BMC medical physics最新文献

{"title":"Microwave open-ended coaxial dielectric probe: interpretation of the sensing volume re-visited.","authors":"Paul M Meaney,&nbsp;Andrew P Gregory,&nbsp;Neil R Epstein,&nbsp;Keith D Paulsen","doi":"10.1186/1756-6649-14-3","DOIUrl":"https://doi.org/10.1186/1756-6649-14-3","url":null,"abstract":"<p><strong>Background: </strong>Tissue dielectric properties are specific to physiological changes and consequently have been pursued as imaging biomarkers of cancer and other pathological disorders. However, a recent study (Phys Med Biol 52:2637-2656, 2007; Phys Med Biol 52:6093-6115, 2007), which utilized open-ended dielectric probing techniques and a previously established sensing volume, reported that the dielectric property contrast may only be 10% or less between breast cancer and normal fibroglandular tissue whereas earlier data suggested ratios of 4:1 and higher may exist. Questions about the sensing volume of this probe relative to the amount of tissue interrogated raise the distinct possibility that the conclusions drawn from that study may have been over interpreted.</p><p><strong>Methods: </strong>We performed open-ended dielectric probe measurements in two-layer compositions consisting of a background liquid and a planar piece of Teflon that was translated to predetermined distances away from the probe tip to assess the degree to which the probe produced property estimates representative of the compositional averages of the dielectric properties of the two materials resident within a small sensing volume around the tip of the probe.</p><p><strong>Results: </strong>When Teflon was in contact with the probe, the measured properties were essentially those of pure Teflon whereas the properties were nearly identical to those of the intervening liquid when the Teflon was located more than 2 mm from the probe tip. However, when the Teflon was moved closer to the probe tip, the dielectric property measurements were not linearly related to the compositional fraction of the two materials, but reflected nearly 50% of those of the intervening liquid at separation distances as small as 0.2 mm, and approximately 90% of the liquid when the Teflon was located 0.5 mm from the probe tip.</p><p><strong>Conclusion: </strong>These results suggest that the measurement methods reported in the most recent breast tissue dielectric property study are not likely to return the compositional averages of the breast tissue specimens evaluated, and thus, the conclusions reached about the expected dielectric property contrast in breast cancer from this specimen study may not be correct.</p>","PeriodicalId":87528,"journal":{"name":"BMC medical physics","volume":"14 ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2014-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1756-6649-14-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32488554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of cervical cells based on fractal and Euclidian geometrical measurements: Intrinsic Geometric Cellular Organization.","authors":"Signed E Prieto Bohórquez,&nbsp;Javier O Rodríguez Velásquez,&nbsp;S Catalina Correa Herrera,&nbsp;M Yolanda Soracipa Muñoz","doi":"10.1186/1756-6649-14-2","DOIUrl":"https://doi.org/10.1186/1756-6649-14-2","url":null,"abstract":"<p><strong>Background: </strong>Fractal geometry has been the basis for the development of a diagnosis of preneoplastic and neoplastic cells that clears up the undetermination of the atypical squamous cells of undetermined significance (ASCUS).</p><p><strong>Methods: </strong>Pictures of 40 cervix cytology samples diagnosed with conventional parameters were taken. A blind study was developed in which the clinic diagnosis of 10 normal cells, 10 ASCUS, 10 L-SIL and 10 H-SIL was masked. Cellular nucleus and cytoplasm were evaluated in the generalized Box-Counting space, calculating the fractal dimension and number of spaces occupied by the frontier of each object. Further, number of pixels occupied by surface of each object was calculated. Later, the mathematical features of the measures were studied to establish differences or equalities useful for diagnostic application. Finally, the sensibility, specificity, negative likelihood ratio and diagnostic concordance with Kappa coefficient were calculated.</p><p><strong>Results: </strong>Simultaneous measures of the nuclear surface and the subtraction between the boundaries of cytoplasm and nucleus, lead to differentiate normality, L-SIL and H-SIL. Normality shows values less than or equal to 735 in nucleus surface and values greater or equal to 161 in cytoplasm-nucleus subtraction. L-SIL cells exhibit a nucleus surface with values greater than or equal to 972 and a subtraction between nucleus-cytoplasm higher to 130. L-SIL cells show cytoplasm-nucleus values less than 120. The rank between 120-130 in cytoplasm-nucleus subtraction corresponds to evolution between L-SIL and H-SIL. Sensibility and specificity values were 100%, the negative likelihood ratio was zero and Kappa coefficient was equal to 1.