Biochemistry and Cell Biology最新文献_第10页

Dysregulation of insulin-like growth factor-1 signaling in postnatal bone elongation. 出生后骨伸长中胰岛素样生长因子-1信号传导的失调。

IF 2.9 3区生物学

Biochemistry and Cell Biology Pub Date : 2023-10-01 Epub Date: 2023-05-29 DOI: 10.1139/bcb-2023-0025

Cassaundra A White, Maria A Serrat

引用次数: 0

AKT1 participates in ferroptosis vulnerability by driving autophagic degradation of FTH1 in cisplatin-resistant ovarian cancer. AKT1通过驱动FTH1在顺铂耐药的卵巢癌症中的自噬降解参与脱铁性疾病的易感性。

IF 2.9 3区生物学

Biochemistry and Cell Biology Pub Date : 2023-10-01 Epub Date: 2023-04-03 DOI: 10.1139/bcb-2022-0361

Zhikun Shi, Hao Yuan, Lanqing Cao, Yang Lin

引用次数: 1

Mechanism of myocardial fibrosis regulation by IGF-1R in atrial fibrillation through the PI3K/Akt/FoxO3a pathway. IGF-1R通过PI3K/Akt/FoxO3a途径调节心房颤动心肌纤维化的机制。

IF 2.9 3区生物学

Biochemistry and Cell Biology Pub Date : 2023-10-01 Epub Date: 2023-04-05 DOI: 10.1139/bcb-2022-0199

Pei Zhang, Huilin Li, An Zhang, Xiao Wang, Qiyuan Song, Zhan Li, Weizong Wang, Jingwen Xu, Yinglong Hou, Yong Zhang

{"title":"Mechanism of myocardial fibrosis regulation by IGF-1R in atrial fibrillation through the PI3K/Akt/FoxO3a pathway.","authors":"Pei Zhang, Huilin Li, An Zhang, Xiao Wang, Qiyuan Song, Zhan Li, Weizong Wang, Jingwen Xu, Yinglong Hou, Yong Zhang","doi":"10.1139/bcb-2022-0199","DOIUrl":"10.1139/bcb-2022-0199","url":null,"abstract":"Atrial structural remodeling takes on a critical significance to the occurrence and maintenance of atrial fibrillation (AF). As revealed by recent data, insulin-like growth factor-1 receptor (IGF-1R) plays a certain role in tissue fibrosis. In this study, the mechanism of IGF-1R in atrial structural remodeling was examined based on in vivo and in vitro experiments. First, cluster analysis of AF hub genes was conducted, and then the molecular mechanism was proposed by which IGF-1R regulates myocardial fibrosis via the PI3K/Akt/FoxO3a pathway. Subsequently, the mentioned mechanism was verified in human cardiac fibroblasts (HCFs) and rats transduced with IGF-1 overexpression type 9 adeno-associated viruses. The results indicated that IGF-1R activation up-regulated collagen Ⅰ protein expression and Akt phosphorylation in HCFs and rat atrium. The administration of LY294002 reversed the above phenomenon, improved the shortening of atrial effective refractory period, and reduced the increased incidence of AF and atrial fibrosis in rats. The transfection of FoxO3a siRNA reduced the anti-fibrotic effect of LY294002 in HCFs. The above data revealed that activation of IGF-1R takes on a vital significance to atrial structural remodeling by facilitating myocardial fibrosis and expediting the occurrence and maintenance of AF through the regulation of the PI3K/Akt/FoxO3a signaling pathway.","PeriodicalId":8775,"journal":{"name":"Biochemistry and Cell Biology","volume":" ","pages":"432-442"},"PeriodicalIF":2.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9827091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum pro-surfactant protein B is correlated with clinical properties in osteosarcoma patients. 骨肉瘤患者血清表面活性物质前体蛋白B与临床特性相关。

IF 2.9 3区生物学

Biochemistry and Cell Biology Pub Date : 2023-10-01 Epub Date: 2023-05-16 DOI: 10.1139/bcb-2022-0179

Shi Feng, Di Fu, Yong Zhang, Le Zhang, Yingnan Ji, Hongqiu Li, Liang A

引用次数: 0

Telomere biology and ribosome biogenesis: structural and functional interconnections. 端粒生物学和核糖体生物发生：结构和功能的相互联系。

