{"title":"Mitochondrial disease: Replacing the powerhouse of the cell","authors":"Mallory I. Frederick","doi":"10.5206/uwomj.v88i2.8067","DOIUrl":"https://doi.org/10.5206/uwomj.v88i2.8067","url":null,"abstract":"The mitochondria are called the powerhouses of the cell because they make most of the energy required by our cells. Diseases caused by mitochondrial mutations always occur in the children of women with mitochondrial disease and, due to this central role in energy production, can be extremely detrimental. A recently developed preventative therapy, mitochondrial replacement therapy, reduces carryover of mitochondrial disease from mother to child. Though these “three-parent babies” are born without mitochondrial disease, this type of gene editing carries ethical implications and unexplored effects on future generations.","PeriodicalId":87852,"journal":{"name":"University of Western Ontario medical journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81425265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Do no harm","authors":"Hasan Hawilo, E. Quint","doi":"10.5206/uwomj.v88i2.7302","DOIUrl":"https://doi.org/10.5206/uwomj.v88i2.7302","url":null,"abstract":"Physician wellness and burnout have long been important topics in Canadian health care. Though burnout presents in various occupations, physicians experience unique professional challenges that predispose them to experience burnout. Elements inciting this chronic condition are introduced early in medical education, reinforced during residency training, and poorly addressed during clinical practice. Substantial evidence demonstrates that burnout has significant and undesirable impacts on patient outcomes and care delivery. Physician quality of life and well-being as well as health care spending are also negatively impacted by burnout. However, there is an ongoing need to apply these research results in the clinical setting. Currently, research suggests that individual, cultural, and organizational factors play a role in the development and maintenance of burnout. Best practices to prevent burnout and manage its effects, including interventions during medical education and greater work autonomy, are required to address barriers to wellness at each of these levels.","PeriodicalId":87852,"journal":{"name":"University of Western Ontario medical journal","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80720612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Funding options for the management of major depressive disorder in Canada","authors":"C. Piccininni, J. Fletcher","doi":"10.5206/uwomj.v88i2.7918","DOIUrl":"https://doi.org/10.5206/uwomj.v88i2.7918","url":null,"abstract":"Major depressive disorder (MDD) is highly prevalent in Canada and the care and support of individuals affected by this illness is associated with high societal costs. In this article, we provide a sample case of a patient diagnosed with MDD, and present different management and funding options that would be available to her in the current health care system. We demonstrate that there exists a large degree of variability in services that can be accessed based on type of insurance coverage. As a result of the high cost of care for MDD, many patients have immense difficulty funding a prescription for antidepressants or a course of psychological therapy. Yet leaving mental illness untreated is associated with greater costs due to worse patient outcomes. Increased investment in effective prevention and early intervention efforts may be one way to bring about long-term cost savings.","PeriodicalId":87852,"journal":{"name":"University of Western Ontario medical journal","volume":"334 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86786446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Virtual reality exposure-based therapy as an emerging treatment modality for anxiety disorders","authors":"Wenxuan Wang, Sean Wong","doi":"10.5206/uwomj.v88i2.7920","DOIUrl":"https://doi.org/10.5206/uwomj.v88i2.7920","url":null,"abstract":"Anxiety disorders are the most prevalent mental health condition, affecting one-third of the population during their lifetime. Patient with anxiety may experience overwhelming fear to an irrational fear that can impair everyday functioning. Current treatment for anxiety disorders include pharmacological (i.e. selective serotonin reuptake inhibitors) and psychological (i.e. cognitive behavioural therapy) intervention. Cognitive behavioural therapy is an effective exposure-based therapy utilizing repetitive exposure to the feared stimulus to develop desensitization and tolerance but holds high dropout rates due to unbearable anxiety for patients. Recognizing this challenge, virtual reality technology is emerging as a promising tool for patients to challenge their fear in a simulated environment based on individual progression. This article explores the new development of virtual reality technology as an effective treatment modality for anxiety disorders to enhance current approaches in mental