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Copper-catalyzed yne-allylic substitutions: concept and recent developments. 铜催化的炔烯丙基置换：概念和最新进展。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI: 10.3762/bjoc.20.232
Shuang Yang, Xinqiang Fang
{"title":"Copper-catalyzed yne-allylic substitutions: concept and recent developments.","authors":"Shuang Yang, Xinqiang Fang","doi":"10.3762/bjoc.20.232","DOIUrl":"10.3762/bjoc.20.232","url":null,"abstract":"<p><p>The catalytic (asymmetric) allylation and propargylation have been established as powerful strategies allowing access to enantioenriched α-chiral alkenes and alkynes. In this context, combining allylic and propargylic substitutions offers new opportunities to expand the scope of transition metal-catalyzed substitution reactions. Since its discovery in 2022, copper-catalyzed yne-allylic substitution has undergone rapid development and significant progress has been made using the key copper vinyl allenylidene intermediates. This review summarizes the developments and illustrates the influences of copper salt, ligand, and substitution pattern of the substrate on the regioselectivity and stereoselectivity.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"20 ","pages":"2739-2775"},"PeriodicalIF":2.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of a pyrene derivative with cationic [60]fullerene in phospholipid membranes and its effects on photodynamic actions. 芘衍生物与阳离子[60]富勒烯在磷脂膜中的相互作用及其对光动力作用的影响。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.3762/bjoc.20.231
Hayato Takagi, Çetin Çelik, Ryosuke Fukuda, Qi Guo, Tomohiro Higashino, Hiroshi Imahori, Yoko Yamakoshi, Tatsuya Murakami
{"title":"Interaction of a pyrene derivative with cationic [60]fullerene in phospholipid membranes and its effects on photodynamic actions.","authors":"Hayato Takagi, Çetin Çelik, Ryosuke Fukuda, Qi Guo, Tomohiro Higashino, Hiroshi Imahori, Yoko Yamakoshi, Tatsuya Murakami","doi":"10.3762/bjoc.20.231","DOIUrl":"10.3762/bjoc.20.231","url":null,"abstract":"<p><p>We have reported that upon visible light irradiation, ferrocene-porphyrin-[60]fullerene triad molecules yield long-lived charge-separated states, enabling the control of the plasma membrane potential (<i>V</i> <sub>m</sub>) in living cells. These previous studies indicated that the localization of the triad molecules in a specific intra-membrane orientation and the suppression of the photodynamic actions of the [60]fullerene (C<sub>60</sub>) moiety are likely important to achieve fast and safe control of <i>V</i> <sub>m</sub>, respectively. In this study, by mimicking our previous system of triad molecules and living cells, we report a simplified model system with a cationic C<sub>60</sub> derivative (catC<sub>60</sub>) and a liposome with embedded 1-pyrenebutyric acid (PyBA) to demonstrate that the addition of PyBA was important to achieve fast and safer control of <i>V</i> <sub>m</sub>.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"20 ","pages":"2732-2738"},"PeriodicalIF":2.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of spiroindolenines through a one-pot multistep process mediated by visible light. 以可见光为媒介，通过一步法多步骤合成螺吲哚啉。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI: 10.3762/bjoc.20.230
Francesco Gambuti, Jacopo Pizzorno, Chiara Lambruschini, Renata Riva, Lisa Moni
{"title":"Synthesis of spiroindolenines through a one-pot multistep process mediated by visible light.","authors":"Francesco Gambuti, Jacopo Pizzorno, Chiara Lambruschini, Renata Riva, Lisa Moni","doi":"10.3762/bjoc.20.230","DOIUrl":"10.3762/bjoc.20.230","url":null,"abstract":"<p><p>Spiro-heterocyclic indolenines are privileged scaffolds widely present in numerous indole alkaloids. Here, we develop a novel approach for the one-pot multistep synthesis of different spiro[indole-isoquinolines]. The protocol proposed involves the visible light mediated oxidation of <i>N</i>-aryl tertiary amines using bromochloroform with the generation of a reactive iminium species, which reacts with an isocyanide and an electron-rich aniline in a three-component Ugi-type reaction to give an α-aminoamidine. This compound might undergo an additional visible light-mediated oxidation to furnish a second iminium intermediate, which acts as electrophile in an intramolecular electrophilic aromatic substitution giving the final spiro-indolenine. The scope of the process has been investigated with respect to all three components. Simple operations, mild conditions, and good yields make this strategy a convenient and sustainable way to obtain novel spiro-indolenine derivatives.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"20 ","pages":"2722-2731"},"PeriodicalIF":2.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Young investigators in natural products chemistry, biosynthesis, and enzymology. 天然产品化学、生物合成和酶学领域的年轻研究人员。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI: 10.3762/bjoc.20.229
