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Recent Progress in Rapid Biosensor Fabrication Methods: Focus on Electrical Potential Application 快速生物传感器制造方法研究进展:以电势应用为重点
IF 4.3 3区 工程技术
BioChip Journal Pub Date : 2023-11-28 DOI: 10.1007/s13206-023-00127-x
Yejin Yoon, Yein Kwon, Hanbin Park, Siyun Lee, Chulhwan Park, Taek Lee
{"title":"Recent Progress in Rapid Biosensor Fabrication Methods: Focus on Electrical Potential Application","authors":"Yejin Yoon, Yein Kwon, Hanbin Park, Siyun Lee, Chulhwan Park, Taek Lee","doi":"10.1007/s13206-023-00127-x","DOIUrl":"https://doi.org/10.1007/s13206-023-00127-x","url":null,"abstract":"<p>The coronavirus disease pandemic has led to an urgent need for rapid and accurate viral diagnosis. Therefore, rapid biosensors, not only for viruses but also for the detection of bacteria, disease diagnosis, and environmental monitoring, have been actively researched. Biosensors analyze the binding of biomolecules and target substances mainly based on electrochemical, electrical, or optical methods. To achieve precise and rapid diagnosis, it is crucial to reduce the time required for biomolecule–target substance binding. Typically, biomolecules reach the target substances through random diffusion, and to overcome the limitations associated herewith, biosensors have been integrated with alternating current (AC) electrokinetics (ACEK) technology. ACEK, through the application of alternating voltages, converts electrical energy into fluid motion, inducing pumping, mixing, concentration, and separation of the fluid. Its low power consumption makes it highly promising as a point-of-care diagnostic device. In this paper, we review the advancements in three ACEK technologies: AC electrothermal flow, AC electro-osmosis, and AC di-electrophoresis, to discuss the development of rapid biosensor fabrication methods based on electrical potential applications.</p>","PeriodicalId":8768,"journal":{"name":"BioChip Journal","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138514063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining Ultrasound-Mediated Intracellular Delivery with Microfluidics in Various Applications 超声介导的细胞内递送与微流体在各种应用中的结合
IF 4.3 3区 工程技术
BioChip Journal Pub Date : 2023-11-28 DOI: 10.1007/s13206-023-00128-w
Guangyong Huang, Lin Lin, Shixiong Wu, Haojie Dang, Xuesong Cheng, Ying Liu, Hui You
{"title":"Combining Ultrasound-Mediated Intracellular Delivery with Microfluidics in Various Applications","authors":"Guangyong Huang, Lin Lin, Shixiong Wu, Haojie Dang, Xuesong Cheng, Ying Liu, Hui You","doi":"10.1007/s13206-023-00128-w","DOIUrl":"https://doi.org/10.1007/s13206-023-00128-w","url":null,"abstract":"<p>Ultrasound-mediated intracellular delivery is one of the popular technologies based on membrane rupture at present. To date, ultrasound directly acts on a large number of cells to achieve cargo delivery and has been widely used in drug delivery, disease therapy and other fields. However, the existing macroscopic methods can no longer meet the requirements of accurate tracking and analysis and are prone to extensive cell damage and even death. With the rapid advancements in microfluidic technologies, the combination of ultrasound and microfluidics (CUM) technology can effectively improve the delivery efficiency and cell survival rates. This new technology has rapidly become a new direction and focus of research. Thus, we analysed the mechanism of sonoporation and the effect of acoustic waves in a microfluidic channel. In addition, we reviewed the application of these new technologies in terms of structure and fabrication of ultrasound transducers and microfluidic devices. As regards our main objective, we hope to help researchers better understand the future developments and the challenges of new technologies. With this review, researchers can promote the development of new technologies to solve the current challenges of intracellular delivery and advance clinical applications.</p>","PeriodicalId":8768,"journal":{"name":"BioChip Journal","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138514076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid and Ultrasensitive Detection of Staphylococcus aureus Using a Gold-Interdigitated Single-Wave-Shaped Electrode (Au-ISWE) Electrochemical Biosensor 金-互指单波电极(Au-ISWE)电化学生物传感器快速超灵敏检测金黄色葡萄球菌
