Archivos peruanos de patologia y clinica最新文献

{"title":"Fibromatosis ligamentoide mesentérica","authors":"Verónica García Yllán, María de Jesús Checa Peña, Severino Rey Nodar","doi":"10.47579/ap.v3.i2.0091","DOIUrl":"https://doi.org/10.47579/ap.v3.i2.0091","url":null,"abstract":"La fibromatosis ligamentoide (fibromatosis invasiva, fibroma desmoide) es una neoplasia mesenquimatosa, intermedia entre los tumores benignos y malignos, de origen fibroso, que de manera infrecuente puede afectar el mesenterio. Se presenta el caso de un paciente masculino con tumoración fibrosa intraabdominal a nivel de raíz de mesenterio. Se realiza una revisión de la literatura.","PeriodicalId":87886,"journal":{"name":"Archivos peruanos de patologia y clinica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74012588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linfadenitis axilar por silicona. Presentación de un caso diagnosticado por punción aspiración con aguja fina","authors":"A. Pérez López, María Victoria López Soto, Reynaldo Álvarez Santana","doi":"10.47579/ap.v3.i2.0094","DOIUrl":"https://doi.org/10.47579/ap.v3.i2.0094","url":null,"abstract":"La linfadenopatía por silicona es una rara complicación en pacientes con implantes mamarios, a menudo es confundida con tumores primarios o secundarios. Se trata de una paciente femenina de 42 años, con implantes mamarios desde hace 12 años, que consulta por presentar dolor y aumento de volumen axilar bilateral. Se realizó ultrasonido, mamografía y punción aspiración con aguja fina, donde se apreciaron: histiocitos y células gigantes fagocitando las partículas de silicona, entremezclada con linfocitos. Hicieron explante de las prótesis y vaciamiento axilar del primer nivel bilateral. El caso reportado evidencia la utilidad de la punción aspiración con aguja fina como herramienta para el diagnóstico diferencial de adenopatías axilares en pacientes con prótesis mamarias.","PeriodicalId":87886,"journal":{"name":"Archivos peruanos de patologia y clinica","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77032353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inusual localización de un tumor inusual. Comunicación breve de un caso","authors":"J. Lagos, Adoni Duarte","doi":"10.47579/ap.v3.i2.0093","DOIUrl":"https://doi.org/10.47579/ap.v3.i2.0093","url":null,"abstract":"El adenocarcinoma de células caliciformes o goblet cell carcinoma, es una neoplasia poco frecuente, reconocida por la OMS, que característicamente presenta componente mixto: exocrino y endocrino. Es un tumor casi exclusivo del apéndice cecal, pero se han reportado situaciones en las que surge en otros segmentos del tubo digestivo. Se presenta el caso de un hombre de 86 años con adenocarcinoma de células caliciformes extrapendicular en colon derecho. El estudio morfológico del apéndice cecal no demostró neoplasia. Se revisa la literatura referente a esta infrecuente neoplasia.","PeriodicalId":87886,"journal":{"name":"Archivos peruanos de patologia y clinica","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79524520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Displasia alveolo-capilar con mal alineamiento de las venas pulmonares. Reporte de un caso sobreviviente","authors":"Fermín Lobo, Haimar Hernández Jiménez, Severino Rey","doi":"10.47579/ap.v3.i1.0084","DOIUrl":"https://doi.org/10.47579/ap.v3.i1.0084","url":null,"abstract":"La displasia alveolo-capilar con mal alineamiento de venas pulmonares es una malformación congénita letal en la mayoría de los casos que consiste en el desarrollo vascular anómalo de los pulmones asociado a hipertensión pulmonar severa del recién nacido y desarrollo de insuficiencia cardíaca fatal. Recientemente se han descrito casos de afectación localizada en uno o ambos pulmones asociados a supervivencia a largo plazo en algunos pacientes. Se reporta el caso de un recién nacido y se describen los hallazgos histopatológicos encontrados en la biopsia pulmonar realizada.","PeriodicalId":87886,"journal":{"name":"Archivos peruanos de patologia y clinica","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84515560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental finding of a primary cardiac leiomyosarcoma originating from the right atrium of a 25-year old male. A Case Report","authors":"Anna Katrina M. Donato, Felipe, Jr. S. Templo","doi":"10.47579/ap.v3.i1.0085","DOIUrl":"https://doi.org/10.47579/ap.v3.i1.0085","url":null,"abstract":"BACKGROUND: Primary cardiac tumors are extremely rare and encompass less than 1% of all documented cardiac neoplasms with a majority of these being benign. Among the malignant primary cardiac tumors, leiomyosarcoma accounts for only 1% all documented cases and it commonly involves the left atrium. We present a rare case of a primary cardiac leiomyosarcoma originating from the right atrium of a 25-year-old male.CASE: The patient was a 25-year-old Filipino male who presented with progressive dyspnea, orthopnea, and a large, heterogenous, ovoid mass attached