Biochimica et biophysica acta最新文献

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Forces measured with micro-fabricated cantilevers during actomyosin interactions produced by filaments containing different myosin isoforms and loop 1 structures. 在含有不同肌球蛋白异构体和环1结构的细丝产生的肌动球蛋白相互作用中,用微制造悬臂梁测量的力。
Biochimica et biophysica acta Pub Date : 2013-03-01
Albert Kalganov, Nabil Shalabi, Nedjma Zitouni, Linda Hussein Kachmar, Anne-Marie Lauzon, Dilson E Rassier
{"title":"Forces measured with micro-fabricated cantilevers during actomyosin interactions produced by filaments containing different myosin isoforms and loop 1 structures.","authors":"Albert Kalganov,&nbsp;Nabil Shalabi,&nbsp;Nedjma Zitouni,&nbsp;Linda Hussein Kachmar,&nbsp;Anne-Marie Lauzon,&nbsp;Dilson E Rassier","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>There is evidence that the actin-activated ATP kinetics and the mechanical work produced by muscle myosin molecules are regulated by two surface loops, located near the ATP binding pocket (loop 1), and in a region that interfaces with actin (loop 2). These loops regulate force and velocity of contraction, and have been investigated mostly in single molecules. There is a lack of information of the work produced by myosin molecules ordered in filaments and working cooperatively, which is the actual muscle environment.</p><p><strong>Methods: </strong>We use micro-fabricated cantilevers to measure forces produced by myosin filaments isolated from mollusk muscles, skeletal muscles, and smooth muscles containing variations in the structure of loop 1 (tonic and phasic myosins). We complemented the experiments with in-vitro assays to measure the velocity of actin motility.</p><p><strong>Results: </strong>Smooth muscle myosin filaments produced more force than skeletal and mollusk myosin filaments when normalized per filament overlap. Skeletal muscle myosin propelled actin filaments in a higher sliding velocity than smooth muscle myosin. The values for force and velocity were consistent with previous studies using myosin molecules, and suggest a close correlation with the myosin isoform and structure of surface loop 1.</p><p><strong>General significance: </strong>The technique using micro-fabricated cantilevers to measure force of filaments allows for the investigation of the relation between myosin structure and contractility, allowing experiments to be conducted with an array of different myosin isoforms. Using the technique we observed that the work produced by myosin molecules is regulated by amino-acid sequences aligned in specific loops.</p>","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":"1830 3","pages":"2710-9"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31429527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WITHDRAWN: Hsp70 overexpression coordinately regulates myocardial hypertrophy, fibrosis and contractile function in 5-HT(2B) blockade mediated anti-hypertrophic effect. 撤回:Hsp70过表达在5-羟色胺(2B)阻断介导的抗肥厚作用中协调调节心肌肥厚、纤维化和收缩功能
Biochimica et biophysica acta Pub Date : 2012-05-29 DOI: 10.1016/j.bbadis.2012.05.011
Saurabh Bharti, Ratnakar Singh, Rajiv Kumar, Salma Malik, Tajamul Hussain, Omar S Al-Attas, Dharamvir Singh Arya
{"title":"WITHDRAWN: Hsp70 overexpression coordinately regulates myocardial hypertrophy, fibrosis and contractile function in 5-HT(2B) blockade mediated anti-hypertrophic effect.","authors":"Saurabh Bharti, Ratnakar Singh, Rajiv Kumar, Salma Malik, Tajamul Hussain, Omar S Al-Attas, Dharamvir Singh Arya","doi":"10.1016/j.bbadis.2012.05.011","DOIUrl":"10.1016/j.bbadis.2012.05.011","url":null,"abstract":"<p><p>This article has been withdrawn at the request of the editors. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.</p>","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":" ","pages":"None"},"PeriodicalIF":0.0,"publicationDate":"2012-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30662136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A special issue in tribute to John F. Oram. 这是向约翰·f·奥拉姆致敬的特刊。
Biochimica et biophysica acta Pub Date : 2012-03-01
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引用次数: 0
WITHDRAWN: Evidence for the critical roles of NF-κB p65 and specificity proteins in the apoptosis-inducing activity of proteasome inhibitors in leukemia cells. 撤回:NF-κB p65 和特异性蛋白在蛋白酶体抑制剂诱导白血病细胞凋亡活性中发挥关键作用的证据。