</p><p><strong>Conclusions: </strong>A new diagnostic methodology of clinic applicability was developed based on fractal and euclidean geometry, which is useful for evaluation of cervix cytology.</p>","PeriodicalId":87528,"journal":{"name":"BMC medical physics","volume":"14 ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2014-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1756-6649-14-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32271433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewer acknowledgement 2013","authors":"P. O'donovan","doi":"10.1186/1756-6649-14-1","DOIUrl":"https://doi.org/10.1186/1756-6649-14-1","url":null,"abstract":"","PeriodicalId":87528,"journal":{"name":"BMC medical physics","volume":"14 1","pages":"1 - 1"},"PeriodicalIF":0.0,"publicationDate":"2014-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1756-6649-14-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65773470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of actigraphs uniaxial and triaxial accelerometers for assessment of physical activity in adults in laboratory conditions.","authors":"Louise A Kelly,&nbsp;Duncan Ge McMillan,&nbsp;Alexandra Anderson,&nbsp;Morgan Fippinger,&nbsp;Gunnar Fillerup,&nbsp;Jane Rider","doi":"10.1186/1756-6649-13-5","DOIUrl":"https://doi.org/10.1186/1756-6649-13-5","url":null,"abstract":"<p><strong>Background: </strong>Few studies to date have directly compared the Actigraphs GT1M and the GT3X, it would be of tremendous value to know if these accelerometers give similar information about intensities of PA. Knowing if output is similar would have implications for cross-examination of studies. The purpose of the study was to assess the validity of the GT1M and the GT3X Actigraph accelerometers for the assessment of physical activity against oxygen consumption in laboratory conditions.</p><p><strong>Methods: </strong>Forty-two college-aged participants aged 18-25 years wore the GT1M and the GT3X on their right hip during treadmill exercise at three different speeds, slow walking 4.8 km.h-1, fast walking 6.4 km.h-1, and running 9.7 km.h-1). Oxygen consumption was measured minute-by minute using a metabolic system. Bland-Altman plots were used to assess agreement between activity counts from the GT3X and GT1M, and correlations were assessed the ability of the accelerometers to assess physical activity.</p><p><strong>Results: </strong>Bias for 4.8 km.h-1 was 2814.4 cpm (limits 1211.3 to 4417.4), for 6.4 km.h-1 was 3713.6 cpm (limits 1573.2 to 5854.0), and for 9.7 km.h-1 was-3811.2 cpm (limits 842.1 to 6780.3). Correlations between counts per minute for the GT1M and the GT3X were significantly correlated with VO2 (r = 0.881, p < 0.001; r = 0.810, p < 0.001 respectively).</p><p><strong>Conclusion: </strong>The present study showed that both the GT1M and the GT3X accurately measure physical activity when compared to oxygen consumption.</p>","PeriodicalId":87528,"journal":{"name":"BMC medical physics","volume":"13 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2013-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1756-6649-13-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31904702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time prostate motion assessment: image-guidance and the temporal dependence of intra-fraction motion.","authors":"Avilash K Cramer,&nbsp;Amanu G Haile,&nbsp;Sanja Ognjenovic,&nbsp;Tulsee S Doshi,&nbsp;William Matthew Reilly,&nbsp;Katherine E Rubinstein,&nbsp;Nima Nabavizadeh,&nbsp;Thuan Nguyen,&nbsp;Lu Z Meng,&nbsp;Martin Fuss,&nbsp;James A Tanyi,&nbsp;Arthur Y Hung","doi":"10.1186/1756-6649-13-4","DOIUrl":"https://doi.org/10.1186/1756-6649-13-4","url":null,"abstract":"<p><strong>Background: </strong>The rapid adoption of image-guidance in prostate intensity-modulated radiotherapy (IMRT) results in longer treatment times, which may result in larger intrafraction motion, thereby negating the advantage of image-guidance. This study aims to qualify and quantify the contribution of image-guidance to the temporal dependence of intrafraction motion during prostate IMRT.</p><p><strong>Methods: </strong>One-hundred and forty-three patients who underwent conventional IMRT (n=67) or intensity-modulated arc therapy (IMAT/RapidArc, n=76) for localized prostate cancer were evaluated. Intrafraction motion assessment was based on continuous RL (lateral), SI (longitudinal), and AP (vertical) positional detection of electromagnetic transponders at 10 Hz. Daily motion amplitudes were reported as session mean, median, and root-mean-square (RMS) displacements. Temporal effect was evaluated by categorizing treatment sessions into 4 different classes: IMRTc (transponder only localization), IMRTcc (transponder + CBCT localization), IMATc (transponder only localization), or IMATcc (transponder + CBCT localization).