3区 工程技术
BioChip Journal Pub Date : 2023-11-14 DOI: 10.1007/s13206-023-00126-y
My-Van Tieu, Duc Trung Pham, Hien T. Ngoc Le, Thi Xoan Hoang, Sungbo Cho
{"title":"Rapid and Ultrasensitive Detection of Staphylococcus aureus Using a Gold-Interdigitated Single-Wave-Shaped Electrode (Au-ISWE) Electrochemical Biosensor","authors":"My-Van Tieu, Duc Trung Pham, Hien T. Ngoc Le, Thi Xoan Hoang, Sungbo Cho","doi":"10.1007/s13206-023-00126-y","DOIUrl":"https://doi.org/10.1007/s13206-023-00126-y","url":null,"abstract":"","PeriodicalId":8768,"journal":{"name":"BioChip Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134953791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Controlled Transcription-Driven Light-Up Aptamer Amplification for Nucleoside Triphosphate Detection 三磷酸核苷检测受控转录驱动的点亮适体扩增
3区 工程技术
BioChip Journal Pub Date : 2023-10-25 DOI: 10.1007/s13206-023-00124-0
Deok-Gyu Lee, Hye-Jin Lim, Ha-Yeong Lee, Dong-Myung Kim, Kyung-Ho Lee, Ju-Young Byun, Yong-Beom Shin
{"title":"A Controlled Transcription-Driven Light-Up Aptamer Amplification for Nucleoside Triphosphate Detection","authors":"Deok-Gyu Lee, Hye-Jin Lim, Ha-Yeong Lee, Dong-Myung Kim, Kyung-Ho Lee, Ju-Young Byun, Yong-Beom Shin","doi":"10.1007/s13206-023-00124-0","DOIUrl":"https://doi.org/10.1007/s13206-023-00124-0","url":null,"abstract":"","PeriodicalId":8768,"journal":{"name":"BioChip Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135113970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced Antitumor Effect of the Combination of Bacille Calmette-Guérin and an Immune Checkpoint Inhibitor in Bladder Cancer-On-a-Chip Bacille calmette - gusamrin联合免疫检查点抑制剂对膀胱癌芯片抗肿瘤作用的增强
3区 工程技术
BioChip Journal Pub Date : 2023-10-17 DOI: 10.1007/s13206-023-00125-z
Se Young Choi, Mirinae Kim, Su Jeong Kang, Young Wook Choi, Sejung Maeng, Sung-Hwan Kim, In Ho Chang
{"title":"Enhanced Antitumor Effect of the Combination of Bacille Calmette-Guérin and an Immune Checkpoint Inhibitor in Bladder Cancer-On-a-Chip","authors":"Se Young Choi, Mirinae Kim, Su Jeong Kang, Young Wook Choi, Sejung Maeng, Sung-Hwan Kim, In Ho Chang","doi":"10.1007/s13206-023-00125-z","DOIUrl":"https://doi.org/10.1007/s13206-023-00125-z","url":null,"abstract":"","PeriodicalId":8768,"journal":{"name":"BioChip Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136032790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous Isolation of Stem-Cell-Derived Extracellular Vesicles (SC-EVs) by Recycled Magnetic Beads in Microfluidic Channels 微流控通道中再生磁珠连续分离干细胞来源的细胞外囊泡(sc - ev
3区 工程技术
BioChip Journal Pub Date : 2023-10-04 DOI: 10.1007/s13206-023-00122-2
Haeun Yu, Jaejeung Kim, Jianning Yu, Kyung-A Hyun, Jae-Yol Lim, Yeo-Jun Yoon, Sunyoung Park, Hyo-Il Jung
{"title":"Continuous Isolation of Stem-Cell-Derived Extracellular Vesicles (SC-EVs) by Recycled Magnetic Beads in Microfluidic Channels","authors":"Haeun Yu, Jaejeung Kim, Jianning Yu, Kyung-A Hyun, Jae-Yol Lim, Yeo-Jun Yoon, Sunyoung Park, Hyo-Il Jung","doi":"10.1007/s13206-023-00122-2","DOIUrl":"https://doi.org/10.1007/s13206-023-00122-2","url":null,"abstract":"Stem cells produce nanosized particles known as extracellular vesicles (SC-EVs), which therapeutically affect stem cells. EVs are more abundantly produced, exhibit better stability, and possess lower immune rejection rates than stem cells. However, the traditional methods of isolating EVs, such as ultracentrifugation, possess limitations that require a complex process and consume more time. Moreover, it is difficult to isolate specific EVs that have target surface proteins that affect regenerative effects. To address these limitations, a new dual-mode horseshoe-shaped orifice micromixer (DM-HOMM) chip that can bind antibody-conjugated micromagnetic beads and SC-EVs and sequentially elute specific SC-EVs on the beads using an eluent was developed. For effective