Jeffrey D Rudolf, Lena Barra, Takayoshi Awakawa
{"title":"Young investigators in natural products chemistry, biosynthesis, and enzymology.","authors":"Jeffrey D Rudolf, Lena Barra, Takayoshi Awakawa","doi":"10.3762/bjoc.20.229","DOIUrl":"https://doi.org/10.3762/bjoc.20.229","url":null,"abstract":"","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"20 ","pages":"2720-2721"},"PeriodicalIF":2.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of benzo[f]quinazoline-1,3(2H,4H)-diones. 苯并[f]喹唑啉-1,3(2H,4H)-二酮的合成。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2024-10-28 eCollection Date: 2024-01-01 DOI: 10.3762/bjoc.20.228
Ruben Manuel Figueira de Abreu, Peter Ehlers, Peter Langer
{"title":"Synthesis of benzo[<i>f</i>]quinazoline-1,3(2<i>H</i>,4<i>H</i>)-diones.","authors":"Ruben Manuel Figueira de Abreu, Peter Ehlers, Peter Langer","doi":"10.3762/bjoc.20.228","DOIUrl":"10.3762/bjoc.20.228","url":null,"abstract":"<p><p>We report the synthesis of polycyclic uracil derivatives. The method is based on palladium-catalysed Sonogashira-Hagihara and Suzuki-Miyaura cross-coupling reactions followed by Brønsted acid-mediated cycloisomerisation. The developed methodology tolerates various functional groups and leads to moderate up to quantitative yields of the final products. The impact of different functional groups on the optical properties was studied by UV-vis and fluorescence spectroscopy.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"20 ","pages":"2708-2719"},"PeriodicalIF":2.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
5th International Symposium on Synthesis and Catalysis (ISySyCat2023). 第五届合成与催化国际研讨会（ISySyCat2023）。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2024-10-28 eCollection Date: 2024-01-01 DOI: 10.3762/bjoc.20.227
Anthony J Burke, Elisabete P Carreiro
{"title":"5th International Symposium on Synthesis and Catalysis (ISySyCat2023).","authors":"Anthony J Burke, Elisabete P Carreiro","doi":"10.3762/bjoc.20.227","DOIUrl":"10.3762/bjoc.20.227","url":null,"abstract":"","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"20 ","pages":"2704-2707"},"PeriodicalIF":2.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of fluoroalkenes and fluoroenynes via cross-coupling reactions using novel multihalogenated vinyl ethers. 使用新型多卤代乙烯基醚通过交叉偶联反应合成氟烯和氟炔。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2024-10-24 eCollection Date: 2024-01-01 DOI: 10.3762/bjoc.20.226
Yukiko Karuo, Keita Hirata, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote
{"title":"Synthesis of fluoroalkenes and fluoroenynes via cross-coupling reactions using novel multihalogenated vinyl ethers.","authors":"Yukiko Karuo, Keita Hirata, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote","doi":"10.3762/bjoc.20.226","DOIUrl":"10.3762/bjoc.20.226","url":null,"abstract":"<p><p>In this study, we develop the synthesis methods of fluoroalkenes and fluoroenynes via Suzuki-Miyaura and Sonogashira cross-coupling reactions using novel multihalogenated fluorovinyl ethers, which are easily prepared from the reaction between phenols and 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane). These reactions make use of the unique structure of multihalogenated fluorovinyl ethers, which contains a reactive bromine atom, to afford a series of fluoroalkenes and fluoroenynes in moderate to high yields.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"20 ","pages":"2691-2703"},"PeriodicalIF":2.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoluminescence color-tuning with polymer-dispersed fluorescent films containing two fluorinated diphenylacetylene-type fluorophores. 利用含有两种氟化二苯基乙炔型荧光团的聚合物分散荧光膜进行光致发光颜色调节。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2024-10-23 eCollection Date: 2024-01-01 DOI: 10.3762/bjoc.20.225
Kazuki Kobayashi, Shigeyuki Yamada, Motohiro Yasui, Tsutomu Konno