</p><p><strong>Results: </strong>Mean/median session times were 4.15/3.99 min (IMATc), 12.74/12.19 min (IMATcc), 5.99/5.77 min (IMRTc), and 12.98/12.39 min (IMRTcc), with significant pair-wise difference (p<0.0001) between all category combinations except for IMRTcc vs. IMATcc (p>0.05). Median intrafraction motion difference between CBCT and non-CBCT categories strongly correlated with time for RMS (t-value=17.29; p<0.0001), SI (t-value=-4.25; p<0.0001), and AP (t-value=2.76; p<0.0066), with a weak correlation for RL (t-value=1.67; p=0.0971). Treatment time reduction with non-CBCT treatment categories showed reductions in the observed intrafraction motion: systematic error (Σ)<0.6 mm and random error (σ)<1.2 mm compared with ≤0.8 mm and <1.6 mm, respectively, for CBCT-involved treatment categories.</p><p><strong>Conclusions: </strong>For treatment durations >4-6 minutes, and without any intrafraction motion mitigation protocol in place, patient repositioning is recommended, with at least the acquisition of the lateral component of an orthogonal image pair in the absence of volumetric imaging.</p>","PeriodicalId":87528,"journal":{"name":"BMC medical physics","volume":"13 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2013-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1756-6649-13-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31752980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictions of CD4 lymphocytes' count in HIV patients from complete blood count.","authors":"Javier O Rodríguez,&nbsp;Signed E Prieto,&nbsp;Catalina Correa,&nbsp;Carlos E Pérez,&nbsp;Jessica T Mora,&nbsp;Juan Bravo,&nbsp;Yolanda Soracipa,&nbsp;Luisa F Alvarez","doi":"10.1186/1756-6649-13-3","DOIUrl":"https://doi.org/10.1186/1756-6649-13-3","url":null,"abstract":"<p><strong>Background: </strong>HIV diagnosis, prognostic and treatment requires T CD4 lymphocytes' number from flow cytometry, an expensive technique often not available to people in developing countries. The aim of this work is to apply a previous developed methodology that predicts T CD4 lymphocytes' value based on total white blood cell (WBC) count and lymphocytes count applying sets theory, from information taken from the Complete Blood Count (CBC).</p><p><strong>Methods: </strong>Sets theory was used to classify into groups named A, B, C and D the number of leucocytes/mm3, lymphocytes/mm3, and CD4/μL3 subpopulation per flow cytometry of 800 HIV diagnosed patients. Union between sets A and C, and B and D were assessed, and intersection between both unions was described in order to establish the belonging percentage to these sets. Results were classified into eight ranges taken by 1000 leucocytes/mm3, calculating the belonging percentage of each range with respect to the whole sample.</p><p><strong>Results: </strong>Intersection (A ∪ C) ∩ (B ∪ D) showed an effectiveness in the prediction of 81.44% for the range between 4000 and 4999 leukocytes, 91.89% for the range between 3000 and 3999, and 100% for the range below 3000.</p><p><strong>Conclusions: </strong>Usefulness and clinical applicability of a methodology based on sets theory were confirmed to predict the T CD4 lymphocytes' value, beginning with WBC and lymphocytes' count from CBC. This methodology is new, objective, and has lower costs than the flow cytometry which is currently considered as Gold Standard.</p>","PeriodicalId":87528,"journal":{"name":"BMC medical physics","volume":"13 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2013-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1756-6649-13-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31731491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose mapping sensitivity to deformable registration uncertainties in fractionated radiotherapy - applied to prostate proton treatments.","authors":"David Tilly, Nina Tilly, Anders Ahnesjö","doi":"10.1186/1756-6649-13-2","DOIUrl":"10.1186/1756-6649-13-2","url":null,"abstract":"<p><strong>Background: </strong>Calculation of accumulated dose in fractionated radiotherapy based on spatial mapping of the dose points generally requires deformable image registration (DIR). The accuracy of the accumulated dose thus depends heavily on the DIR quality. This motivates investigations of how the registration uncertainty influences dose planning objectives and treatment outcome predictions.A framework was developed where the dose mapping can be associated with a variable known uncertainty to simulate the DIR uncertainties in a clinical workflow. The framework enabled us to study the dependence of dose planning metrics, and the predicted treatment outcome, on the DIR uncertainty. The additional planning margin needed to compensate for the dose mapping uncertainties can also be determined. We applied the simulation framework to a hypofractionated proton treatment of the prostate using two different scanning beam spot sizes to also study the dose mapping sensitivity to penumbra widths.