IF 2.9 3区生物学

Biochemistry and Cell Biology Pub Date : 2023-10-01 Epub Date: 2023-03-29 DOI: 10.1139/bcb-2022-0383

Liia R Valeeva, Liliia R Abdulkina, Inna A Agabekian, Eugene V Shakirov

{"title":"Telomere biology and ribosome biogenesis: structural and functional interconnections.","authors":"Liia R Valeeva, Liliia R Abdulkina, Inna A Agabekian, Eugene V Shakirov","doi":"10.1139/bcb-2022-0383","DOIUrl":"10.1139/bcb-2022-0383","url":null,"abstract":"Telomeres are nucleoprotein structures that play a pivotal role in the protection and maintenance of eukaryotic chromosomes. Telomeres and the enzyme telomerase, which replenishes telomeric DNA lost during replication, are important factors necessary to ensure continued cell proliferation. Cell proliferation is also dependent on proper and efficient protein synthesis, which is carried out by ribosomes. Mutations in genes involved in either ribosome biogenesis or telomere biology result in cellular abnormalities and can cause human genetic diseases, defined as ribosomopathies and telomeropathies, respectively. Interestingly, recent discoveries indicate that many of the ribosome assembly and rRNA maturation factors have additional noncanonical functions in telomere biology. Similarly, several key proteins and enzymes involved in telomere biology, including telomerase, have unexpected roles in rRNA transcription and maturation. These observations point to an intriguing cross-talk mechanism potentially explaining the multiple pleiotropic symptoms of mutations in many causal genes identified in various telomeropathy and ribosomopathy diseases. In this review, we provide a brief summary of eukaryotic telomere and rDNA loci structures, highlight several universal features of rRNA and telomerase biogenesis, evaluate intriguing interconnections between telomere biology and ribosome assembly, and conclude with an assessment of overlapping features of human diseases of telomeropathies and ribosomopathies.","PeriodicalId":8775,"journal":{"name":"Biochemistry and Cell Biology","volume":" ","pages":"394-409"},"PeriodicalIF":2.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9368277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astrocyte-specific Ca²⁺ activity: Mechanisms of action, experimental tools, and roles in ethanol-induced dysfunction. 星形胶质细胞特异性Ca2+活性：作用机制、实验工具和在乙醇诱导的功能障碍中的作用。

IF 2.4 3区生物学

Biochemistry and Cell Biology Pub Date : 2023-10-01 Epub Date: 2023-03-29 DOI: 10.1139/bcb-2023-0008

O R Coulter, C D Walker, M-L Risher

{"title":"Astrocyte-specific Ca2+ activity: Mechanisms of action, experimental tools, and roles in ethanol-induced dysfunction.","authors":"O R Coulter, C D Walker, M-L Risher","doi":"10.1139/bcb-2023-0008","DOIUrl":"10.1139/bcb-2023-0008","url":null,"abstract":"Astrocytes are a subtype of non-neuronal glial cells that reside in the central nervous system. Astrocytes have extensive peripheral astrocytic processes that ensheathe synapses to form the tripartite synapse. Through a multitude of pathways, astrocytes can influence synaptic development and structural maturation, respond to neuronal signals, and modulate synaptic transmission. Over the last decade, strong evidence has emerged demonstrating that astrocytes can influence behavioral outcomes in various animal models of cognition. However, the full extent of how astrocytes influence brain function is still being revealed. Astrocyte calcium (Ca2+) signaling has emerged as an important driver of astrocyte-neuronal communication allowing intricate crosstalk through mechanisms that are still not fully understood. Here, we will review the field's current understanding of astrocyte Ca2+ signaling and discuss the sophisticated state-of-the-art tools and approaches used to continue unraveling astrocytes' interesting role in brain function. Using the field of pre-clinical ethanol (EtOH) studies in the context of alcohol use disorder, we focus on how these novel approaches have helped to reveal an important role for astrocyte Ca2+ function in regulating EtOH consumption and how astrocyte Ca2+ dysfunction contributes to the cognitive deficits that emerge after EtOH exposure in a rodent model.","PeriodicalId":8775,"journal":{"name":"Biochemistry and Cell Biology","volume":" ","pages":"410-421"},"PeriodicalIF":2.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10010321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of financial challenges faced by graduate students in Canada. 加拿大研究生面临的财务挑战分析。