{"title":"Photoluminescence color-tuning with polymer-dispersed fluorescent films containing two fluorinated diphenylacetylene-type fluorophores.","authors":"Kazuki Kobayashi, Shigeyuki Yamada, Motohiro Yasui, Tsutomu Konno","doi":"10.3762/bjoc.20.225","DOIUrl":"10.3762/bjoc.20.225","url":null,"abstract":"<p><p>The development of organic light-emitting devices has driven demand for new luminescent materials, particularly after the 2001 discovery of aggregation-induced emission. This study focuses on fluorinated diphenylacetylene-based luminescent molecules, revealing that specific molecular modifications can enhance fluorescence and achieve a wide range of photoluminescence colors. A simple and effective luminescence color-tuning method is proposed to investigate the photoluminescence behavior of two-component polymer dispersion films blended with two types of fluorinated diphenylacetylenes, namely blue- and yellow- or red-fluorescent fluorinated diphenylacetylenes. It is confirmed that if blue and green-yellow or yellow fluorophores are blended in appropriate ratios, a binary blend with color coordinates (0.20, 0.32) can be achieved, which approaches the white point of pure white emission. These findings contribute to the development of effective lighting and display devices as new white-light-emitting materials.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"20 ","pages":"2682-2690"},"PeriodicalIF":2.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational design for enantioselective CO2 capture: asymmetric frustrated Lewis pairs in epoxide transformations. 对映选择性二氧化碳捕获的计算设计：环氧化物转化中的不对称受挫路易斯对。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2024-10-22 eCollection Date: 2024-01-01 DOI: 10.3762/bjoc.20.224
Maxime Ferrer, Iñigo Iribarren, Tim Renningholtz, Ibon Alkorta, Cristina Trujillo
{"title":"Computational design for enantioselective CO<sub>2</sub> capture: asymmetric frustrated Lewis pairs in epoxide transformations.","authors":"Maxime Ferrer, Iñigo Iribarren, Tim Renningholtz, Ibon Alkorta, Cristina Trujillo","doi":"10.3762/bjoc.20.224","DOIUrl":"10.3762/bjoc.20.224","url":null,"abstract":"<p><p>Carbon capture and utilisation (CCU) technologies offer a compelling strategy to mitigate rising atmospheric carbon dioxide levels. Despite extensive research on the CO<sub>2</sub> insertion into epoxides to form cyclic carbonates, the stereochemical implications of this reaction have been largely overlooked, despite the prevalence of racemic epoxide solutions. This study introduces an in silico approach to design asymmetric frustrated Lewis pairs (FLPs) aimed at controlling reaction stereochemistry. Four FLP scaffolds, incorporating diverse Lewis acids (LA), Lewis bases (LB), and substituents, were assessed via volcano plot analysis to identify the most promising catalysts. By strategically modifying LB substituents to induce asymmetry, a stereoselective catalytic scaffold was developed, favouring one enantiomer from both epoxide enantiomers. This work advances the in silico design of FLPs, highlighting their potential as asymmetric CCU catalysts with implications for optimising catalyst efficiency and selectivity in sustainable chemistry applications.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"20 ","pages":"2668-2681"},"PeriodicalIF":2.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transition-metal-free decarbonylation-oxidation of 3-arylbenzofuran-2(3H)-ones: access to 2-hydroxybenzophenones. 3- 芳基苯并呋喃-2(3H)-酮的无过渡金属脱羰基氧化反应：获得 2-羟基二苯甲酮。
IF 2.2 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI: 10.3762/bjoc.20.223
Bhaskar B Dhotare, Seema V Kanojia, Chahna K Sakhiya, Amey Wadawale, Dibakar Goswami
{"title":"Transition-metal-free decarbonylation-oxidation of 3-arylbenzofuran-2(3<i>H</i>)-ones: access to 2-hydroxybenzophenones.","authors":"Bhaskar B Dhotare, Seema V Kanojia, Chahna K Sakhiya, Amey Wadawale, Dibakar Goswami","doi":"10.3762/bjoc.20.223","DOIUrl":"10.3762/bjoc.20.223","url":null,"abstract":"<p><p>A transition-metal-free decarbonylation-oxidation protocol for the conversion of 3-arylbenzofuran-2(3<i>H</i>)-ones to 2-hydroxybenzophenones under mild conditions has been developed. NMR studies confirmed the role of in-situ-generated hydroperoxide in the conversion. The protocol was applied to a diverse range of substrates to access the target products in good to excellent yields. A structure-activity study for the 5-substituted-2-hydroxybenzophenones towards UV-protection abilities has been verified by mathematical calculations.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"20 ","pages":"2655-2667"},"PeriodicalIF":2.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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