</p><p><strong>Results: </strong>The planning parameter most sensitive to the DIR uncertainty was found to be the target D95. We found that the registration mean absolute error needs to be ≤0.20 cm to obtain an uncertainty better than 3% of the calculated D95 for intermediate sized penumbras. Use of larger margins in constructing PTV from CTV relaxed the registration uncertainty requirements to the cost of increased dose burdens to the surrounding organs at risk.</p><p><strong>Conclusions: </strong>The DIR uncertainty requirements should be considered in an adaptive radiotherapy workflow since this uncertainty can have significant impact on the accumulated dose. The simulation framework enabled quantification of the accuracy requirement for DIR algorithms to provide satisfactory clinical accuracy in the accumulated dose.</p>","PeriodicalId":87528,"journal":{"name":"BMC medical physics","volume":"13 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2013-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31507979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 2D Hotelling filter - a quantitative noise-reducing principal-component filter for dynamic PET data, with applications in patient dose reduction.","authors":"Jan Axelsson,&nbsp;Jens Sörensen","doi":"10.1186/1756-6649-13-1","DOIUrl":"https://doi.org/10.1186/1756-6649-13-1","url":null,"abstract":"<p><strong>Background: </strong>In this paper we apply the principal-component analysis filter (Hotelling filter) to reduce noise from dynamic positron-emission tomography (PET) patient data, for a number of different radio-tracer molecules. We furthermore show how preprocessing images with this filter improves parametric images created from such dynamic sequence.We use zero-mean unit variance normalization, prior to performing a Hotelling filter on the slices of a dynamic time-series. The Scree-plot technique was used to determine which principal components to be rejected in the filter process. This filter was applied to [11C]-acetate on heart and head-neck tumors, [18F]-FDG on liver tumors and brain, and [11C]-Raclopride on brain. Simulations of blood and tissue regions with noise properties matched to real PET data, was used to analyze how quantitation and resolution is affected by the Hotelling filter. Summing varying parts of a 90-frame [18F]-FDG brain scan, we created 9-frame dynamic scans with image statistics comparable to 20 MBq, 60 MBq and 200 MBq injected activity. Hotelling filter performed on slices (2D) and on volumes (3D) were compared.</p><p><strong>Results: </strong>The 2D Hotelling filter reduces noise in the tissue uptake drastically, so that it becomes simple to manually pick out regions-of-interest from noisy data. 2D Hotelling filter introduces less bias than 3D Hotelling filter in focal Raclopride uptake. Simulations show that the Hotelling filter is sensitive to typical blood peak in PET prior to tissue uptake have commenced, introducing a negative bias in early tissue uptake. Quantitation on real dynamic data is reliable. Two examples clearly show that pre-filtering the dynamic sequence with the Hotelling filter prior to Patlak-slope calculations gives clearly improved parametric image quality. We also show that a dramatic dose reduction can be achieved for Patlak slope images without changing image quality or quantitation.</p><p><strong>Conclusions: </strong>The 2D Hotelling-filtering of dynamic PET data is a computer-efficient method that gives visually improved differentiation of different tissues, which we have observed improve manual or automated region-of-interest delineation of dynamic data. Parametric Patlak images on Hotelling-filtered data display improved clarity, compared to non-filtered Patlak slope images without measurable loss of quantitation, and allow a dramatic decrease in patient injected dose.</p>","PeriodicalId":87528,"journal":{"name":"BMC medical physics","volume":"13 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2013-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1756-6649-13-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31347641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiscale forward electromagnetic model of uterine contractions during pregnancy.","authors":"Patricio S La Rosa, Hari Eswaran, Hubert Preissl, Arye Nehorai","doi":"10.1186/1756-6649-12-4","DOIUrl":"10.1186/1756-6649-12-4","url":null,"abstract":"<p><strong>Background: </strong>Analyzing and monitoring uterine contractions during pregnancy is relevant to the field of reproductive health assessment. Its clinical importance is grounded in the need to reliably predict the onset of labor at term and pre-term. Preterm