IF 2.9 3区生物学

Biochemistry and Cell Biology Pub Date : 2023-08-01 Epub Date: 2023-04-11 DOI: 10.1139/bcb-2023-0021

Sarah Jane Laframboise, Thomas Bailey, Anh-Thu Dang, Mercedes Rose, Zier Zhou, Matthew D Berg, Stephen Holland, Sami Aftab Abdul, Kaela O'Connor, Sara El-Sahli, Dominique M Boucher, Garrett Fairman, Jacky Deng, Katherine Shaw, Nathaniel Noblett, Alexa D'Addario, Madelaine Empey, Keaton Sinclair

{"title":"Analysis of financial challenges faced by graduate students in Canada.","authors":"Sarah Jane Laframboise, Thomas Bailey, Anh-Thu Dang, Mercedes Rose, Zier Zhou, Matthew D Berg, Stephen Holland, Sami Aftab Abdul, Kaela O'Connor, Sara El-Sahli, Dominique M Boucher, Garrett Fairman, Jacky Deng, Katherine Shaw, Nathaniel Noblett, Alexa D'Addario, Madelaine Empey, Keaton Sinclair","doi":"10.1139/bcb-2023-0021","DOIUrl":"10.1139/bcb-2023-0021","url":null,"abstract":"Graduate students are vital to the creation of research and innovation in Canada. The National Graduate Student Finance Survey was launched in 2021 by the Ottawa Science Policy Network to investigate the financial realities of Canadian graduate students. Closing in April 2022, the survey received 1305 responses from graduate students representing various geographical locations, years of study, fields of education, and demographic backgrounds. The results capture a snapshot into graduate student finances, including an in-depth analysis of stipends, scholarships, debt, tuition, and living expenses. In its entirety, we found that the majority of graduate students are facing serious financial concerns. This is largely due to stagnant funding for students both from federal and provincial granting agencies and from within their institutions. This reality is even worse for international students, members of historically underrepresented communities, and those with dependents, all of whom experience additional challenges that impact their financial security. Based on our findings, we propose several recommendations to the Tri-Council agencies (Natural Sciences and Engineering Research Council, Social Science and Humanities Research Council, and Canadian Institute for Health Research) and academic institutions to strengthen graduate student finances and help sustain the future of research in Canada.","PeriodicalId":8775,"journal":{"name":"Biochemistry and Cell Biology","volume":"101 4","pages":"326-360"},"PeriodicalIF":2.9,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9900386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Retraction: Role of the TSLP-DC-OX40L pathway in asthma pathogenesis and airway inflammation in mice. 收缩：TSLP-DC-OX40L通路在小鼠哮喘发病机制和气道炎症中的作用。

IF 2.9 3区生物学

Biochemistry and Cell Biology Pub Date : 2023-08-01 Epub Date: 2023-03-28 DOI: 10.1139/bcb-2023-0071

引用次数: 0

Retraction: MiR-204 suppresses cell proliferation and promotes apoptosis in ovarian granulosa cells via targeting TPT1 in polycystic ovary syndrome. 缩回:MiR-204在多囊卵巢综合征中通过靶向TPT1抑制卵巢颗粒细胞增殖，促进细胞凋亡。

IF 2.9 3区生物学

Biochemistry and Cell Biology Pub Date : 2023-08-01 DOI: 10.1139/bcb-2023-0070

引用次数: 0

Retraction: MiR-301b promotes the proliferation, mobility, and epithelial-to-mesenchymal transition of bladder cancer cells by targeting EGR1. 回缩：MiR-301b通过靶向EGR1促进膀胱癌症细胞的增殖、迁移和上皮-间质转化。

IF 2.9 3区生物学

Biochemistry and Cell Biology Pub Date : 2023-08-01 Epub Date: 2023-03-28 DOI: 10.1139/bcb-2023-0074

引用次数: 0