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Monoamine oxidase and aspartate aminotransferase in cellular fractions of thyroid gland in rats after hypophysectomy and TSH stimulation. 脑下垂体切除术和促甲状腺激素刺激后大鼠甲状腺细胞组分中的单胺氧化酶和天冬氨酸氨基转移酶
Biochemistry and experimental biology Pub Date : 1979-01-01
J Knopp, J Orlicky
{"title":"Monoamine oxidase and aspartate aminotransferase in cellular fractions of thyroid gland in rats after hypophysectomy and TSH stimulation.","authors":"J Knopp,&nbsp;J Orlicky","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Unlabelled: </strong>Monoamine oxidase (MAO) and aspartate aminotransferase activities in cellular fractions of thyroid gland in rats after hypophysectomy and TSH treatment were investigated. MAO and aspartate aminotransferase activities in thyroid mitochondria were decreased after hypophysectomy and significantly increased after daily injection of TSH during five days to hypophysectomized rats. In microsomes after hypophysectomy a similar decrease of MAO activity was found but TSH was without effect on this activity.</p><p><strong>In conclusion: </strong>it is evident that MAO and aspartate aminotransferase in thyroid mitochondria the enzymes which could be a source for hydrogen peroxide to catalyze thyroid hormone synthesis are under the regulatory influence of TSH.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"15 3","pages":"257-61"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11759989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic effects of phallolysin on a human heteroploid cell line. 阳草溶素对人异倍体细胞系的细胞毒作用。
Biochemistry and experimental biology Pub Date : 1979-01-01
E Ginelli, M L Tenchini, R Di Lernia
{"title":"Cytotoxic effects of phallolysin on a human heteroploid cell line.","authors":"E Ginelli,&nbsp;M L Tenchini,&nbsp;R Di Lernia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of Phallolysin on cellular growth, macromolecular biosyntheses and cellular membrane structure was analysed using cells from the EUE line. Concentrations of the toxin that do not affect cellular growth, as determined by plating efficiency, have no effect on RNA or protein synthesis, but stimulate DNA synthesis. The doses of Phallolysin that inhibit cell survival do not affect macromolecular biosyntheses, but greatly increase the percentage of cells stainable with Trypan blue after 1 hour of incubation. At the same dose of the toxin the cells, analysed by electron microscopy, show increased vacuolization indicating an alteration of the membrane apparatus.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"15 3","pages":"263-8"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11759990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributions toward the study of changes in the microvascular-tissual system in diabetes mellitus (Observations on 50 biopsies of the finger-tip). 对糖尿病微血管组织系统变化研究的贡献(50例指尖活检观察)。
Biochemistry and experimental biology Pub Date : 1979-01-01
G Trevisan, F Silvestri, E Ponte
{"title":"Contributions toward the study of changes in the microvascular-tissual system in diabetes mellitus (Observations on 50 biopsies of the finger-tip).","authors":"G Trevisan,&nbsp;F Silvestri,&nbsp;E Ponte","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fifty biopsies of finger-tips, from diabetic patients were examined. We wish to emphasize, of damage in the blocking devices and in the preglomic arterioles as opposed to the limited modifications produced in the small dermic and hypodermic arteries. The glomera are almost constantly affected in their various components: in particular, the fusion of the glomic capsule with the intra- and extraglomic connective should be noted, as well as the presence of accumulated P.A.S. positive material among the mioepithelioid cells in the intermediate segment. The capillaries are frequently affected by hyperplasia of the intimal endothelium, sometimes with subocclusive phenomena, while the basal membrane is thickened and P.A.S. positive more often in extraglomic than in intraglomic capillaries.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"15 2","pages":"139-45"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11760264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinetics of lactate dehydrogenase and other enzyme studies in human serum in leukemia. 白血病患者血清乳酸脱氢酶及其他酶的动力学研究。
Biochemistry and experimental biology Pub Date : 1979-01-01
S A Al-Mudhaffar, M B Rassam