elution from the microbead-SC-EV complex, four types of eluents were used to control pH and ionic strength between antibodies and surface proteins in EVs. In addition, we investigated the reusability of antibody-conjugated micromagnetic beads. The beads indicated identical binding efficiencies between the antibodies and specific SC-EVs for three repeated cycles using the dual-mode chip. CD63+ EVs collected by the chip exhibited higher cell viability and regeneration effects than untreated and total EVs. This SC-EVs’ isolation method possesses the potential for targeted therapeutic applications and enhanced regenerative effects.","PeriodicalId":8768,"journal":{"name":"BioChip Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135592564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Thrombosis Formation and Growth Using Microfluidic Chips and Multiphase Computational Fluid Dynamics 基于微流控芯片和多相计算流体动力学的血栓形成和生长分析
3区 工程技术
BioChip Journal Pub Date : 2023-09-28 DOI: 10.1007/s13206-023-00123-1
Dong-Hwi Ham, Ji-Seob Choi, Pyeong-Ho Jeong, Jung-Hyun Kim, Helem Betsua Flores Marcial, Jin-Ho Choi, Woo-Tae Park
{"title":"Analysis of Thrombosis Formation and Growth Using Microfluidic Chips and Multiphase Computational Fluid Dynamics","authors":"Dong-Hwi Ham, Ji-Seob Choi, Pyeong-Ho Jeong, Jung-Hyun Kim, Helem Betsua Flores Marcial, Jin-Ho Choi, Woo-Tae Park","doi":"10.1007/s13206-023-00123-1","DOIUrl":"https://doi.org/10.1007/s13206-023-00123-1","url":null,"abstract":"","PeriodicalId":8768,"journal":{"name":"BioChip Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135387384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
In Vitro Assays of Neurite Outgrowth and Synapse Formation Using Thermoplasmonic Ablation Technique 利用热等离子体消融技术体外测定神经突生长和突触形成
3区 工程技术
BioChip Journal Pub Date : 2023-09-26 DOI: 10.1007/s13206-023-00121-3
Nari Hong, Yoonkey Nam
{"title":"In Vitro Assays of Neurite Outgrowth and Synapse Formation Using Thermoplasmonic Ablation Technique","authors":"Nari Hong, Yoonkey Nam","doi":"10.1007/s13206-023-00121-3","DOIUrl":"https://doi.org/10.1007/s13206-023-00121-3","url":null,"abstract":"","PeriodicalId":8768,"journal":{"name":"BioChip Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134960962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of an Aptamer-Based Signal-On Probe and a Paper-Based Origami Preconcentrator for Small Molecule Biomarkers Detection 基于适配体的信号探针和基于纸张的折纸预浓缩器在小分子生物标志物检测中的集成
3区 工程技术
BioChip Journal Pub Date : 2023-09-21 DOI: 10.1007/s13206-023-00119-x
Na Eun Lee, Ji Hye Hong, Seungmin Lee, Yong Kyoung Yoo, Kang Hyeon Kim, Jeong Soo Park, Cheonjung Kim, Junghyo Yoon, Dae Sung Yoon, Jeong Hoon Lee
{"title":"Integration of an Aptamer-Based Signal-On Probe and a Paper-Based Origami Preconcentrator for Small Molecule Biomarkers Detection","authors":"Na Eun Lee, Ji Hye Hong, Seungmin Lee, Yong Kyoung Yoo, Kang Hyeon Kim, Jeong Soo Park, Cheonjung Kim, Junghyo Yoon, Dae Sung Yoon, Jeong Hoon Lee","doi":"10.1007/s13206-023-00119-x","DOIUrl":"https://doi.org/10.1007/s13206-023-00119-x","url":null,"abstract":"","PeriodicalId":8768,"journal":{"name":"BioChip Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136154594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-Loaded Polyethylene Glycol (PEG) Resin for High-Purity Peptide Synthesis and Cell Binding Assays 用于高纯度肽合成和细胞结合试验的低负荷聚乙二醇(PEG)树脂
3区 工程技术
BioChip Journal Pub Date : 2023-09-19 DOI: 10.1007/s13206-023-00120-4
Seongsoo Kim, Jeeyeon Park, Hye-Won Kim, Jinsik Kim, Joonwon Bae, Min Hee Lee, Dong-Sik Shin
{"title":"Low-Loaded Polyethylene Glycol (PEG) Resin for High-Purity Peptide Synthesis and Cell Binding Assays","authors":"Seongsoo Kim, Jeeyeon Park, Hye-Won Kim, Jinsik Kim, Joonwon Bae, Min Hee Lee, Dong-Sik Shin","doi":"10.1007/s13206-023-00120-4","DOIUrl":"https://doi.org/10.1007/s13206-023-00120-4","url":null,"abstract":"","PeriodicalId":8768,"journal":{"name":"BioChip Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135061140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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