health care.","PeriodicalId":87852,"journal":{"name":"University of Western Ontario medical journal","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88490938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An exploration of sociological factors that contribute to physician burnout","authors":"Jennifer R. Gray","doi":"10.5206/uwomj.v88i2.7301","DOIUrl":"https://doi.org/10.5206/uwomj.v88i2.7301","url":null,"abstract":"A discussion about mental health and how it relates to the medical profession is incomplete without exploring the concept of burnout. The implications of physician burnout are profound, and it is plaguing the medical community at epidemic rates. Current research focuses on which occupational factors may be contributing to this problem. Other approaches involve investigating the efficacy of building resilience at the individual level as a means of combatting burnout. Examining this issue through a broader lens and considering sociocultural factors that may be influencing how medicine is experienced by those in the field is remarkably untouched in the literature. This article will discuss how several changes in contemporary Canadian society may be underlying factors in physician burnout. The increasing penetrance of the internet into patient-physician interactions, the rise of online review platforms and widespread secularization in a domain that continues to face issues that evidence-based medicine fails to explain will all be addressed. This is merely a preliminary discussion to fortify current initiatives aimed at promoting awareness of and preventing physician burnout. ","PeriodicalId":87852,"journal":{"name":"University of Western Ontario medical journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80046265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interventions to improve recruitment and retention of physicians in rural and remote Canada: a systematic review","authors":"C. Lafortune, J. Gustafson","doi":"10.5206/uwomj.v88i1.6184","DOIUrl":"https://doi.org/10.5206/uwomj.v88i1.6184","url":null,"abstract":"Purpose: Rural and remote regions of Canada struggle to attract and retain an adequate healthcare workforce to provide the healthcare needed by their local residents. The purpose of this systematic review is to explore current literature that has analyzed strategies for recruitment and retention of physicians to rural and remote regions in Canada. \u0000Methods: Scopus and PubMed were searched for articles. To be included in the review, the titles yielded from the initial search had to be in English and meet one of the inclusion criteria: (1) address rural and/or remote healthcare, (2) focus on medical students or physicians, and (3) discuss recruitment or retention strategies. Titles were excluded that discussed non-OECD countries, or that were not original journal articles. The final sample of articles were analyzed by both reviewers for content and emerging themes. \u0000Summary of Results and Conclusion: The initial search yielded a total of 3397 titles for review. After applying criteria described above, 35 articles remained for review. A variety of recruitment and retention themes were identified targeting physicians before, during, and after their medical education. The most effective strategies consistently appear to be those aimed before medical education, specifically admitting medical students who have a rural background. This review aims to provide a summary of the currently available research to assist with evidence-based decision making to increase supply and retention of rural physicians. \u0000","PeriodicalId":87852,"journal":{"name":"University of Western Ontario medical journal","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82601568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inborn errors of metabolism in newcomer and refugee populations in Ontario, CA","authors":"Srinitya Gannavarapu, M. Prasad, C. Prasad","doi":"10.5206/uwomj.v88i1.6187","DOIUrl":"https://doi.org/10.5206/uwomj.v88i1.6187","url":null,"abstract":"Inborn errors of metabolism (IEM) are a heterogenous group of rare, inherited disorders that impair the biochemical processes involved in metabolism. Many are treated with various restrictive diets in early infancy, prior to the appearance of symptoms to improve the overall outcomes of the affected individuals. Identification of individuals at a risk of developing metabolic disorders through newborn screening (NBS) programs and the subsequent early diagnosis and treatment are an invaluable aspect of healthcare in Canada. Incorporation of Canada’s expanding population of refugees and new immigrants presents with potential challenges and changes. Without the availability of NBS programs in many countries contributing to the refugee influx in Canada, it may be difficult to identify patients who are affected with these rare conditions. This article discusses: 1) the utility of newborn screening and diagnosis of metabolic diseases in immigrant and refugee populations, with complex