{"title":"Kinetics of lactate dehydrogenase and other enzyme studies in human serum in leukemia.","authors":"S A Al-Mudhaffar,&nbsp;M B Rassam","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The activity of some of the clinically important enzymes was investigated in leukemic sera at 37 degrees, using the Beckman Enzyme Activity Analyzer were found to be slightly elevated in some untreated cases of leukemia (1.), while ALP was found to be frequently elevated. Untreated patients with l. had normal or below normal SCPK activity. The most characteristic and significant rise in activity, was found to be associated with SLDH and SHBDH in most cases of acute l. (86%) and in CML, while any elevation observed in CLL, was very slight. The general kinetic parameters of SLDH and SHBDH, were investigated at 37 degrees in acute leukemic patients. These included optimum substrate concentrations (NADH, pyruvate, and 2-oxobutyrate), the rate of pyruvate and 2-oxobutyrate reduction, substrate-velocity relationship, Km (pyruvate), Km (NADH), Km (2-oxobutyrate) as well as the effect of temperature and pH on the kinetics of the reaction. These kinetic characteristics were found to be differently affected by the leukemic process.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"15 2","pages":"155-65"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11511877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of antihistamines on anaphylactoid oedema in rats using a modified plethysmometer for measuring foot volume. 用改良容积计测量足部容积，观察抗组胺药对大鼠类过敏性水肿的影响。
Biochemistry and experimental biology Pub Date : 1979-01-01
R A Elegbe, D D Oyebola
{"title":"Effect of antihistamines on anaphylactoid oedema in rats using a modified plethysmometer for measuring foot volume.","authors":"R A Elegbe,&nbsp;D D Oyebola","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study reports the quantitative effect of the H1--and H2--receptor antagonists on dextran-induced anaphylactoid oedema in rats. The findings indicate that mepyramine, promethazine and chlorpromazine which are H1--receptor antagonists significantly inhibited this anaphylactoid oedema. While on the other hand burimamide an H2--receptor antagonist at doses below 500 micrograms/kg inhibit dextran-induced oedema but at higher doses enhances oedema formation in the test rats. E.D50 values obtained for mepyramine, chlorpromazine and promethazine are 5.01 mg/kg, 0.36 mg/kg, 1.78 mg/kg respectively. The dual effects of burimamide on dextran-induced oedema merits further investigation and confirmation with the aid of other H1--and/or H2--receptor systems. A modification of the plethysmometric method of Buttle et. al. (1957) is also described.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"15 1","pages":"57-60"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11266533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The biostructural theory and the criticism of contemporary molecularism: a new concept on the nature of living matter. 生物结构理论与当代分子主义批判:关于生命本质的新概念。
Biochemistry and experimental biology Pub Date : 1979-01-01
E Macovschi
{"title":"The biostructural theory and the criticism of contemporary molecularism: a new concept on the nature of living matter.","authors":"E Macovschi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"15 1","pages":"81-93"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11751983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of a long term oral administration of a hypercholesterolic diet on rat liver substructures. 长期口服高胆固醇饮食对大鼠肝脏亚结构的影响。
Biochemistry and experimental biology Pub Date : 1979-01-01
C Pignatti, E F Levi, M Cocchi
{"title":"Effect of a long term oral administration of a hypercholesterolic diet on rat liver substructures.","authors":"C Pignatti,&nbsp;E F Levi,&nbsp;M Cocchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of high cholesterol diets on ultrastructure morphologic alterations of rat liver have been investigated. It has been verified that these diets induce the biochemical and morphological damage, as well as death in a shorter time than alipidic or sole saturated lipid diets. Moreover it has been established that the anatomic irreversible damage appears at the last stage, just before death.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"15 1","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11751979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlations between cutaneous and retinal microaneurysms in diabetes mellitus (preliminary note). 糖尿病患者皮肤和视网膜微动脉瘤的相关性(初步说明)。