births can cause health problems or even be fatal for the fetus. Currently, there are no objective methods for consistently predicting the onset of labor based on sensing of the mechanical or electrophysiological aspects of uterine contractions. Therefore, modeling uterine contractions could help to better interpret such measurements and to develop more accurate methods for predicting labor. In this work, we develop a multiscale forward electromagnetic model of myometrial contractions during pregnancy. In particular, we introduce a model of myometrial current source densities and compute its magnetic field and action potential at the abdominal surface, using Maxwell's equations and a four-compartment volume conductor geometry. To model the current source density at the myometrium we use a bidomain approach. We consider a modified version of the Fitzhugh-Nagumo (FHN) equation for modeling ionic currents in each myocyte, assuming a plateau-type transmembrane potential, and we incorporate the anisotropic nature of the uterus by designing conductivity-tensor fields.</p><p><strong>Results: </strong>We illustrate our modeling approach considering a spherical uterus and one pacemaker located in the fundus. We obtained a travelling transmembrane potential depolarizing from -56 mV to -16 mV and an average potential in the plateau area of -25 mV with a duration, before hyperpolarization, of 35 s, which is a good approximation with respect to the average recorded transmembrane potentials at term reported in the technical literature. Similarly, the percentage of myometrial cells contracting as a function of time had the same symmetric properties and duration as the intrauterine pressure waveforms of a pregnant human myometrium at term.</p><p><strong>Conclusions: </strong>We introduced a multiscale modeling approach of uterine contractions which allows for incorporating electrophysiological and anatomical knowledge of the myometrium jointly. Our results are in good agreement with the values reported in the experimental technical literature, and these are potentially important as a tool for helping in the characterization of contractions and for predicting labor using magnetomyography (MMG) and electromyography (EMG).</p>","PeriodicalId":87528,"journal":{"name":"BMC medical physics","volume":"12 ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2012-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31026303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study of radiosensitivity in left handed compared to right handed healthy women.","authors":"Meysam Khosravifarsani,&nbsp;Ali Shabestani Monfared,&nbsp;Haleh Akhavan-Niaki,&nbsp;Dariush Moslemi,&nbsp;Karimollah Hajian-Tilaki,&nbsp;Farideh Elahimanesh,&nbsp;Sajad Borzoueisileh,&nbsp;Nayer Seyfizadeh,&nbsp;Mehrangiz Amiri","doi":"10.1186/1756-6649-12-3","DOIUrl":"https://doi.org/10.1186/1756-6649-12-3","url":null,"abstract":"<p><strong>Unlabelled: </strong></p><p><strong>Background: </strong>Radiosensitivity is an inheriting trait that mainly depends on genetic factors. it is well known in similar dose of ionizing radiation and identical biological characteristics 9-10 percent of normal population have higher radiation response. Some reports indicate that distribution of breast cancer, immune diseases including autoimmune diseases as example lupus, Myasthenia Gravies and even the rate of allergy are more frequent in left handed individuals compared to right handed individuals. The main goal of the present study is determination of radiosensitivity in left handed compared to right handed in healthy women by cytokinesis blocked micronuclei [CBMN] assay.5 ml peripheral fresh blood sample was taken from 100 healthy women including 60 right handed and 40 left handed. The age of participants was between 20-25 old years and they had been matched by sex. After blood sampling, blood samples were divided to 2 groups including irradiated and non-irradiated lymphocytes that irradiated lymphocytes were exposed to 2 Gy CO-60 Gama rays source then chromosomal aberrations was analyzed by CBMN [Cytokinesis Blocked Micronuclei Assay].</p><p><strong>Results: </strong>Our results have shown radiosensitivity index [RI] in left-handers compared to right-handers is higher. Furthermore, the mean MN frequency is elevated in irradiated lymphocytes of left-handers in comparison with right-handers.</p><p><strong>Conclusion: </strong>Our results from CBMN assay have shown radiosensitivity in the left handed is higher than right handed women but more attempts need to prove this hypothesis.</p>","PeriodicalId":87528,"journal":{"name":"BMC medical physics","volume":"12 ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2012-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1756-6649-12-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30856864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}