at the atrial septum measuring 7.0 cm x 3.16cm in widest dimension on 2D-echocardiography. The patient eventually underwent emergency excision of the right atrial mass. Post-operatively, the patient did not tolerate the procedure and ultimately expired after attempts of cardiopulmonary resuscitation.HISTOPATHOLOGIC FINDINGS: Microscopic sections show a spindle-cell neoplasm with irregular fascicles and whorled configurations interspersed with inflammatory cells in a fibromyxoid stroma. The spindle cells showed pleomorphic, hyperchromatic nuclei, some with prominent nucleoli and eosinophilic cytoplasm. Mitotic figures, areas of necrosis, and hemorrhages are seen. Immunohistochemical studies show reactivity of the neoplastic cells to Smooth Muscle Actin (SMA) and Vimentin. Masson’s Trichrome Stain is also positive. S100, Myogenin, and Desmin show non-reactivity. Proliferation index is at 15-20% using Ki-67 and p53.CONCLUSION: Primary cardiac leiomyosarcoma is an extremely rare tumor occurring in less than 1% of all documented primary malignant cardiac neoplasms. Metastases originating from other sites are more common. It has an aggressive clinical course and a dismal prognosis with features overlapping that of other soft tissue neoplasms. Hence, additional immunohistochemical studies and special stains should be employed to arrive with a definitive diagnosis so that appropriate management and intervention may be offered to affected patients.","PeriodicalId":87886,"journal":{"name":"Archivos peruanos de patologia y clinica","volume":"169 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78704787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Hridaya to the heart. Contributions by the ancient Indian masters of Ayurveda to the discovery of the cardiovascular system","authors":"Aditya D. Kulkarni, Singaravel Saranya","doi":"10.47579/ap.v3.i1.0083","DOIUrl":"https://doi.org/10.47579/ap.v3.i1.0083","url":null,"abstract":"The history of discovery of the cardiovascular system (CVS) is a fascinating story full of twists, wrong turns and insightful revelations, contributed to by philosophers and physicians the world over. However, whenever this history is discussed, the contributions described in Ayurveda, the traditional healthcare discipline of India, are overlooked.\u0000Ayurveda is one of the oldest traditional healthcare systems in the world with sound theoretical and practical foundations. The ancient masters of Ayurveda discoursed prolifically on all aspects of medicine and surgery, including the structure and function of the heart and circulatory system.\u0000In this short article, we discuss the history of discovery of various aspects of the CVS, highlighting the many contributions of the Ayurvedic School of Medicine.","PeriodicalId":87886,"journal":{"name":"Archivos peruanos de patologia y clinica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90620917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tres escenarios diferentes de lesiones pseudotumorales biliopancreáticas","authors":"Manuel. F Molina Centelles, Liliana F. Castillo Paredes, Judith Pérez Rojas","doi":"10.47579/ap.v3.i1.0088","DOIUrl":"https://doi.org/10.47579/ap.v3.i1.0088","url":null,"abstract":"Las lesiones pseudotumorales biliopancreáticas son lesiones infrecuentes formadoras de masas que pueden conllevar una clínica obstructiva y simular una neoplasia. El diagnóstico definitivo se realiza tras el estudio anatomopatológico, generalmente de la pieza quirúrgica. La etiología más frecuente es la inflamatoria autoinmune, encontrándose también lesiones sólido-quísticas. En este sentido, describimos tres casos clínico-patológicos con un diagnóstico de sospecha de adenocarcinoma en los que el estudio anatomopatológico informó tres patologías benignas pancreáticas. El objetivo es contribuir a su evidencia científica y el correcto diagnóstico, evaluación y seguimiento de las patologías descritas a pesar de su infrecuencia.","PeriodicalId":87886,"journal":{"name":"Archivos peruanos de patologia y clinica","volume":"23 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72398140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aneurysm of the membranous septum. A potential cause of sudden death","authors":"R. Kothari, Pranita Zare, P. Vaideeswar","doi":"10.47579/ap.v3.i1.0082","DOIUrl":"https://doi.org/10.47579/ap.v3.i1.0082","url":null,"abstract":"Aneurysms of the membranous septum are extremely rare malformations that are usually asymptomatic. However, they have the potential for varied complications including sudden cardiac death. Reported here is a case of sudden death in a 25-year-old woman. A medico-legal autopsy revealed a large aneurysm of the membranous septum. It is speculated that the infiltration of fibrous tissue from the aneurysm into the atrioventricular conduction axis may have led to the observed mortality.","PeriodicalId":87886,"journal":{"name":"Archivos peruanos de patologia y