medical presentations, and 2) a recent diagnosis of succinic semialdehyde dehydrogenase deficiency (an IEM) in a refugee child past the age limit of NBS. An increasingly complicated and diverse refugee population requires a need for revision of existing healthcare practices pertaining to the diagnosis of rare diseases.","PeriodicalId":87852,"journal":{"name":"University of Western Ontario medical journal","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84031438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary health care of marginalized and refugee populations","authors":"Jovana Momic, Ruchi Sharan","doi":"10.5206/uwomj.v88i1.6236","DOIUrl":"https://doi.org/10.5206/uwomj.v88i1.6236","url":null,"abstract":"Dr. Allison Henderson is a local family physician with a passion for refugee healthcare and treating London’s most marginalized populations. After completing her medical training and pursuing additional studies at the London School of Hygiene and Tropical Medicine in the UK, she spent over four years working as a physician in rural communities in subSaharan Africa. Since returning to London in 2016, she has been working at the London Intercommunity Health Center (LIHC) and Cross Cultural Learner Center (CCLC), where she treats newly arrived Syrian and Yazidi refugees and some of London’s most disadvantaged populations. We had the privilege of meeting Dr. Henderson at the LIHC to discuss her work with refugee populations who have experienced severe trauma and ways that her team is helping them cope and start to heal.","PeriodicalId":87852,"journal":{"name":"University of Western Ontario medical journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83518272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"“Our people are feeling there’s no hope for the future”: Indigenous teenagers and youth culture as a coping strategy in the archive of the Sioux Lookout Zone Hospital, 1969-1996","authors":"North de Pencier, Drishti Dhawan, G. McKinley","doi":"10.5206/uwomj.v88i1.6109","DOIUrl":"https://doi.org/10.5206/uwomj.v88i1.6109","url":null,"abstract":"Introduction: To analyze the use of youth culture as a coping mechanism by youth in the Sioux Lookout Zone from 1969 to 1996. \u0000Method: This project employs an archival research method to study the records of the Sioux Lookout Zone Hospital, located at the University of Toronto. The hospital was operated by the federal government for Status Indians. From 1969 to 1996, the hospital’s medical service was provided by the University of Toronto. \u0000Discussion: The period of 1969 to 1996 was a challenging time for teenagers in the Sioux Lookout Zone. They had poor job prospects and often struggled with the loneliness of attending high school in southern communities. They turned to youth culture as a coping mechanism, sometimes in healthier ways such as rock music and fashion, but also in less healthy ways such as substance use and gang membership. \u0000Conclusion: This project serves as a case study of the challenges that faced youth in the Sioux Lookout Zone in order to contribute to our understanding of the historical antecedents of the poor health outcomes of youth in the Sioux Lookout Zone today.","PeriodicalId":87852,"journal":{"name":"University of Western Ontario medical journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82070033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Taking Down Statues","authors":"M. Lund","doi":"10.5206/uwomj.v88i1.6178","DOIUrl":"https://doi.org/10.5206/uwomj.v88i1.6178","url":null,"abstract":"In 2018, demands to remove a statue of James Marion Sims – the inventor of the vaginal speculum and a number of revolutionary surgical techniques – continue a recent trend that has seen a re-evaluation of the legacy of the man known as the “father of gynecology” as well as other historical figures. His innovations, which revolutionized women’s surgical care, came as the result of horrific experimentation on slave women. Despite the availability of anaesthetic agents, he used none during his experiments. One of his subjects was operated on thirty times. Beginning in the late 20th century, revisionist historians started to draw attention to his unethical and inhumane experiments and have begun to view him not as a medical pioneer but as an oppressor. However, in textbooks as well as in the academic literature, the medical community continues to hold a predominantly positive and uncritical view of Sims and his experiments. In this paper, a brief history of Sims’ surgical experiments and contributions to gynecology is described. His surgical legacy is discussed, and contemporaneous and modern reactions to his experiments are compared. Finally, a brief discussion of the relevance of historical mistreatment on the healthcare of vulnerable populations is provided.","PeriodicalId":87852,"journal":{"name":"University of Western Ontario medical journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78785722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}