":"171 - 177"},"PeriodicalIF":0.0,"publicationDate":"2012-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79377293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical auditory evoked potentials in children using hearing aids","authors":"E. Kolkaila, A. Emara, T. Gabr","doi":"10.3109/1651386X.2012.699610","DOIUrl":"https://doi.org/10.3109/1651386X.2012.699610","url":null,"abstract":"Abstract Cortical auditory evoked potentials (CAEPs) are considered the electrophysiological equivalent of the pure tone audiogram (PTA) and can be used to assess the functional consequences of auditory deprivation and hearing aid acclimatization. Objectives: Threshold estimation and central auditory system evaluation in normal hearing children and those with hearing loss using cortical auditory evoked potentials. Study design: This work involved two groups: GI (20 normal hearing children) and GII (36 children with moderately-severe flat sensorineural hearing loss. The second group was divided into two subgroups: GIIa (20 children fitted with hearing aids) and GIIb (16 children not yet fitted with a hearing aid). Methodology: Basic audiological evaluation and CAEPs using speech and tone stimuli were performed and compared. The latencies and amplitude of different CAEP components were compared between both groups at the same sensation level. Results: GIIb showed a larger difference at 500 Hz compared to other frequencies, in contrast to GI and GIIa. CAEP latencies were significantly delayed in GIIb compared to GI or GIIa but CAEP amplitude showed no significant difference. Conclusions: Tone or speech evoked-cortical potentials can be used for threshold estimation in children with a high degree of consistency across different frequencies. Hearing aids can impact on cortical processing of simple or complex stimuli.","PeriodicalId":88223,"journal":{"name":"Audiological medicine","volume":"7 3 1","pages":"132 - 142"},"PeriodicalIF":0.0,"publicationDate":"2012-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83805601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}