clinica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75526161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Características radiológicas de las lesiones del tórax","authors":"Severino Rey, Juan Esteban Huerta Brunel, Inmaculada Concepción Pérez Caballero, C. Cárdenas","doi":"10.47579/ap.v3.i1.0087","DOIUrl":"https://doi.org/10.47579/ap.v3.i1.0087","url":null,"abstract":"Las neoplasias torácicas pueden ser benignas y malignas, y afectar a cada uno de los componentes del tórax, siendo las más frecuentes las metástasis derivadas de las propias neoplasias primarias y de las neoplasias extratorácicas. Las imágenes constituyen un aspecto integral en la evaluación de pacientes con neoplasias en el tórax que por lo general provocan quejas indolentes o inespecíficas. La evaluación comienza con una radiografía de tórax y puede ser complementada por técnicas de imágenes más avanzadas con tomografía computarizada, resonancia magnética y Tomografía por Emisión de Positrones con Fluorodesoxiglucosa. El radiólogo es responsable de distinguir los procesos neoplásicos de las complicaciones asociadas y secundarias al tratamiento. El análisis radiográfico de las anomalías torácicas constituye un desafío dada la superposición de numerosas estructuras anatómicas de diversas morfologías y densidades radiológicas.","PeriodicalId":87886,"journal":{"name":"Archivos peruanos de patologia y clinica","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78309784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological characteristics and immunophenotype of six cases of cardiac myofibroblastic sarcoma in a single tertiary hospital, Philippine Heart Center, from 2000 to 2018","authors":"Glenn Nathaniel S.D. Valloso, F. Templo, A. D. de Luna","doi":"10.47579/ap.v3.i1.0086","DOIUrl":"https://doi.org/10.47579/ap.v3.i1.0086","url":null,"abstract":"Myofibroblastic sarcoma (MS) is a rare malignant tumor of myofibroblast. Myofibroblasts were primarily described by Gabbiani et al. by means of electron microscopy. These spindle cells have features common with smooth muscle cells and fibroblast. Vasudev et al. first reported the pathologic characteristics of MS in 1978. Mentzel et al. coined the term “low-grade MS” after immunohistochemical and ultrastructural profiling in a series of cases. This study was undertaken to analyze the clinicopathologic, histopathologic, and immunohistochemical characteristics of MS cases arising in the heart. \u0000This is a descriptive study performed at the Philippine Heart Center. All twelve cases diagnosed as cardiac MS and other cardiac spindle cell tumors included in the Philippine Heart Center Pathology Cardiac Registry from 2000 to 2018 were reviewed. Six of the twelve cases were later proven or reclassified as MS. \u0000The six patients with MS were composed of three males (50%) and three females (50%) with a mean age of 57.5 and SD of 9.91. Four of the cases were from the left atrium (68%), one was from the right atrium (16%), and one was biatrial (16%). The tumor size ranged from 3.0 to 8.7 cm with a mean size of 5.57 cm and SD of 1.60. All six cases were treated surgically; four by excision (68%), one by debulking (16%), and one by both excision and debulking (16%). Histologically, the six tumors were predominantly composed of pleomorphic to monomorphic spindle cells arranged in syncytium, storiform, fascicles, and dense cellular sheets, some are intersecting at angles. The individual tumor cells are spindled with elongated nuclei with blunted ends, granular to open chromatin pattern, inconspicuous nucleoli, and scanty to moderate amount of eosinophilic to amphophilic cytoplasm. Cytoplasmic membrane are indistinct. Lymphoplasmacytic infiltrates are present with a mean of 28.67 per 10 high power fields, range of 7-91, and SD of 33.07. Mitosis are present with a mean of 12.17 per 10 high power fields, range of 3-32, and SD of 10.93. Necrosis of less than 50% is present in 4 of 6 cases (67%). Two cases (33%) showed no necrosis. Trichrome stain showed collagen deposits in five of six cases (83%). Immunohistochemically, all six cases of MS showed reactivity for vimentin and smooth muscle actin (100%). Three of six cases were reactive to calponin (50%). All six cases show non-reactivity against h-caldesmon (0%). Two of the six cases were reactive with desmin (33%). Two of the six cases were reactive with CD99 (33%). Only one of six cases were reactive to pancytokeratin (17%). No significant differences between proliferation indices using Ki-67 and p53 were observed. \u0000The application of the panel of immunohistochemical stains can aid in the diagnosis of MS in particular h-caldesmon which when negative rules-out smooth muscle tumors. MS consistently expresses vimentin and smooth muscle actin. Expression of calponin, desmin, and CD99 is variable. Prognostic value of proli","PeriodicalId":87886,"journal":{"name":"Archivos peruanos de patologia y clinica","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81177294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}