Biochimica et biophysica acta Pub Date : 2012-01-10 DOI: 10.1016/j.bbadis.2012.01.002
Simone Reuter, Subash C Gupta, Ramaswamy Kannappan, Bharat B Aggarwal
{"title":"WITHDRAWN: Evidence for the critical roles of NF-κB p65 and specificity proteins in the apoptosis-inducing activity of proteasome inhibitors in leukemia cells.","authors":"Simone Reuter, Subash C Gupta, Ramaswamy Kannappan, Bharat B Aggarwal","doi":"10.1016/j.bbadis.2012.01.002","DOIUrl":"10.1016/j.bbadis.2012.01.002","url":null,"abstract":"<p><p>This article has been withdrawn at the request of editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.</p>","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":" ","pages":"None"},"PeriodicalIF":0.0,"publicationDate":"2012-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870997/pdf/nihms523603.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30403764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstracts of the 17th European Bioenergetics Conference, September 15-20, 2012, Freiburg, Germany. 第17届欧洲生物能量学会议摘要,2012年9月15-20日,德国弗莱堡。
Biochimica et biophysica acta Pub Date : 2012-01-01
{"title":"Abstracts of the 17th European Bioenergetics Conference, September 15-20, 2012, Freiburg, Germany.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":"1817 Suppl ","pages":"S1-162"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31002995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "Statin blocks Rho/Rho-kinase signalling and disrupts the actin cytoskeleton: relationship to enhancement of LPS-mediated nitric oxide synthesis in vascular smooth muscle cells" [Biochem.Biophys.Acta 1689(2004)267-72]. “他汀类药物阻断Rho/Rho激酶信号传导并破坏肌动蛋白细胞骨架:与血管平滑肌细胞中脂多糖介导的一氧化氮合成增强的关系”[生物化学,生物物理学]。学报1689(2004)267 - 72]。
Biochimica et biophysica acta Pub Date : 2011-09-01
{"title":"Retraction notice to \"Statin blocks Rho/Rho-kinase signalling and disrupts the actin cytoskeleton: relationship to enhancement of LPS-mediated nitric oxide synthesis in vascular smooth muscle cells\" [Biochem.Biophys.Acta 1689(2004)267-72].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":"1812 9","pages":"1200"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29956449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proceedings of the 11th Meeting of the European Calcium Society. September 6-9, 2010. Warsaw, Poland. 欧洲钙学会第11届会议论文集。2010年9月6日至9日。华沙,波兰。
Biochimica et biophysica acta Pub Date : 2011-05-01
{"title":"Proceedings of the 11th Meeting of the European Calcium Society. September 6-9, 2010. Warsaw, Poland.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":" ","pages":"908-1127"},"PeriodicalIF":0.0,"publicationDate":"2011-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29857912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Special issue in honor of Klaus Ruckpaul. 纪念克劳斯·拉克保罗的特刊。
Biochimica et biophysica acta Pub Date : 2011-01-01
{"title":"Special issue in honor of Klaus Ruckpaul.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":"1814 1","pages":"1-264"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29751183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ferritin: structures, properties and applications. Special issue dedicated to Pauline M. Harrison. 铁蛋白:结构、性质及应用。宝琳·m·哈里森的特刊。
Biochimica et biophysica acta Pub Date : 2010-08-01
{"title":"Ferritin: structures, properties and applications. Special issue dedicated to Pauline M. Harrison.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":"1800 8","pages":"687-897"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29180718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstracts of the 16th European Bioenergetics Conference, 17-22 July 2010, Warsaw, Poland. 第16届欧洲生物能量学会议摘要,2010年7月17-22日,波兰华沙。
Biochimica et biophysica acta Pub Date : 2010-07-01
{"title":"Abstracts of the 16th European Bioenergetics Conference, 17-22 July 2010, Warsaw, Poland.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8811,"journal":{"name":"Biochimica et biophysica acta","volume":"1797 Suppl ","pages":"1-144"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29271432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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