Biochemistry and experimental biology Pub Date : 1979-01-01
G Trevisan, G Ravalico, E Ponte
{"title":"Correlations between cutaneous and retinal microaneurysms in diabetes mellitus (preliminary note).","authors":"G Trevisan,&nbsp;G Ravalico,&nbsp;E Ponte","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A group of diabetic patients was submitted to a capillaroscopic examination at the level of the peri-ungual vallum and to a fluoroangiographic examination of the retina, for the evaluation of possible correlations between vessel conditions in to various districts. The Authors remarked that the subjects affected by proliferative diabetic retinopathy presented a greater dilatation of the ansae at cutaneous level, with haemorrhagic extravasations in 70% of the cases. On the contrary, on the subjects with nonproliferative diabetic retinopathy numerous aneurysmal \"buttons\" were noted at cutaneous level, both apically and laterally along the vascular ansa.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"15 1","pages":"65-8"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11751982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enzyme histochemical, biochemical and metabolic effects of Solcoseryl in connection with its radioprotective capability. 与辐射防护能力有关的茄雪酰的酶组织化学、生化和代谢作用。
Biochemistry and experimental biology Pub Date : 1979-01-01
D Bauer, A Locker, P Grigoriadis, H G Goslar, K H Jaeger
{"title":"Enzyme histochemical, biochemical and metabolic effects of Solcoseryl in connection with its radioprotective capability.","authors":"D Bauer,&nbsp;A Locker,&nbsp;P Grigoriadis,&nbsp;H G Goslar,&nbsp;K H Jaeger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The lethal irradiation with gamma-rays (LD 100/30) of adult mice at ambient temperature of 32.5 degrees C heavily alterates the pattern of LDH in liver. In close correspondence with the radioprotective effect of Solcoseryl on the survival rate of irradiated mice -- which amounts to 100% as compared with 40% survival of solely heat adapted animals -- Solcoseryl normalizes the LDH distribution both histochemically and biochemically. Since Solcoseryl alone generally enhances enzyme activity the normalization observed is obviously attributable to an intrinsically regulatory property of this natural compound.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"15 2","pages":"147-53"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11760265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies of fibrinolytic activity of uremic and longterm hemodialytic patients with special reference to fibrinolytic inhibitor. 尿毒症和长期血液透析患者纤溶活性的研究，特别参考纤溶抑制剂。
Biochemistry and experimental biology Pub Date : 1979-01-01
T Homma, T Ichikawa
{"title":"Studies of fibrinolytic activity of uremic and longterm hemodialytic patients with special reference to fibrinolytic inhibitor.","authors":"T Homma,&nbsp;T Ichikawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fibrinolytic activities on cases with chronic renal failure, 13 cases at pre and post introduction of hemodialysis and 40 cases at pre and post hemodialysis of maintenance hemodialysis with 38 normal controls were investigated. The plasminogen activator of untreated chronic renal failure was lower than controls, yet increased with the introduction of hemodialysis. On the other hand the antiplasmin was lowered with the introduction. In cases with maintenance hemodialysis, the plasminogen activator was lower than controls, but was elevated with hemodialysis. The level of antiactivator was higher in uremia of either pre or post hemodialysis than controls. The levels of alpha 2-macroglobulin and alpha 1-antitrypsin were reduced at prehemodialysis state comparing to controls, and yet, increased with hemodialysis, respectively. The low molecular weight antiplasmin and antiactivator, molecular weight below 30,000 were separated with Sephadex G-50 gel filtration of plasma. The low molecular weight fibrinolysis inhibitors of plasma with untreated uremia were elevated comparing to controls, but decreased with the hemodialysis. The removable fibrinolytic inhibitors were indicated, however, the ratio of the low molecular weight fibrinolytic inhibitors to the total fibrinolytic inhibitors were little.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"15 3","pages":"229-36"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11340898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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